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CA2989795C - Particules inorganiques a liberation prolongee a charge rapide en substance medicamenteuse - Google Patents

Particules inorganiques a liberation prolongee a charge rapide en substance medicamenteuse Download PDF

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Publication number
CA2989795C
CA2989795C CA2989795A CA2989795A CA2989795C CA 2989795 C CA2989795 C CA 2989795C CA 2989795 A CA2989795 A CA 2989795A CA 2989795 A CA2989795 A CA 2989795A CA 2989795 C CA2989795 C CA 2989795C
Authority
CA
Canada
Prior art keywords
nanoparticles
microaggregate
nanoparticle
pores
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2989795A
Other languages
English (en)
Other versions
CA2989795A1 (fr
Inventor
Sanjib Bhattacharyya
Paul Ducheyne
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of CA2989795A1 publication Critical patent/CA2989795A1/fr
Application granted granted Critical
Publication of CA2989795C publication Critical patent/CA2989795C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6923—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Ceramic Engineering (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

La présente invention concerne des nanoparticules comprenant un matériau inorganique présentant des pores qui peuvent absorber rapidement des principes actifs pharmaceutique et ensuite libérer de tels principes actifs de manière calculée pendant une période de temps prolongée. Les nanoparticules peuvent être agrégées afin de former des micro-agrégats qui apportent les mêmes avantages d'absorption rapide et de libération prolongée de principes actifs pharmaceutiques. L'absorption rapide permet de préparer des nanoparticules et micro-agrégats chargés d'une substance médicamenteuse essentiellement en même temps que le moment de traitement, comme pendant un procédé chirurgical. L'invention concerne également des procédés de préparation de tels micro-agrégats et nanoparticules, ainsi que des procédés d'administration d'un principe actif pharmaceutique à l'aide de ces micro-agrégats et nanoparticules.
CA2989795A 2015-06-16 2016-05-13 Particules inorganiques a liberation prolongee a charge rapide en substance medicamenteuse Active CA2989795C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562180345P 2015-06-16 2015-06-16
US62/180,345 2015-06-16
PCT/US2016/032408 WO2016204896A1 (fr) 2015-06-16 2016-05-13 Particules inorganiques à libération prolongée à charge rapide en substance médicamenteuse

Publications (2)

Publication Number Publication Date
CA2989795A1 CA2989795A1 (fr) 2016-12-22
CA2989795C true CA2989795C (fr) 2023-12-12

Family

ID=57545871

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2989795A Active CA2989795C (fr) 2015-06-16 2016-05-13 Particules inorganiques a liberation prolongee a charge rapide en substance medicamenteuse

Country Status (3)

Country Link
EP (1) EP3310342A4 (fr)
CA (1) CA2989795C (fr)
WO (1) WO2016204896A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000023665A1 (it) * 2020-10-07 2022-04-07 Brenta S R L Sistema di nanoparticelle per il veicolo e la somministrazione di principi attivi e relativo metodo di produzione, nonché attività di eradicazione di biofilm

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7195780B2 (en) * 2002-10-21 2007-03-27 University Of Florida Nanoparticle delivery system
DE102005016873A1 (de) * 2005-04-12 2006-10-19 Magforce Nanotechnologies Ag Nanopartikel-Wirstoff-Konjugate
US20070116773A1 (en) * 2005-07-05 2007-05-24 Interuniversitair Microelektronica Centrum (Imec) Metal nanostructures and pharmaceutical compositions
FR2921661B1 (fr) * 2007-10-01 2013-05-31 Centre Nat Rech Scient Solide hybride organique inorganique a surface modifiee.
WO2009111638A1 (fr) * 2008-03-05 2009-09-11 Baxter International Inc. Compositions et procédés d’administration de médicament
US8790621B2 (en) * 2010-04-12 2014-07-29 Iowa State University Research Foundation, Inc. Nanoparticles and nanoparticle compositions
WO2012142240A1 (fr) * 2011-04-13 2012-10-18 The Trustees Of The University Of Pennsylvania Nanoparticules mésoporeuses revêtues
AU2012249553A1 (en) * 2011-04-29 2013-10-24 Selecta Biociences, Inc. Tolerogenic synthetic nanocarriers for allergy therapy
US9567265B2 (en) * 2012-11-30 2017-02-14 Iowa State University Research Foundation, Inc. Catalysts and methods of using the same

Also Published As

Publication number Publication date
EP3310342A1 (fr) 2018-04-25
EP3310342A4 (fr) 2019-03-06
WO2016204896A1 (fr) 2016-12-22
CA2989795A1 (fr) 2016-12-22

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