CA3136633A1 - Compositions pharmaceutiques et methodes de traitement de troubles mentaux, comportementaux et cognitifs - Google Patents
Compositions pharmaceutiques et methodes de traitement de troubles mentaux, comportementaux et cognitifs Download PDFInfo
- Publication number
- CA3136633A1 CA3136633A1 CA3136633A CA3136633A CA3136633A1 CA 3136633 A1 CA3136633 A1 CA 3136633A1 CA 3136633 A CA3136633 A CA 3136633A CA 3136633 A CA3136633 A CA 3136633A CA 3136633 A1 CA3136633 A1 CA 3136633A1
- Authority
- CA
- Canada
- Prior art keywords
- memantine
- azelastine
- pharmaceutical composition
- disease
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 20
- 230000003542 behavioural effect Effects 0.000 title claims abstract description 10
- 208000010877 cognitive disease Diseases 0.000 title claims abstract description 9
- 230000003340 mental effect Effects 0.000 title claims abstract description 9
- 229960004640 memantine Drugs 0.000 claims abstract description 52
- MBUVEWMHONZEQD-UHFFFAOYSA-N Azeptin Chemical compound C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 MBUVEWMHONZEQD-UHFFFAOYSA-N 0.000 claims abstract description 45
- 229960004574 azelastine Drugs 0.000 claims abstract description 45
- 150000003839 salts Chemical class 0.000 claims abstract description 44
- 208000024827 Alzheimer disease Diseases 0.000 claims description 28
- LDDHMLJTFXJGPI-UHFFFAOYSA-N memantine hydrochloride Chemical compound Cl.C1C(C2)CC3(C)CC1(C)CC2(N)C3 LDDHMLJTFXJGPI-UHFFFAOYSA-N 0.000 claims description 20
- 239000002552 dosage form Substances 0.000 claims description 11
- 229960004335 azelastine hydrochloride Drugs 0.000 claims description 8
- YEJAJYAHJQIWNU-UHFFFAOYSA-N azelastine hydrochloride Chemical group Cl.C1CN(C)CCCC1N1C(=O)C2=CC=CC=C2C(CC=2C=CC(Cl)=CC=2)=N1 YEJAJYAHJQIWNU-UHFFFAOYSA-N 0.000 claims description 8
- 229960000967 memantine hydrochloride Drugs 0.000 claims description 7
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- BUGYDGFZZOZRHP-UHFFFAOYSA-N memantine Chemical compound C1C(C2)CC3(C)CC1(C)CC2(N)C3 BUGYDGFZZOZRHP-UHFFFAOYSA-N 0.000 abstract description 41
- 239000004480 active ingredient Substances 0.000 abstract description 4
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- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 9
- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 description 9
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- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 7
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- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
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- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 description 1
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- 230000016273 neuron death Effects 0.000 description 1
- 239000004090 neuroprotective agent Substances 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 230000002276 neurotropic effect Effects 0.000 description 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 201000000980 schizophrenia Diseases 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne une composition pharmaceutique contenant les ingrédients thérapeutiquement actifs de l'azélastine ou un sel pharmaceutiquement acceptable de l'azélastine et de la mémantine ou un sel pharmaceutiquement acceptable de mémantine. L'invention concerne également une méthode d'utilisation de la composition pharmaceutique pour traiter des patients souffrant de troubles mentaux, comportementaux, cognitifs.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2019/027293 WO2020209872A1 (fr) | 2019-04-12 | 2019-04-12 | Compositions pharmaceutiques et méthodes de traitement de troubles mentaux, comportementaux et cognitifs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3136633A1 true CA3136633A1 (fr) | 2020-10-15 |
Family
ID=72751206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3136633A Pending CA3136633A1 (fr) | 2019-04-12 | 2019-04-12 | Compositions pharmaceutiques et methodes de traitement de troubles mentaux, comportementaux et cognitifs |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3952840A4 (fr) |
| JP (1) | JP7365426B2 (fr) |
| CN (1) | CN113939276A (fr) |
| AU (1) | AU2019445048A1 (fr) |
| CA (1) | CA3136633A1 (fr) |
| WO (1) | WO2020209872A1 (fr) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11318144B2 (en) | 2019-04-12 | 2022-05-03 | LA PharmaTech Inc. | Compositions and methods for treating Alzheimer's disease and Parkinson's disease |
| US11351179B1 (en) | 2021-08-05 | 2022-06-07 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of psychiatric disorders |
| US11389458B2 (en) | 2019-04-12 | 2022-07-19 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating parkinson's and huntington's disease |
| US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
| US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
| US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10966989B2 (en) | 2019-04-12 | 2021-04-06 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating mental, behavioral, cognitive disorders |
| US10639314B1 (en) | 2019-04-30 | 2020-05-05 | LA PharmaTech Inc. | Method of treating Alzheimer's disease |
| US10898493B2 (en) | 2019-04-12 | 2021-01-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for psychiatric symptoms of patients with Alzheimer's disease |
| CA3137393A1 (fr) * | 2019-04-30 | 2020-11-05 | Jianmin Wang | Procede de traitement de troubles mentaux, comportementaux et cognitifs |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT2522365T (lt) * | 2004-11-24 | 2017-02-10 | Meda Pharmaceuticals Inc. | Kompozicijos, apimančios azelastiną, ir jų panaudojimo būdai |
| WO2014018563A2 (fr) * | 2012-07-23 | 2014-01-30 | The Board Of Trustees Of The Leland Stanford Junior University | Procédés pour le traitement du cancer |
| EP3532060A4 (fr) * | 2016-10-28 | 2020-08-26 | Chase Pharmaceuticals Corporation | Combinaisons et utilisation de mémantine |
| JP7198575B2 (ja) | 2017-07-11 | 2023-01-04 | キョーリンリメディオ株式会社 | メマンチン塩酸塩含有口腔内崩壊錠 |
-
2019
- 2019-04-12 WO PCT/US2019/027293 patent/WO2020209872A1/fr not_active Ceased
- 2019-04-12 CN CN201980095322.XA patent/CN113939276A/zh active Pending
- 2019-04-12 JP JP2021556914A patent/JP7365426B2/ja active Active
- 2019-04-12 CA CA3136633A patent/CA3136633A1/fr active Pending
- 2019-04-12 AU AU2019445048A patent/AU2019445048A1/en not_active Abandoned
- 2019-04-12 EP EP19924315.5A patent/EP3952840A4/fr active Pending
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11318144B2 (en) | 2019-04-12 | 2022-05-03 | LA PharmaTech Inc. | Compositions and methods for treating Alzheimer's disease and Parkinson's disease |
| US11389458B2 (en) | 2019-04-12 | 2022-07-19 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treating parkinson's and huntington's disease |
| US11690849B2 (en) | 2019-04-12 | 2023-07-04 | LA PharmaTech Inc. | Method of treating dementia |
| US11744833B2 (en) | 2019-04-12 | 2023-09-05 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of insomnia |
| US11938139B2 (en) | 2019-04-12 | 2024-03-26 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for anxiety, depression and other psychiatric disorders |
| US12138269B2 (en) | 2019-04-12 | 2024-11-12 | LA PharmaTech Inc. | Method of treating dementia |
| US11351179B1 (en) | 2021-08-05 | 2022-06-07 | LA PharmaTech Inc. | Pharmaceutical compositions and methods for treatment of psychiatric disorders |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3952840A4 (fr) | 2022-11-23 |
| JP7365426B2 (ja) | 2023-10-19 |
| JP2022535644A (ja) | 2022-08-10 |
| CN113939276A (zh) | 2022-01-14 |
| AU2019445048A1 (en) | 2021-12-02 |
| EP3952840A1 (fr) | 2022-02-16 |
| WO2020209872A1 (fr) | 2020-10-15 |
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