[go: up one dir, main page]

CA3173030C - Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali - Google Patents

Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali Download PDF

Info

Publication number
CA3173030C
CA3173030C CA3173030A CA3173030A CA3173030C CA 3173030 C CA3173030 C CA 3173030C CA 3173030 A CA3173030 A CA 3173030A CA 3173030 A CA3173030 A CA 3173030A CA 3173030 C CA3173030 C CA 3173030C
Authority
CA
Canada
Prior art keywords
psychoactive
alkaloid
solvent
weight
psychoactive alkaloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3173030A
Other languages
English (en)
Other versions
CA3173030A1 (fr
Inventor
Benjamin Lightburn
Ryan Moss
Lisa Ranken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Psilo Scientific Ltd
Original Assignee
Psilo Scientific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA3088384A external-priority patent/CA3088384C/fr
Priority claimed from CA3097246A external-priority patent/CA3097246C/fr
Priority claimed from CA3101765A external-priority patent/CA3101765A1/fr
Priority claimed from CA3103707A external-priority patent/CA3103707C/fr
Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd
Publication of CA3173030A1 publication Critical patent/CA3173030A1/fr
Application granted granted Critical
Publication of CA3173030C publication Critical patent/CA3173030C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/078—Psilocybe
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0253—Fluidised bed of solid materials
    • B01D11/0257—Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B01D11/0284—Multistage extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0292—Treatment of the solvent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Mycology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Linvention concerne lextraction de composés psychoactifs dorganismes destinés à être utilisés en médecine. L'extraction est réalisée avec un acide fort ou une base forte pour favoriser ou inhiber la déphosphorylation. L'extrait sous forme de suspension est standardisé avec un excipient ajouté de telle sorte que, lorsqu'elle est séchée, la composition en poudre a une concentration en alcaloïde psychoactif totale spécifiée avec un rapport connu de phosphorylé en alcaloïdes psychoactifs déphosphorylés.
CA3173030A 2020-06-17 2021-06-14 Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali Active CA3173030C (fr)

Applications Claiming Priority (15)

Application Number Priority Date Filing Date Title
US202063040317P 2020-06-17 2020-06-17
US63/040,317 2020-06-17
US202063046089P 2020-06-30 2020-06-30
US63/046,089 2020-06-30
CA3088384A CA3088384C (fr) 2020-06-17 2020-07-29 Extraction de composes psychoactifs de champignons psilocybines
CA3089455A CA3089455C (fr) 2020-06-17 2020-08-07 Extraction au methanol de composes psychoactifs de champignons
CA3089455 2020-08-07
CA3088384 2020-09-27
CA3097246A CA3097246C (fr) 2020-10-23 2020-10-23 Processus d`obtention d`une solution alcaloide psychoactive purifiee
CA3097246 2020-10-23
CA3101765A CA3101765A1 (fr) 2020-12-04 2020-12-04 Extraction d'alcaloide psychoactif et composition avec dephosphorylation controlee
CA3101765 2020-12-04
CA3103707A CA3103707C (fr) 2020-12-18 2020-12-18 Composition normalisee d'extrait d'alcaloide psychoactif
CA3103707 2020-12-18
CA3169140A CA3169140C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloides psychoactifs capables de phosphorylation a dephosphorylation controlee

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3169140A Division CA3169140C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloides psychoactifs capables de phosphorylation a dephosphorylation controlee

Publications (2)

Publication Number Publication Date
CA3173030A1 CA3173030A1 (fr) 2021-12-17
CA3173030C true CA3173030C (fr) 2024-05-14

Family

ID=79268788

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3173030A Active CA3173030C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali
CA3169140A Active CA3169140C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloides psychoactifs capables de phosphorylation a dephosphorylation controlee

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3169140A Active CA3169140C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloides psychoactifs capables de phosphorylation a dephosphorylation controlee

Country Status (2)

Country Link
CA (2) CA3173030C (fr)
WO (1) WO2021253116A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220092509A (ko) 2019-10-01 2022-07-01 엠피리언 뉴로사이언스, 인크. 트립타민 발현을 조절하는 균류의 유전자 공학
US20240050502A1 (en) * 2020-12-16 2024-02-15 Caamtech, Inc. Amanita muscaria compounds
EP4155306A1 (fr) 2021-01-15 2023-03-29 Beckley Psytech Limited Analogue neuroactif d'ergoline
US20220370413A1 (en) 2021-03-06 2022-11-24 Mind Medicine, Inc. Formulations of psilocin that have enhanced stability
WO2023130076A2 (fr) 2021-12-31 2023-07-06 Empyrean Neuroscience, Inc. Cibles et voies pour la production de composés alcaloïdes
EP4486448A1 (fr) 2022-03-04 2025-01-08 Reset Pharmaceuticals, Inc. Co-cristaux ou sels comprenant de la psilocine
US12264131B2 (en) 2022-08-19 2025-04-01 Beckley Psytech Limited Pharmaceutically acceptable salts and compositions thereof
US12246005B2 (en) 2023-06-13 2025-03-11 Beckley Psytech Limited 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations
GB202313750D0 (en) * 2023-09-08 2023-10-25 Psyence Group Inc A process for obtaining a purified psychoactive alkaloid

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU36879A1 (fr) 1958-02-21

Also Published As

Publication number Publication date
CA3169140C (fr) 2024-10-22
WO2021253116A1 (fr) 2021-12-23
CA3173030A1 (fr) 2021-12-17
CA3169140A1 (fr) 2021-12-17

Similar Documents

Publication Publication Date Title
CA3173030C (fr) Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali
AU2023285751B2 (en) Powdered Composition Containing a Mushroom Extract Comprising a Psychoactive Alkaloid
US11382942B2 (en) Extraction of psychoactive compounds from psilocybin fungus
US11510952B2 (en) Ethanol extraction of psychoactive compounds from psilocybin fungus
CA3137016C (fr) Extraction d'alcaloide psychoactif et composition avec dephosphorylationattenuees

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220907

EEER Examination request

Effective date: 20220907

EEER Examination request

Effective date: 20220907

EEER Examination request

Effective date: 20220907

EEER Examination request

Effective date: 20220907

EEER Examination request

Effective date: 20220907

EEER Examination request

Effective date: 20220907