CA2827561A1 - Test diagnostique des taux d'acides gras omega-3 pour la prise en charge alimentaire des patients atteints d'une maladie cardiovasculaire - Google Patents

Test diagnostique des taux d'acides gras omega-3 pour la prise en charge alimentaire des patients atteints d'une maladie cardiovasculaire Download PDF

Info

Publication number: CA2827561A1
Authority: CA; Canada
Prior art keywords: omega; formulation; epa; dha; acid
Prior art date: 2011-02-16
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2827561A

Other languages

English (en)

Inventor

George Jackowski

Rachelle MACSWEENEY

Nisar Shaikh

Jason Yantha

Valerie SCHINI-KERTH

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pivotal Therapeutics Inc

Original Assignee

Pivotal Therapeutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2011-02-16

Filing date

2012-02-14

Publication date

2012-08-23

2012-02-14 Application filed by Pivotal Therapeutics Inc filed Critical Pivotal Therapeutics Inc

2012-08-23 Publication of CA2827561A1 publication Critical patent/CA2827561A1/fr

Status Abandoned legal-status Critical Current

Links

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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

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Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Investigating Or Analysing Biological Materials (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2827561A 2011-02-16 2012-02-14 Test diagnostique des taux d'acides gras omega-3 pour la prise en charge alimentaire des patients atteints d'une maladie cardiovasculaire Abandoned CA2827561A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201161457270P	2011-02-16	2011-02-16
US61/457,270		2011-02-16
PCT/US2012/025010 WO2012112517A1 (fr)	2011-02-16	2012-02-14	Test diagnostique des taux d'acides gras oméga-3 pour la prise en charge alimentaire des patients atteints d'une maladie cardiovasculaire

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CA2827561A1 true CA2827561A1 (fr)	2012-08-23

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EP (1)	EP2675443A1 (fr)
JP (1)	JP2014506891A (fr)
CA (1)	CA2827561A1 (fr)
WO (1)	WO2012112517A1 (fr)

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JP6399655B2 (ja)	2012-01-06	2018-10-03	オムセラ・ファーマシューティカルズ・インコーポレイテッド	遊離酸型のオメガ−３多価不飽和脂肪酸のｄｐａ濃縮組成物
US9492545B2 (en)	2012-05-07	2016-11-15	Omthera Pharmaceuticals Inc.	Compositions of statins and omega-3 fatty acids
WO2016077399A1 (fr) *	2014-11-11	2016-05-19	Pivotal Therapeutics Inc.	Dosage diagnostique et réactifs utilisables en vue de la détection et de la différentiation d'acides gras polyinsaturés
CN116492339A (zh) *	2015-11-13	2023-07-28	深圳君圣泰生物技术有限公司	一种组合物及其用途、药物制剂
US20200400694A1 (en) *	2018-03-13	2020-12-24	Denka Company Limited	Method for assisting determination of risk of cardiovascular disease or the like

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2119000A1 (fr)	1993-03-19	1994-09-20	David Frederick Horrobin	Formulation pour fumeurs
ITMI20012384A1 (it)	2001-11-12	2003-05-12	Quatex Nv	Uso di acidi grassi poliinsaturi per la prevenzione primaria di eventi cardiovascolari maggiori
FR2862873A1 (fr) *	2003-12-01	2005-06-03	Pf Medicament	Utilisation des acides gras polyinsatures omega 3 dans l'apnee du sommeil
US20060211762A1 (en) *	2004-12-06	2006-09-21	Rongen Roelof M	Omega-3 fatty acids and dyslipidemic agent for lipid therapy
CN101098690A (zh) *	2004-12-06	2008-01-02	瑞莱恩特医药品有限公司	用于血脂治疗的ω-3脂肪酸和脂血异常剂
EP1919468A4 (fr) *	2005-07-18	2010-02-10	Reliant Pharmaceuticals Inc	Traitement au moyen d'inhibiteurs d'absorption de cholesterol a base d'azetidinone et d'acide gras omega-3 et produit de combinaison de ceux-ci
US7652068B2 (en) *	2005-12-20	2010-01-26	Cenestra Llc	Omega 3 fatty acid formulations
AU2006327995B2 (en) *	2005-12-23	2012-09-13	N.V. Nutricia	Infant nutritional compositions for preventing obesity
ATE509624T1 (de) *	2005-12-23	2011-06-15	Nutricia Nv	Zusammensetzung enthaltend mehrfach ungesättigte fettsäuren, proteine, mangan und/oder molybden und nukleotide/nukleoside, zur behandlung von demenz
US20100130611A1 (en)	2006-12-20	2010-05-27	Cenestra Llc	Omega 3 fatty acid formulations
ES2979118T3 (es) *	2009-03-09	2024-09-24	Basf As	Composiciones que comprenden una mezcla de aceites de ácidos grasos y un ácido graso libre, y procedimientos y usos de las mismas

2012
- 2012-02-14 JP JP2013554538A patent/JP2014506891A/ja active Pending
- 2012-02-14 CA CA2827561A patent/CA2827561A1/fr not_active Abandoned
- 2012-02-14 WO PCT/US2012/025010 patent/WO2012112517A1/fr not_active Ceased
- 2012-02-14 EP EP12705589.5A patent/EP2675443A1/fr not_active Withdrawn

Also Published As

Publication number	Publication date
EP2675443A1 (fr)	2013-12-25
JP2014506891A (ja)	2014-03-20
WO2012112517A1 (fr)	2012-08-23

Publication	Publication Date	Title
CA2827585A1 (fr)	2012-08-23	Statine et acides gras omega-3 (epa, dha et dpa) utilises dans les maladies cardiovasculaires
Mischoulon et al.	2000	Docosahexanoic acid and ω-3 fatty acids in depression
US20150246012A1 (en)	2015-09-03	Omega 3 fatty acid for use as a prescription medical food and omega 3 fatty acid diagnostic assay for the dietary management of cardiovascular patients with cardiovascular disease (cvd) who are deficient in blood epa and dha levels
CA2827561A1 (fr)	2012-08-23	Test diagnostique des taux d'acides gras omega-3 pour la prise en charge alimentaire des patients atteints d'une maladie cardiovasculaire
US20150224075A1 (en)	2015-08-13	Omega 3 formulations for treatment of risk factors for cardiovascular disease and protection against sudden death
US20150119414A1 (en)	2015-04-30	Statin and omega 3 fatty acids for reduction of apolipoprotein-b levels
CA2827579A1 (fr)	2012-08-23	Preparations a base d'omega-3 comprenant epa, dha et dpa pour le traitement des facteurs de risque dans la maladie cardiovasculaire
US8715648B2 (en)	2014-05-06	Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (CVD) and diabetics
CA2827555A1 (fr)	2012-08-23	Inhibiteur de l'absorption du cholesterol (azetidinone) et acides gras omega 3 (epa, dha, dpa) pour la reduction du cholesterol et pour la reduction des evenements cardiovasculaires
Pfister et al.	2021	N-3 Polyunsaturated fatty acid ethyl esters decrease the invasion, but not the proliferation, of human colorectal cancer cells via a PI3K-dependent mechanism in vitro
EP2675444A1 (fr)	2013-12-25	Préparations comprenant des acides gras oméga-3 et un agent anti-obésité pour la réduction du poids corporel chez les patients atteints d'une maladie cardiovasculaire et chez les diabétiques
US9248138B2 (en)	2016-02-02	Process and composition for stabilization of vulnerable plaque utilizing a combination of a statin and omega 3 fatty acids
US8952000B2 (en)	2015-02-10	Cholesterol absorption inhibitor and omega 3 fatty acids for the reduction of cholesterol and for the prevention or reduction of cardiovascular, cardiac and vascular events
WO2015106177A1 (fr)	2015-07-16	Procédé et composition de stabilisation de plaques vulnerables à l'aide d'une combinaison composée d'une statine et d'acides gras omega 3
US20150272920A1 (en)	2015-10-01	Method for treating obesity with anti-obesity formulations and omega 3 fatty acids for the reduction of body weight in cardiovascular disease patients (cvd) and diabetics

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