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CL2017000609A1 - Terapia de combinación con cenicriviroc para el tratamiento de la fibrosis - Google Patents

Terapia de combinación con cenicriviroc para el tratamiento de la fibrosis

Info

Publication number
CL2017000609A1
CL2017000609A1 CL2017000609A CL2017000609A CL2017000609A1 CL 2017000609 A1 CL2017000609 A1 CL 2017000609A1 CL 2017000609 A CL2017000609 A CL 2017000609A CL 2017000609 A CL2017000609 A CL 2017000609A CL 2017000609 A1 CL2017000609 A1 CL 2017000609A1
Authority
CL
Chile
Prior art keywords
receiver
cvc
cenicriviroc
agonist
fibrosis
Prior art date
Application number
CL2017000609A
Other languages
English (en)
Inventor
Eric Lefebvre
Original Assignee
Tobira Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tobira Therapeutics Inc filed Critical Tobira Therapeutics Inc
Publication of CL2017000609A1 publication Critical patent/CL2017000609A1/es

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Endocrinology (AREA)
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  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

<p>EL CENICRIVIROC (CVC) ES UN ANTAGONISTA ORALMENTE ACTIVO DE UNIÓN DE LIGANDO AL RECEPTOR DE QUIMIOCINA C-C TIPO 5 (CCR5) Y EL RECEPTOR DE QUIMIOCINA C-C DE TIPO 2 (CCR2). CVC BLOQUEA LA UNIÓN DE RANTES, MIP-LA Y MIP-1 B A CCR5, Y DE MCP-1/CCL2 A CCR2. SE PROPORCIONAN EN LA PRESENTE MÉTODOS PARA TRATAR LA FIBROSIS Y AFECCIONES RELACIONADAS QUE COMPRENDEN LA COADMINISTRACIÓN DE CVC CON AGONISTAS DE FXR, VITAMINA E DE DOSIS ELEVADA (>400 IU/D), UN AGONISTA DEL RECEPTOR ALFA ACTIVADO POR EL PROLIFERADOR DE PEROXISOMA (PPAR-A), AGONISTA DE PPAR-?, AGONISTA DE PPAR-D YIO ANTAGONISTAS DE QUIMIOCINA.</p>
CL2017000609A 2014-09-12 2017-03-13 Terapia de combinación con cenicriviroc para el tratamiento de la fibrosis CL2017000609A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462049591P 2014-09-12 2014-09-12
US201462076264P 2014-11-06 2014-11-06

Publications (1)

Publication Number Publication Date
CL2017000609A1 true CL2017000609A1 (es) 2017-12-11

Family

ID=55459630

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2017000609A CL2017000609A1 (es) 2014-09-12 2017-03-13 Terapia de combinación con cenicriviroc para el tratamiento de la fibrosis

Country Status (14)

Country Link
US (2) US20170319548A1 (es)
EP (2) EP3191100A4 (es)
JP (2) JP2017526713A (es)
KR (1) KR20170066418A (es)
CN (1) CN106999593A (es)
AU (1) AU2015314830B2 (es)
BR (1) BR112017004708A2 (es)
CA (1) CA2960284A1 (es)
CL (1) CL2017000609A1 (es)
IL (1) IL250960B (es)
MX (1) MX2017003215A (es)
RU (1) RU2723559C2 (es)
SG (2) SG11201701871SA (es)
WO (1) WO2016040860A1 (es)

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WO2016040860A1 (en) 2016-03-17
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