CA2821378A1 - Polytherapie combinant un inducteur et un inhibiteur d'autophagie pour le traitement de neoplasmes - Google Patents

Polytherapie combinant un inducteur et un inhibiteur d'autophagie pour le traitement de neoplasmes Download PDF

Info

Publication number: CA2821378A1
Authority: CA; Canada
Prior art keywords: akt; alkyl; inhibitor; autophagy; cells
Prior art date: 2010-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2821378A

Other languages

English (en)

Inventor

Kui Lin

Michael Degtyarev

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Genentech Inc

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-12-23

Filing date

2010-12-23

Publication date

2012-06-28

2010-12-23 Application filed by Genentech Inc filed Critical Genentech Inc

2012-06-28 Publication of CA2821378A1 publication Critical patent/CA2821378A1/fr

Status Abandoned legal-status Critical Current

Links

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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/00—Structure or type of the nucleic acid
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/531—Stem-loop; Hairpin

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Medicinal Chemistry (AREA)
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Veterinary Medicine (AREA)
Physics & Mathematics (AREA)
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Plant Pathology (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Epidemiology (AREA)
Virology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2821378A 2010-12-23 2010-12-23 Polytherapie combinant un inducteur et un inhibiteur d'autophagie pour le traitement de neoplasmes Abandoned CA2821378A1 (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/US2010/062096 WO2012087336A1 (fr)	2010-12-23	2010-12-23	Polythérapie combinant un inducteur et un inhibiteur d'autophagie pour le traitement de néoplasmes

Publications (1)

Publication Number	Publication Date
CA2821378A1 true CA2821378A1 (fr)	2012-06-28

Family

ID=46314300

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2821378A Abandoned CA2821378A1 (fr)	2010-12-23	2010-12-23	Polytherapie combinant un inducteur et un inhibiteur d'autophagie pour le traitement de neoplasmes

Country Status (9)

Country	Link
EP (1)	EP2655619A4 (fr)
JP (1)	JP2014507129A (fr)
KR (1)	KR20130132956A (fr)
CN (1)	CN103403161A (fr)
BR (1)	BR112013015891A2 (fr)
CA (1)	CA2821378A1 (fr)
MX (1)	MX2013007171A (fr)
RU (1)	RU2013134359A (fr)
WO (1)	WO2012087336A1 (fr)

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JP6052540B2 (ja) *	2012-12-21	2016-12-27	国立大学法人福井大学	Ａｔｇ７変異体を用いたオートファジーの抑制方法
ES2871816T3 (es)	2012-12-27	2021-11-02	Sanofi Sa	Anticuerpos anti-LAMP1 y conjugados anticuerpo-fármaco, y usos de los mismos
KR101461916B1 (ko)	2013-11-04	2014-11-19	현대자동차 주식회사	커플드 토션 빔 액슬 타입 현가장치
MY199705A (en) *	2015-12-22	2023-11-20	Incyte Corp	Heterocyclic compounds as immunomodulators
US20180179202A1 (en)	2016-12-22	2018-06-28	Incyte Corporation	Heterocyclic compounds as immunomodulators
EP3578549A4 (fr)	2017-02-03	2021-01-13	Tohoku University	Composé hétérocyclique
WO2018226776A1 (fr) *	2017-06-08	2018-12-13	The Penn State Research Foundation	Analyse pour la surveillance de l'achèvement d'autophagosomes
US11898155B2 (en)	2017-12-07	2024-02-13	Pearl Kogyo Co., Ltd.	Method for introducing molecule and composition containing inhibitor
CN108103194B (zh) *	2017-12-27	2021-05-18	中国医学科学院药用植物研究所	一种抑制胃癌细胞mgc-803的靶点及其应用
KR102095749B1 (ko) *	2018-12-20	2020-04-01	충남대학교 산학협력단	S6k1 유전자 발현 억제제 또는 s6k1 단백질 활성 억제제를 유효성분으로 포함하는, 미토콘드리아 내 자가포식 장애로 발생되는 질병의 예방 또는 치료용 조성물
CN111593068B (zh) *	2019-01-28	2023-10-17	广州溯原生物科技股份有限公司	新型基因治疗载体pIRES-Rsirt2/4-Tet-nap的制备方法及应用
CN110592044B (zh) *	2019-07-26	2021-06-22	中国农业科学院蔬菜花卉研究所	蛋白激酶Fused编码基因及其在防治小菜蛾中的应用
CN120005876A (zh) *	2023-11-15	2025-05-16	纳肽得(青岛)生物医药有限公司	抑制血管紧张素原表达的siRNA及其用途

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EP1856247B1 (fr) *	2005-01-19	2016-05-04	The Trustees of The University of Pennsylvania	Régulation de l'autophagie et de la survie cellulaire
WO2007014327A2 (fr) *	2005-07-27	2007-02-01	University Of Florida Research Foundation, Inc.	Petits composes corrigeant un mauvais repliement des proteines et utilisations de ceux-ci
US8063050B2 (en) *	2006-07-06	2011-11-22	Array Biopharma Inc.	Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA95641C2 (xx) *	2006-07-06	2011-08-25	Эррей Биофарма Инк.	Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы
WO2008007122A2 (fr) *	2006-07-14	2008-01-17	Astex Therapeutics Limited	Combinaisons pharmaceutiques
US8476282B2 (en) *	2008-11-03	2013-07-02	Intellikine Llc	Benzoxazole kinase inhibitors and methods of use
WO2010140862A2 (fr) *	2009-06-05	2010-12-09	Seol Dai-Wu	CASSETTE D'EXPRESSION DE shARN MULTI-CISTRONIQUE POUR SUPPRIMER UN OU PLUSIEURS GÈNES CIBLES

2010
- 2010-12-23 EP EP10861010.6A patent/EP2655619A4/fr not_active Withdrawn
- 2010-12-23 RU RU2013134359/15A patent/RU2013134359A/ru not_active Application Discontinuation
- 2010-12-23 JP JP2013546098A patent/JP2014507129A/ja active Pending
- 2010-12-23 CA CA2821378A patent/CA2821378A1/fr not_active Abandoned
- 2010-12-23 WO PCT/US2010/062096 patent/WO2012087336A1/fr not_active Ceased
- 2010-12-23 KR KR1020137019575A patent/KR20130132956A/ko not_active Withdrawn
- 2010-12-23 BR BR112013015891A patent/BR112013015891A2/pt not_active IP Right Cessation
- 2010-12-23 CN CN2010800712519A patent/CN103403161A/zh active Pending
- 2010-12-23 MX MX2013007171A patent/MX2013007171A/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
CN103403161A (zh)	2013-11-20
WO2012087336A1 (fr)	2012-06-28
RU2013134359A (ru)	2015-01-27
BR112013015891A2 (pt)	2016-10-04
KR20130132956A (ko)	2013-12-05
EP2655619A1 (fr)	2013-10-30
JP2014507129A (ja)	2014-03-27
EP2655619A4 (fr)	2014-10-22
MX2013007171A (es)	2013-11-04

Publication	Publication Date	Title
CA2821378A1 (fr)	2012-06-28	Polytherapie combinant un inducteur et un inhibiteur d'autophagie pour le traitement de neoplasmes
CN105828822B (zh)	2019-10-18	用于治疗癌症的组合疗法
Frémin et al.	2007	ERK2 but not ERK1 plays a key role in hepatocyte replication: an RNAi‐mediated ERK2 knockdown approach in wild‐type and ERK1 null hepatocytes
Du et al.	2019	Silence of LncRNA GAS5 protects cardiomyocytes H9c2 against hypoxic injury via sponging miR-142-5p
US20140004209A1 (en)	2014-01-02	Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
CN103917228B (zh)	2018-04-20	用于治疗过度增生性障碍、优选具有受损的p53功能的过度增生性障碍的包含CIP2A沉默剂的药物组合
Sriram et al.	2013	Triple combination of siRNAs targeting TGFβ1, TGFβR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts
KR20100038377A (ko)	2010-04-14	암의 예방／치료제
Sun et al.	2018	MicroRNA-148b-3p is involved in regulating hypoxia/reoxygenation-induced injury of cardiomyocytes in vitro through modulating SIRT7/p53 signaling
US20190388426A1 (en)	2019-12-26	Perk and ire-1a inhibitors against neurodevelopmental disorders
Lee et al.	2023	Vactosertib, TGF-β receptor I inhibitor, augments the sensitization of the anti-cancer activity of gemcitabine in pancreatic cancer
CA2895690A1 (fr)	2014-06-26	Agent induisant l'apoptose comprenant des suppresseurs de gst-.pi. et d`akt
Wang et al.	2022	Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR
US20200268753A1 (en)	2020-08-27	Perk and ire-1a inhibitors against neurodevelopmental disorders
Zhang et al.	2019	MicroRNA-451 inhibits vascular smooth muscle cell migration and intimal hyperplasia after vascular injury via Ywhaz/p38 MAPK pathway
Li et al.	2016	Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells
Islam et al.	2014	Tranilast, an orally active antiallergic compound, inhibits extracellular matrix production in human uterine leiomyoma and myometrial cells
Wang et al.	2006	Silencing of sigma-1 receptor induces cell death in human lens cells
Lin et al.	2024	Upregulation of miR-20b-5p inhibits trophoblast invasion by blocking autophagy in recurrent miscarriage
WO2012175798A2 (fr)	2012-12-27	Polythérapie
Gopalan et al.	2014	Therapeutic effect of a multi-targeted imidazolium compound in hepatocellular carcinoma
KR102220965B1 (ko)	2021-02-26	포스파티딜이노시톨 3-키나제 억제제 및 아로마타제 억제제를 포함하는 제약 조합물
HK1187367A (en)	2014-04-04	Autophagy inducer and inhibitor combination therapy for the treatment of neoplasms
WO2014048071A1 (fr)	2014-04-03	Procédé et composition pharmaceutique pour inhiber la voie de signalisation pi3k/akt/mtor
EP3223843B1 (fr)	2019-06-19	Facteur dérivé de l'épithélium pigmentaire (pedf) pour le traitement de fibromes utérins

Legal Events

Date	Code	Title	Description
2017-02-05	FZDE	Discontinued	Effective date: 20161223