CA3118051A1 - Formulation aerosolisable - Google Patents
Formulation aerosolisable Download PDFInfo
- Publication number
- CA3118051A1 CA3118051A1 CA3118051A CA3118051A CA3118051A1 CA 3118051 A1 CA3118051 A1 CA 3118051A1 CA 3118051 A CA3118051 A CA 3118051A CA 3118051 A CA3118051 A CA 3118051A CA 3118051 A1 CA3118051 A1 CA 3118051A1
- Authority
- CA
- Canada
- Prior art keywords
- aerosolisable formulation
- acid
- amount
- nicotine
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 493
- 238000009472 formulation Methods 0.000 title claims abstract description 456
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 198
- 229960002715 nicotine Drugs 0.000 claims abstract description 179
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 179
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 107
- 239000000443 aerosol Substances 0.000 claims abstract description 61
- 239000000796 flavoring agent Substances 0.000 claims abstract description 57
- 235000019634 flavors Nutrition 0.000 claims abstract description 56
- 238000000034 method Methods 0.000 claims abstract description 39
- 239000002253 acid Substances 0.000 claims description 131
- 229920000858 Cyclodextrin Polymers 0.000 claims description 85
- 229940097362 cyclodextrins Drugs 0.000 claims description 58
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 33
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 claims description 10
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 5
- 239000005711 Benzoic acid Substances 0.000 claims description 5
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 5
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- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims description 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims description 4
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 4
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- RADIRXJQODWKGQ-HWKANZROSA-N 2-Ethoxy-5-(1-propenyl)phenol Chemical compound CCOC1=CC=C(\C=C\C)C=C1O RADIRXJQODWKGQ-HWKANZROSA-N 0.000 claims description 2
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 claims description 2
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- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 claims description 2
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- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
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- 235000019260 propionic acid Nutrition 0.000 claims description 2
- 229940107700 pyruvic acid Drugs 0.000 claims description 2
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims description 2
- 239000011975 tartaric acid Substances 0.000 claims description 2
- 235000002906 tartaric acid Nutrition 0.000 claims description 2
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- 235000012141 vanillin Nutrition 0.000 claims description 2
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- 239000003571 electronic cigarette Substances 0.000 description 12
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- 239000002585 base Substances 0.000 description 5
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- 231100000167 toxic agent Toxicity 0.000 description 4
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- 150000001735 carboxylic acids Chemical class 0.000 description 2
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- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/10—Chemical features of tobacco products or tobacco substitutes
- A24B15/16—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes
- A24B15/167—Chemical features of tobacco products or tobacco substitutes of tobacco substitutes in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/24—Treatment of tobacco products or tobacco substitutes by extraction; Tobacco extracts
- A24B15/241—Extraction of specific substances
- A24B15/243—Nicotine
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
- A24B15/32—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances by acyclic compounds
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/05—Devices without heating means
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Manufacture Of Tobacco Products (AREA)
- Jellies, Jams, And Syrups (AREA)
- Colloid Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
L'invention concerne une formulation aérosolisable comprenant (i) de l'eau en une quantité d'au moins 85% en poids sur la base de la formulation aérosolisable; et (ii) de la nicotine. L'invention concerne également un procédé de formation d'un aérosol, le procédé comprenant l'aérosolisation d'une formulation aérosolisable comprenant (i) de l'eau en une quantité d'au moins 85% en poids sur la base de la formulation aérosolisable; et (ii) de la nicotine ou un ou plusieurs arômes.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1817865.7 | 2018-11-01 | ||
| GBGB1817865.7A GB201817865D0 (en) | 2018-11-01 | 2018-11-01 | Aerosolisable formulation |
| PCT/GB2019/053092 WO2020089637A1 (fr) | 2018-11-01 | 2019-10-31 | Formulation aérosolisable |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3118051A1 true CA3118051A1 (fr) | 2020-05-07 |
Family
ID=64655353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3118051A Pending CA3118051A1 (fr) | 2018-11-01 | 2019-10-31 | Formulation aerosolisable |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20210386110A1 (fr) |
| EP (2) | EP4353091B1 (fr) |
| JP (1) | JP7703445B2 (fr) |
| KR (1) | KR102684717B1 (fr) |
| CN (1) | CN113015444A (fr) |
| AU (1) | AU2019371079B2 (fr) |
| BR (1) | BR112021008556A2 (fr) |
| CA (1) | CA3118051A1 (fr) |
| ES (1) | ES2984536T3 (fr) |
| GB (1) | GB201817865D0 (fr) |
| IL (1) | IL282523A (fr) |
| MX (1) | MX2021005123A (fr) |
| MY (1) | MY204015A (fr) |
| PL (2) | PL3873245T3 (fr) |
| UA (1) | UA128040C2 (fr) |
| WO (1) | WO2020089637A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201817860D0 (en) | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolised formulation |
| GB201817859D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| GB202013489D0 (en) | 2020-08-27 | 2020-10-14 | Nicoventures Holdings Ltd | Consumable |
| US11771132B2 (en) | 2020-08-27 | 2023-10-03 | Rai Strategic Holdings, Inc. | Atomization nozzle for aerosol delivery device |
| US11771136B2 (en) | 2020-09-28 | 2023-10-03 | Rai Strategic Holdings, Inc. | Aerosol delivery device |
| IT202100022172A1 (it) * | 2021-08-23 | 2023-02-23 | Natural Acad S R L | Composizione liquida medicale per somministrazione aerea |
| KR20240028723A (ko) * | 2022-08-25 | 2024-03-05 | 주식회사 케이티앤지 | 산을 포함하는 흡연물품 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0462094U (fr) * | 1990-10-09 | 1992-05-27 | ||
| AU717600B2 (en) * | 1993-07-26 | 2000-03-30 | Mcneil Ab | Improved nicotine lozenge and therapeutic method for smoking cessation |
| US20080138399A1 (en) * | 1999-07-16 | 2008-06-12 | Aradigm Corporation | Dual release nicotine formulations, and systems and methods for their use |
| SE0104388D0 (sv) * | 2001-12-27 | 2001-12-27 | Pharmacia Ab | New formulation and use and manufacture thereof |
| US20030159702A1 (en) * | 2002-01-21 | 2003-08-28 | Lindell Katarina E.A. | Formulation and use manufacture thereof |
| US7767698B2 (en) * | 2002-06-03 | 2010-08-03 | Mcneil Ab | Formulation and use thereof |
| WO2004060351A2 (fr) * | 2002-12-31 | 2004-07-22 | Nektar Therapeutics | Formulation pharmaceutique ayant un agent actif insoluble |
| SE0300520D0 (sv) * | 2003-02-28 | 2003-02-28 | Pharmacia Ab | A container comprising nicotine and the use and manufacture thereof |
| US20070267033A1 (en) * | 2006-02-09 | 2007-11-22 | Philip Morris Usa Inc. | Gamma cyclodextrin flavoring-release additives |
| CN101583354A (zh) * | 2006-12-01 | 2009-11-18 | 阿拉迪姆公司 | 用于终止烟草使用的系统 |
| GB0700889D0 (en) * | 2007-01-17 | 2007-02-21 | British American Tobacco Co | Tobacco, tobacco derivative and/or tobacco substitute products, preparation and uses thereof |
| US20080286340A1 (en) * | 2007-05-16 | 2008-11-20 | Sven-Borje Andersson | Buffered nicotine containing products |
| GB0918129D0 (en) * | 2009-10-16 | 2009-12-02 | British American Tobacco Co | Control of puff profile |
| US9333229B2 (en) * | 2013-10-16 | 2016-05-10 | William Bjorncrantz | Winterized crude cannabis extracts and methods of preparation and use |
| TWI664918B (zh) * | 2014-05-21 | 2019-07-11 | 瑞士商菲利浦莫里斯製品股份有限公司 | 可感應加熱的菸草產品 |
| GB2528673B (en) * | 2014-07-25 | 2020-07-01 | Nicoventures Holdings Ltd | Aerosol provision system |
| GB201413835D0 (en) * | 2014-08-05 | 2014-09-17 | Nicoventures Holdings Ltd | Electronic vapour provision system |
| GB2535427A (en) | 2014-11-07 | 2016-08-24 | Nicoventures Holdings Ltd | Solution |
| US20160198759A1 (en) | 2015-01-13 | 2016-07-14 | Zip Llc | E-cigarette or vaping fluid |
| DE102015117811A1 (de) * | 2015-10-20 | 2017-04-20 | Chv Pharma Gmbh & Co. Kg | Inhalator sowie wirkstoffhaltige Zubereitung für einen Inhalator |
| US20170325494A1 (en) * | 2016-05-16 | 2017-11-16 | Lunatech, Llc | Liquid composition containing nicotine from non-tobacco source for use with electronic vaporizing devices |
| US12114688B2 (en) * | 2017-10-24 | 2024-10-15 | Rai Strategic Holdings, Inc. | Method for formulating aerosol precursor for aerosol delivery device |
| GB2569940B (en) * | 2017-11-01 | 2022-10-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
| US20190328040A1 (en) * | 2018-04-30 | 2019-10-31 | Zayd Abdulfuhah Turbi | Systems and Methods for Buffered Aerosol Drug Delivery |
| EP3574902A1 (fr) * | 2018-06-01 | 2019-12-04 | Yatzz Limited | Formulation de nicotine et mode d'administration |
| GB201817859D0 (en) * | 2018-11-01 | 2018-12-19 | Nicoventures Trading Ltd | Aerosolisable formulation |
-
2018
- 2018-11-01 GB GBGB1817865.7A patent/GB201817865D0/en not_active Ceased
-
2019
- 2019-10-31 PL PL19798365.3T patent/PL3873245T3/pl unknown
- 2019-10-31 MX MX2021005123A patent/MX2021005123A/es unknown
- 2019-10-31 UA UAA202102224A patent/UA128040C2/uk unknown
- 2019-10-31 EP EP24152849.6A patent/EP4353091B1/fr active Active
- 2019-10-31 JP JP2021523256A patent/JP7703445B2/ja active Active
- 2019-10-31 MY MYPI2021002221A patent/MY204015A/en unknown
- 2019-10-31 CN CN201980075317.2A patent/CN113015444A/zh active Pending
- 2019-10-31 US US17/290,319 patent/US20210386110A1/en active Pending
- 2019-10-31 PL PL24152849.6T patent/PL4353091T3/pl unknown
- 2019-10-31 BR BR112021008556-4A patent/BR112021008556A2/pt unknown
- 2019-10-31 KR KR1020217012916A patent/KR102684717B1/ko active Active
- 2019-10-31 ES ES19798365T patent/ES2984536T3/es active Active
- 2019-10-31 CA CA3118051A patent/CA3118051A1/fr active Pending
- 2019-10-31 AU AU2019371079A patent/AU2019371079B2/en active Active
- 2019-10-31 EP EP19798365.3A patent/EP3873245B1/fr active Active
- 2019-10-31 WO PCT/GB2019/053092 patent/WO2020089637A1/fr not_active Ceased
-
2021
- 2021-04-21 IL IL282523A patent/IL282523A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2020089637A1 (fr) | 2020-05-07 |
| ES2984536T3 (es) | 2024-10-29 |
| MY204015A (en) | 2024-07-31 |
| AU2019371079A1 (en) | 2021-05-27 |
| JP7703445B2 (ja) | 2025-07-07 |
| BR112021008556A2 (pt) | 2021-08-03 |
| PL3873245T3 (pl) | 2024-07-29 |
| EP4353091A3 (fr) | 2024-07-10 |
| US20210386110A1 (en) | 2021-12-16 |
| EP3873245B1 (fr) | 2024-02-28 |
| IL282523A (en) | 2021-06-30 |
| EP3873245A1 (fr) | 2021-09-08 |
| EP4353091A2 (fr) | 2024-04-17 |
| KR20210075107A (ko) | 2021-06-22 |
| PL4353091T3 (pl) | 2025-11-24 |
| JP2022506094A (ja) | 2022-01-17 |
| GB201817865D0 (en) | 2018-12-19 |
| UA128040C2 (uk) | 2024-03-20 |
| NZ775331A (en) | 2024-09-27 |
| KR102684717B1 (ko) | 2024-07-11 |
| CN113015444A (zh) | 2021-06-22 |
| AU2019371079B2 (en) | 2022-07-14 |
| MX2021005123A (es) | 2021-06-15 |
| EP4353091B1 (fr) | 2025-08-06 |
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