CA3202227A1 - Compositions et procedes pour vaccins peptidiques optimises - Google Patents
Compositions et procedes pour vaccins peptidiques optimisesInfo
- Publication number
- CA3202227A1 CA3202227A1 CA3202227A CA3202227A CA3202227A1 CA 3202227 A1 CA3202227 A1 CA 3202227A1 CA 3202227 A CA3202227 A CA 3202227A CA 3202227 A CA3202227 A CA 3202227A CA 3202227 A1 CA3202227 A1 CA 3202227A1
- Authority
- CA
- Canada
- Prior art keywords
- peptide
- seq
- hla
- sequence
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001164—GTPases, e.g. Ras or Rho
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- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/05—Hydrolases acting on acid anhydrides (3.6) acting on GTP; involved in cellular and subcellular movement (3.6.5)
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Abstract
La présente divulgation concerne des procédés, des systèmes et des compositions d'acide nucléique et de séquences peptidiques. La présente divulgation concerne une séquence d'acide nucléique codant pour au moins deux séquences d'acides aminés choisies dans le groupe constitué par SEQ ID NO : 1 à 6, SEQ ID NO : 8 à 10, SEQ ID NO : 12 à 28 et SEQ ID NO : 30 à 41. La présente divulgation concerne également une composition peptidique immunogène comprenant au moins un peptide choisi dans le groupe constitué par SEQ ID NO : 42 à 65. La présente divulgation concerne une composition comprenant des séquences d'acide nucléique codant pour au moins deux séquences d'acides aminés choisies dans le groupe constitué par SEQ ID NO : 1550 à 1593. La présente divulgation concerne en outre une séquence d'acide nucléique codant pour au moins une séquence d'acides aminés choisie dans le groupe constitué par SEQ ID NO : 1595 à 1661.
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
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| US17/100,630 US11058751B1 (en) | 2020-11-20 | 2020-11-20 | Compositions for optimized RAS peptide vaccines |
| US17/100,630 | 2020-11-20 | ||
| US17/114,237 US11161892B1 (en) | 2020-12-07 | 2020-12-07 | Method of compact peptide vaccines using residue optimization |
| US17/114,237 | 2020-12-07 | ||
| US17/336,960 US11235039B1 (en) | 2020-11-20 | 2021-06-02 | Immunogenic compositions comprising nucleic acids for RAS peptides |
| US17/336,960 | 2021-06-02 | ||
| US17/389,875 | 2021-07-30 | ||
| US17/389,875 US11421015B2 (en) | 2020-12-07 | 2021-07-30 | Method of compact peptide vaccines using residue optimization |
| US202163249235P | 2021-09-28 | 2021-09-28 | |
| US63/249,235 | 2021-09-28 | ||
| PCT/US2021/060013 WO2022109220A1 (fr) | 2020-11-20 | 2021-11-19 | Compositions et procédés pour vaccins peptidiques optimisés |
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| CA3202227A1 true CA3202227A1 (fr) | 2022-05-27 |
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| JP (1) | JP2023551204A (fr) |
| AU (1) | AU2021381384A1 (fr) |
| CA (1) | CA3202227A1 (fr) |
| WO (1) | WO2022109220A1 (fr) |
Cited By (1)
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| WO2024160126A1 (fr) * | 2023-01-30 | 2024-08-08 | 深圳新合睿恩生物医疗科技有限公司 | Procédé et appareil de conception en tandem de vaccins multi-épitopes, dispositif et support de stockage |
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| US20240131133A1 (en) * | 2022-10-10 | 2024-04-25 | Think Therapeutics, Inc. | Compositions and methods for optimized kras peptide vaccines |
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| US9884893B2 (en) * | 2012-05-21 | 2018-02-06 | Distributed Bio, Inc. | Epitope focusing by variable effective antigen surface concentration |
| WO2016154047A2 (fr) * | 2015-03-20 | 2016-09-29 | Memorial Sloan-Kettering Cancer Center | Protéines de liaison à l'antigène monoclonales à des produits oncogènes intracellulaires |
| WO2016172722A1 (fr) * | 2015-04-23 | 2016-10-27 | Nantomics, Llc | Néo-épitopes de cancer |
| EP3294324A1 (fr) * | 2015-05-13 | 2018-03-21 | Agenus Inc. | Vaccins pour le traitement et la prévention du cancer |
| WO2016187508A2 (fr) * | 2015-05-20 | 2016-11-24 | The Broad Institute Inc. | Néo-antigènes partagés |
| IL264425B2 (en) * | 2016-08-02 | 2023-09-01 | Us Secretary Department Of Health And Human Services | t cell receptors against kras-g20 |
| CN110402145A (zh) * | 2016-10-26 | 2019-11-01 | 莫得纳特斯公司 | 用于增强免疫应答的信使核糖核酸及其使用方法 |
| US20190351039A1 (en) * | 2017-02-01 | 2019-11-21 | Modernatx, Inc. | Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides |
| WO2018145020A1 (fr) * | 2017-02-03 | 2018-08-09 | The Medical College Of Wisconsin, Inc. | Compositions de vaccin peptidique kras et procédé d'utilisation |
| CN108395479B (zh) * | 2017-02-06 | 2021-07-16 | 高军 | 一种有关kras基因突变的t细胞受体 |
| MX2020014243A (es) * | 2018-06-19 | 2021-05-12 | Biontech Us Inc | Neoantigenos y usos de los mismos. |
| TW202039534A (zh) * | 2018-12-14 | 2020-11-01 | 美商美國禮來大藥廠 | KRAS變體mRNA分子 |
| WO2020210202A1 (fr) * | 2019-04-11 | 2020-10-15 | The Board Of Trustees Of The Leland Stanford Junior University | Lymphocytes t cytotoxiques, spécifiques de formes mutées du récepteur du facteur de croissance épidermique, destinés à être utilisés dans le traitement du cancer |
| US11058751B1 (en) * | 2020-11-20 | 2021-07-13 | Think Therapeutics, Inc. | Compositions for optimized RAS peptide vaccines |
| US11161892B1 (en) * | 2020-12-07 | 2021-11-02 | Think Therapeutics, Inc. | Method of compact peptide vaccines using residue optimization |
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- 2021-11-19 EP EP21895640.7A patent/EP4247401A4/fr active Pending
- 2021-11-19 AU AU2021381384A patent/AU2021381384A1/en active Pending
- 2021-11-19 JP JP2023530750A patent/JP2023551204A/ja active Pending
- 2021-11-19 CA CA3202227A patent/CA3202227A1/fr active Pending
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2024160126A1 (fr) * | 2023-01-30 | 2024-08-08 | 深圳新合睿恩生物医疗科技有限公司 | Procédé et appareil de conception en tandem de vaccins multi-épitopes, dispositif et support de stockage |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2023551204A (ja) | 2023-12-07 |
| WO2022109220A1 (fr) | 2022-05-27 |
| EP4247401A4 (fr) | 2025-06-11 |
| EP4247401A1 (fr) | 2023-09-27 |
| AU2021381384A1 (en) | 2023-06-22 |
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