CL2008001126A1 - Compuestos derivados de pirimidinona condensada con heterociclos; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, sindrome metabolico y obesidad. - Google Patents
Compuestos derivados de pirimidinona condensada con heterociclos; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, sindrome metabolico y obesidad.Info
- Publication number
- CL2008001126A1 CL2008001126A1 CL200801126A CL2008001126A CL2008001126A1 CL 2008001126 A1 CL2008001126 A1 CL 2008001126A1 CL 200801126 A CL200801126 A CL 200801126A CL 2008001126 A CL2008001126 A CL 2008001126A CL 2008001126 A1 CL2008001126 A1 CL 2008001126A1
- Authority
- CL
- Chile
- Prior art keywords
- pirimidinone
- heterocicles
- obesity
- diabetes
- condensed
- Prior art date
Links
- 208000001145 Metabolic Syndrome Diseases 0.000 title 1
- 208000008589 Obesity Diseases 0.000 title 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 235000020824 obesity Nutrition 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US92545007P | 2007-04-20 | 2007-04-20 | |
| US95334207P | 2007-08-01 | 2007-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008001126A1 true CL2008001126A1 (es) | 2008-10-24 |
Family
ID=39655056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200801126A CL2008001126A1 (es) | 2007-04-20 | 2008-04-18 | Compuestos derivados de pirimidinona condensada con heterociclos; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, sindrome metabolico y obesidad. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100190687A1 (es) |
| EP (1) | EP2148869A1 (es) |
| JP (1) | JP2010524940A (es) |
| CN (1) | CN102015677A (es) |
| AR (1) | AR066121A1 (es) |
| CA (1) | CA2684633A1 (es) |
| CL (1) | CL2008001126A1 (es) |
| MX (1) | MX2009011358A (es) |
| PE (1) | PE20090151A1 (es) |
| TW (1) | TW200900403A (es) |
| WO (1) | WO2008130581A1 (es) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8232282B2 (en) | 2006-09-28 | 2012-07-31 | Dainippon Sumitomo Pharma Co., Ltd. | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same |
| US20110275647A1 (en) * | 2009-02-23 | 2011-11-10 | Msd K.K. | Pyrimidin-4-(3h)-one derivatives |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US20130109703A1 (en) | 2010-03-18 | 2013-05-02 | Boehringer Ingelheim International Gmbh | Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions |
| CN102234287B (zh) | 2010-04-26 | 2015-08-05 | 上海阳帆医药科技有限公司 | 硝基咪唑类化合物、其制备方法和用途 |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| CN102464661B (zh) * | 2010-11-16 | 2015-04-01 | 天津药明康德新药开发有限公司 | 一种5,6,7,8-四氢-咪唑并[1,5-a]吡嗪-1-羧酸乙酯的制备方法 |
| ES2602813T3 (es) | 2011-06-09 | 2017-02-22 | Rhizen Pharmaceuticals S.A. | Nuevos compuestos como moduladores de GPR-119 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2872127A1 (en) | 2012-07-11 | 2015-05-20 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| EP2921480B1 (en) | 2012-11-19 | 2017-10-11 | Takeda Pharmaceutical Company Limited | Nitrogen-containing heterocyclic compound |
| JP2016222621A (ja) * | 2015-06-02 | 2016-12-28 | 学校法人九州文化学園 | メラニン合成促進組成物 |
| BR112018000041A2 (pt) | 2015-07-31 | 2018-09-04 | Pfizer Inc. | Derivados de carbamato de 1,1,1-trifluoro-3- hidroxipropan-2-ila e derivados de carbamato de 1,1,1-trifluoro-4-hidroxibutan-2-ila como inibidores de magl |
| SG11201906417RA (en) | 2017-01-20 | 2019-08-27 | Pfizer | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors |
| SG11201906427QA (en) | 2017-01-23 | 2019-08-27 | Pfizer | Heterocyclic spiro compounds as magl inhibitors |
| CN110452157B (zh) * | 2018-12-28 | 2020-11-03 | 广州市朗启医药科技有限责任公司 | 常山酮及其中间体的合成方法 |
| TW202100524A (zh) * | 2019-03-14 | 2021-01-01 | 愛爾蘭商健生科學愛爾蘭無限公司 | 用於治療hbv感染或hbv誘發疾病之稠合環嘧啶酮衍生物 |
| GB202103704D0 (en) * | 2021-03-17 | 2021-04-28 | Pathios Therapeutics Ltd | Compounds |
| BR112022024771A2 (pt) * | 2020-06-05 | 2022-12-27 | Pathios Therapeutics Ltd | N-(fenilaminocarbonil)tetra-hidro-isoquinolinas e compostos relacionados como moduladores de gpr65 |
| EP4161516A4 (en) * | 2020-06-09 | 2024-08-07 | Dana-Farber Cancer Institute, Inc. | ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF |
| WO2022053010A1 (en) * | 2020-09-11 | 2022-03-17 | Janssen Sciences Ireland Unlimited Company | Fused ring pyrimidone derivatives for use in the treatment of hbv infection or of hbv-induced diseases |
| AU2021365812A1 (en) | 2020-10-21 | 2023-05-11 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| US11957683B2 (en) | 2021-06-18 | 2024-04-16 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| IL291418B2 (en) | 2022-03-16 | 2024-05-01 | Anima Biotech Inc | Substances that function as modulators of cMYC-mRNA translation and their uses for cancer treatment |
| WO2023205645A1 (en) | 2022-04-20 | 2023-10-26 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| WO2025137307A1 (en) * | 2023-12-20 | 2025-06-26 | Gasherbrum Bio, Inc. | Heterocyclic glp-1 agonists |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5449682A (en) * | 1990-02-13 | 1995-09-12 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted benzyl element |
| US5264439A (en) * | 1990-02-13 | 1993-11-23 | Merck & Co., Inc. | Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element |
| US5240938A (en) * | 1991-02-13 | 1993-08-31 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring |
| US5385894A (en) * | 1991-03-06 | 1995-01-31 | Merck & Co., Inc. | Disubstituted 6-aminoquinazolinones |
| US5401745A (en) * | 1993-03-19 | 1995-03-28 | Merck & Co., Inc. | Quinazolinones substituted with phenoxyphenylacetic acid derivatives |
| US5420133A (en) * | 1993-03-19 | 1995-05-30 | Merck & Co., Inc. | Quinazolinones substituted with phenoxyphenylacetic acid derivatives |
| US5409926A (en) * | 1993-07-19 | 1995-04-25 | Merck & Co., Inc. | AT-2 antagonist inhibition of vascular restenosis |
| EP1006113A1 (en) * | 1998-12-02 | 2000-06-07 | Pfizer Products Inc. | Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use to inhibit abnormal cell growth |
| JP3438186B2 (ja) * | 2000-12-01 | 2003-08-18 | 山之内製薬株式会社 | 糖尿病治療剤スクリーニング方法 |
| DE602004017703D1 (de) * | 2003-02-24 | 2008-12-24 | Arena Pharm Inc | Phenyl- und pyridylpiperidinderivate als modulatoren des glucose-metabolismus |
| KR20080080136A (ko) * | 2005-11-22 | 2008-09-02 | 스미스클라인 비참 코포레이션 | 칼실리틱 화합물 |
| US8232282B2 (en) * | 2006-09-28 | 2012-07-31 | Dainippon Sumitomo Pharma Co., Ltd. | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same |
-
2008
- 2008-04-17 EP EP08742980A patent/EP2148869A1/en not_active Withdrawn
- 2008-04-17 WO PCT/US2008/004933 patent/WO2008130581A1/en not_active Ceased
- 2008-04-17 CN CN2008800186357A patent/CN102015677A/zh active Pending
- 2008-04-17 US US12/596,341 patent/US20100190687A1/en not_active Abandoned
- 2008-04-17 JP JP2010504080A patent/JP2010524940A/ja not_active Withdrawn
- 2008-04-17 MX MX2009011358A patent/MX2009011358A/es unknown
- 2008-04-17 CA CA002684633A patent/CA2684633A1/en not_active Abandoned
- 2008-04-18 AR ARP080101618A patent/AR066121A1/es not_active Application Discontinuation
- 2008-04-18 PE PE2008000681A patent/PE20090151A1/es not_active Application Discontinuation
- 2008-04-18 TW TW097114371A patent/TW200900403A/zh unknown
- 2008-04-18 CL CL200801126A patent/CL2008001126A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200900403A (en) | 2009-01-01 |
| PE20090151A1 (es) | 2009-02-26 |
| US20100190687A1 (en) | 2010-07-29 |
| CA2684633A1 (en) | 2008-10-30 |
| MX2009011358A (es) | 2009-11-05 |
| AR066121A1 (es) | 2009-07-22 |
| EP2148869A1 (en) | 2010-02-03 |
| CN102015677A (zh) | 2011-04-13 |
| JP2010524940A (ja) | 2010-07-22 |
| WO2008130581A1 (en) | 2008-10-30 |
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