CL2013001609A1 - Uso de compuestos fenil o piridin sustituidos como intermediarios para la preparacion de un compuesto conjugado de dimeros de pirrolo[1,4]benzodiazepina (pbd) (divisional de la solicitud 489-2012). - Google Patents
Uso de compuestos fenil o piridin sustituidos como intermediarios para la preparacion de un compuesto conjugado de dimeros de pirrolo[1,4]benzodiazepina (pbd) (divisional de la solicitud 489-2012).Info
- Publication number
- CL2013001609A1 CL2013001609A1 CL2013001609A CL2013001609A CL2013001609A1 CL 2013001609 A1 CL2013001609 A1 CL 2013001609A1 CL 2013001609 A CL2013001609 A CL 2013001609A CL 2013001609 A CL2013001609 A CL 2013001609A CL 2013001609 A1 CL2013001609 A1 CL 2013001609A1
- Authority
- CL
- Chile
- Prior art keywords
- dimeros
- pbd
- benzodiazepine
- pyrrolo
- divisional
- Prior art date
Links
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical compound N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- 150000003222 pyridines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0904043A FR2949469A1 (fr) | 2009-08-25 | 2009-08-25 | Derives anticancereux, leur preparation et leur application en therapeutique |
| FR0904368A FR2949470B1 (fr) | 2009-08-25 | 2009-09-11 | Derives anticancereux, leur preparation et leur application therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013001609A1 true CL2013001609A1 (es) | 2013-11-04 |
Family
ID=41720559
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012000489A CL2012000489A1 (es) | 2009-08-25 | 2012-02-24 | Compuestos dimeros de pirrolo[2,1 c][1,4]benzodiazepin-5-ona (tomaimicina); conjugados de estos compuestos; procedimiento de preparacion de los conjugados; composicion farmaceutica que comprende a los compuestos o al conjugado; y uso de los compuestos y del conjugado como anticancerosos. |
| CL2013001609A CL2013001609A1 (es) | 2009-08-25 | 2013-06-05 | Uso de compuestos fenil o piridin sustituidos como intermediarios para la preparacion de un compuesto conjugado de dimeros de pirrolo[1,4]benzodiazepina (pbd) (divisional de la solicitud 489-2012). |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2012000489A CL2012000489A1 (es) | 2009-08-25 | 2012-02-24 | Compuestos dimeros de pirrolo[2,1 c][1,4]benzodiazepin-5-ona (tomaimicina); conjugados de estos compuestos; procedimiento de preparacion de los conjugados; composicion farmaceutica que comprende a los compuestos o al conjugado; y uso de los compuestos y del conjugado como anticancerosos. |
Country Status (34)
| Country | Link |
|---|---|
| US (2) | US8481042B2 (es) |
| EP (1) | EP2470547B1 (es) |
| JP (1) | JP5889189B2 (es) |
| KR (1) | KR20130026405A (es) |
| CN (1) | CN102753559B (es) |
| AR (1) | AR078143A1 (es) |
| AU (1) | AU2010288382B2 (es) |
| BR (1) | BR112012004146A2 (es) |
| CA (1) | CA2772102C (es) |
| CL (2) | CL2012000489A1 (es) |
| CO (1) | CO6612210A2 (es) |
| CR (1) | CR20120085A (es) |
| DO (1) | DOP2012000038A (es) |
| EA (1) | EA026488B1 (es) |
| EC (1) | ECSP12011688A (es) |
| ES (1) | ES2484690T3 (es) |
| FR (2) | FR2949469A1 (es) |
| GT (1) | GT201200046A (es) |
| HN (1) | HN2012000437A (es) |
| IL (1) | IL218262A0 (es) |
| MA (1) | MA33600B1 (es) |
| MX (1) | MX2012002434A (es) |
| MY (1) | MY157469A (es) |
| NI (1) | NI201200031A (es) |
| NZ (1) | NZ598401A (es) |
| PE (1) | PE20120992A1 (es) |
| PH (1) | PH12012500391A1 (es) |
| SG (1) | SG178537A1 (es) |
| TN (1) | TN2012000053A1 (es) |
| TW (1) | TWI477275B (es) |
| UA (1) | UA106507C2 (es) |
| UY (1) | UY32854A (es) |
| WO (1) | WO2011023883A1 (es) |
| ZA (1) | ZA201201397B (es) |
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| JP5875083B2 (ja) | 2010-04-15 | 2016-03-02 | メディミューン リミテッド | 増殖性疾患治療用ピロロベンゾジアゼピン |
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| US9399073B2 (en) | 2011-10-14 | 2016-07-26 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines |
| WO2013055990A1 (en) | 2011-10-14 | 2013-04-18 | Seattle Genetics, Inc. | Pyrrolobenzodiazepines and targeted conjugates |
| EA026643B1 (ru) | 2011-10-14 | 2017-04-28 | Сиэтл Дженетикс, Инк. | Пирролбензодиазепины и конъюгаты направленного действия |
| WO2013092998A1 (en) | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of antibodies |
| NZ741211A (en) | 2012-05-15 | 2019-09-27 | Seattle Genetics Inc | Self-stabilizing linker conjugates |
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| UY32913A (es) * | 2009-10-02 | 2011-04-29 | Sanofi Aventis | Nuevos maitansinoides y el uso de dichos maitansinoides para preparar conjugados con un anticuero |
| FR2963007B1 (fr) * | 2010-07-26 | 2013-04-05 | Sanofi Aventis | Derives anticancereux, leur preparation et leur application therapeutique |
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2009
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2010
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