CL2004001968A1 - METHOD FOR PREPARING A MONOMERIC CONJUGATE OF CALIQUEAMYCIN DERIVATIVES AND A PROTEIC CARRIER, IN THE MIDDLE OF NON-NUCLEIFILE TAMPONING, WITH T-BUTANOL AS A CO-SOLVENT. - Google Patents
METHOD FOR PREPARING A MONOMERIC CONJUGATE OF CALIQUEAMYCIN DERIVATIVES AND A PROTEIC CARRIER, IN THE MIDDLE OF NON-NUCLEIFILE TAMPONING, WITH T-BUTANOL AS A CO-SOLVENT.Info
- Publication number
- CL2004001968A1 CL2004001968A1 CL2004001968A CL2004001968A CL2004001968A1 CL 2004001968 A1 CL2004001968 A1 CL 2004001968A1 CL 2004001968 A CL2004001968 A CL 2004001968A CL 2004001968 A CL2004001968 A CL 2004001968A CL 2004001968 A1 CL2004001968 A1 CL 2004001968A1
- Authority
- CL
- Chile
- Prior art keywords
- around
- caliqueamycin
- derivatives
- solvent
- solution
- Prior art date
Links
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 title abstract 2
- 239000006184 cosolvent Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 238000011534 incubation Methods 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- -1 CARBOXYL Chemical class 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 238000004220 aggregation Methods 0.000 abstract 1
- 230000002776 aggregation Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Landscapes
- Peptides Or Proteins (AREA)
Abstract
LA PRESENTE INVENCION DESCRIBE UN METODO PARA LA PREPARACION DE CONJUGADOS DERIVADOS PORTADORES DE CALIQUEAMICINA CON MAYOR CARGA DE DROGA/RENDIMIENTO Y AGREGACION REDUCIDA. ESTOS CONJUGADOS SON PEPARADOS MEDIANTE LA INCUBACION DE DERIBADOS DE CALIQUEAMICINA Y UN PORTADOR PROTEINACE O EN UNA SOLUCION QUE COMPRENDE UNA SOLUCION TAMPONADA, NO-NULEOFILICA, COMPATIBLE CON PROTEINAS, UN CO-SOLVENTE SELECCIONADO DE UN GRUPO CONSISTENTE EN PROPILEN GLICOL, ETANOL,DMSO Y COMBINACIONES DE ESTOS, ADEMAS, DE UN ADITIVO QUE COMPRENDE AL MENOS UN ACIDO CARBOXILICO C6-C18 CON UN pH EN EL RANGO DE ALREDEDOR DE 25 GRADOS C. HASTA ALREDEDOR DE 4,0 A 8,5 Y A UNA TEMPERATURA EN EL RANGO DE ALREDEDOR DE 25 GRADOS C. HASTA ALREDEDOR DE 37 GRADOS C. DURANTE UN PERIODO EN EL RANGO DE ALREDEDOR DE 15 MINUTOS HASTA ALREDEDOR DE 24 HORAS, Y RECUPERANDOSE CONJUGADOS PUEDEN SER PREPARADOS POR MEDIO DE LA INCUBACION DE DERIVADOS DE LA CALIQUEAMICINA Y UN PORTADOR PROTEINACEO EN UNA SOLUCION QUE COMPRENDE UNA SOLUCION TAMPONADA, NO-NUCLEOFILICA, COMPATIBLE CON PROTEINA Y UN CO-SOLVENTE QUE COMPRENDE T-BUTANOL.THE PRESENT INVENTION DESCRIBES A METHOD FOR THE PREPARATION OF DERIVED CONJUGATES CARRIED BY CALIQUEAMYCIN WITH GREATER DRUG / PERFORMANCE LOAD AND REDUCED AGGREGATION. THESE CONJUGATES ARE PEPARED THROUGH THE INCUBATION OF CALIQUEAMYCIN DERIVATIVES AND A PROTEINACE CARRIER OR IN A SOLUTION THAT INCLUDES A STAMPED, NON-NULEOPHILIC SOLUTION, COMPATIBLE WITH PROTEINS, A SELECTED SOLVENT OF A CONSPENDENT DOLLAR GROUP, COMBINATIONS OF THESE, IN ADDITION, TO AN ADDITIVE THAT INCLUDES AT LEAST A C6-C18 CARBOXYL ACID WITH A pH IN THE RANGE OF AROUND 25 DEGREES C. TO AROUND 4.0 TO 8.5 AND TO A TEMPERATURE IN THE RANGE OF AROUND OF 25 DEGREES C. UP TO AROUND 37 DEGREES C. DURING A PERIOD IN THE RANGE OF AROUND 15 MINUTES UNTIL AROUND 24 HOURS, AND RECOVERING CONJUGATES CAN BE PREPARED THROUGH THE INCUBATION OF CALIQUEAMICIN DERIVATIVES AND A CARRIER A SOLUTION THAT INCLUDES A STAMPED, NON-NUCLEOPHILIC SOLUTION, COMPATIBLE WITH PROTEIN AND A CO-SOLVENT THAT INCLUDES T-BUTANOL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/654,505 US5714586A (en) | 1995-06-07 | 1996-05-28 | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2004001968A1 true CL2004001968A1 (en) | 2005-06-03 |
Family
ID=40263144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2004001968A CL2004001968A1 (en) | 1996-05-28 | 2004-07-30 | METHOD FOR PREPARING A MONOMERIC CONJUGATE OF CALIQUEAMYCIN DERIVATIVES AND A PROTEIC CARRIER, IN THE MIDDLE OF NON-NUCLEIFILE TAMPONING, WITH T-BUTANOL AS A CO-SOLVENT. |
Country Status (1)
| Country | Link |
|---|---|
| CL (1) | CL2004001968A1 (en) |
-
2004
- 2004-07-30 CL CL2004001968A patent/CL2004001968A1/en unknown
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