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CL2008003667A1 - Proceso de preparacion de etil-6,7,8,9-tetrahidro-9-hidroxi-2-metil-4h-pirido[1,2-a]piridin-4-ona; y uno de los intermediarios considerados en el proceso descrito; util en la preparacion de paliperidona. - Google Patents

Proceso de preparacion de etil-6,7,8,9-tetrahidro-9-hidroxi-2-metil-4h-pirido[1,2-a]piridin-4-ona; y uno de los intermediarios considerados en el proceso descrito; util en la preparacion de paliperidona.

Info

Publication number
CL2008003667A1
CL2008003667A1 CL2008003667A CL2008003667A CL2008003667A1 CL 2008003667 A1 CL2008003667 A1 CL 2008003667A1 CL 2008003667 A CL2008003667 A CL 2008003667A CL 2008003667 A CL2008003667 A CL 2008003667A CL 2008003667 A1 CL2008003667 A1 CL 2008003667A1
Authority
CL
Chile
Prior art keywords
preparation
paliperidone
intermediaries
pyrido
pyridin
Prior art date
Application number
CL2008003667A
Other languages
English (en)
Inventor
Jiri Bartl
Benovsky Petr
Krajcovic Jozef
Original Assignee
Synthon Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Bv filed Critical Synthon Bv
Publication of CL2008003667A1 publication Critical patent/CL2008003667A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento de preparación de paliperidona que comprende acilar bajo condiciones de vilsmeier o friedel-craft un compuesto derivado de pirimidina, transformar dicho compuesto en un peroxo-compuesto; compuesto intermediario derivado de pirimidina; y uso del compuesto para la preparación de paliperidona.
CL2008003667A 2007-12-10 2008-12-10 Proceso de preparacion de etil-6,7,8,9-tetrahidro-9-hidroxi-2-metil-4h-pirido[1,2-a]piridin-4-ona; y uno de los intermediarios considerados en el proceso descrito; util en la preparacion de paliperidona. CL2008003667A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1254607P 2007-12-10 2007-12-10

Publications (1)

Publication Number Publication Date
CL2008003667A1 true CL2008003667A1 (es) 2010-06-04

Family

ID=40352126

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2008003667A CL2008003667A1 (es) 2007-12-10 2008-12-10 Proceso de preparacion de etil-6,7,8,9-tetrahidro-9-hidroxi-2-metil-4h-pirido[1,2-a]piridin-4-ona; y uno de los intermediarios considerados en el proceso descrito; util en la preparacion de paliperidona.

Country Status (6)

Country Link
US (1) US7977480B2 (es)
EP (1) EP2235009B1 (es)
AR (1) AR069621A1 (es)
CL (1) CL2008003667A1 (es)
ES (1) ES2436658T3 (es)
WO (1) WO2009074333A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ585789A (en) 2007-12-10 2012-03-30 Novartis Ag Pyrazine-2-carboxamide derivatives to treat diseases mediated by blockade of the epithelial sodium channel
EP2318405A2 (en) * 2008-07-11 2011-05-11 Synthon B.V. Paliperidone ketone
EP2321311B1 (en) * 2008-07-11 2012-09-19 Synthon B.V. Synthesis of paliperidone
KR101867988B1 (ko) * 2016-11-02 2018-06-15 주식회사 엔지켐생명과학 팔리페리돈 중간체 및 이를 이용한 팔리페리돈의 제조방법
CN117777131B (zh) * 2024-02-27 2024-06-11 合肥华方医药科技有限公司 一种帕利哌酮及其关键中间体的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4804663A (en) 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
US5158952A (en) * 1988-11-07 1992-10-27 Janssen Pharmaceutica N.V. 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use
US5688799A (en) * 1993-11-23 1997-11-18 Janssen Pharmaceutica N.V. 9-Hydroxy-pyrido 1,2-a!pyrimidin-4-one ether derivatives
KR20080004575A (ko) 2005-05-04 2008-01-09 팜드 메디케어 프리베이트 리미티드 염소화 반응을 위한 디(트리클로로메틸)카보네이트 유래의빌스마이어 헥크 시약의 합성
EP2178872A1 (en) * 2007-07-27 2010-04-28 Synthon B.V. Paliperidone derivatives

Also Published As

Publication number Publication date
US7977480B2 (en) 2011-07-12
AR069621A1 (es) 2010-02-03
ES2436658T3 (es) 2014-01-03
EP2235009B1 (en) 2013-10-30
US20090156810A1 (en) 2009-06-18
EP2235009A1 (en) 2010-10-06
WO2009074333A1 (en) 2009-06-18

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