CL2007001663A1 - Uso de un antagonista de cgrp de formula definida (a), sus enantiomeros, sus diastereomeros, sus mezclas y sus sales para preparar un medicamento util para prevenir o tratar el dolor visceral. - Google Patents
Uso de un antagonista de cgrp de formula definida (a), sus enantiomeros, sus diastereomeros, sus mezclas y sus sales para preparar un medicamento util para prevenir o tratar el dolor visceral.Info
- Publication number
- CL2007001663A1 CL2007001663A1 CL2007001663A CL2007001663A CL2007001663A1 CL 2007001663 A1 CL2007001663 A1 CL 2007001663A1 CL 2007001663 A CL2007001663 A CL 2007001663A CL 2007001663 A CL2007001663 A CL 2007001663A CL 2007001663 A1 CL2007001663 A1 CL 2007001663A1
- Authority
- CL
- Chile
- Prior art keywords
- prevent
- diastereomers
- enantiomers
- mixtures
- salts
- Prior art date
Links
- 208000009935 visceral pain Diseases 0.000 title abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- 229940127597 CGRP antagonist Drugs 0.000 title 1
- 239000003735 calcitonin gene related peptide receptor antagonist Substances 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 108060001064 Calcitonin Proteins 0.000 abstract 1
- 208000018522 Gastrointestinal disease Diseases 0.000 abstract 1
- 229940083963 Peptide antagonist Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Nutrition Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Uso de un antagonista del péptido relacionado con el gen calcitonina (cgrp) para prevenir o tratar el dolor visceral y trastornos gastrointestinales; y composición farmacéutica que comprende al compuesto.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06011787 | 2006-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2007001663A1 true CL2007001663A1 (es) | 2008-01-25 |
Family
ID=37101671
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2007001662A CL2007001662A1 (es) | 2006-06-08 | 2007-06-07 | Uso de compuestos especificos derivados de 2-oxo-1,2,4,5-tetrahidro-1,3-benzodiazepin-3-ilpiperidina antagonistas de cgrp para preparar un medicamento util para prevenir o tratar el dolor visceral y para prevenir o tratar trastornos gastrointestinales; composicion farmaceutica; y uso de la composicion. |
| CL2007001663A CL2007001663A1 (es) | 2006-06-08 | 2007-06-07 | Uso de un antagonista de cgrp de formula definida (a), sus enantiomeros, sus diastereomeros, sus mezclas y sus sales para preparar un medicamento util para prevenir o tratar el dolor visceral. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2007001662A CL2007001662A1 (es) | 2006-06-08 | 2007-06-07 | Uso de compuestos especificos derivados de 2-oxo-1,2,4,5-tetrahidro-1,3-benzodiazepin-3-ilpiperidina antagonistas de cgrp para preparar un medicamento util para prevenir o tratar el dolor visceral y para prevenir o tratar trastornos gastrointestinales; composicion farmaceutica; y uso de la composicion. |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20080139591A1 (es) |
| EP (2) | EP2029233A2 (es) |
| JP (2) | JP2009539800A (es) |
| KR (1) | KR20090021214A (es) |
| CN (1) | CN101500653A (es) |
| AR (2) | AR061272A1 (es) |
| AU (1) | AU2007255395A1 (es) |
| BR (1) | BRPI0712492A2 (es) |
| CA (2) | CA2654047A1 (es) |
| CL (2) | CL2007001662A1 (es) |
| EA (1) | EA200802381A1 (es) |
| EC (1) | ECSP089025A (es) |
| IL (1) | IL195712A0 (es) |
| MX (1) | MX2008015562A (es) |
| NO (1) | NO20085051L (es) |
| PE (2) | PE20080370A1 (es) |
| TW (2) | TW200815010A (es) |
| UY (2) | UY30399A1 (es) |
| WO (2) | WO2007141285A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20080370A1 (es) * | 2006-06-08 | 2008-06-13 | Boehringer Ingelheim Int | Derivados de quinazolinona como antagonistas de cgrp |
| WO2010070023A2 (en) * | 2008-12-19 | 2010-06-24 | Boehringer Ingelheim International Gmbh | Formulations |
| FR2963738B1 (fr) * | 2010-08-10 | 2012-09-28 | Assist Publ Hopitaux De Paris | Compose destine au traitement des douleurs abdominales fonctionnelles |
| US9745373B2 (en) | 2011-05-20 | 2017-08-29 | Alderbio Holdings Llc | Anti-CGRP compositions and use thereof |
| SG194973A1 (en) | 2011-05-20 | 2013-12-30 | Alderbio Holdings Llc | Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers |
| AU2012258976B8 (en) | 2011-05-20 | 2017-07-20 | H. Lundbeck A/S | Use of anti-CGRP or anti-CGRP-R antibodies or antibody fragments to treat or prevent chronic and acute forms of diarrhea |
| US20170114122A1 (en) | 2015-10-23 | 2017-04-27 | Alderbio Holdings Llc | Regulation of glucose metabolism using anti-cgrp antibodies |
| TWI636041B (zh) * | 2015-08-12 | 2018-09-21 | 美國禮來大藥廠 | Cgrp受體拮抗劑 |
| GB201519195D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
| GB201519194D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP receptor antagonists |
| GB201519196D0 (en) | 2015-10-30 | 2015-12-16 | Heptares Therapeutics Ltd | CGRP Receptor Antagonists |
| EP3366286A1 (en) | 2017-02-22 | 2018-08-29 | Johannes Keller | Compounds for treating sepsis |
| AU2020206241A1 (en) | 2019-01-08 | 2021-08-26 | H. Lundbeck A/S | Acute treatment and rapid treatment of headache using anti-CGRP antibodies |
| KR20210124867A (ko) | 2020-04-06 | 2021-10-15 | 하. 룬드벡 아크티에셀스카브 | 항-cgrp 항체를 사용하는 편두통 관련 성가심 증상 (mbs) 의 치료 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5291960A (en) * | 1992-11-30 | 1994-03-08 | Ford Motor Company | Hybrid electric vehicle regenerative braking energy recovery system |
| DE10250082A1 (de) | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE10250080A1 (de) * | 2002-10-25 | 2004-05-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| US7595312B2 (en) | 2002-10-25 | 2009-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Selected CGRP antagonists, processes for preparing them and their use as pharmaceutical compositions |
| WO2005041757A2 (en) * | 2003-10-29 | 2005-05-12 | University Of Rochester | Detection of neuropeptides associated with pelvic pain disorders and uses thereof |
| DE102004015723A1 (de) | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE102004019492A1 (de) * | 2004-04-22 | 2005-11-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE102004063752A1 (de) * | 2004-12-29 | 2006-07-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung ausgewählter CGRP-Antagonisten zur Bekämpfung menopausaler Hitzewallungen |
| DE102004063755A1 (de) * | 2004-12-29 | 2006-07-20 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung von CGRP-Antagonisten zur Behandlung und Vorbeugung von Hitzewallungen bei Patienten mit Prostatakrebs |
| DE102004063753A1 (de) * | 2004-12-29 | 2006-07-13 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verwendung ausgewählter CGRP-Antagonisten in Kombination mit anderen Arzneistoffen gegen Migräne für die Behandlung von Migräne |
| EP1770091A1 (de) | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| CN101146799A (zh) * | 2005-03-23 | 2008-03-19 | 贝林格尔·英格海姆国际有限公司 | Cgrp拮抗剂、其制备方法以及其作为药物的用途 |
| US7491717B2 (en) | 2005-03-23 | 2009-02-17 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
| DE102005038831A1 (de) | 2005-08-17 | 2007-02-22 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| EP1770087A1 (de) * | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| EP1770086A1 (de) | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| DE102006017827A1 (de) * | 2006-04-13 | 2007-10-18 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue kristalline Verbindungen |
| PE20080370A1 (es) * | 2006-06-08 | 2008-06-13 | Boehringer Ingelheim Int | Derivados de quinazolinona como antagonistas de cgrp |
-
2007
- 2007-06-06 PE PE2007000697A patent/PE20080370A1/es not_active Application Discontinuation
- 2007-06-06 JP JP2009513686A patent/JP2009539800A/ja active Pending
- 2007-06-06 MX MX2008015562A patent/MX2008015562A/es not_active Application Discontinuation
- 2007-06-06 WO PCT/EP2007/055543 patent/WO2007141285A1/en not_active Ceased
- 2007-06-06 WO PCT/EP2007/055542 patent/WO2007141284A2/en not_active Ceased
- 2007-06-06 CN CNA2007800289541A patent/CN101500653A/zh active Pending
- 2007-06-06 EP EP07729917A patent/EP2029233A2/en not_active Withdrawn
- 2007-06-06 AU AU2007255395A patent/AU2007255395A1/en not_active Abandoned
- 2007-06-06 JP JP2009513685A patent/JP2009539799A/ja active Pending
- 2007-06-06 BR BRPI0712492-9A patent/BRPI0712492A2/pt not_active IP Right Cessation
- 2007-06-06 CA CA002654047A patent/CA2654047A1/en not_active Abandoned
- 2007-06-06 CA CA002654048A patent/CA2654048A1/en not_active Abandoned
- 2007-06-06 EA EA200802381A patent/EA200802381A1/ru unknown
- 2007-06-06 KR KR1020097000327A patent/KR20090021214A/ko not_active Withdrawn
- 2007-06-06 PE PE2007000698A patent/PE20080153A1/es not_active Application Discontinuation
- 2007-06-06 EP EP07729918A patent/EP2029234A1/en not_active Withdrawn
- 2007-06-07 TW TW096120441A patent/TW200815010A/zh unknown
- 2007-06-07 CL CL2007001662A patent/CL2007001662A1/es unknown
- 2007-06-07 CL CL2007001663A patent/CL2007001663A1/es unknown
- 2007-06-07 UY UY30399A patent/UY30399A1/es not_active Application Discontinuation
- 2007-06-07 TW TW096120440A patent/TW200808791A/zh unknown
- 2007-06-07 UY UY30398A patent/UY30398A1/es not_active Application Discontinuation
- 2007-06-08 US US11/760,054 patent/US20080139591A1/en not_active Abandoned
- 2007-06-08 AR ARP070102481A patent/AR061272A1/es unknown
- 2007-06-08 US US11/760,057 patent/US7807666B2/en active Active
- 2007-06-08 AR ARP070102480A patent/AR061271A1/es not_active Application Discontinuation
-
2008
- 2008-12-04 IL IL195712A patent/IL195712A0/en unknown
- 2008-12-04 NO NO20085051A patent/NO20085051L/no not_active Application Discontinuation
- 2008-12-31 EC EC2008009025A patent/ECSP089025A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA200802381A1 (ru) | 2009-06-30 |
| CL2007001662A1 (es) | 2008-01-25 |
| TW200815010A (en) | 2008-04-01 |
| WO2007141284A2 (en) | 2007-12-13 |
| CN101500653A (zh) | 2009-08-05 |
| AU2007255395A1 (en) | 2007-12-13 |
| UY30398A1 (es) | 2008-01-31 |
| CA2654047A1 (en) | 2007-12-13 |
| AR061272A1 (es) | 2008-08-13 |
| US20080139537A1 (en) | 2008-06-12 |
| US20080139591A1 (en) | 2008-06-12 |
| PE20080153A1 (es) | 2008-04-14 |
| IL195712A0 (en) | 2009-09-01 |
| AR061271A1 (es) | 2008-08-13 |
| JP2009539799A (ja) | 2009-11-19 |
| EP2029233A2 (en) | 2009-03-04 |
| KR20090021214A (ko) | 2009-02-27 |
| BRPI0712492A2 (pt) | 2012-08-21 |
| TW200808791A (en) | 2008-02-16 |
| WO2007141285A1 (en) | 2007-12-13 |
| JP2009539800A (ja) | 2009-11-19 |
| EP2029234A1 (en) | 2009-03-04 |
| CA2654048A1 (en) | 2007-12-13 |
| ECSP089025A (es) | 2009-01-30 |
| NO20085051L (no) | 2008-12-19 |
| MX2008015562A (es) | 2008-12-17 |
| UY30399A1 (es) | 2008-01-31 |
| WO2007141284A3 (en) | 2008-03-06 |
| PE20080370A1 (es) | 2008-06-13 |
| US7807666B2 (en) | 2010-10-05 |
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