CL2008000020A1 - Compuestos derivados de 2,4-dianilinopirimidinas sustituidas, inhibidores de proteinas cinasas; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades inflamatorias, diabetes y tumores malignos. - Google Patents
Compuestos derivados de 2,4-dianilinopirimidinas sustituidas, inhibidores de proteinas cinasas; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades inflamatorias, diabetes y tumores malignos.Info
- Publication number
- CL2008000020A1 CL2008000020A1 CL2008000020A CL2008000020A CL2008000020A1 CL 2008000020 A1 CL2008000020 A1 CL 2008000020A1 CL 2008000020 A CL2008000020 A CL 2008000020A CL 2008000020 A CL2008000020 A CL 2008000020A CL 2008000020 A1 CL2008000020 A1 CL 2008000020A1
- Authority
- CL
- Chile
- Prior art keywords
- dianilinopyrimidines
- diabetes
- prevention
- substituted
- treatment
- Prior art date
Links
- GKFFFOLFBJUEFN-UHFFFAOYSA-N 2-n,4-n-diphenylpyrimidine-2,4-diamine Chemical class C=1C=NC(NC=2C=CC=CC=2)=NC=1NC1=CC=CC=C1 GKFFFOLFBJUEFN-UHFFFAOYSA-N 0.000 title abstract 2
- 229940045988 antineoplastic drug protein kinase inhibitors Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000002265 prevention Effects 0.000 title abstract 2
- 239000003909 protein kinase inhibitor Chemical class 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000036210 malignancy Effects 0.000 abstract 1
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- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
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Abstract
Compuestos derivados de 2,4-dianilinopirimidinas sustituidas, inhibidores de proteínas cinasas; procedimiento de preparación; composición farmacéutica; y uso para el tratamiento o prevención de enfermedades inflamatorias, diabetes y tumores malignos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0700064A FR2911138B1 (fr) | 2007-01-05 | 2007-01-05 | Nouveaux derives de n, n'-2,4-dianilinopyrimidines, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008000020A1 true CL2008000020A1 (es) | 2009-01-23 |
Family
ID=38283986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2008000020A CL2008000020A1 (es) | 2007-01-05 | 2008-01-03 | Compuestos derivados de 2,4-dianilinopirimidinas sustituidas, inhibidores de proteinas cinasas; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento o prevencion de enfermedades inflamatorias, diabetes y tumores malignos. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100093668A1 (es) |
| EP (1) | EP2118092A1 (es) |
| JP (1) | JP2010514821A (es) |
| CN (1) | CN101605783A (es) |
| AR (1) | AR064730A1 (es) |
| CA (1) | CA2672959A1 (es) |
| CL (1) | CL2008000020A1 (es) |
| FR (1) | FR2911138B1 (es) |
| TW (1) | TW200900068A (es) |
| UY (1) | UY30857A1 (es) |
| WO (1) | WO2008099073A1 (es) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7737145B2 (en) | 2005-12-29 | 2010-06-15 | Estrellita Pharmaceuticals, Llc | Diamine derivatives as inhibitors of leukotriene A4 hydrolase |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| PT2300013T (pt) * | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2011144742A1 (en) | 2010-05-21 | 2011-11-24 | Chemilia Ab | Novel pyrimidine derivatives |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| EP2688883B1 (en) | 2011-03-24 | 2016-05-18 | Noviga Research AB | Pyrimidine derivatives |
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| EP2760862B1 (en) | 2011-09-27 | 2015-10-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| CN103204827B (zh) | 2012-01-17 | 2014-12-03 | 上海科州药物研发有限公司 | 作为蛋白激酶抑制剂的苯并噻二唑化合物及其制备方法和用途 |
| AU2013204563B2 (en) | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| CN103833771A (zh) * | 2012-11-22 | 2014-06-04 | 天津滨江药物研发有限公司 | 作为蛋白激酶Mek抑制剂的苯并五元杂环化合物及其制备方法和用途 |
| CA2905340C (en) | 2013-03-12 | 2022-05-31 | Celtaxsys, Inc. | Low dose oral formulations of acebilustat |
| MX2015011677A (es) | 2013-03-14 | 2016-07-08 | Celtaxsys Inc | Inhibidores de leucotrieno a4 hidrolasa. |
| JP6534650B2 (ja) | 2013-03-14 | 2019-06-26 | セルタクシス,インコーポレイテッド | ロイコトリエンa4加水分解酵素の阻害剤 |
| EP2968265A4 (en) | 2013-03-14 | 2016-12-28 | Celtaxsys Inc | INHIBITORS OF THE LEUKOTRIEN A4 HYDROLASE |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| EP3157916B1 (en) | 2014-06-19 | 2018-12-12 | ARIAD Pharmaceuticals, Inc. | Heteroaryl compounds for kinase inhibition |
| US11168068B2 (en) | 2016-07-18 | 2021-11-09 | Janssen Pharmaceutica Nv | Tau PET imaging ligands |
| GB201617758D0 (en) * | 2016-10-20 | 2016-12-07 | Almac Discovery Limited | Pharmaceutical compounds |
| BR112020023107A2 (pt) | 2018-05-14 | 2021-02-02 | Ariad Pharmaceuticals, Inc. | sais farmacêuticos de derivados de pirimidina e método de tratamento de distúrbios |
| WO2019232306A1 (en) | 2018-05-31 | 2019-12-05 | Celtaxsys, Inc. | Method of reducing pulmonary exacerbations in respiratory disease patients |
| WO2020117972A1 (en) * | 2018-12-04 | 2020-06-11 | The Board Of Regents Of The University Of Texas System | Therapeutics targeting mutant adenomatous polyposis coli (apc) for the treatment of cancer |
| PH12022551379A1 (en) | 2019-12-06 | 2023-05-03 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
| KR20250001911A (ko) * | 2023-06-29 | 2025-01-07 | (주)아이젠사이언스 | 신규 셀레노펜 유도체 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0004890D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0004888D0 (en) * | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| EP1598343A1 (de) * | 2004-05-19 | 2005-11-23 | Boehringer Ingelheim International GmbH | 2-Arylaminopyrimidine als PLK Inhibitoren |
| MX2007004488A (es) * | 2004-10-13 | 2007-09-11 | Wyeth Corp | Analogos de anilino-pirimidina n-bencenosulfonilo sustituidos. |
| MX2008000574A (es) * | 2005-07-11 | 2008-03-14 | Sanofi Aventis | Nuevos derivados de 2,4-dianilinopirimidinas, la preparacion de los mismos, su uso como medicamentos, composiciones farmaceuticas y, en particular, como inhibidores ikk. |
| FR2911137B1 (fr) * | 2007-01-05 | 2009-02-20 | Sanofi Aventis Sa | Nouveaux derives de 2,4-dianilinopyrimides, leur preparation a titre de medicaments, compositions pharmaceutiques et notamment comme inhibiteurs de ikk |
-
2007
- 2007-01-05 FR FR0700064A patent/FR2911138B1/fr not_active Expired - Fee Related
-
2008
- 2008-01-02 CN CNA2008800041451A patent/CN101605783A/zh active Pending
- 2008-01-02 CA CA002672959A patent/CA2672959A1/fr not_active Abandoned
- 2008-01-02 JP JP2009544426A patent/JP2010514821A/ja not_active Withdrawn
- 2008-01-02 WO PCT/FR2008/000002 patent/WO2008099073A1/fr not_active Ceased
- 2008-01-02 EP EP08750461A patent/EP2118092A1/fr not_active Withdrawn
- 2008-01-03 AR ARP080100012A patent/AR064730A1/es unknown
- 2008-01-03 CL CL2008000020A patent/CL2008000020A1/es unknown
- 2008-01-04 UY UY30857A patent/UY30857A1/es not_active Application Discontinuation
- 2008-01-04 TW TW097100454A patent/TW200900068A/zh unknown
-
2009
- 2009-07-01 US US12/495,998 patent/US20100093668A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010514821A (ja) | 2010-05-06 |
| AR064730A1 (es) | 2009-04-22 |
| EP2118092A1 (fr) | 2009-11-18 |
| FR2911138A1 (fr) | 2008-07-11 |
| CN101605783A (zh) | 2009-12-16 |
| TW200900068A (en) | 2009-01-01 |
| WO2008099073A1 (fr) | 2008-08-21 |
| FR2911138B1 (fr) | 2009-02-20 |
| CA2672959A1 (fr) | 2008-08-21 |
| US20100093668A1 (en) | 2010-04-15 |
| UY30857A1 (es) | 2008-09-02 |
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