CA3035616A1 - Schema posologique pour le traitement de tumeurs solides - Google Patents
Schema posologique pour le traitement de tumeurs solides Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Un schéma posologique comprend l'administration de 4,4,4-trifluoro-N-[(1S)-2-[[(7S)-5-(2-hydroxyethyl)-6-oxo-7H-pyrido[2,3-d][3]benzazepin-7-yl]amino]-1-methyl-2-oxo-ethyl]butanamide ou un sel ou un hydrate pharmaceutiquement acceptable de celui-ci pour traiter un cancer de tumeur solide à une dose de charge spécifiée pendant une période définie de doses, suivies d'une dose d'entretien et éventuellement l'administration d'un corticostéroïde pendant l'administration de la dose de charge.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201662381911P | 2016-08-31 | 2016-08-31 | |
| US62/381,911 | 2016-08-31 | ||
| PCT/US2017/048308 WO2018044662A1 (fr) | 2016-08-31 | 2017-08-24 | Schéma posologique pour le traitement de tumeurs solides |
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|---|---|
| CA3035616A1 true CA3035616A1 (fr) | 2018-03-08 |
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| CA3035616A Pending CA3035616A1 (fr) | 2016-08-31 | 2017-08-24 | Schema posologique pour le traitement de tumeurs solides |
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| US (1) | US20190209581A1 (fr) |
| EP (1) | EP3506905B1 (fr) |
| JP (2) | JP2019526632A (fr) |
| KR (1) | KR102512899B1 (fr) |
| CN (2) | CN116473978A (fr) |
| AU (1) | AU2017321011B2 (fr) |
| BR (1) | BR112019002461A2 (fr) |
| CA (1) | CA3035616A1 (fr) |
| ES (1) | ES2977556T3 (fr) |
| IL (2) | IL305136A (fr) |
| MA (1) | MA46086A (fr) |
| MX (1) | MX387397B (fr) |
| SG (2) | SG10202107832UA (fr) |
| WO (1) | WO2018044662A1 (fr) |
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| TWI609687B (zh) | 2015-04-14 | 2018-01-01 | 美國禮來大藥廠 | 平滑肌肉瘤之標靶性治療 |
| RU2754452C2 (ru) | 2016-04-12 | 2021-09-02 | Эли Лилли Энд Компани | Комбинированная терапия ингибиторами notch и pi3k/mtor для применения в лечении рака |
| RU2747788C2 (ru) | 2016-04-12 | 2021-05-14 | Эли Лилли Энд Компани | Комбинированная терапия ингибиторами notch и cdk4/6 для лечения рака |
| WO2017200969A1 (fr) | 2016-05-20 | 2017-11-23 | Eli Lilly And Company | Traitement d'association utilisant des inhibiteurs de notch et de pd-1 ou pd-l1 |
| CA3039405A1 (fr) | 2016-10-12 | 2018-04-19 | Eli Lilly And Company | Traitement cible de lymphome a cellules t matures |
| JP2020507605A (ja) | 2017-02-17 | 2020-03-12 | フレッド ハッチンソン キャンサー リサーチ センター | Ｂｃｍａ関連癌および自己免疫疾患の治療のための併用療法 |
| EP3706754A1 (fr) | 2017-11-06 | 2020-09-16 | Juno Therapeutics, Inc. | Association d'une thérapie cellulaire et d'un inhibiteur de gamma secrétase |
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| US46206A (en) | 1865-02-07 | Improved vessel for holding petroleum | ||
| US8633179B2 (en) * | 2007-03-13 | 2014-01-21 | The Trustees Of Columbia University In The City Of New York | Synergistic interaction of NOTCH-1 inhibitors with glucocorticoids |
| WO2009064458A2 (fr) * | 2007-11-13 | 2009-05-22 | Meritage Pharma, Inc. | Compositions pour le traitement de l'inflammation des voies gastro-intestinales |
| AR087107A1 (es) | 2011-07-27 | 2014-02-12 | Lilly Co Eli | Compuesto inhibidor de la señalizacion de la trayectoria notch |
| MX2017000363A (es) * | 2014-07-11 | 2017-04-27 | Genentech Inc | Inhibicion de la via de notch. |
| TWI609687B (zh) * | 2015-04-14 | 2018-01-01 | 美國禮來大藥廠 | 平滑肌肉瘤之標靶性治療 |
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- 2017-08-24 MX MX2019002066A patent/MX387397B/es unknown
- 2017-08-24 BR BR112019002461A patent/BR112019002461A2/pt not_active Application Discontinuation
- 2017-08-24 SG SG10202107832UA patent/SG10202107832UA/en unknown
- 2017-08-24 AU AU2017321011A patent/AU2017321011B2/en active Active
- 2017-08-24 IL IL305136A patent/IL305136A/en unknown
- 2017-08-24 IL IL264924A patent/IL264924B2/en unknown
- 2017-08-24 EP EP17761723.0A patent/EP3506905B1/fr active Active
- 2017-08-24 CN CN202310314953.4A patent/CN116473978A/zh active Pending
- 2017-08-24 MA MA046086A patent/MA46086A/fr unknown
- 2017-08-24 JP JP2019531873A patent/JP2019526632A/ja active Pending
- 2017-08-24 US US16/328,267 patent/US20190209581A1/en not_active Abandoned
- 2017-08-24 ES ES17761723T patent/ES2977556T3/es active Active
- 2017-08-24 SG SG11201901325UA patent/SG11201901325UA/en unknown
- 2017-08-24 KR KR1020197005847A patent/KR102512899B1/ko active Active
- 2017-08-24 WO PCT/US2017/048308 patent/WO2018044662A1/fr not_active Ceased
- 2017-08-24 CN CN201780052146.2A patent/CN109562114A/zh active Pending
- 2017-08-24 CA CA3035616A patent/CA3035616A1/fr active Pending
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2022
- 2022-12-27 JP JP2022209634A patent/JP2023052108A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL264924A (fr) | 2019-04-30 |
| CN109562114A (zh) | 2019-04-02 |
| AU2017321011A1 (en) | 2019-02-21 |
| IL305136A (en) | 2023-10-01 |
| IL264924B1 (en) | 2023-09-01 |
| MX2019002066A (es) | 2019-06-03 |
| MX387397B (es) | 2025-03-18 |
| IL264924B2 (en) | 2024-01-01 |
| SG11201901325UA (en) | 2019-03-28 |
| WO2018044662A1 (fr) | 2018-03-08 |
| ES2977556T3 (es) | 2024-08-26 |
| EP3506905A1 (fr) | 2019-07-10 |
| US20190209581A1 (en) | 2019-07-11 |
| JP2019526632A (ja) | 2019-09-19 |
| BR112019002461A2 (pt) | 2019-05-14 |
| MA46086A (fr) | 2019-07-10 |
| SG10202107832UA (en) | 2021-09-29 |
| KR20190042591A (ko) | 2019-04-24 |
| KR102512899B1 (ko) | 2023-03-23 |
| JP2023052108A (ja) | 2023-04-11 |
| EP3506905B1 (fr) | 2024-03-20 |
| CN116473978A (zh) | 2023-07-25 |
| AU2017321011B2 (en) | 2023-08-03 |
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