CL2008002954A1 - Compuestos derivados de 1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahidrociclopenta-(5,6)nafto-(1,2-f)indazol heterociclo o carbociclo sustituido; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento de asma, epoc, rinits alergica. - Google Patents
Compuestos derivados de 1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahidrociclopenta-(5,6)nafto-(1,2-f)indazol heterociclo o carbociclo sustituido; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento de asma, epoc, rinits alergica.Info
- Publication number
- CL2008002954A1 CL2008002954A1 CL2008002954A CL2008002954A CL2008002954A1 CL 2008002954 A1 CL2008002954 A1 CL 2008002954A1 CL 2008002954 A CL2008002954 A CL 2008002954A CL 2008002954 A CL2008002954 A CL 2008002954A CL 2008002954 A1 CL2008002954 A1 CL 2008002954A1
- Authority
- CL
- Chile
- Prior art keywords
- tetradecahydrocyclopenta
- naphtho
- copd
- asthma
- treatment
- Prior art date
Links
- 206010039085 Rhinitis allergic Diseases 0.000 title abstract 2
- 201000010105 allergic rhinitis Diseases 0.000 title abstract 2
- 208000006673 asthma Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0036—Nitrogen-containing hetero ring
- C07J71/0042—Nitrogen only
- C07J71/0047—Nitrogen only at position 2(3)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuestos derivados de 1,2,3,3a,4,5,7,10,10a,10b,11,12,12a-tetradecahidrociclopenta-{5,6}nafto-{1,2-f}indazol-heterociclo o carbociclo sustituido; procedimiento de preparación; composición farmacéutica; y su uso en el tratamiento del asma, epoc y rinitis alérgica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97741607P | 2007-10-04 | 2007-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008002954A1 true CL2008002954A1 (es) | 2010-01-15 |
Family
ID=40328402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2008002954A CL2008002954A1 (es) | 2007-10-04 | 2008-10-03 | Compuestos derivados de 1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahidrociclopenta-(5,6)nafto-(1,2-f)indazol heterociclo o carbociclo sustituido; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento de asma, epoc, rinits alergica. |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US8163724B2 (es) |
| EP (1) | EP2207788A1 (es) |
| JP (1) | JP2010540612A (es) |
| KR (1) | KR20100087147A (es) |
| CN (1) | CN101883778A (es) |
| AR (1) | AR068734A1 (es) |
| AU (1) | AU2008306593C1 (es) |
| BR (1) | BRPI0817941A2 (es) |
| CA (1) | CA2700181A1 (es) |
| CL (1) | CL2008002954A1 (es) |
| CO (1) | CO6270214A2 (es) |
| CR (1) | CR11345A (es) |
| DO (1) | DOP2010000094A (es) |
| EA (1) | EA201000436A1 (es) |
| IL (1) | IL204611A0 (es) |
| MX (1) | MX2010003698A (es) |
| NI (1) | NI201000043A (es) |
| NZ (1) | NZ584160A (es) |
| PE (1) | PE20090776A1 (es) |
| TW (1) | TW200918047A (es) |
| UY (1) | UY31375A1 (es) |
| WO (1) | WO2009044200A1 (es) |
| ZA (1) | ZA201002223B (es) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA201000436A1 (ru) | 2007-10-04 | 2010-10-29 | Астразенека Аб | Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью |
| KR20100102121A (ko) * | 2007-12-20 | 2010-09-20 | 아스트라제네카 아베 | 글루코코르티코스테로이드 수용체 효능제로서 작용하는 스테로이드 유도체 |
| UY32520A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
| UY32525A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| UY32521A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Combinación para emplear en el tratamiento de enfermedades respiratorias |
| UY32523A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| AR077101A1 (es) | 2009-06-16 | 2011-08-03 | Schering Corp | Esteroides de heteroarilo (3,2-c), como agonistas de receptor glucocorticoide, composiciones y usos de los mismos |
| GB0913345D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | New combination 802 |
| WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
| WO2011154826A1 (en) * | 2010-06-11 | 2011-12-15 | Rhodes Technologies | Process for n-dealkylation of tertiary amines |
| GB201016912D0 (en) * | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| JP2014501785A (ja) * | 2011-01-07 | 2014-01-23 | コーセプト セラピューティクス, インコーポレイテッド | ステロイドおよびグルココルチコイド受容体アンタゴニスト組合せ治療 |
| US9126945B2 (en) | 2011-03-18 | 2015-09-08 | Bayer Intellectual Property Gmbh | N-(3-carbamoylphenly)-1H-pyrazole-5-carboxamide derivatives and the use thereof for controlling animal pests |
| US9526729B2 (en) * | 2013-01-29 | 2016-12-27 | Hsiao Lily Yu | Medicament for treating peripheral neuropathies |
| EP3049089B1 (en) * | 2013-09-25 | 2019-08-21 | Van Andel Research Institute | Highly potent glucocorticoids |
| EP3525870B1 (en) * | 2016-10-14 | 2023-05-10 | Van Andel Research Institute | Highly potent glucocorticoids |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB933868A (en) | 1958-12-08 | 1963-08-14 | American Cyanamid Co | Process for fluorinating steroids |
| NL237293A (es) * | 1959-02-16 | |||
| US3129218A (en) * | 1961-11-01 | 1964-04-14 | Merck & Co Inc | 2-alkoxymethylene steroids of the androstane and pregnane series |
| US3072639A (en) * | 1962-03-05 | 1963-01-08 | Merck & Co Inc | 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them |
| US3364203A (en) * | 1965-09-09 | 1968-01-16 | Syntex Corp | 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation |
| US3471477A (en) * | 1967-10-18 | 1969-10-07 | Syntex Corp | 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids |
| DE2727367A1 (de) | 1977-06-14 | 1979-01-04 | Schering Ag | Neue kortikoide |
| DE2735110A1 (de) * | 1977-08-04 | 1979-02-15 | Hoechst Ag | Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung |
| DE2817988A1 (de) * | 1978-04-25 | 1979-11-08 | Hoechst Ag | Corticoid 17-alkylcarbonate und verfahren zu deren herstellung |
| JPS6067495A (ja) | 1983-09-22 | 1985-04-17 | Ota Seiyaku Kk | ピラゾール誘導体 |
| SE8306370D0 (sv) * | 1983-11-18 | 1983-11-18 | Draco Ab | Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions |
| WO1994025478A1 (en) | 1993-04-29 | 1994-11-10 | Instytut Farmaceutyczny | 16α,17α-ACETAL GLUCOCORTICOSTEROIDAL DERIVATIVES |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| WO1997030035A1 (en) | 1996-02-13 | 1997-08-21 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
| PT885198E (pt) | 1996-03-05 | 2002-06-28 | Astrazeneca Ab | Derivados de 4-anilinoquinazolina |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| AU2001258628A1 (en) | 2000-05-31 | 2001-12-11 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| MXPA02012905A (es) | 2000-07-07 | 2004-07-30 | Angiogene Pharm Ltd | Derivados de colquinol como agentes de dano vascular.. |
| BR0112225A (pt) | 2000-07-07 | 2003-05-06 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto, e, processo papa preparar um composto |
| GB0110411D0 (en) | 2001-04-27 | 2001-06-20 | Astrazeneca Ab | Chemical process |
| CA2445839A1 (en) * | 2001-04-30 | 2002-11-07 | Glaxo Group Limited | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha |
| ITMI20022606A1 (it) | 2002-12-09 | 2004-06-10 | Farmabios Spa | Processo di sintesi di steroidi polialogenati. |
| WO2005028495A1 (en) | 2003-09-24 | 2005-03-31 | Glaxo Group Limited | Anti-inflammatory glucocorticoids |
| WO2005063777A1 (en) | 2003-12-23 | 2005-07-14 | Corus Pharma | Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation |
| GB0507165D0 (en) * | 2005-04-08 | 2005-05-18 | Glaxo Group Ltd | Novel crystalline pharmaceutical product |
| WO2007054974A2 (en) | 2005-09-28 | 2007-05-18 | Arch Pharmalab Limited | A green chemistry process for the preparation of pregnadiene esters |
| EA201000436A1 (ru) | 2007-10-04 | 2010-10-29 | Астразенека Аб | Стероидные [3,2-с]пиразольные соединения, обладающие глюкокортикоидной активностью |
| KR20100102121A (ko) | 2007-12-20 | 2010-09-20 | 아스트라제네카 아베 | 글루코코르티코스테로이드 수용체 효능제로서 작용하는 스테로이드 유도체 |
| WO2009108118A1 (en) | 2008-02-27 | 2009-09-03 | Astrazeneca Ab | 16 alpha, 17 alpa-acetal glucocorticosteroidal derivatives and their use |
| UY32523A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| UY32525A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticosteroides |
| UY32521A (es) | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Combinación para emplear en el tratamiento de enfermedades respiratorias |
| UY32520A (es) * | 2009-04-03 | 2010-10-29 | Astrazeneca Ab | Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides |
-
2008
- 2008-10-02 EA EA201000436A patent/EA201000436A1/ru unknown
- 2008-10-02 AU AU2008306593A patent/AU2008306593C1/en not_active Ceased
- 2008-10-02 KR KR1020107009780A patent/KR20100087147A/ko not_active Withdrawn
- 2008-10-02 BR BRPI0817941 patent/BRPI0817941A2/pt not_active IP Right Cessation
- 2008-10-02 NZ NZ584160A patent/NZ584160A/en not_active IP Right Cessation
- 2008-10-02 JP JP2010527546A patent/JP2010540612A/ja active Pending
- 2008-10-02 CN CN2008801190932A patent/CN101883778A/zh active Pending
- 2008-10-02 CA CA2700181A patent/CA2700181A1/en not_active Abandoned
- 2008-10-02 MX MX2010003698A patent/MX2010003698A/es active IP Right Grant
- 2008-10-02 WO PCT/GB2008/050890 patent/WO2009044200A1/en not_active Ceased
- 2008-10-02 EP EP08806706A patent/EP2207788A1/en not_active Ceased
- 2008-10-03 US US12/245,275 patent/US8163724B2/en not_active Expired - Fee Related
- 2008-10-03 PE PE2008001725A patent/PE20090776A1/es not_active Application Discontinuation
- 2008-10-03 TW TW097138109A patent/TW200918047A/zh unknown
- 2008-10-03 UY UY31375A patent/UY31375A1/es not_active Application Discontinuation
- 2008-10-03 AR ARP080104343A patent/AR068734A1/es not_active Application Discontinuation
- 2008-10-03 CL CL2008002954A patent/CL2008002954A1/es unknown
-
2010
- 2010-03-18 IL IL204611A patent/IL204611A0/en unknown
- 2010-03-26 NI NI201000043A patent/NI201000043A/es unknown
- 2010-03-29 ZA ZA2010/02223A patent/ZA201002223B/en unknown
- 2010-03-31 DO DO2010000094A patent/DOP2010000094A/es unknown
- 2010-04-05 CO CO10037849A patent/CO6270214A2/es not_active Application Discontinuation
- 2010-04-05 CR CR11345A patent/CR11345A/es not_active Application Discontinuation
-
2012
- 2012-03-12 US US13/417,626 patent/US20120178726A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| UY31375A1 (es) | 2009-05-29 |
| CA2700181A1 (en) | 2009-04-09 |
| TW200918047A (en) | 2009-05-01 |
| ZA201002223B (en) | 2010-12-29 |
| DOP2010000094A (es) | 2012-08-15 |
| AR068734A1 (es) | 2009-12-02 |
| KR20100087147A (ko) | 2010-08-03 |
| MX2010003698A (es) | 2010-04-21 |
| WO2009044200A1 (en) | 2009-04-09 |
| CO6270214A2 (es) | 2011-04-20 |
| EA201000436A1 (ru) | 2010-10-29 |
| AU2008306593A1 (en) | 2009-04-09 |
| CN101883778A (zh) | 2010-11-10 |
| NI201000043A (es) | 2012-09-10 |
| US8163724B2 (en) | 2012-04-24 |
| US20120178726A1 (en) | 2012-07-12 |
| EP2207788A1 (en) | 2010-07-21 |
| US20090286835A1 (en) | 2009-11-19 |
| NZ584160A (en) | 2011-05-27 |
| JP2010540612A (ja) | 2010-12-24 |
| AU2008306593B2 (en) | 2012-04-12 |
| CR11345A (es) | 2010-07-15 |
| BRPI0817941A2 (pt) | 2015-05-05 |
| AU2008306593C1 (en) | 2012-10-04 |
| IL204611A0 (en) | 2010-11-30 |
| PE20090776A1 (es) | 2009-07-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2008002954A1 (es) | Compuestos derivados de 1,2,3,3a,3b,4,5,7,10,10a,10b,11,12,12a-tetradecahidrociclopenta-(5,6)nafto-(1,2-f)indazol heterociclo o carbociclo sustituido; procedimiento de preparacion; composicion farmaceutica; y su uso en el tratamiento de asma, epoc, rinits alergica. | |
| CL2011002787A1 (es) | Compuestos derivados de 1-cianoetilheterociclilcarboxamida sustituidos, inhibidores de dipeptidilpeptidasa i (dppi) o catepsina c; composicion farmaceutica; combinacion faramceutica; y su uso en el tratamiento del asma, la enfermedad obstructiva cronica o la rinitis alergica. | |
| CL2008003694A1 (es) | Compuestos derivados de heterociclo-2-carboxamida sustituida; composicion farmaceutica; combinacion farmaceutica; y su uso como inhibidores de dipeptidil peptidasa iv (dpp-iv) en el tratamiento del asma, epoc y rinitis alergica. | |
| CL2008000307A1 (es) | Compuestos derivados de cromen-2-ona sustituido; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como ateroesclerosis, asma, rinitis alergica y epoc. | |
| NO20084912L (no) | Bisykliske derivater som CETP-inhibitorer | |
| ATE516286T1 (de) | 5-(ä1,3,4üoxadiazol-2-yl)-1h-indazol und 5-(ä1,3, 4üthiadiazol-2-yl)-1h-indazol derivate als sgk- inhibitoren zur behandlung von diabetes | |
| CL2008002689A1 (es) | Compuestos derivados de heterociclo 1,4 piperidina sustituida; compuestos intermediarios; composicion farmaceutica; proceso de preparacion; y su uso en el tratamiento del alzheimer y esquizofrenia. | |
| CL2012002250A1 (es) | Compuestos heterociclicos fusionados derivados de pirimidinonas, inhibidores potentes de cdc7; composicion farmaceutica; y su uso en la prevencion o el tratamiento del cancer. | |
| ATE530540T1 (de) | Pyrimidonverbindungen als gsk-3-inhibitoren | |
| CL2009000119A1 (es) | Compuestos derivados de amino-bencimidazoles sustituidos; composicion farmaceutica; y su uso en el tratamiento del alzheimer. | |
| CL2009001248A1 (es) | Compuestos derivados de indazolilo sustituido con fenilo, que actúan como moduladores de glucocorticoides; composición y combinación farmacéutica que comprenden a uno de los compuestos; y uso de los compuestos en la preparación de medicamentos para el tratamiento de enfermedades inflamatorias y respiratorias. | |
| CL2008001593A1 (es) | Compuestos derivados de heterociclos, antagonistas para el ccr2; y uso de los compuestos para tratar afecciones o enfermedades del tracto respiratorio, como enfermedad pulmonar obstructiva cronica y asma. | |
| NO20082026L (no) | Deazapuriner som er nyttige som inhibitorer for Janus-kinaser | |
| CL2007000806A1 (es) | Compuestos derivados de heteropentaciclos sustituidos; proceso de preparacion; compuestos intermediarios; composicion farmaceutica; y uso en el tratamiento del cancer. | |
| CL2007002207A1 (es) | Compuestos derivados de sulfonilaminas; composicion farmaceutica; y uso de los compuestos en el tratamiento del glaucoma. | |
| CL2008003847A1 (es) | Compuestos derivados de 6-fenilpirazin-2-carboxamida y 6-fenilpirazin-2-carbotioamida, inhibidores de dgat-1; composicion farmaceutica; y su uso en el tratamiento de la diabetes mellitus y obesidad. | |
| NI200700296A (es) | Imidazoquinolinas como inhibidores de cinasa de lipido | |
| CL2008003473A1 (es) | Compuestos derivados de fenilpiperidina sustituidos por heterociclos; procedimiento de preparacion; composicion farmaceutica que lo comprende; y uso en el tratamiento del trastorno cardiovasculares, tromboembolicos y tumorales; usos in vitro. | |
| EA201171081A1 (ru) | Производные индола в качестве антагонистов рецептора crth2 | |
| CL2007003765A1 (es) | Compuestos derivados de 2-oxo-4-hidroxi-benzotiazol; procesode preparacion; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de enfermedades tales como epoc, bronquitis, asma y bronquiectasias. | |
| CR20110100A (es) | Nuevos derivados de sulfamida sustituida | |
| ATE489371T1 (de) | Benzamidglucokinaseaktivatoren | |
| ATE553093T1 (de) | Indazolderivate zur hemmung von trpv1 und verwendungen davon | |
| CL2007000789A1 (es) | Compuestos derivados de malonamida, inhibidores de la gamma-secretasa; proceso de preparacion; composicion farmaceutica; y su uso en el tratamiento de la enfermedad de alzheimer. | |
| NO20093542L (no) | Inhibering av tumormetastase ved hjelp av anti-neuropilin 2-antistoffer |