CA2812570A1 - Formulations d'opioides a liberation controlee - Google Patents

Formulations d'opioides a liberation controlee Download PDF

Info

Publication number: CA2812570A1
Authority: CA; Canada
Prior art keywords: oxycodone; salt; opioid; pharmaceutical formulation; formulation
Prior art date: 2010-09-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2812570A

Other languages

English (en)

Inventor

Edward M. Rudnic

Michael Vachon

Gary W. Pace

Joseph Berry

Felix De La Iglesia

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

QRxPharma Ltd

Original Assignee

QRxPharma Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-09-24

Filing date

2011-09-23

Publication date

2012-03-29

2011-02-09 Priority claimed from US13/024,319 external-priority patent/US20110195989A1/en

2011-09-23 Application filed by QRxPharma Ltd filed Critical QRxPharma Ltd

2012-03-29 Publication of CA2812570A1 publication Critical patent/CA2812570A1/fr

Status Abandoned legal-status Critical Current

Links

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238000004148 unit process Methods 0.000 description 1
229960002004 valdecoxib Drugs 0.000 description 1
LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
208000009935 visceral pain Diseases 0.000 description 1
239000001993 wax Substances 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
229940045860 white wax Drugs 0.000 description 1
108020001612 μ-opioid receptors Proteins 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2812570A 2010-09-24 2011-09-23 Formulations d'opioides a liberation controlee Abandoned CA2812570A1 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US38622710P	2010-09-24	2010-09-24
US61/386,227		2010-09-24
US13/024,319 US20110195989A1 (en)	2010-02-09	2011-02-09	Controlled Release Formulations of Opioids
US13/024,319		2011-02-09
PCT/US2011/053132 WO2012040651A2 (fr)	2010-09-24	2011-09-23	Formulations d'opioïdes à libération contrôlée

Publications (1)

Publication Number	Publication Date
CA2812570A1 true CA2812570A1 (fr)	2012-03-29

Family

ID=44741728

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2812570A Abandoned CA2812570A1 (fr)	2010-09-24	2011-09-23	Formulations d'opioides a liberation controlee

Country Status (6)

Country	Link
EP (1)	EP2618820A2 (fr)
JP (1)	JP2013537915A (fr)
CN (1)	CN103476403A (fr)
AU (1)	AU2011305161A1 (fr)
CA (1)	CA2812570A1 (fr)
WO (1)	WO2012040651A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1429744A1 (fr)	2001-09-21	2004-06-23	Egalet A/S	Systeme a liberation de polymere de morphine
EP1429739A1 (fr)	2001-09-21	2004-06-23	Egalet A/S	Systeme de liberation a base de polymere
DE602004031096D1 (de)	2003-03-26	2011-03-03	Egalet As	Morphin-system mit kontrollierter freisetzung
CA2687192C (fr)	2007-06-04	2015-11-24	Egalet A/S	Compositions pharmaceutiques a liberation controlee pour un effet prolonge
NZ597283A (en)	2009-06-24	2013-07-26	Egalet Ltd	Controlled release formulations
AU2013204592A1 (en) *	2012-04-09	2013-10-24	QRxPharma Ltd.	Controlled release formulations of opioids
US9549899B2 (en)	2012-07-06	2017-01-24	Egalet Ltd.	Abuse deterrent pharmaceutical compositions for controlled release
DK3169315T3 (da) *	2014-07-17	2020-08-10	Pharmaceutical Manufacturing Res Services In	Væskefyldt doseringsform til forhindring af misbrug med øjeblikkelig frigivelse
IL273627B2 (en)	2017-12-20	2025-03-01	Purdue Pharma Lp	Morphine sulfate dosage forms for abuse deterrence
CN114515282B (zh) *	2020-11-19	2023-09-08	山东大学	Sorbic acid在制备抗冠状病毒感染药物中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5965161A (en) *	1994-11-04	1999-10-12	Euro-Celtique, S.A.	Extruded multi-particulates
US20060240105A1 (en) *	1998-11-02	2006-10-26	Elan Corporation, Plc	Multiparticulate modified release composition
US6419960B1 (en) *	1998-12-17	2002-07-16	Euro-Celtique S.A.	Controlled release formulations having rapid onset and rapid decline of effective plasma drug concentrations
UA81224C2 (uk) *	2001-05-02	2007-12-25	Euro Celtic S A	Дозована форма оксикодону та її застосування
US20030092724A1 (en) *	2001-09-18	2003-05-15	Huaihung Kao	Combination sustained release-immediate release oral dosage forms with an opioid analgesic and a non-opioid analgesic
WO2003039561A1 (fr) *	2001-11-02	2003-05-15	Elan Corporation, Plc	Composition pharmaceutique
US8906413B2 (en) *	2003-05-12	2014-12-09	Supernus Pharmaceuticals, Inc.	Drug formulations having reduced abuse potential
CA2593165A1 (fr)	2005-01-05	2006-07-13	Regents Of The University Of Minnesota	Conjugues analgesiques
MX2007011977A (es) *	2005-03-28	2007-12-07	Orexo Ab	Composiciones farmaceuticas novedosas utiles en el tratamiento del dolor.
US20090082466A1 (en)	2006-01-27	2009-03-26	Najib Babul	Abuse Resistant and Extended Release Formulations and Method of Use Thereof
CN101534827A (zh) *	2006-11-07	2009-09-16	尼克塔治疗亚拉巴马公司	阿片样物质激动剂和阿片样物质拮抗剂的剂型和联合给药
US20090291975A1 (en) *	2008-05-20	2009-11-26	Warren Stern	Dual opioid pain therapy
US20110195989A1 (en) *	2010-02-09	2011-08-11	Rudnic Edward M	Controlled Release Formulations of Opioids

2011
- 2011-09-23 CN CN2011800562785A patent/CN103476403A/zh active Pending
- 2011-09-23 AU AU2011305161A patent/AU2011305161A1/en not_active Abandoned
- 2011-09-23 JP JP2013530379A patent/JP2013537915A/ja active Pending
- 2011-09-23 EP EP11764653.9A patent/EP2618820A2/fr not_active Withdrawn
- 2011-09-23 CA CA2812570A patent/CA2812570A1/fr not_active Abandoned
- 2011-09-23 WO PCT/US2011/053132 patent/WO2012040651A2/fr not_active Ceased

Also Published As

Publication number	Publication date
AU2011305161A1 (en)	2013-05-09
WO2012040651A2 (fr)	2012-03-29
EP2618820A2 (fr)	2013-07-31
WO2012040651A3 (fr)	2012-05-18
CN103476403A (zh)	2013-12-25
JP2013537915A (ja)	2013-10-07

Publication	Publication Date	Title
US20110195989A1 (en)	2011-08-11	Controlled Release Formulations of Opioids
US20130022646A1 (en)	2013-01-24	Controlled Release Formulations of Opioids
CA2812570A1 (fr)	2012-03-29	Formulations d'opioides a liberation controlee
JP5844312B2 (ja)	2016-01-13	事故的誤用および不法転用を防止するための耐破砕性錠剤
RU2599846C2 (ru)	2016-10-20	Новые и эффективные лекарственые формы тапентадола
JP6550157B2 (ja)	2019-07-24	Ｇａｂａ類似体及びオピオイドを含む新規胃内滞留型剤形
US20110287093A1 (en)	2011-11-24	Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats
RS12104A (sr)	2007-04-10	Formulacije opioidnog agonista sa oslobodivim i izdvojenim antagonistom
SG172818A1 (en)	2011-08-29	Abuse resistant melt extruded formulation having reduced alcohol interaction
EP2219612A1 (fr)	2010-08-25	Formulation à libération contrôlée évitant les utilisations impropres
RS50407B (sr)	2009-12-31	Oralne formulacije opijatnog agonista otporne na mehaničke,termičke i/ili hemijske promene fizičkih osobina doznog oblika
IL235150A (en)	2017-06-29	Pharmaceuticals
CA2301883A1 (fr)	1999-03-18	Compositions contenant des unites multiples a liberation modifiee de substances medicamenteuses anti-inflammatoires non steroides (nsaid)
NO323574B1 (no)	2007-06-11	Multippelenhets doseringsmateriale for modifisert avgivelse
CA2627058A1 (fr)	2007-05-18	Forme pharmaceutique orale microparticulaire anti-mesusage
CN107213128A (zh)	2017-09-29	控释氢可酮制剂
EP2367541A1 (fr)	2011-09-28	Composition à libération contrôlée prévenant un mésusage
WO2009088673A2 (fr)	2009-07-16	Composition pharmaceutique
AU2013204592A1 (en)	2013-10-24	Controlled release formulations of opioids
AU2018219999A1 (en)	2018-09-06	Pharmaceutical composition
HK1165705A (en)	2012-10-12	Misuse preventative, controlled release formulation
AU2014216026A1 (en)	2014-09-11	Pharmaceutical composition
AU2012202717A1 (en)	2012-05-31	Crush-resistant tablets intended to prevent accidental misuse and unlawful diversion

Legal Events

Date	Code	Title	Description
2016-11-06	FZDE	Dead	Effective date: 20160923