CA3187827A1 - Formulations a liberation modifiee de formes modifiees de trimetazidine - Google Patents
Formulations a liberation modifiee de formes modifiees de trimetazidineInfo
- Publication number
- CA3187827A1 CA3187827A1 CA3187827A CA3187827A CA3187827A1 CA 3187827 A1 CA3187827 A1 CA 3187827A1 CA 3187827 A CA3187827 A CA 3187827A CA 3187827 A CA3187827 A CA 3187827A CA 3187827 A1 CA3187827 A1 CA 3187827A1
- Authority
- CA
- Canada
- Prior art keywords
- hours
- imb
- trimetazidine
- dose
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 239000004700 high-density polyethylene Substances 0.000 description 1
- 229940084986 human chorionic gonadotropin Drugs 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
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- 230000001771 impaired effect Effects 0.000 description 1
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- 150000002500 ions Chemical class 0.000 description 1
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- 208000028867 ischemia Diseases 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000006101 laboratory sample Substances 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
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- 210000005228 liver tissue Anatomy 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
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- 230000000813 microbial effect Effects 0.000 description 1
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- 230000000116 mitigating effect Effects 0.000 description 1
- 230000005787 mitochondrial ATP synthesis coupled electron transport Effects 0.000 description 1
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- 210000001616 monocyte Anatomy 0.000 description 1
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- 230000007935 neutral effect Effects 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-M nicotinate Chemical compound [O-]C(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-M 0.000 description 1
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 1
- 229920001220 nitrocellulos Polymers 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000007310 pathophysiology Effects 0.000 description 1
- CYXKNKQEMFBLER-UHFFFAOYSA-N perhexiline Chemical compound C1CCCNC1CC(C1CCCCC1)C1CCCCC1 CYXKNKQEMFBLER-UHFFFAOYSA-N 0.000 description 1
- 229960000989 perhexiline Drugs 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
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- 230000000704 physical effect Effects 0.000 description 1
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- 239000011591 potassium Substances 0.000 description 1
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- 239000003755 preservative agent Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940039716 prothrombin Drugs 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000006479 redox reaction Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000012429 release testing Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 235000015096 spirit Nutrition 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
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- 235000019698 starch Nutrition 0.000 description 1
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- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne des compositions pharmaceutiques qui contiennent des formulations à libération modifiée de formes modifiées de trimétazidine, telles que CV-8972. Les compositions comprennent un polymère érodable, tel que l'hydroxypropylméthylcellulose (HPMC), qui permet une libération prolongée de la forme modifiée de trimétazidine et de ses produits métaboliques dans le corps. L'invention concerne également des méthodes de traitement de pathologies, notamment d'une angine et d'une insuffisance cardiaque, à l'aide de ces compositions.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063046117P | 2020-06-30 | 2020-06-30 | |
| US202063046115P | 2020-06-30 | 2020-06-30 | |
| US63/046,115 | 2020-06-30 | ||
| US63/046,117 | 2020-06-30 | ||
| US202163183294P | 2021-05-03 | 2021-05-03 | |
| US202163183299P | 2021-05-03 | 2021-05-03 | |
| US63/183,299 | 2021-05-03 | ||
| US63/183,294 | 2021-05-03 | ||
| PCT/US2021/039303 WO2022005926A1 (fr) | 2020-06-30 | 2021-06-28 | Formulations à libération modifiée de formes modifiées de trimétazidine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3187827A1 true CA3187827A1 (fr) | 2022-01-06 |
Family
ID=79315460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3187827A Pending CA3187827A1 (fr) | 2020-06-30 | 2021-06-28 | Formulations a liberation modifiee de formes modifiees de trimetazidine |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP4171232A4 (fr) |
| JP (1) | JP2023531802A (fr) |
| KR (1) | KR20230028535A (fr) |
| CN (1) | CN116234555A (fr) |
| AU (1) | AU2021299197A1 (fr) |
| CA (1) | CA3187827A1 (fr) |
| IL (1) | IL299544A (fr) |
| WO (1) | WO2022005926A1 (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20250035269A (ko) * | 2023-09-05 | 2025-03-12 | 주식회사 뉴캔서큐어바이오 | 트리메타지딘을 포함하는 코팅정 조성물 및 이의 제조방법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE517619T1 (de) * | 2006-06-09 | 2011-08-15 | Ucb Pharma Gmbh | Stabilisierte pharmazeutische zusammensetzung mit fesoterodin |
| PE20080669A1 (es) * | 2006-09-08 | 2008-07-18 | Drugtech Corp | Composicion de liberacion sostenida que comprende levodopa |
| ITFI20130184A1 (it) * | 2013-08-01 | 2015-02-02 | Valpharma Internat S P A | Una formulazione farmaceutica di gliclazide a rilascio modificato, somministrabile per via orale, e suo metodo di produzione. |
| US11207271B2 (en) * | 2016-03-09 | 2021-12-28 | Nls Pharmaceutics Ag | Mazindol IR/SR multilayer tablet and its use for the treatment of attention deficit/hyperactivity disorder (ADHD) |
| US10556013B2 (en) * | 2017-06-20 | 2020-02-11 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| US10980747B2 (en) * | 2017-11-27 | 2021-04-20 | Shin-Etsu Chemical Co., Ltd. | Composition for solid preparation, solid preparation, and method for producing the same |
| CN109908096A (zh) * | 2017-12-12 | 2019-06-21 | 武汉武药科技有限公司 | 一种盐酸曲美他嗪缓释片及其制备方法 |
| EP4497474A3 (fr) * | 2018-10-17 | 2025-04-23 | Imbria Pharmaceuticals, Inc. | Procédés de traitement de maladies rhumatismales à l'aide de composés à base de trimétazidine |
-
2021
- 2021-06-28 AU AU2021299197A patent/AU2021299197A1/en active Pending
- 2021-06-28 JP JP2022581463A patent/JP2023531802A/ja active Pending
- 2021-06-28 IL IL299544A patent/IL299544A/en unknown
- 2021-06-28 KR KR1020237003154A patent/KR20230028535A/ko active Pending
- 2021-06-28 WO PCT/US2021/039303 patent/WO2022005926A1/fr not_active Ceased
- 2021-06-28 EP EP21832842.5A patent/EP4171232A4/fr active Pending
- 2021-06-28 CN CN202180051890.7A patent/CN116234555A/zh active Pending
- 2021-06-28 CA CA3187827A patent/CA3187827A1/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2021299197A1 (en) | 2023-02-02 |
| IL299544A (en) | 2023-02-01 |
| KR20230028535A (ko) | 2023-02-28 |
| WO2022005926A1 (fr) | 2022-01-06 |
| EP4171232A1 (fr) | 2023-05-03 |
| CN116234555A (zh) | 2023-06-06 |
| JP2023531802A (ja) | 2023-07-25 |
| EP4171232A4 (fr) | 2024-07-24 |
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| Tablets et al. | Pr SANDOZ SAXAGLIPTIN | |
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| Agent | KOMBOGLYZE® |