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CL2012003521A1 - Derivado piperidino (r)-n-((r)-1-((3s-4s)-4-(4-clorofenil)-3,4-dihidroxi-3-metilpiperidin-1-il)-3-metil-1-oxobutan-2-il)-3,3-difluorociclopentanocarboxamida, modulador receptor quimiocinas; composicion farmaceutica; y uso del compuesto y su composicion en enfermedades inflamatorias y autoinmunitarias, entre otras. - Google Patents

Derivado piperidino (r)-n-((r)-1-((3s-4s)-4-(4-clorofenil)-3,4-dihidroxi-3-metilpiperidin-1-il)-3-metil-1-oxobutan-2-il)-3,3-difluorociclopentanocarboxamida, modulador receptor quimiocinas; composicion farmaceutica; y uso del compuesto y su composicion en enfermedades inflamatorias y autoinmunitarias, entre otras.

Info

Publication number
CL2012003521A1
CL2012003521A1 CL2012003521A CL2012003521A CL2012003521A1 CL 2012003521 A1 CL2012003521 A1 CL 2012003521A1 CL 2012003521 A CL2012003521 A CL 2012003521A CL 2012003521 A CL2012003521 A CL 2012003521A CL 2012003521 A1 CL2012003521 A1 CL 2012003521A1
Authority
CL
Chile
Prior art keywords
composition
inflammatory
compound
autoimmune diseases
chemokine receptor
Prior art date
Application number
CL2012003521A
Other languages
English (en)
Inventor
Robert J Cherney
John V Duncia
Daniel S Gardner
Joseph B Santella
Zhongyu Wang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CL2012003521A1 publication Critical patent/CL2012003521A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Veterinary Medicine (AREA)
  • Public Health (AREA)
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  • Immunology (AREA)
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  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)

Abstract

Compuesto específico derivado de piperidinilo de fórmula (I), modulador de la actividad de recepctor de quimiocinas; composición farmacéutica que lo comprende; uso del compuesto y de la composición para el tratamiento de enfermedades inflamatorias y autoinmunitarias tales como osteoartritis, aneurisma, enfermedad de Crohn, colitis ulcerosa, lupus, asma, esclerosis múltiple, entre otras.
CL2012003521A 2010-06-16 2012-12-12 Derivado piperidino (r)-n-((r)-1-((3s-4s)-4-(4-clorofenil)-3,4-dihidroxi-3-metilpiperidin-1-il)-3-metil-1-oxobutan-2-il)-3,3-difluorociclopentanocarboxamida, modulador receptor quimiocinas; composicion farmaceutica; y uso del compuesto y su composicion en enfermedades inflamatorias y autoinmunitarias, entre otras. CL2012003521A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35522510P 2010-06-16 2010-06-16

Publications (1)

Publication Number Publication Date
CL2012003521A1 true CL2012003521A1 (es) 2013-02-15

Family

ID=44278764

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2012003521A CL2012003521A1 (es) 2010-06-16 2012-12-12 Derivado piperidino (r)-n-((r)-1-((3s-4s)-4-(4-clorofenil)-3,4-dihidroxi-3-metilpiperidin-1-il)-3-metil-1-oxobutan-2-il)-3,3-difluorociclopentanocarboxamida, modulador receptor quimiocinas; composicion farmaceutica; y uso del compuesto y su composicion en enfermedades inflamatorias y autoinmunitarias, entre otras.

Country Status (20)

Country Link
US (1) US8642622B2 (es)
EP (1) EP2582670B1 (es)
JP (1) JP5795797B2 (es)
KR (1) KR20130032357A (es)
CN (1) CN103068800B (es)
AR (1) AR081943A1 (es)
AU (1) AU2011268373B2 (es)
BR (1) BR112012031768A2 (es)
CL (1) CL2012003521A1 (es)
CO (1) CO6650362A2 (es)
EA (1) EA022395B1 (es)
IL (1) IL223368A0 (es)
MA (1) MA34377B1 (es)
MX (1) MX2012014068A (es)
NZ (1) NZ605741A (es)
SG (1) SG186064A1 (es)
TN (1) TN2012000581A1 (es)
TW (1) TW201206435A (es)
WO (1) WO2011159852A1 (es)
ZA (1) ZA201300380B (es)

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