CA3208941A1 - Polypropylene modifie par un faisceau d'atomes neutres accelere (anab) pour reduire la colonisation bacterienne sans antibiotiques - Google Patents
Polypropylene modifie par un faisceau d'atomes neutres accelere (anab) pour reduire la colonisation bacterienne sans antibiotiques Download PDFInfo
- Publication number
- CA3208941A1 CA3208941A1 CA3208941A CA3208941A CA3208941A1 CA 3208941 A1 CA3208941 A1 CA 3208941A1 CA 3208941 A CA3208941 A CA 3208941A CA 3208941 A CA3208941 A CA 3208941A CA 3208941 A1 CA3208941 A1 CA 3208941A1
- Authority
- CA
- Canada
- Prior art keywords
- clusters
- anab
- accelerated
- argon atoms
- polypropylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000894006 Bacteria Species 0.000 title claims abstract description 58
- 230000007935 neutral effect Effects 0.000 title claims abstract description 23
- 239000004743 Polypropylene Substances 0.000 title claims description 32
- -1 polypropylene Polymers 0.000 title claims description 32
- 229920001155 polypropylene Polymers 0.000 title claims description 32
- 239000003242 anti bacterial agent Substances 0.000 title abstract description 15
- 229940088710 antibiotic agent Drugs 0.000 title abstract description 15
- 239000007943 implant Substances 0.000 claims abstract description 7
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 48
- 238000000034 method Methods 0.000 claims description 30
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 5
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- 231100000517 death Toxicity 0.000 description 3
- CBOIHMRHGLHBPB-UHFFFAOYSA-N hydroxymethyl Chemical compound O[CH2] CBOIHMRHGLHBPB-UHFFFAOYSA-N 0.000 description 3
- 238000003384 imaging method Methods 0.000 description 3
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- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- 241000192125 Firmicutes Species 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 102100028965 Proteoglycan 4 Human genes 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
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- 238000012286 ELISA Assay Methods 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 102000015728 Mucins Human genes 0.000 description 1
- 108010063954 Mucins Proteins 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 241000233805 Phoenix Species 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 208000031650 Surgical Wound Infection Diseases 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 208000035091 Ventral Hernia Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000002835 absorbance Methods 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000010065 bacterial adhesion Effects 0.000 description 1
- 239000003782 beta lactam antibiotic agent Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
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- 238000012239 gene modification Methods 0.000 description 1
- 230000005017 genetic modification Effects 0.000 description 1
- 235000013617 genetically modified food Nutrition 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
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- 239000007788 liquid Substances 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000002355 open surgical procedure Methods 0.000 description 1
- 230000000399 orthopedic effect Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
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- 238000001356 surgical procedure Methods 0.000 description 1
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- 238000012876 topography Methods 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000002132 β-lactam antibiotic Substances 0.000 description 1
- 229940124586 β-lactam antibiotics Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/048—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Artificial Filaments (AREA)
Abstract
Les surfaces d'un matériau d'implant chirurgical sont modifiées avec un faisceau d'atome neutre accéléré, des propriétés de surface du matériau modifié sont caractérisées, et une réduction de la large gamme de colonisation bactérienne sur de telles surfaces est obtenue sans utiliser d'antibiotiques.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163140513P | 2021-01-22 | 2021-01-22 | |
| US63/140,513 | 2021-01-22 | ||
| PCT/US2022/013388 WO2022159751A1 (fr) | 2021-01-22 | 2022-01-21 | Polypropylène modifié par un faisceau d'atomes neutres accéléré (anab) pour réduire la colonisation bactérienne sans antibiotiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3208941A1 true CA3208941A1 (fr) | 2022-07-28 |
Family
ID=82549876
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3208941A Pending CA3208941A1 (fr) | 2021-01-22 | 2022-01-21 | Polypropylene modifie par un faisceau d'atomes neutres accelere (anab) pour reduire la colonisation bacterienne sans antibiotiques |
Country Status (3)
| Country | Link |
|---|---|
| CA (1) | CA3208941A1 (fr) |
| DE (1) | DE112022000720T5 (fr) |
| WO (1) | WO2022159751A1 (fr) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7105199B2 (en) * | 2001-05-11 | 2006-09-12 | Exogenesis Corporation | Methods of adhering drugs to the surface of medical devices through ion beam surface modification |
| US8933290B2 (en) * | 2007-06-26 | 2015-01-13 | Sofradim Production Sas | Mesh implant |
| RU2653581C2 (ru) * | 2013-02-04 | 2018-05-15 | Эксодженезис Корпорейшн | Способ и устройство для направления пучка нейтральных частиц |
| DE102013014295A1 (de) * | 2013-08-22 | 2015-02-26 | Johnson & Johnson Medical Gmbh | Chirurgisches Implantat |
| WO2015175665A1 (fr) * | 2014-05-13 | 2015-11-19 | Dsm Ip Assets B.V. | Composés bioadhésifs et procédés de synthèse et d'utilisation |
| CN114899096A (zh) * | 2015-10-14 | 2022-08-12 | 艾克索乔纳斯公司 | 使用基于气体团簇离子束技术的中性射束处理的超浅蚀刻方法以及由此产生的物品 |
| US11101134B2 (en) * | 2018-09-10 | 2021-08-24 | Exogenesis Corporation | Method and apparatus to eliminate contaminant particles from an accelerated neutral atom beam and thereby protect a beam target |
-
2022
- 2022-01-21 CA CA3208941A patent/CA3208941A1/fr active Pending
- 2022-01-21 WO PCT/US2022/013388 patent/WO2022159751A1/fr not_active Ceased
- 2022-01-21 DE DE112022000720.6T patent/DE112022000720T5/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE112022000720T5 (de) | 2023-11-16 |
| WO2022159751A1 (fr) | 2022-07-28 |
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