CA3129328A1 - Compositions contenant un derive de pyrimidine - Google Patents
Compositions contenant un derive de pyrimidine Download PDFInfo
- Publication number
- CA3129328A1 CA3129328A1 CA3129328A CA3129328A CA3129328A1 CA 3129328 A1 CA3129328 A1 CA 3129328A1 CA 3129328 A CA3129328 A CA 3129328A CA 3129328 A CA3129328 A CA 3129328A CA 3129328 A1 CA3129328 A1 CA 3129328A1
- Authority
- CA
- Canada
- Prior art keywords
- pyrimidine
- base
- composition
- palmitate
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 118
- 150000003230 pyrimidines Chemical class 0.000 title claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 30
- VWFCHDSQECPREK-LURJTMIESA-N Cidofovir Chemical compound NC=1C=CN(C[C@@H](CO)OCP(O)(O)=O)C(=O)N=1 VWFCHDSQECPREK-LURJTMIESA-N 0.000 claims abstract description 21
- 229960000724 cidofovir Drugs 0.000 claims abstract description 21
- 206010040872 skin infection Diseases 0.000 claims abstract description 18
- 206010040882 skin lesion Diseases 0.000 claims abstract description 17
- 231100000444 skin lesion Toxicity 0.000 claims abstract description 17
- -1 hexitidine Chemical compound 0.000 claims description 26
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 claims description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 24
- 201000010153 skin papilloma Diseases 0.000 claims description 21
- 230000003902 lesion Effects 0.000 claims description 18
- 208000000260 Warts Diseases 0.000 claims description 17
- 238000009472 formulation Methods 0.000 claims description 16
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 16
- 235000019271 petrolatum Nutrition 0.000 claims description 16
- MXCVHSXCXPHOLP-UHFFFAOYSA-N 4-oxo-6-propylchromene-2-carboxylic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=CC(CCC)=CC=C21 MXCVHSXCXPHOLP-UHFFFAOYSA-N 0.000 claims description 15
- 244000144927 Aloe barbadensis Species 0.000 claims description 14
- 235000002961 Aloe barbadensis Nutrition 0.000 claims description 14
- 235000011399 aloe vera Nutrition 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 14
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 claims description 13
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 claims description 13
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 12
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 12
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 12
- 239000000839 emulsion Substances 0.000 claims description 12
- 229940108325 retinyl palmitate Drugs 0.000 claims description 12
- 235000019172 retinyl palmitate Nutrition 0.000 claims description 12
- 239000011769 retinyl palmitate Substances 0.000 claims description 12
- 235000011187 glycerol Nutrition 0.000 claims description 11
- 241000701085 Human alphaherpesvirus 3 Species 0.000 claims description 10
- 241001529453 unidentified herpesvirus Species 0.000 claims description 10
- 239000004264 Petrolatum Substances 0.000 claims description 9
- 240000006365 Vitis vinifera Species 0.000 claims description 9
- XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 claims description 9
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 9
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims description 9
- 229940066842 petrolatum Drugs 0.000 claims description 9
- 208000007514 Herpes zoster Diseases 0.000 claims description 8
- 241000701806 Human papillomavirus Species 0.000 claims description 8
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 claims description 8
- XNKLLVCARDGLGL-JGVFFNPUSA-N Stavudine Chemical compound O=C1NC(=O)C(C)=CN1[C@H]1C=C[C@@H](CO)O1 XNKLLVCARDGLGL-JGVFFNPUSA-N 0.000 claims description 8
- 239000003443 antiviral agent Substances 0.000 claims description 8
- 229960000541 cetyl alcohol Drugs 0.000 claims description 8
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 8
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 8
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 8
- 235000000072 L-ascorbyl-6-palmitate Nutrition 0.000 claims description 7
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 6
- HMCTXMOKMWELFJ-UHFFFAOYSA-N 2-(pyridin-3-ylmethylsulfanyl)pyrimidine Chemical compound C=1C=CN=CC=1CSC1=NC=CC=N1 HMCTXMOKMWELFJ-UHFFFAOYSA-N 0.000 claims description 6
- OQDPVLVUJFGPGQ-UHFFFAOYSA-N 2-[4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl]pyrimidine Chemical compound C=1C=C2OCOC2=CC=1CN(CC1)CCN1C1=NC=CC=N1 OQDPVLVUJFGPGQ-UHFFFAOYSA-N 0.000 claims description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 6
- WOVKYSAHUYNSMH-RRKCRQDMSA-N 5-bromodeoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-RRKCRQDMSA-N 0.000 claims description 6
- 244000144725 Amygdalus communis Species 0.000 claims description 6
- 235000003840 Amygdalus nana Nutrition 0.000 claims description 6
- WOVKYSAHUYNSMH-UHFFFAOYSA-N BROMODEOXYURIDINE Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C(Br)=C1 WOVKYSAHUYNSMH-UHFFFAOYSA-N 0.000 claims description 6
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims description 6
- 235000011432 Prunus Nutrition 0.000 claims description 6
- 241000220299 Prunus Species 0.000 claims description 6
- 235000003893 Prunus dulcis var amara Nutrition 0.000 claims description 6
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 6
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 claims description 6
- 241000209140 Triticum Species 0.000 claims description 6
- 235000021307 Triticum Nutrition 0.000 claims description 6
- 244000098338 Triticum aestivum Species 0.000 claims description 6
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims description 6
- 235000009754 Vitis X bourquina Nutrition 0.000 claims description 6
- 235000012333 Vitis X labruscana Nutrition 0.000 claims description 6
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 claims description 6
- 235000010385 ascorbyl palmitate Nutrition 0.000 claims description 6
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 6
- 229940008099 dimethicone Drugs 0.000 claims description 6
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 229960004413 flucytosine Drugs 0.000 claims description 6
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 6
- 229930182478 glucoside Natural products 0.000 claims description 6
- 150000008131 glucosides Chemical class 0.000 claims description 6
- 229940075529 glyceryl stearate Drugs 0.000 claims description 6
- 235000002532 grape seed extract Nutrition 0.000 claims description 6
- 108700019599 monomethylolglycine Proteins 0.000 claims description 6
- 229960005323 phenoxyethanol Drugs 0.000 claims description 6
- CXEBHWXMQKIKPJ-UHFFFAOYSA-N phosphoric acid;n-propan-2-ylpyrimidin-2-amine Chemical compound OP(O)(O)=O.CC(C)NC1=NC=CC=N1 CXEBHWXMQKIKPJ-UHFFFAOYSA-N 0.000 claims description 6
- 229920002401 polyacrylamide Polymers 0.000 claims description 6
- 235000014774 prunus Nutrition 0.000 claims description 6
- XVRCWGVHAICWOW-UHFFFAOYSA-N pyrido[2,3-d]pyrimidine-6-carboxylic acid Chemical compound N1=CN=CC2=CC(C(=O)O)=CN=C21 XVRCWGVHAICWOW-UHFFFAOYSA-N 0.000 claims description 6
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 claims description 6
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 claims description 6
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 6
- PYAOPMWCFSVFOT-UHFFFAOYSA-N tisopurine Chemical compound SC1=NC=NC2=C1C=NN2 PYAOPMWCFSVFOT-UHFFFAOYSA-N 0.000 claims description 6
- 229940042585 tocopherol acetate Drugs 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 6
- 229920001285 xanthan gum Polymers 0.000 claims description 6
- 235000010493 xanthan gum Nutrition 0.000 claims description 6
- 229940082509 xanthan gum Drugs 0.000 claims description 6
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims description 5
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims description 5
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims description 5
- AQXXZDYPVDOQEE-MXDQRGINSA-N Pyrantel pamoate Chemical compound CN1CCCN=C1\C=C\C1=CC=CS1.C1=CC=C2C(CC=3C4=CC=CC=C4C=C(C=3O)C(=O)O)=C(O)C(C(O)=O)=CC2=C1 AQXXZDYPVDOQEE-MXDQRGINSA-N 0.000 claims description 5
- 229960000684 cytarabine Drugs 0.000 claims description 5
- ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 claims description 5
- 229960004716 idoxuridine Drugs 0.000 claims description 5
- 239000012188 paraffin wax Substances 0.000 claims description 5
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 5
- IEDVJHCEMCRBQM-UHFFFAOYSA-N trimethoprim Chemical compound COC1=C(OC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 IEDVJHCEMCRBQM-UHFFFAOYSA-N 0.000 claims description 5
- 229960002555 zidovudine Drugs 0.000 claims description 5
- 201000006082 Chickenpox Diseases 0.000 claims description 4
- 208000007766 Kaposi sarcoma Diseases 0.000 claims description 4
- 208000003351 Melanosis Diseases 0.000 claims description 4
- 208000031888 Mycoses Diseases 0.000 claims description 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 4
- 206010046980 Varicella Diseases 0.000 claims description 4
- 239000003925 fat Substances 0.000 claims description 4
- 229960000961 floxuridine Drugs 0.000 claims description 4
- 208000008588 molluscum contagiosum Diseases 0.000 claims description 4
- NQDJXKOVJZTUJA-UHFFFAOYSA-N nevirapine Chemical compound C12=NC=CC=C2C(=O)NC=2C(C)=CC=NC=2N1C1CC1 NQDJXKOVJZTUJA-UHFFFAOYSA-N 0.000 claims description 4
- ZJAOAACCNHFJAH-UHFFFAOYSA-N phosphonoformic acid Chemical compound OC(=O)P(O)(O)=O ZJAOAACCNHFJAH-UHFFFAOYSA-N 0.000 claims description 4
- WSWJIZXMAUYHOE-UHFFFAOYSA-N tetroxoprim Chemical compound C1=C(OC)C(OCCOC)=C(OC)C=C1CC1=CN=C(N)N=C1N WSWJIZXMAUYHOE-UHFFFAOYSA-N 0.000 claims description 4
- 150000003626 triacylglycerols Chemical class 0.000 claims description 4
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 4
- 229920002554 vinyl polymer Polymers 0.000 claims description 4
- 239000003871 white petrolatum Substances 0.000 claims description 4
- ZPNHGSNYBLXGOL-UHFFFAOYSA-N (4-amino-2-methoxypyrimidin-5-yl)methanol Chemical compound COC1=NC=C(CO)C(N)=N1 ZPNHGSNYBLXGOL-UHFFFAOYSA-N 0.000 claims description 3
- UJQBOUAGWGVOTI-XSSZXYGBSA-N 1-[(2r,4s,5r)-4-azido-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@](O)(N=[N+]=[N-])C1 UJQBOUAGWGVOTI-XSSZXYGBSA-N 0.000 claims description 3
- OLOCXIJVDIVAHH-FXRZFVDSSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid;1-methyl-2-[(e)-2-(3-methylthiophen-2-yl)ethenyl]-5,6-dihydro-4h-pyrimidine Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CN1CCCN=C1\C=C\C1=C(C)C=CS1 OLOCXIJVDIVAHH-FXRZFVDSSA-N 0.000 claims description 3
- WREGKURFCTUGRC-UHFFFAOYSA-N 4-Amino-1-[5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one Chemical compound O=C1N=C(N)C=CN1C1OC(CO)CC1 WREGKURFCTUGRC-UHFFFAOYSA-N 0.000 claims description 3
- STOUQLCLVFGFLT-UHFFFAOYSA-N 4-phenylselanylpyrimidine Chemical compound C=1C=NC=NC=1[Se]C1=CC=CC=C1 STOUQLCLVFGFLT-UHFFFAOYSA-N 0.000 claims description 3
- HRZQMMXCASMDBP-UHFFFAOYSA-N 5-[(3,5-dimethoxy-4-methylsulfanylphenyl)methyl]pyrimidine-2,4-diamine Chemical compound COC1=C(SC)C(OC)=CC(CC=2C(=NC(N)=NC=2)N)=C1 HRZQMMXCASMDBP-UHFFFAOYSA-N 0.000 claims description 3
- IDPUKCWIGUEADI-UHFFFAOYSA-N 5-[bis(2-chloroethyl)amino]uracil Chemical compound ClCCN(CCCl)C1=CNC(=O)NC1=O IDPUKCWIGUEADI-UHFFFAOYSA-N 0.000 claims description 3
- JTOUASWUIMAMAD-UHFFFAOYSA-N 7-[2-hydroxy-3-[4-(3-phenylsulfanylpropyl)piperazin-1-yl]propyl]-1,3-dimethylpurine-2,6-dione Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CC(O)CN(CC1)CCN1CCCSC1=CC=CC=C1 JTOUASWUIMAMAD-UHFFFAOYSA-N 0.000 claims description 3
- 206010008570 Chloasma Diseases 0.000 claims description 3
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims description 3
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims description 3
- WFWLQNSHRPWKFK-UHFFFAOYSA-N Tegafur Chemical compound O=C1NC(=O)C(F)=CN1C1OCCC1 WFWLQNSHRPWKFK-UHFFFAOYSA-N 0.000 claims description 3
- OGEAASSLWZDQBM-UHFFFAOYSA-N Temelastine Chemical compound C1=NC(C)=CC=C1CC(C(N1)=O)=CN=C1NCCCCC1=NC=C(Br)C=C1C OGEAASSLWZDQBM-UHFFFAOYSA-N 0.000 claims description 3
- GSNOZLZNQMLSKJ-UHFFFAOYSA-N Trapidil Chemical compound CCN(CC)C1=CC(C)=NC2=NC=NN12 GSNOZLZNQMLSKJ-UHFFFAOYSA-N 0.000 claims description 3
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims description 3
- 229950004398 broxuridine Drugs 0.000 claims description 3
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 claims description 3
- 229960002768 dipyridamole Drugs 0.000 claims description 3
- 229960002949 fluorouracil Drugs 0.000 claims description 3
- 239000004220 glutamic acid Substances 0.000 claims description 3
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 claims description 3
- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 claims description 3
- 229960000582 mepyramine Drugs 0.000 claims description 3
- 229960000485 methotrexate Drugs 0.000 claims description 3
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 3
- 229950008901 metioprim Drugs 0.000 claims description 3
- 239000002777 nucleoside Substances 0.000 claims description 3
- 229960005010 orotic acid Drugs 0.000 claims description 3
- HIANJWSAHKJQTH-UHFFFAOYSA-N pemirolast Chemical compound CC1=CC=CN(C2=O)C1=NC=C2C=1N=NNN=1 HIANJWSAHKJQTH-UHFFFAOYSA-N 0.000 claims description 3
- 229960004439 pemirolast Drugs 0.000 claims description 3
- JOHZPMXAZQZXHR-UHFFFAOYSA-N pipemidic acid Chemical compound N1=C2N(CC)C=C(C(O)=O)C(=O)C2=CN=C1N1CCNCC1 JOHZPMXAZQZXHR-UHFFFAOYSA-N 0.000 claims description 3
- 229960001732 pipemidic acid Drugs 0.000 claims description 3
- 229960004310 piribedil Drugs 0.000 claims description 3
- 208000017805 post-transplant lymphoproliferative disease Diseases 0.000 claims description 3
- 239000002718 pyrimidine nucleoside Substances 0.000 claims description 3
- RPQXVSUAYFXFJA-HGRQIUPRSA-N saxitoxin Chemical compound NC(=O)OC[C@@H]1N=C(N)N2CCC(O)(O)[C@@]22N=C(N)N[C@@H]12 RPQXVSUAYFXFJA-HGRQIUPRSA-N 0.000 claims description 3
- RPQXVSUAYFXFJA-UHFFFAOYSA-N saxitoxin hydrate Natural products NC(=O)OCC1N=C(N)N2CCC(O)(O)C22NC(N)=NC12 RPQXVSUAYFXFJA-UHFFFAOYSA-N 0.000 claims description 3
- 229950000090 tasuldine Drugs 0.000 claims description 3
- 229960001674 tegafur Drugs 0.000 claims description 3
- WFWLQNSHRPWKFK-ZCFIWIBFSA-N tegafur Chemical compound O=C1NC(=O)C(F)=CN1[C@@H]1OCCC1 WFWLQNSHRPWKFK-ZCFIWIBFSA-N 0.000 claims description 3
- 229950005829 temelastine Drugs 0.000 claims description 3
- 229960004809 tetroxoprim Drugs 0.000 claims description 3
- 229960001787 tisopurine Drugs 0.000 claims description 3
- 229960000363 trapidil Drugs 0.000 claims description 3
- 229960001082 trimethoprim Drugs 0.000 claims description 3
- 229940035893 uracil Drugs 0.000 claims description 3
- 229960001055 uracil mustard Drugs 0.000 claims description 3
- 239000001993 wax Substances 0.000 claims description 3
- YRCRRHNVYVFNTM-UHFFFAOYSA-N 1,1-dihydroxy-3-ethoxy-2-butanone Chemical compound CCOC(C)C(=O)C(O)O YRCRRHNVYVFNTM-UHFFFAOYSA-N 0.000 claims description 2
- UBCHPRBFMUDMNC-UHFFFAOYSA-N 1-(1-adamantyl)ethanamine Chemical compound C1C(C2)CC3CC2CC1(C(N)C)C3 UBCHPRBFMUDMNC-UHFFFAOYSA-N 0.000 claims description 2
- BPOMPTVRBWXZBY-UHFFFAOYSA-N 4-[[1-ethoxy-2-oxo-2-(4-phenylphenyl)ethyl]amino]benzoic acid Chemical compound C=1C=C(C=2C=CC=CC=2)C=CC=1C(=O)C(OCC)NC1=CC=C(C(O)=O)C=C1 BPOMPTVRBWXZBY-UHFFFAOYSA-N 0.000 claims description 2
- LHCOVOKZWQYODM-CPEOKENHSA-N 4-amino-1-[(2r,5s)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;1-[(2r,4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1.O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 LHCOVOKZWQYODM-CPEOKENHSA-N 0.000 claims description 2
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 claims description 2
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Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne des compositions et des méthodes pour traiter des lésions cutanées et des infections cutanées à l'aide d'un dérivé de pyrimidine administré par voie topique tel que le cidofovir.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962928396P | 2019-10-31 | 2019-10-31 | |
| US62/928,396 | 2019-10-31 | ||
| US16/797,186 | 2020-02-21 | ||
| US16/797,186 US20200253994A1 (en) | 2019-02-11 | 2020-02-21 | Pyrimidine derivative containing compositions |
| PCT/US2020/019402 WO2020168358A2 (fr) | 2019-02-11 | 2020-02-24 | Compositions contenant un dérivé de pyrimidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3129328A1 true CA3129328A1 (fr) | 2020-08-20 |
Family
ID=77663209
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3129328A Pending CA3129328A1 (fr) | 2019-10-31 | 2020-02-24 | Compositions contenant un derive de pyrimidine |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP2022536234A (fr) |
| CA (1) | CA3129328A1 (fr) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6919598A (en) * | 1997-04-17 | 1998-11-13 | Dumex-Alpharma A/S | A novel bioadhesive drug delivery system based on liquid crystals |
| US20090176743A1 (en) * | 2005-07-29 | 2009-07-09 | Priscilla Schaffer | Methods for treating or preventing reactivation of a latent herpesvirus infection |
| WO2014081976A1 (fr) * | 2012-11-21 | 2014-05-30 | Aviratek Biomedical Solutions, Llc | Procédé et compositions pour l'utilisation d'extraits botaniques dans le traitement d'infections virales, du cancer, de la douleur, de la démangeaison et de l'inflammation |
-
2020
- 2020-02-24 CA CA3129328A patent/CA3129328A1/fr active Pending
- 2020-02-24 JP JP2021546301A patent/JP2022536234A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2022536234A (ja) | 2022-08-15 |
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