CL2008000618A1 - Compuestos derivados de etil-amida del acido 5-(2,4-dihidroxi-5-isopropil-fenil)-4-(4-morfolin 4-il metil-fenil)-isoxazol-3-carboxilico; composicion farmaceutica que comprende a dicho compuesto; y su uso para el tratamiento de un trastorno mediado po - Google Patents

Compuestos derivados de etil-amida del acido 5-(2,4-dihidroxi-5-isopropil-fenil)-4-(4-morfolin 4-il metil-fenil)-isoxazol-3-carboxilico; composicion farmaceutica que comprende a dicho compuesto; y su uso para el tratamiento de un trastorno mediado po

Info

Publication number: CL2008000618A1
Authority: CL; Chile
Prior art keywords: phenyl; dihidroxi; isopropil; morfolin; amida
Prior art date: 2007-03-01

Application number

CL200800618A

Other languages

English (en)

Inventor

Martin James Dymock B Drysdale

Original Assignee

Novartis Ag Vernalis R & D Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-01

Filing date

2008-02-29

Publication date

2008-09-12

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38134307&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008000618(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-02-29 Application filed by Novartis Ag Vernalis R & D Ltd filed Critical Novartis Ag Vernalis R & D Ltd

2008-09-12 Publication of CL2008000618A1 publication Critical patent/CL2008000618A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CL200800618A 2007-03-01 2008-02-29 Compuestos derivados de etil-amida del acido 5-(2,4-dihidroxi-5-isopropil-fenil)-4-(4-morfolin 4-il metil-fenil)-isoxazol-3-carboxilico; composicion farmaceutica que comprende a dicho compuesto; y su uso para el tratamiento de un trastorno mediado po CL2008000618A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP07103346		2007-03-01

Publications (1)

Publication Number	Publication Date
CL2008000618A1 true CL2008000618A1 (es)	2008-09-12

Family

ID=38134307

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200800618A CL2008000618A1 (es)	2007-03-01	2008-02-29	Compuestos derivados de etil-amida del acido 5-(2,4-dihidroxi-5-isopropil-fenil)-4-(4-morfolin 4-il metil-fenil)-isoxazol-3-carboxilico; composicion farmaceutica que comprende a dicho compuesto; y su uso para el tratamiento de un trastorno mediado po

Country Status (40)

Country	Link
US (3)	US8163747B2 (es)
EP (2)	EP2131845B1 (es)
JP (1)	JP2010520176A (es)
KR (1)	KR20090122218A (es)
CN (2)	CN101636162A (es)
AR (1)	AR065519A1 (es)
AT (1)	ATE552836T1 (es)
AU (1)	AU2008220800B2 (es)
BR (1)	BRPI0807992A2 (es)
CA (1)	CA2678043A1 (es)
CL (1)	CL2008000618A1 (es)
CO (1)	CO6210828A2 (es)
CR (1)	CR10989A (es)
CY (1)	CY1113805T1 (es)
DK (1)	DK2131845T3 (es)
DO (1)	DOP2009000209A (es)
EA (1)	EA017075B1 (es)
EC (1)	ECSP099602A (es)
ES (1)	ES2384906T3 (es)
GE (1)	GEP20115309B (es)
GT (1)	GT200900236A (es)
HR (1)	HRP20120535T1 (es)
IL (1)	IL200401A0 (es)
MA (1)	MA31204B1 (es)
MX (1)	MX2009009233A (es)
NI (1)	NI200900161A (es)
NZ (1)	NZ578854A (es)
PA (1)	PA8771101A1 (es)
PE (1)	PE20090166A1 (es)
PL (1)	PL2131845T3 (es)
PT (1)	PT2131845E (es)
RS (1)	RS52351B (es)
SI (1)	SI2131845T1 (es)
SM (1)	SMAP200900080A (es)
TN (1)	TN2009000357A1 (es)
TW (1)	TW200844102A (es)
UA (1)	UA101950C2 (es)
UY (1)	UY30943A1 (es)
WO (1)	WO2008104595A1 (es)
ZA (1)	ZA200905417B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TW200922595A (en) *	2007-10-12	2009-06-01	Novartis Ag	Organic compounds
TWI450898B (zh) *	2008-07-04	2014-09-01	Sigma Tau Res Switzerland Sa	具有抗腫瘤活性之芳基異唑化合物
US8309578B2 (en)	2008-11-25	2012-11-13	Nerviano Medical Sciences S.R.L.	Bicyclic pyrazole and isoxazole derivatives as antitumor and antineurodegenerative agents
IN2012DN05192A (es) *	2010-01-21	2015-10-23	Aprea Ab
EP2536714A4 (en) *	2010-02-17	2013-07-03	Il Dong Pharma	NEW 5-LOW HETEROCYCLIC DERIVATIVES AND METHOD OF MANUFACTURING THEREOF
KR20120031854A (ko)	2010-09-27	2012-04-04	한국전자통신연구원	시간 및 주파수 특징을 이용하는 음악 음원 분리 장치 및 방법
WO2013015661A2 (en) *	2011-07-28	2013-01-31	Ildong Pharm Co.,Ltd.	Novel prodrugs of 5-(2,4-dihydroxy-5-isopropylphenyl)-n-ethyl-4-(5-methyl1-1,2,4-oxadiazol-3-yl)isoxazole-3-carboxamide
FR3039401B1 (fr) *	2015-07-31	2018-07-13	Les Laboratoires Servier	Nouvelle association entre le 3-[(3-{[4-(4-morpholinylmethyl)-1h-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1h-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione et un inhibiteur de la tyr kinase du egfr

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1611112B1 (en) *	2003-02-11	2012-08-22	Vernalis (Cambridge) Limited	Isoxazole compounds as inhibitors of heat shock proteins
US20060070405A1 (en) *	2004-10-06	2006-04-06	Anheuser-Busch, Inc.	Method for the production of amber glass with reduced sulfur-containing emissions
EP2120900A2 (en)	2007-02-15	2009-11-25	Novartis AG	Combination of lbh589 with other therapeutic agents for treating cancer
WO2010069458A1 (de)	2008-12-17	2010-06-24	Merck Patent Gmbh	Hexahalochromat(lll)-komplexe

2008
- 2008-02-28 HR HRP20120535AT patent/HRP20120535T1/hr unknown
- 2008-02-28 US US12/529,090 patent/US8163747B2/en active Active
- 2008-02-28 AU AU2008220800A patent/AU2008220800B2/en not_active Ceased
- 2008-02-28 EA EA200901141A patent/EA017075B1/ru not_active IP Right Cessation
- 2008-02-28 ES ES08717228T patent/ES2384906T3/es active Active
- 2008-02-28 PT PT08717228T patent/PT2131845E/pt unknown
- 2008-02-28 EP EP08717228A patent/EP2131845B1/en active Active
- 2008-02-28 BR BRPI0807992-7A2A patent/BRPI0807992A2/pt not_active IP Right Cessation
- 2008-02-28 KR KR1020097018126A patent/KR20090122218A/ko not_active Ceased
- 2008-02-28 AR ARP080100831A patent/AR065519A1/es not_active Application Discontinuation
- 2008-02-28 EP EP11192158.1A patent/EP2545921A3/en not_active Withdrawn
- 2008-02-28 PL PL08717228T patent/PL2131845T3/pl unknown
- 2008-02-28 RS RS20120263A patent/RS52351B/sr unknown
- 2008-02-28 GE GEAP200811444A patent/GEP20115309B/en unknown
- 2008-02-28 DK DK08717228.4T patent/DK2131845T3/da active
- 2008-02-28 SI SI200830688T patent/SI2131845T1/sl unknown
- 2008-02-28 NZ NZ578854A patent/NZ578854A/en not_active IP Right Cessation
- 2008-02-28 JP JP2009551218A patent/JP2010520176A/ja active Pending
- 2008-02-28 AT AT08717228T patent/ATE552836T1/de active
- 2008-02-28 WO PCT/EP2008/052443 patent/WO2008104595A1/en not_active Ceased
- 2008-02-28 CN CN200880005490.7A patent/CN101636162A/zh active Pending
- 2008-02-28 CA CA002678043A patent/CA2678043A1/en not_active Abandoned
- 2008-02-28 CN CN201110226727.8A patent/CN102302500A/zh active Pending
- 2008-02-28 MX MX2009009233A patent/MX2009009233A/es active IP Right Grant
- 2008-02-28 UY UY30943A patent/UY30943A1/es not_active Application Discontinuation
- 2008-02-28 UA UAA200908592A patent/UA101950C2/ru unknown
- 2008-02-29 PE PE2008000418A patent/PE20090166A1/es not_active Application Discontinuation
- 2008-02-29 PA PA20088771101A patent/PA8771101A1/es unknown
- 2008-02-29 CL CL200800618A patent/CL2008000618A1/es unknown
- 2008-02-29 TW TW097107239A patent/TW200844102A/zh unknown
2009
- 2009-08-03 ZA ZA200905417A patent/ZA200905417B/xx unknown
- 2009-08-13 IL IL200401A patent/IL200401A0/en unknown
- 2009-08-21 CR CR10989A patent/CR10989A/es not_active Application Discontinuation
- 2009-08-28 EC EC2009009602A patent/ECSP099602A/es unknown
- 2009-08-28 TN TNP2009000357A patent/TN2009000357A1/fr unknown
- 2009-08-28 NI NI200900161A patent/NI200900161A/es unknown
- 2009-08-31 DO DO2009000209A patent/DOP2009000209A/es unknown
- 2009-08-31 MA MA32191A patent/MA31204B1/fr unknown
- 2009-08-31 GT GT200900236A patent/GT200900236A/es unknown
- 2009-09-01 CO CO09092694A patent/CO6210828A2/es not_active Application Discontinuation
- 2009-09-30 SM SM200900080T patent/SMAP200900080A/it unknown
2012
- 2012-03-08 US US13/415,268 patent/US8487095B2/en not_active Expired - Fee Related
- 2012-07-09 CY CY20121100610T patent/CY1113805T1/el unknown
2013
- 2013-07-10 US US13/938,659 patent/US20130296556A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US8163747B2 (en)	2012-04-24
TN2009000357A1 (en)	2010-12-31
US20100093732A1 (en)	2010-04-15
JP2010520176A (ja)	2010-06-10
TW200844102A (en)	2008-11-16
MX2009009233A (es)	2010-06-02
EP2545921A2 (en)	2013-01-16
DK2131845T3 (da)	2012-07-16
EP2545921A3 (en)	2013-04-10
AU2008220800A1 (en)	2008-09-04
NI200900161A (es)	2010-07-27
CY1113805T1 (el)	2016-07-27
GEP20115309B (en)	2011-10-25
AU2008220800B2 (en)	2012-02-16
NZ578854A (en)	2012-03-30
EA200901141A1 (ru)	2010-04-30
US8487095B2 (en)	2013-07-16
PE20090166A1 (es)	2009-03-14
UY30943A1 (es)	2008-10-31
SI2131845T1 (sl)	2013-02-28
CA2678043A1 (en)	2008-09-04
HRP20120535T1 (hr)	2012-07-31
US20120172592A1 (en)	2012-07-05
EP2131845B1 (en)	2012-04-11
RS52351B (sr)	2012-12-31
CN102302500A (zh)	2012-01-04
UA101950C2 (ru)	2013-05-27
SMAP200900080A (it)	2010-01-19
PT2131845E (pt)	2012-07-10
BRPI0807992A2 (pt)	2014-06-17
CN101636162A (zh)	2010-01-27
PL2131845T3 (pl)	2012-09-28
PA8771101A1 (es)	2009-02-09
AR065519A1 (es)	2009-06-10
ECSP099602A (es)	2009-12-28
US20130296556A1 (en)	2013-11-07
ZA200905417B (en)	2010-05-26
MA31204B1 (fr)	2010-02-01
ES2384906T3 (es)	2012-07-13
KR20090122218A (ko)	2009-11-26
CR10989A (es)	2010-03-01
HK1139073A1 (en)	2010-09-10
GT200900236A (es)	2011-09-14
IL200401A0 (en)	2010-04-29
DOP2009000209A (es)	2009-09-15
ATE552836T1 (de)	2012-04-15
EA017075B1 (ru)	2012-09-28
WO2008104595A1 (en)	2008-09-04
EP2131845A1 (en)	2009-12-16
CO6210828A2 (es)	2010-10-20

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