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CA3055204A1 - Compositions et procedes pour induire des anticorps anti-vih-1 - Google Patents

Compositions et procedes pour induire des anticorps anti-vih-1 Download PDF

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Publication number
CA3055204A1
CA3055204A1 CA3055204A CA3055204A CA3055204A1 CA 3055204 A1 CA3055204 A1 CA 3055204A1 CA 3055204 A CA3055204 A CA 3055204A CA 3055204 A CA3055204 A CA 3055204A CA 3055204 A1 CA3055204 A1 CA 3055204A1
Authority
CA
Canada
Prior art keywords
envelope
hiv
antibodies
trimer
env
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3055204A
Other languages
English (en)
Inventor
Barton F. Haynes
Kevin O. Saunders
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Duke University
Original Assignee
Duke University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2017/020823 external-priority patent/WO2017152146A2/fr
Application filed by Duke University filed Critical Duke University
Publication of CA3055204A1 publication Critical patent/CA3055204A1/fr
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • C07K14/15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16HIV-1 ; HIV-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55577Saponins; Quil A; QS21; ISCOMS
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16111Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Selon certains aspects, l'invention concerne des immunogènes du VIH-1, comprenant des enveloppes (CH0848) et des sélections de ces dernières, et des procédés d'immunisation en essaim à l'aide de combinaisons d'enveloppes de VIH-1.
CA3055204A 2017-03-03 2018-03-02 Compositions et procedes pour induire des anticorps anti-vih-1 Pending CA3055204A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
PCT/US2017/020823 WO2017152146A2 (fr) 2016-03-03 2017-03-03 Compositions et procédés pour induire des anticorps du vih-1
USPCT/US2017/020823 2017-03-03
US201862624620P 2018-01-31 2018-01-31
US62/624,620 2018-01-31
PCT/US2018/020788 WO2018161049A1 (fr) 2017-03-03 2018-03-02 Compositions et procédés pour induire des anticorps anti-vih-1

Publications (1)

Publication Number Publication Date
CA3055204A1 true CA3055204A1 (fr) 2018-09-07

Family

ID=63371208

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3055204A Pending CA3055204A1 (fr) 2017-03-03 2018-03-02 Compositions et procedes pour induire des anticorps anti-vih-1

Country Status (3)

Country Link
EP (1) EP3589315A4 (fr)
CA (1) CA3055204A1 (fr)
WO (1) WO2018161049A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11884704B2 (en) 2016-03-01 2024-01-30 Duke University Compositions comprising HIV envelopes to induce CH235 lineage antibodies

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11318197B2 (en) 2016-03-03 2022-05-03 Duke University Compositions and methods for inducing HIV-1 antibodies
US11246920B2 (en) 2016-03-03 2022-02-15 Duke University Compositions and methods for inducing HIV-1 antibodies
CA3039089A1 (fr) 2016-10-03 2018-04-12 Duke University Procedes d'identification d'immunogenes par ciblage de mutations improbables
US20210009640A1 (en) * 2018-03-02 2021-01-14 Duke University Compositions comprising hiv envelopes to induce hiv-1 antibodies
CA3115232A1 (fr) * 2018-10-01 2020-04-09 Duke University Compositions comprenant des enveloppes de vih pour induire des anticorps contre le vih-1
US12138304B2 (en) 2018-10-01 2024-11-12 Duke University HIV-1 envelope stabilizing mutations
EP4464380A3 (fr) * 2018-12-04 2025-05-07 The Rockefeller University Immunogènes vaccinaux contre le vih
WO2022087031A1 (fr) * 2020-10-19 2022-04-28 Duke University Compositions comprenant des enveloppes de vih pour induire des anticorps contre le vih-1
WO2022165182A1 (fr) * 2021-01-28 2022-08-04 Duke University Compositions comprenant des enveloppes de vih pour induire des anticorps contre le vih-1
WO2022192262A1 (fr) * 2021-03-08 2022-09-15 Duke University Nanoparticules de glycopeptides de l'enveloppe du vih-1 et leurs utilisations
US20250340597A1 (en) * 2021-10-11 2025-11-06 Duke University Compositions comprising hiv envelopes to induce hiv-1 antibodies

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014043386A1 (fr) * 2012-09-12 2014-03-20 Duke University Anticorps du lignage clonal
WO2015127108A1 (fr) 2014-02-19 2015-08-27 Duke University Enveloppes du vih -1 trimères des compositions et leurs utilisations
AU2015240883B2 (en) * 2014-03-31 2021-09-02 Duke University Compositions comprising CH848 envelopes and uses thereof
US10400015B2 (en) 2014-09-04 2019-09-03 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Recombinant HIV-1 envelope proteins and their use

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11884704B2 (en) 2016-03-01 2024-01-30 Duke University Compositions comprising HIV envelopes to induce CH235 lineage antibodies

Also Published As

Publication number Publication date
EP3589315A4 (fr) 2021-06-23
EP3589315A1 (fr) 2020-01-08
WO2018161049A8 (fr) 2018-10-04
WO2018161049A1 (fr) 2018-09-07

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