CA2955668A1 - Systeme de signalisation de recepteur antigenique chimerique - Google Patents
Systeme de signalisation de recepteur antigenique chimerique Download PDFInfo
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- CA2955668A1 CA2955668A1 CA2955668A CA2955668A CA2955668A1 CA 2955668 A1 CA2955668 A1 CA 2955668A1 CA 2955668 A CA2955668 A CA 2955668A CA 2955668 A CA2955668 A CA 2955668A CA 2955668 A1 CA2955668 A1 CA 2955668A1
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Abstract
La présente invention concerne un système de signalisation de récepteur d'antigène chimère (CAR) comprenant ; (i) un composant récepteur comprenant un domaine de liaison de l'antigène, un domaine transmembranaire et un premier domaine de liaison ; et (ii) un composant de signalisation intracellulaire et un domaine de signalisation comprenant un deuxième domaine de liaison qui se lie spécifiquement au premier domaine de liaison du composant récepteur ; la liaison des premier et deuxième domaines de liaison étant perturbée par la présence d'un agent, de telle sorte qu'en l'absence de l'agent, le composant récepteur et le composant de signalisation s'hétérodimérisent et la liaison du domaine de liaison de l'antigène à l'antigène résulte en la signalisation par le domaine de signalisation, tandis qu'en la présence de l'agent, le composant récepteur et le composant de signalisation ne s'hétérodimérisent pas et la liaison du domaine de liaison de l'antigène à l'antigène ne résulte pas en la signalisation par le domaine de signalisation.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1415347.2 | 2014-08-29 | ||
| GBGB1415347.2A GB201415347D0 (en) | 2014-08-29 | 2014-08-29 | Signalling system |
| PCT/GB2015/052494 WO2016030691A1 (fr) | 2014-08-29 | 2015-08-28 | Système de signalisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2955668A1 true CA2955668A1 (fr) | 2016-03-03 |
Family
ID=51752358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2955668A Abandoned CA2955668A1 (fr) | 2014-08-29 | 2015-08-28 | Systeme de signalisation de recepteur antigenique chimerique |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10654927B2 (fr) |
| EP (2) | EP3185875B1 (fr) |
| JP (1) | JP6614619B2 (fr) |
| KR (1) | KR102222615B1 (fr) |
| CN (1) | CN106573989B (fr) |
| AU (1) | AU2015308243B2 (fr) |
| BR (1) | BR112017003906A2 (fr) |
| CA (1) | CA2955668A1 (fr) |
| CL (1) | CL2017000438A1 (fr) |
| ES (1) | ES2910008T3 (fr) |
| GB (1) | GB201415347D0 (fr) |
| IL (1) | IL250101B (fr) |
| MX (1) | MX376613B (fr) |
| NZ (1) | NZ728674A (fr) |
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| WO (1) | WO2016030691A1 (fr) |
| ZA (1) | ZA201700466B (fr) |
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| CN107475276A (zh) * | 2017-09-05 | 2017-12-15 | 深圳大学 | 嵌合抗原受体及其表达基因、四环素调节的嵌合抗原受体修饰的t细胞及其应用 |
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| JP7335272B2 (ja) | 2018-05-15 | 2023-08-29 | オートラス リミテッド | キメラ抗原受容体 |
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| KR102839381B1 (ko) | 2018-08-29 | 2025-07-28 | 내셔널 유니버시티 오브 싱가포르 | 유전적으로 변형된 면역 세포의 생존 및 확장을 특이적으로 자극하는 방법 |
| JP7605735B2 (ja) * | 2018-09-05 | 2024-12-24 | ポセイダ セラピューティクス，インコーポレイティド | 同種異系細胞組成物およびその使用方法 |
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| EP4132962A1 (fr) | 2020-04-09 | 2023-02-15 | Autolus Limited | Molécule |
| GB202101491D0 (en) | 2021-02-03 | 2021-03-17 | Autolus Ltd | Molecule |
| GB202007044D0 (en) | 2020-05-13 | 2020-06-24 | Autolus Ltd | Method |
| GB202017343D0 (en) | 2020-11-02 | 2020-12-16 | Autolus Ltd | Cell |
| GB202104030D0 (en) | 2021-03-23 | 2021-05-05 | Autolus Ltd | Signalling system |
| GB202115329D0 (en) | 2021-10-25 | 2021-12-08 | Autolus Ltd | Chimeric cytokine receptor |
| GB202209920D0 (en) | 2022-07-06 | 2022-08-17 | Autolus Ltd | Cell |
| GB202219568D0 (en) | 2022-12-22 | 2023-02-08 | Autolus Ltd | Chimeric antigen receptor |
| GB202312009D0 (en) | 2023-08-04 | 2023-09-20 | Autolus Ltd | Methods and cell compositions |
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| EP2534257B1 (fr) | 2010-02-12 | 2017-09-27 | Oncomed Pharmaceuticals, Inc. | Procédés d'identification et d'isolement de cellules exprimant un polypeptide |
| KR102064230B1 (ko) * | 2013-02-15 | 2020-01-13 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | 키메라 항원 수용체 및 이의 이용 방법 |
| BR112015028387B1 (pt) | 2013-05-13 | 2023-04-11 | Cellectis | Receptor antigênico quimérico específico para cd19, polinucleotídeo, vetor de expressão, método in vitro para manipulação e uso de uma célula imune |
| MX373687B (es) * | 2013-11-21 | 2020-07-07 | Ucl Business Ltd | Célula natural (nk) |
| JP6793902B2 (ja) | 2013-12-20 | 2020-12-02 | ノバルティス アーゲー | 調節可能キメラ抗原受容体 |
| WO2015142661A1 (fr) | 2014-03-15 | 2015-09-24 | Novartis Ag | Récepteur d'antigène chimèrique régulable |
| GB201405845D0 (en) | 2014-04-01 | 2014-05-14 | Ucl Business Plc | Signalling system |
| US9791929B2 (en) * | 2014-10-31 | 2017-10-17 | Elwha Llc | Tactile control system |
| CA3224507A1 (fr) * | 2014-12-24 | 2016-06-30 | Autolus Limited | Cellule coexprimant des recepteurs d'antigene chimeriques liant cd19 et cd22 |
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| EP3402885A4 (fr) * | 2016-01-11 | 2019-07-03 | The Board of Trustees of the Leland Stanford Junior University | Protéines chimériques et méthodes de régulation de l'expression génique |
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| GB201610515D0 (en) | 2016-06-16 | 2016-08-03 | Autolus Ltd | Cell |
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| EP3185875A1 (fr) | 2017-07-05 |
| CN106573989A (zh) | 2017-04-19 |
| MX376613B (es) | 2025-03-07 |
| IL250101B (en) | 2020-11-30 |
| RU2017105515A3 (fr) | 2018-10-01 |
| RU2731638C2 (ru) | 2020-09-07 |
| CN106573989B (zh) | 2022-02-01 |
| AU2015308243B2 (en) | 2020-01-30 |
| BR112017003906A2 (pt) | 2018-02-27 |
| SG11201700171VA (en) | 2017-02-27 |
| KR102222615B1 (ko) | 2021-03-05 |
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