CL2007003262A1 - Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, entre otras enfermedades. - Google Patents

Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, entre otras enfermedades.

Info

Publication number: CL2007003262A1
Authority: CL; Chile
Prior art keywords: benzotiepina; hyperlipidemia; diabetes; diseases; dioxide
Prior art date: 2006-11-14

Application number

CL200703262A

Other languages

English (en)

Inventor

Heiner Frick Wendelin Glombik

Original Assignee

Sanofi Aventis Deutschland

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-11-14

Filing date

2007-11-13

Publication date

2008-05-30

2007-11-13 Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland

2008-05-30 Publication of CL2007003262A1 publication Critical patent/CL2007003262A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C07H5/06—Aminosugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
- A61K31/708—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid having oxo groups directly attached to the purine ring system, e.g. guanosine, guanylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/04—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to nitrogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Diabetes (AREA)
Epidemiology (AREA)
Obesity (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Endocrinology (AREA)
Child & Adolescent Psychology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

CL200703262A 2006-11-14 2007-11-13 Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, entre otras enfermedades. CL2007003262A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102006053635A DE102006053635B4 (de)	2006-11-14	2006-11-14	Neue mit Benzylresten substituierte 1,4-Benzothiepin-1,1-Dioxidderivate, diese Verbindungen enthaltende Arzneimittel und deren Verwendung

Publications (1)

Publication Number	Publication Date
CL2007003262A1 true CL2007003262A1 (es)	2008-05-30

Family

ID=39092812

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200703262A CL2007003262A1 (es)	2006-11-14	2007-11-13	Compuestos derivados de 1,4-benzotiepina-1,1-dioxido; composicion farmaceutica; y su uso para el tratamiento de trastornos del metabolismo de lipidos, hiperlipidemia, resistencia a la insulina, diabetes y trastornos del snc, entre otras enfermedades.

Country Status (37)

Country	Link
US (1)	US7956085B2 (es)
EP (1)	EP2084172B1 (es)
JP (1)	JP5301453B2 (es)
KR (1)	KR101489168B1 (es)
CN (1)	CN101535326B (es)
AR (2)	AR063786A1 (es)
AT (1)	ATE492554T1 (es)
AU (1)	AU2007321496B2 (es)
BR (1)	BRPI0718813B8 (es)
CA (2)	CA2669230C (es)
CL (1)	CL2007003262A1 (es)
CO (1)	CO6190534A2 (es)
CR (1)	CR10733A (es)
CY (1)	CY1111166T1 (es)
DE (2)	DE102006053635B4 (es)
DK (1)	DK2084172T3 (es)
EC (1)	ECSP099327A (es)
ES (1)	ES2358371T3 (es)
GT (1)	GT200900125A (es)
HR (1)	HRP20110197T1 (es)
IL (1)	IL198718A (es)
MA (1)	MA30883B1 (es)
MX (1)	MX2009003958A (es)
MY (1)	MY148429A (es)
NI (1)	NI200900076A (es)
NO (2)	NO342236B1 (es)
NZ (1)	NZ576762A (es)
PE (1)	PE20081493A1 (es)
PL (1)	PL2084172T3 (es)
PT (1)	PT2084172E (es)
RU (1)	RU2456282C2 (es)
SI (1)	SI2084172T1 (es)
SV (1)	SV2009003216A (es)
TN (1)	TN2009000180A1 (es)
TW (1)	TWI414530B (es)
UY (1)	UY30709A1 (es)
WO (1)	WO2008058628A1 (es)

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EP2582709B1 (de)	2010-06-18	2018-01-24	Sanofi	Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
JP2013538215A (ja)	2010-08-31	2013-10-10	エスエヌユーアールアンドディービーファウンデーション	ＰＰＡＲδアゴニストの胎児再プログラミング用途
KR101890959B1 (ko)	2010-11-04	2018-08-22	알비레오 에이비	간질환 치료를 위한 ｉｂａｔ 억제제
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WO2013063526A1 (en) *	2011-10-28	2013-05-02	Lumena Pharmaceuticals, Inc.	Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease
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US10441604B2 (en)	2016-02-09	2019-10-15	Albireo Ab	Cholestyramine pellets and methods for preparation thereof
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US10786529B2 (en)	2016-02-09	2020-09-29	Albireo Ab	Oral cholestyramine formulation and use thereof
WO2017138878A1 (en)	2016-02-09	2017-08-17	Albireo Ab	Oral cholestyramine formulation and use thereof
JP7328207B2 (ja)	2017-08-09	2023-08-16	アルビレオ・アクチボラグ	コレスチラミンペレット、経口コレスチラミン製剤、及びそれらの使用
CA3071285A1 (en)	2017-08-09	2019-02-14	Albireo Ab	Cholestyramine granules, oral cholestyramine formulations and use thereof
CN112449637B (zh)	2018-06-05	2024-03-19	阿尔比里奥公司	苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
US10793534B2 (en)	2018-06-05	2020-10-06	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
SG11202012151XA (en)	2018-06-20	2021-01-28	Albireo Ab	Crystal modifications of odevixibat
US11801226B2 (en)	2018-06-20	2023-10-31	Albireo Ab	Pharmaceutical formulation of odevixibat
US11549878B2 (en)	2018-08-09	2023-01-10	Albireo Ab	In vitro method for determining the adsorbing capacity of an insoluble adsorbant
US11007142B2 (en)	2018-08-09	2021-05-18	Albireo Ab	Oral cholestyramine formulation and use thereof
US10722457B2 (en)	2018-08-09	2020-07-28	Albireo Ab	Oral cholestyramine formulation and use thereof
AU2019324170A1 (en)	2018-08-23	2021-02-18	Seagen, Inc.	Anti-TIGIT antibodies
US10941127B2 (en)	2019-02-06	2021-03-09	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
US10975045B2 (en)	2019-02-06	2021-04-13	Aibireo AB	Benzothiazepine compounds and their use as bile acid modulators
MX2021008981A (es)	2019-02-06	2021-09-08	Albireo Ab	Compuestos de benzotiadiazepina y su uso como moduladores del acido biliar.
AU2020221834B2 (en)	2019-02-12	2025-10-23	Mirum Pharmaceuticals, Inc.	Genotype and dose-dependent response to an ASBTI in patients with bile salt export pump deficiency
US11014898B1 (en)	2020-12-04	2021-05-25	Albireo Ab	Benzothiazepine compounds and their use as bile acid modulators
JP7696898B2 (ja)	2019-12-04	2025-06-23	アルビレオ・アクチボラグ	ベンゾチア（ジ）アゼピン化合物及び胆汁酸モジュレータとしてのそれらの使用
EP4069360B1 (en)	2019-12-04	2024-01-03	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
CA3158184A1 (en)	2019-12-04	2021-08-10	Albireo Ab	Benzothiadiazepine compounds and their use as bile acid modulators
CN114761080B (zh)	2019-12-04	2024-07-23	阿尔比里奥公司	苯并硫杂(二)氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途
ES3002777T3 (en)	2020-08-03	2025-03-07	Albireo Ab	Benzothia(di)azepine compounds and their use as bile acid modulators
EP4243831A1 (en)	2020-11-12	2023-09-20	Albireo AB	Odevixibat for treating progressive familial intrahepatic cholestasis (pfic)
EP4255565A1 (en)	2020-12-04	2023-10-11	Albireo AB	Benzothia(di)azepine compounds and their use as bile acid modulators
TW202313579A (zh)	2021-06-03	2023-04-01	瑞典商艾爾比瑞歐公司	苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
CN119053330A (zh)	2022-04-22	2024-11-29	阿尔比里奥公司	皮下给药asbt抑制剂
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US20240207286A1 (en)	2022-12-09	2024-06-27	Albireo Ab	Asbt inhibitors in the treatment of renal diseases
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2006
- 2006-11-14 DE DE102006053635A patent/DE102006053635B4/de not_active Expired - Fee Related
2007
- 2007-10-30 MX MX2009003958A patent/MX2009003958A/es active IP Right Grant
- 2007-10-30 CA CA2669230A patent/CA2669230C/en active Active
- 2007-10-30 AU AU2007321496A patent/AU2007321496B2/en active Active
- 2007-10-30 DE DE502007006055T patent/DE502007006055D1/de active Active
- 2007-10-30 PT PT07819434T patent/PT2084172E/pt unknown
- 2007-10-30 WO PCT/EP2007/009393 patent/WO2008058628A1/de not_active Ceased
- 2007-10-30 ES ES07819434T patent/ES2358371T3/es active Active
- 2007-10-30 NO NO20091893A patent/NO342236B1/no unknown
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- 2007-10-30 EP EP07819434A patent/EP2084172B1/de active Active
- 2007-10-30 CA CA2865332A patent/CA2865332C/en active Active
- 2007-10-30 DK DK07819434.7T patent/DK2084172T3/da active
- 2007-10-30 AT AT07819434T patent/ATE492554T1/de active
- 2007-10-30 BR BRPI0718813A patent/BRPI0718813B8/pt active IP Right Grant
- 2007-10-30 SI SI200730487T patent/SI2084172T1/sl unknown
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- 2007-10-30 JP JP2009536625A patent/JP5301453B2/ja active Active
- 2007-10-30 KR KR1020097009914A patent/KR101489168B1/ko active Active
- 2007-10-30 CN CN2007800424399A patent/CN101535326B/zh active Active
- 2007-10-30 RU RU2009122470/04A patent/RU2456282C2/ru active
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2009
- 2009-04-03 SV SV2009003216A patent/SV2009003216A/es unknown
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- 2009-05-06 CO CO09045559A patent/CO6190534A2/es not_active Application Discontinuation
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- 2009-05-14 US US12/465,911 patent/US7956085B2/en active Active
2011
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2017
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Also Published As

Publication number	Publication date
BRPI0718813B1 (pt)	2020-12-08
ECSP099327A (es)	2009-06-30
TN2009000180A1 (en)	2010-10-18
SV2009003216A (es)	2010-05-26
BRPI0718813A2 (pt)	2013-12-03
EP2084172A1 (de)	2009-08-05
TWI414530B (zh)	2013-11-11
PT2084172E (pt)	2011-02-10
NZ576762A (en)	2010-11-26
BRPI0718813B8 (pt)	2021-05-25
CR10733A (es)	2009-05-25
AU2007321496A1 (en)	2008-05-22
KR20090082396A (ko)	2009-07-30
PL2084172T3 (pl)	2011-06-30
EP2084172B1 (de)	2010-12-22
CN101535326B (zh)	2012-10-31
CY1111166T1 (el)	2015-06-11
GT200900125A (es)	2011-06-23
NI200900076A (es)	2010-01-29
CN101535326A (zh)	2009-09-16
DE102006053635B4 (de)	2011-06-30
AR063786A1 (es)	2009-02-18
JP2010509379A (ja)	2010-03-25
RU2009122470A (ru)	2010-12-20
NO20180497A1 (no)	2009-07-09
KR101489168B1 (ko)	2015-02-03
SI2084172T1 (sl)	2011-03-31
DK2084172T3 (da)	2011-04-04
AR109033A2 (es)	2018-10-24
PE20081493A1 (es)	2008-11-24
TW200837072A (en)	2008-09-16
RU2456282C2 (ru)	2012-07-20
ATE492554T1 (de)	2011-01-15
CA2865332C (en)	2016-03-29
CA2669230A1 (en)	2008-05-22
MY148429A (en)	2013-04-30
CO6190534A2 (es)	2010-08-19
CA2865332A1 (en)	2008-05-22
NO342236B1 (no)	2018-04-23
UY30709A1 (es)	2008-07-03
HRP20110197T1 (hr)	2011-04-30
ES2358371T3 (es)	2011-05-10
NO344589B1 (no)	2020-02-03
US7956085B2 (en)	2011-06-07
HK1137762A1 (en)	2010-08-06
DE502007006055D1 (de)	2011-02-03
IL198718A (en)	2012-12-31
JP5301453B2 (ja)	2013-09-25
US20100035961A1 (en)	2010-02-11
DE102006053635A1 (de)	2008-05-15
MX2009003958A (es)	2009-04-27
IL198718A0 (en)	2010-02-17
AU2007321496B2 (en)	2012-07-26
MA30883B1 (fr)	2009-11-02
NO20091893L (no)	2009-07-09
CA2669230C (en)	2015-01-13
WO2008058628A1 (de)	2008-05-22

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