CL2018000179A1 - Monoclonal antibodies specific for the human syncytial respiratory virus (vrsh) antigen, produced and secreted by cellular hybridomas, useful for the detection and diagnosis of infection caused by vrsh (sun divisional no. 2152-15) - Google Patents
Monoclonal antibodies specific for the human syncytial respiratory virus (vrsh) antigen, produced and secreted by cellular hybridomas, useful for the detection and diagnosis of infection caused by vrsh (sun divisional no. 2152-15)Info
- Publication number
- CL2018000179A1 CL2018000179A1 CL2018000179A CL2018000179A CL2018000179A1 CL 2018000179 A1 CL2018000179 A1 CL 2018000179A1 CL 2018000179 A CL2018000179 A CL 2018000179A CL 2018000179 A CL2018000179 A CL 2018000179A CL 2018000179 A1 CL2018000179 A1 CL 2018000179A1
- Authority
- CL
- Chile
- Prior art keywords
- vrsh
- hybridomas
- monoclonal antibodies
- detection
- secreted
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title abstract 3
- 210000004408 hybridoma Anatomy 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 230000000241 respiratory effect Effects 0.000 title abstract 2
- 230000001413 cellular effect Effects 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 208000015181 infectious disease Diseases 0.000 title 1
- 102100034574 P protein Human genes 0.000 abstract 1
- 108010015724 Prephenate Dehydratase Proteins 0.000 abstract 1
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Landscapes
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a anticuerpos monoclonales o fragmentos del mismo que se unen a la proteína P del Virus Respiratorio Sincicial humano (VRSh) que comprenden una región variable de la cadena pesada que tiene une secuencie con al menos un 90%, 95% o 99°b de identidad con la SEO ID No:1 o SEO ID 5 o una región variable de la cadena liviana que tiene una secuencia con al menos un 90%, 95°c 099% de identidad con la SEQ ID No:2 o SEQ ID No: 6. La invención también proporciona métodos de diagnóstico ex vivo o in vitro para detección del antígeno viral P de VRSh, en los cuales se utilizan los anticuerpos monoclonales producidos y secretados por los hibridomas 2E6/D2 y 6H5/H1. El invento puede ser usado en kits de detección para VRSh, que comprenda los anticuerpos producidos por los hibridomas mencionados. The present invention relates to monoclonal antibodies or fragments thereof that bind to the P-protein of the Human Syncytial Respiratory Virus (RSVh) comprising a variable region of the heavy chain having a sequence with at least 90%, 95% or 99 ° b identity with SEO ID No: 1 or SEO ID 5 or a variable region of the light chain that has a sequence with at least 90%, 95 ° c 099% identity with SEQ ID No: 2 or SEQ ID No: 6. The invention also provides ex vivo or in vitro diagnostic methods for the detection of RSV P viral antigen, in which the monoclonal antibodies produced and secreted by the 2E6 / D2 and 6H5 / H1 hybridomas are used. The invention can be used in detection kits for RSV, comprising the antibodies produced by the hybridomas mentioned.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2018000179A CL2018000179A1 (en) | 2018-01-22 | 2018-01-22 | Monoclonal antibodies specific for the human syncytial respiratory virus (vrsh) antigen, produced and secreted by cellular hybridomas, useful for the detection and diagnosis of infection caused by vrsh (sun divisional no. 2152-15) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CL2018000179A CL2018000179A1 (en) | 2018-01-22 | 2018-01-22 | Monoclonal antibodies specific for the human syncytial respiratory virus (vrsh) antigen, produced and secreted by cellular hybridomas, useful for the detection and diagnosis of infection caused by vrsh (sun divisional no. 2152-15) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2018000179A1 true CL2018000179A1 (en) | 2018-08-03 |
Family
ID=65561336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2018000179A CL2018000179A1 (en) | 2018-01-22 | 2018-01-22 | Monoclonal antibodies specific for the human syncytial respiratory virus (vrsh) antigen, produced and secreted by cellular hybridomas, useful for the detection and diagnosis of infection caused by vrsh (sun divisional no. 2152-15) |
Country Status (1)
| Country | Link |
|---|---|
| CL (1) | CL2018000179A1 (en) |
-
2018
- 2018-01-22 CL CL2018000179A patent/CL2018000179A1/en unknown
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