CL2009000118A1 -
Compounds derived from azabicyclic carboxamide or carboxathioamide, modulators of trv1; pharmaceutical composition containing them; process of preparation of compounds and intermediates; and use in the treatment of pain, inflammation, metabolic disorders, among others.
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Compounds derived from azabicyclic carboxamide or carboxathioamide, modulators of trv1; pharmaceutical composition containing them; process of preparation of compounds and intermediates; and use in the treatment of pain, inflammation, metabolic disorders, among others.
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Application filed by Sanofi AventisfiledCriticalSanofi Aventis
Publication of CL2009000118A1publicationCriticalpatent/CL2009000118A1/en
208000037265diseases, disorders, signs and symptomsDiseases0.000abstract1
230000001404mediated effectEffects0.000abstract1
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Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Compuestos derivados de carboxamidas azabicíclicas sustituidas; composición farmacéutica; procedimiento de preparación; útil en el tratamiento del dolor, inflamación, trastornos metabólicos, entre otras enfermedades, mediados por el receptor trpv1.Compounds derived from substituted azabicyclic carboxamides; pharmaceutical composition; preparation procedure; useful in the treatment of pain, inflammation, metabolic disorders, among other diseases, mediated by the trpv1 receptor.
CL2009000118A2008-01-222009-01-21
Compounds derived from azabicyclic carboxamide or carboxathioamide, modulators of trv1; pharmaceutical composition containing them; process of preparation of compounds and intermediates; and use in the treatment of pain, inflammation, metabolic disorders, among others.
CL2009000118A1
(en)
Compounds derived from azabicyclic carboxamide or carboxathioamide, modulators of trv1; pharmaceutical composition containing them; process of preparation of compounds and intermediates; and use in the treatment of pain, inflammation, metabolic disorders, among others.
Compounds derived from n-aza-bicyclic carboxamides; intermediate compounds; preparation procedure; pharmaceutical composition; and their use as antagonists or agonists of the trpv1-like receptor to treat pain, inflammation, metabolic, urological, gynecological, gastrointestinal, respiratory disorders.
Compounds derived from benzo (1,4) dioxin-2-ylmethyl-sulfamide; pharmaceutical compositions containing them; process to prepare them and use in the treatment of anxiety, epilepsy, pain, substance abuse, related disorders, among others.
Compounds derived from amides, modulators of the taar1 receptor; obtaining process; pharmaceutical composition; and use in the treatment of diseases such as depression, anxiety, stress, among others.
Compounds derived from piperidinyl substituted lactams, modulators of gpr119; Preparation process; pharmaceutical composition that includes them; treatment method; and use of the compound to treat diseases such as type 2 diabetes, metabolic syndrome, dyslipidemia, hypertension and schizophrenia, among others.
Substituted benzamide derivative compounds, as modulators of taar; preparation procedure; pharmaceutical composition; and its use in the treatment of depression, anxiety disorders, bipolar disorder, schizophrenia, epilepsy, migraine, Alzheimer's disease, metabolic disorders, among others.
Compounds derived from carboxamide and urea comprising aromatic substituted pyrazole, vanilloid receptor binders; pharmaceutical composition that includes them; and its use in the treatment and / or prophylaxis of pain, migraine, parkinson's disease, gastrointestinal disorders, osteoporosis, among other diseases.
Compounds derived from piperidinyl substituted lactams, modulators of gpr119; process to prepare the compounds; pharmaceutical composition comprising the compounds; and use of the compounds in the preparation of medicaments for the treatment or prevention of type 2 diabetes, obesity and related conditions
Amide derivative compounds of tetrahydroisoquinolyl-4-oxobutyric acid; pharmaceutical composition; and use in the treatment of disorders or diseases mediated by potassium channels kcnq2 / 3, such as pain, epilepsy. urinary incontinence, anxiety, among others.
Compounds derived from n-phenyl-4-oxo- (1,4-dihydroquinolin or 1h-quinolin) -3-carboxamide, modulators of the cystic fibrosis transmembrane conductance regulator (cftr); intermediary compounds; pharmaceutical composition; pharmaceutical kit; Preparation process; and use for the treatment of cystic fibrosis, diabetes, among others.
2-amino-quinoline derived compounds, antagonists of the serotonin 5-ht 5a receptor; preparation process, pharmaceutical composition; and use of the compounds in the prevention or treatment of depression, anxiety disorders, schizophrenia, panic disorders, memory disorders, dementia, among others.
Compounds derived from substituted 1,4-benzodiazepines, dipeptidylpeptidase inhibitors iv (dpp-iv); pharmaceutical composition; preparation procedure; and its use in the treatment of diseases such as type 2 diabetes, cataracts, glaucoma, benign prostatic hypertrophy, cancer, among others; intermediate compounds.
Compounds derived from 5-oxy / amino-indazole; glucocorticoid receptor modulators; the process of preparing said compounds; pharmaceutical compositions containing them; pharmaceutical combination; and its use in the treatment of inflammatory conditions, respiratory disorders, asthma and COPD.
Compounds derived from carboxycyclopropyl- (bis-phenyl-oxamides); pharmaceutical composition containing them; process for the preparation of the compositions and the use of the compounds in the treatment of diabetes and cancer disorders among other diseases.
Compounds derived from substituted benzofuran, modulators of the igf1 signaling agent or activator of protein kinase b; pharmaceutical composition that includes them; Useful in the treatment of diseases of the CNS, such as Alzheimer's, among others.
Compounds derived from piperidine 1,4 heterocycle substituted, procedure to prepare these compounds, pharmaceutical composition comprising them and their use for pain therapy and the treatment of diseases such as Alzheimer's, schizophrenia, anxiety and depression.
Carboxamide derived compounds, calpain inhibitors; pharmaceutical composition comprising them; and its use in the treatment of neurodegenerative diseases, alzahimer, pain, among others.