CA3211368A1 - Nouveaux agents de mise en contact de cd123 a base de darpin - Google Patents
Nouveaux agents de mise en contact de cd123 a base de darpinInfo
- Publication number
- CA3211368A1 CA3211368A1 CA3211368A CA3211368A CA3211368A1 CA 3211368 A1 CA3211368 A1 CA 3211368A1 CA 3211368 A CA3211368 A CA 3211368A CA 3211368 A CA3211368 A CA 3211368A CA 3211368 A1 CA3211368 A1 CA 3211368A1
- Authority
- CA
- Canada
- Prior art keywords
- ankyrin repeat
- protein
- binding
- binding protein
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Medicinal Preparation (AREA)
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Abstract
La présente invention concerne des protéines de liaison recombinées comprenant un domaine de répétition d'ankyrine, le domaine de répétition d'ankyrine présentant une spécificité de liaison pour le CD123 humain. De plus, l'invention concerne des acides nucléiques codant de telles protéines de liaison recombinées, des compositions pharmaceutiques comprenant de telles protéines ou de tels acides nucléiques, et l'utilisation de telles protéines de liaison, de tels acides nucléiques ou de telles compositions pharmaceutiques dans des méthodes de traitement ou de diagnostic de maladies, telles que le cancer, par exemple, la leucémie myéloïde aiguë (LAM) chez un mammifère, notamment un être humain.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163158539P | 2021-03-09 | 2021-03-09 | |
| US63/158,539 | 2021-03-09 | ||
| US202163173227P | 2021-04-09 | 2021-04-09 | |
| US63/173,227 | 2021-04-09 | ||
| US202163265187P | 2021-12-09 | 2021-12-09 | |
| US63/265,187 | 2021-12-09 | ||
| PCT/IB2022/052128 WO2022190018A1 (fr) | 2021-03-09 | 2022-03-09 | Nouveaux agents de mise en contact de cd123 à base de darpin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3211368A1 true CA3211368A1 (fr) | 2022-09-15 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3211368A Pending CA3211368A1 (fr) | 2021-03-09 | 2022-03-09 | Nouveaux agents de mise en contact de cd123 a base de darpin |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240150475A1 (fr) |
| EP (1) | EP4304729A1 (fr) |
| JP (1) | JP2024509241A (fr) |
| AU (1) | AU2022233791A1 (fr) |
| CA (1) | CA3211368A1 (fr) |
| WO (1) | WO2022190018A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3178785A1 (fr) | 2020-05-14 | 2021-11-18 | Nicolo RIGAMONTI | Proteines multispecifiques |
| EP4304731A1 (fr) | 2021-03-09 | 2024-01-17 | Molecular Partners AG | Nouveaux agents de mise en contact de lymphocytes t multi-spécifiques à base de darpin |
| WO2024179981A1 (fr) * | 2023-02-27 | 2024-09-06 | Molecular Partners Ag | Darpines utilisées pour réduire l'accumulation rénale de médicaments |
| WO2024251628A1 (fr) * | 2023-06-06 | 2024-12-12 | Molecular Partners Ag | Protéines de liaison à cd16a recombinantes et leur utilisation |
| WO2025163082A1 (fr) * | 2024-01-31 | 2025-08-07 | Molecular Partners Ag | Constructions de liaison spécifiques à dll3 et leur utilisation en radiothérapie |
| WO2025181039A1 (fr) | 2024-03-01 | 2025-09-04 | Molecular Partners Ag | Polythérapies comprenant un dispositif de mise en contact de lymphocytes t multi-spécifiques |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| ATE448301T1 (de) | 2000-09-08 | 2009-11-15 | Univ Zuerich | Sammlung von proteinen mit sich wiederholenden sequenzen (repeat proteins), die repetitive sequenzmodule enthalten |
| US20050048512A1 (en) | 2001-04-26 | 2005-03-03 | Avidia Research Institute | Combinatorial libraries of monomer domains |
| US20040175756A1 (en) | 2001-04-26 | 2004-09-09 | Avidia Research Institute | Methods for using combinatorial libraries of monomer domains |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| WO2005063815A2 (fr) | 2003-11-12 | 2005-07-14 | Biogen Idec Ma Inc. | Variants de polypeptides de liaison au recepteur fc$g(g) et procede apparentes |
| US20060008844A1 (en) | 2004-06-17 | 2006-01-12 | Avidia Research Institute | c-Met kinase binding proteins |
| US9365629B2 (en) | 2007-09-24 | 2016-06-14 | University Of Zurich | Designed armadillo repeat proteins |
| CN107011425B (zh) | 2008-11-03 | 2021-01-01 | 分子组合公司 | 抑制vegf-a受体相互作用的结合蛋白 |
| TWI510246B (zh) | 2010-04-30 | 2015-12-01 | Molecular Partners Ag | 抑制ｖｅｇｆ－ａ受體交互作用的經修飾結合性蛋白質 |
| EP2643349B1 (fr) | 2010-11-26 | 2019-09-04 | Molecular Partners AG | Liaison de protéines de répétition conçues à l'albumine sérique |
| CN104508129A (zh) | 2012-06-28 | 2015-04-08 | 分子伴侣公司 | 设计的与血小板衍生生长因子结合的锚蛋白重复序列蛋白 |
| EP2738180A1 (fr) | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Protéines de liaison comportant au moins deux domaines de liaison ciblant HER2 |
| EP2789630A1 (fr) | 2013-04-09 | 2014-10-15 | EngMab AG | Anticorps bispécifiques contre le CD3e et ROR1 |
| JP6486908B2 (ja) | 2013-05-31 | 2019-03-20 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 肝細胞増殖因子に結合する設計アンキリン反復タンパク質 |
| EP2839842A1 (fr) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bianticorps monovalents bi-spécifiques capables de se lier aux CD123 et CD3 et leurs utilisations |
| JP6552636B2 (ja) | 2015-04-02 | 2019-07-31 | モレキュラー パートナーズ アクチェンゲゼルシャフト | 血清アルブミンに対する結合特異性を有する設計アンキリンリピートドメイン |
| CN109790206A (zh) | 2016-09-22 | 2019-05-21 | 分子组合公司 | 重组结合蛋白及其用途 |
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2022
- 2022-03-09 CA CA3211368A patent/CA3211368A1/fr active Pending
- 2022-03-09 JP JP2023554813A patent/JP2024509241A/ja active Pending
- 2022-03-09 WO PCT/IB2022/052128 patent/WO2022190018A1/fr not_active Ceased
- 2022-03-09 AU AU2022233791A patent/AU2022233791A1/en active Pending
- 2022-03-09 EP EP22711618.3A patent/EP4304729A1/fr active Pending
- 2022-03-09 US US18/281,161 patent/US20240150475A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022190018A1 (fr) | 2022-09-15 |
| EP4304729A1 (fr) | 2024-01-17 |
| JP2024509241A (ja) | 2024-02-29 |
| US20240150475A1 (en) | 2024-05-09 |
| AU2022233791A9 (en) | 2024-01-25 |
| AU2022233791A1 (en) | 2023-09-28 |
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