CA3063180A1 - Inhibiteurs de kinases de regulation du signal d'apoptose 1 et leurs procedes d'utilisation - Google Patents
Inhibiteurs de kinases de regulation du signal d'apoptose 1 et leurs procedes d'utilisation Download PDFInfo
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- CA3063180A1 CA3063180A1 CA3063180A CA3063180A CA3063180A1 CA 3063180 A1 CA3063180 A1 CA 3063180A1 CA 3063180 A CA3063180 A CA 3063180A CA 3063180 A CA3063180 A CA 3063180A CA 3063180 A1 CA3063180 A1 CA 3063180A1
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- 229940095064 tartrate Drugs 0.000 description 1
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
- BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000005309 thioalkoxy group Chemical group 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 229910052905 tridymite Inorganic materials 0.000 description 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
- 125000000025 triisopropylsilyl group Chemical group C(C)(C)[Si](C(C)C)(C(C)C)* 0.000 description 1
- ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
- 235000019871 vegetable fat Nutrition 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 235000014692 zinc oxide Nutrition 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des composés de Formule (I), ou des sels pharmaceutiquement acceptables, un ester, un stéréoisomère, un tautomère, un solvate, un hydrate ou une combinaison de ceux-ci : qui inhibent la kinase de régulation du signal d'apoptose 1 (ASK-1) associée à des troubles auto-immuns, des troubles neurodégénératifs, des maladies inflammatoires, une maladie rénale chronique, ou une maladie cardiovasculaire. La présente invention concerne également des compositions pharmaceutiques contenant les composés précités pour l'administration à un sujet atteint d'une maladie associée à ASK-1. Des méthodes de traitement d'une maladie associée à ASK-1 chez un sujet par administration d'une composition pharmaceutique contenant les composés selon la présente invention sont en outre décrites, où la maladie associée à ASK-1 est plus spécifiquement la stéatose hépatique non alcoolique (NAFLD) et la stéatohépatite non alcoolique (NASH).
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762505202P | 2017-05-12 | 2017-05-12 | |
| US62/505,202 | 2017-05-12 | ||
| US201762523742P | 2017-06-22 | 2017-06-22 | |
| US62/523,742 | 2017-06-22 | ||
| US201762550960P | 2017-08-28 | 2017-08-28 | |
| US62/550,960 | 2017-08-28 | ||
| PCT/US2018/032579 WO2018209354A1 (fr) | 2017-05-12 | 2018-05-14 | Inhibiteurs de kinases de régulation du signal d'apoptose 1 et leurs procédés d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3063180A1 true CA3063180A1 (fr) | 2018-11-15 |
Family
ID=68765952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3063180A Pending CA3063180A1 (fr) | 2017-05-12 | 2018-05-14 | Inhibiteurs de kinases de regulation du signal d'apoptose 1 et leurs procedes d'utilisation |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA3063180A1 (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114470217A (zh) * | 2020-11-24 | 2022-05-13 | 深圳微芯生物科技股份有限公司 | 预防和治疗代谢异常或炎症引起的组织损伤的药物组合物 |
-
2018
- 2018-05-14 CA CA3063180A patent/CA3063180A1/fr active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114470217A (zh) * | 2020-11-24 | 2022-05-13 | 深圳微芯生物科技股份有限公司 | 预防和治疗代谢异常或炎症引起的组织损伤的药物组合物 |
| CN114470217B (zh) * | 2020-11-24 | 2023-06-20 | 深圳微芯生物科技股份有限公司 | 预防和治疗代谢异常或炎症引起的组织损伤的药物组合物 |
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