CA3194325A1 - Nanoparticules lipidiques pour l'administration de vaccins a arnm - Google Patents
Nanoparticules lipidiques pour l'administration de vaccins a arnmInfo
- Publication number
- CA3194325A1 CA3194325A1 CA3194325A CA3194325A CA3194325A1 CA 3194325 A1 CA3194325 A1 CA 3194325A1 CA 3194325 A CA3194325 A CA 3194325A CA 3194325 A CA3194325 A CA 3194325A CA 3194325 A1 CA3194325 A1 CA 3194325A1
- Authority
- CA
- Canada
- Prior art keywords
- mrna
- composition
- lnp
- lipid
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
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- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
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- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
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- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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- A—HUMAN NECESSITIES
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Landscapes
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- Life Sciences & Earth Sciences (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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Abstract
L'invention concerne de nouvelles nanoparticules lipidiques pour l'administration d'acides nucléiques tels que l'ARNm. L'invention concerne également des méthodes de fabrication et d'utilisation de nanoparticules lipidiques pour l'administration d'acides nucléiques tels que l'ARNm.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063110965P | 2020-11-06 | 2020-11-06 | |
| US63/110,965 | 2020-11-06 | ||
| US202163212523P | 2021-06-18 | 2021-06-18 | |
| US63/212,523 | 2021-06-18 | ||
| EP21315198 | 2021-10-13 | ||
| EP21315198.8 | 2021-10-13 | ||
| PCT/US2021/058250 WO2022099003A1 (fr) | 2020-11-06 | 2021-11-05 | Nanoparticules lipidiques pour l'administration de vaccins à arnm |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3194325A1 true CA3194325A1 (fr) | 2022-05-12 |
Family
ID=86184333
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3194325A Pending CA3194325A1 (fr) | 2020-11-06 | 2021-11-05 | Nanoparticules lipidiques pour l'administration de vaccins a arnm |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP4240335A1 (fr) |
| JP (1) | JP2023550600A (fr) |
| KR (1) | KR20230104223A (fr) |
| CN (1) | CN116406299A (fr) |
| AU (1) | AU2021374976A1 (fr) |
| CA (1) | CA3194325A1 (fr) |
| CO (1) | CO2023005218A2 (fr) |
| IL (1) | IL302631A (fr) |
| MX (1) | MX2023005203A (fr) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024097874A1 (fr) * | 2022-11-03 | 2024-05-10 | Modernatx, Inc. | Stabilité chimique de l'arnm |
| WO2024098491A1 (fr) * | 2022-11-11 | 2024-05-16 | 深圳先进技术研究院 | Arnm pour coder un anticorps anti-virus de la grippe aviaire h7n9, son procédé de préparation et son utilisation |
| WO2024098498A1 (fr) * | 2022-11-11 | 2024-05-16 | 深圳先进技术研究院 | Arnm pour le codage d'un anticorps contre le virus de la grippe aviaire h7n9, son procédé de préparation et son utilisation |
| US12150980B2 (en) | 2015-07-30 | 2024-11-26 | Modernatx, Inc. | Concatemeric peptide epitope RNAs |
| US12208288B2 (en) | 2015-10-22 | 2025-01-28 | Modernatx, Inc. | Betacoronavirus RNA vaccines |
| WO2025054383A1 (fr) * | 2023-09-06 | 2025-03-13 | Modernatx, Inc. | Stabilité chimique de l'arnm |
| US12453766B2 (en) | 2018-01-29 | 2025-10-28 | Modernatx, Inc. | RSV RNA vaccines |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025092866A1 (fr) * | 2023-10-31 | 2025-05-08 | 仁景(苏州)生物科技有限公司 | Vaccin à arnm antigrippe multivalent |
| CN120053395A (zh) * | 2023-11-30 | 2025-05-30 | 苏州维益生物科技有限公司 | 含二硫键的核酸-脂质颗粒、药物、用途、及制备方法 |
| CN118725043B (zh) * | 2024-06-27 | 2025-12-05 | 中国人民解放军陆军军医大学 | 用于递送核酸的多肽-脂质组合物及其应用和mRNA疫苗 |
| CN119746089B (zh) * | 2025-03-07 | 2025-06-13 | 细胞生态海河实验室 | 脂质纳米颗粒冷冻保护剂 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS58337B1 (sr) * | 2014-03-24 | 2019-03-29 | Translate Bio Inc | Irnk terapija za lečenje očnih oboljenja |
| RS64331B1 (sr) * | 2015-06-19 | 2023-08-31 | Massachusetts Inst Technology | Alkenil supstituisani 2,5-piperazindioni i njihova primena u sastavima za isporuku agensa u organizam ili ćeliju subjekta |
| TW202309002A (zh) * | 2021-04-15 | 2023-03-01 | 美商轉譯生技公司 | 基於「古德」緩衝液的陽離子脂質 |
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2021
- 2021-11-05 MX MX2023005203A patent/MX2023005203A/es unknown
- 2021-11-05 JP JP2023526888A patent/JP2023550600A/ja active Pending
- 2021-11-05 EP EP21815832.7A patent/EP4240335A1/fr active Pending
- 2021-11-05 CN CN202180073816.5A patent/CN116406299A/zh active Pending
- 2021-11-05 IL IL302631A patent/IL302631A/en unknown
- 2021-11-05 CA CA3194325A patent/CA3194325A1/fr active Pending
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- 2021-11-05 KR KR1020237018750A patent/KR20230104223A/ko active Pending
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2023
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12150980B2 (en) | 2015-07-30 | 2024-11-26 | Modernatx, Inc. | Concatemeric peptide epitope RNAs |
| US12208288B2 (en) | 2015-10-22 | 2025-01-28 | Modernatx, Inc. | Betacoronavirus RNA vaccines |
| US12403336B2 (en) | 2015-10-22 | 2025-09-02 | Modernatx, Inc. | Betacorona virus mRNA vaccines |
| US12403335B2 (en) | 2015-10-22 | 2025-09-02 | Modernatx, Inc. | Betacoronavirus MRNA vaccines |
| US12409347B2 (en) | 2015-10-22 | 2025-09-09 | Modernatx, Inc. | Betacoronavirus mRNA vaccines |
| US12453766B2 (en) | 2018-01-29 | 2025-10-28 | Modernatx, Inc. | RSV RNA vaccines |
| WO2024097874A1 (fr) * | 2022-11-03 | 2024-05-10 | Modernatx, Inc. | Stabilité chimique de l'arnm |
| WO2024098491A1 (fr) * | 2022-11-11 | 2024-05-16 | 深圳先进技术研究院 | Arnm pour coder un anticorps anti-virus de la grippe aviaire h7n9, son procédé de préparation et son utilisation |
| WO2024098498A1 (fr) * | 2022-11-11 | 2024-05-16 | 深圳先进技术研究院 | Arnm pour le codage d'un anticorps contre le virus de la grippe aviaire h7n9, son procédé de préparation et son utilisation |
| WO2025054383A1 (fr) * | 2023-09-06 | 2025-03-13 | Modernatx, Inc. | Stabilité chimique de l'arnm |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4240335A1 (fr) | 2023-09-13 |
| MX2023005203A (es) | 2023-07-13 |
| JP2023550600A (ja) | 2023-12-04 |
| KR20230104223A (ko) | 2023-07-07 |
| IL302631A (en) | 2023-07-01 |
| CO2023005218A2 (es) | 2023-05-19 |
| CN116406299A (zh) | 2023-07-07 |
| AU2021374976A1 (en) | 2023-06-29 |
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