[go: up one dir, main page]

CA2887218A1 - Systeme d'amplification d'une espece d'adn foetal - Google Patents

Systeme d'amplification d'une espece d'adn foetal Download PDF

Info

Publication number
CA2887218A1
CA2887218A1 CA2887218A CA2887218A CA2887218A1 CA 2887218 A1 CA2887218 A1 CA 2887218A1 CA 2887218 A CA2887218 A CA 2887218A CA 2887218 A CA2887218 A CA 2887218A CA 2887218 A1 CA2887218 A1 CA 2887218A1
Authority
CA
Canada
Prior art keywords
dna
fetal
maternal
dna species
methylation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2887218A
Other languages
English (en)
Other versions
CA2887218C (fr
Inventor
Yuk Ming Dennis Lo
Lit Man Poon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chinese University of Hong Kong CUHK
Original Assignee
Chinese University of Hong Kong CUHK
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinese University of Hong Kong CUHK filed Critical Chinese University of Hong Kong CUHK
Priority to CA2973165A priority Critical patent/CA2973165C/fr
Publication of CA2887218A1 publication Critical patent/CA2887218A1/fr
Application granted granted Critical
Publication of CA2887218C publication Critical patent/CA2887218C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Selon un aspect, la présente invention concerne un système damplification dun espace dADN ftal comprenant ceci : i) un échantillon biologique comprenant une espèce dADN provenant de cellules dune femelle enceinte et dun ftus à naître, ledit échantillon biologique étant obtenu soit auprès de la femelle enceinte, soit auprès dun ftus à naître; ii) un réactif permettant disoler lespace dADN de léchantillon biologique; et iii) un réactif permettant damplifier lespace dADN ftal.
CA2887218A 2001-08-31 2002-08-30 Systeme d'amplification d'une espece d'adn foetal Expired - Lifetime CA2887218C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2973165A CA2973165C (fr) 2001-08-31 2002-08-30 Systeme d'amplification d'especes d'adn foetales

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/944,951 US6927028B2 (en) 2001-08-31 2001-08-31 Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
US09/944,951 2001-08-31
CA2456140A CA2456140C (fr) 2001-08-31 2002-08-30 Methodes de detection d'adn provenant de differents individus

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2456140A Division CA2456140C (fr) 2001-08-31 2002-08-30 Methodes de detection d'adn provenant de differents individus

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2973165A Division CA2973165C (fr) 2001-08-31 2002-08-30 Systeme d'amplification d'especes d'adn foetales

Publications (2)

Publication Number Publication Date
CA2887218A1 true CA2887218A1 (fr) 2003-03-13
CA2887218C CA2887218C (fr) 2017-08-22

Family

ID=25482355

Family Applications (4)

Application Number Title Priority Date Filing Date
CA2887218A Expired - Lifetime CA2887218C (fr) 2001-08-31 2002-08-30 Systeme d'amplification d'une espece d'adn foetal
CA2973165A Expired - Lifetime CA2973165C (fr) 2001-08-31 2002-08-30 Systeme d'amplification d'especes d'adn foetales
CA2456140A Expired - Lifetime CA2456140C (fr) 2001-08-31 2002-08-30 Methodes de detection d'adn provenant de differents individus
CA3012120A Expired - Lifetime CA3012120C (fr) 2001-08-31 2002-08-30 Systeme d'amplification d'especes d'adn foetales

Family Applications After (3)

Application Number Title Priority Date Filing Date
CA2973165A Expired - Lifetime CA2973165C (fr) 2001-08-31 2002-08-30 Systeme d'amplification d'especes d'adn foetales
CA2456140A Expired - Lifetime CA2456140C (fr) 2001-08-31 2002-08-30 Methodes de detection d'adn provenant de differents individus
CA3012120A Expired - Lifetime CA3012120C (fr) 2001-08-31 2002-08-30 Systeme d'amplification d'especes d'adn foetales

Country Status (12)

Country Link
US (7) US6927028B2 (fr)
EP (1) EP1421211B1 (fr)
JP (1) JP2005501566A (fr)
CN (1) CN100352939C (fr)
AT (1) ATE353977T1 (fr)
AU (1) AU2002324135A1 (fr)
CA (4) CA2887218C (fr)
DE (1) DE60218182T2 (fr)
DK (1) DK1421211T3 (fr)
ES (1) ES2280562T3 (fr)
PT (1) PT1421211E (fr)
WO (1) WO2003020974A2 (fr)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
US20030211522A1 (en) * 2002-01-18 2003-11-13 Landes Gregory M. Methods for fetal DNA detection and allele quantitation
US6977162B2 (en) * 2002-03-01 2005-12-20 Ravgen, Inc. Rapid analysis of variations in a genome
CA2477611A1 (fr) 2002-03-01 2003-09-12 Ravgen, Inc. Analyse rapide de variations dans un genome
DK1342794T3 (da) * 2002-03-05 2006-04-24 Epigenomics Ag Fremgangsmåde og anordning til at bestemme vævsspecificitet af fritflydende DNA i legemsvæsker
US20070178478A1 (en) * 2002-05-08 2007-08-02 Dhallan Ravinder S Methods for detection of genetic disorders
US7727720B2 (en) * 2002-05-08 2010-06-01 Ravgen, Inc. Methods for detection of genetic disorders
US7442506B2 (en) * 2002-05-08 2008-10-28 Ravgen, Inc. Methods for detection of genetic disorders
EP1599608A4 (fr) * 2003-03-05 2007-07-18 Genetic Technologies Ltd Identification d'adn foetal et de marqueurs de cellule foetale dans du plasma ou du serum maternel
US20050282213A1 (en) * 2003-09-22 2005-12-22 Trisogen Biotechnology Limited Partnership Methods and kits useful for detecting an alteration in a locus copy number
ATE415495T1 (de) * 2003-09-22 2008-12-15 Trisogen Biotechnology Ltd Par Zum nachweis einer änderung einer locus- kopienzahl geeignete verfahren
CA2541706C (fr) * 2003-10-08 2014-02-18 The Trustees Of Boston University Methodes de diagnostic prenatal d'anomalies chromosomiques
US10337054B2 (en) 2004-02-02 2019-07-02 Quantum-Si Incorporated Enrichment of nucleic acid targets
US8529744B2 (en) 2004-02-02 2013-09-10 Boreal Genomics Corp. Enrichment of nucleic acid targets
US8133371B2 (en) 2004-02-02 2012-03-13 The University Of British Columbia Scodaphoresis and methods and apparatus for moving and concentrating particles
US7709194B2 (en) * 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
AU2006236363B2 (en) 2005-04-15 2012-11-01 Epigenomics Ag A method for providing DNA fragments derived from a remote sample
EP2477029A1 (fr) * 2005-06-02 2012-07-18 Fluidigm Corporation Analyse utilisant des dispositifs de partage microfluidique
US9424392B2 (en) 2005-11-26 2016-08-23 Natera, Inc. System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
SI2385143T1 (sl) 2006-02-02 2016-11-30 The Board of Trustees of the Leland Stanford Junior University Office of the General Counsel Neinvazivni genetski presejalni test ploda z digitalno analizo
AU2007223102A1 (en) * 2006-03-06 2007-09-13 The Trustees Of Columbia University In The City Of New York Specific amplification of fetal DNA sequences from a mixed, fetal-maternal source
US7754428B2 (en) 2006-05-03 2010-07-13 The Chinese University Of Hong Kong Fetal methylation markers
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring
US8679741B2 (en) 2006-05-31 2014-03-25 Sequenom, Inc. Methods and compositions for the extraction and amplification of nucleic acid from a sample
EP2589668A1 (fr) 2006-06-14 2013-05-08 Verinata Health, Inc Analyse de cellules rares utilisant la division d'échantillons et les marqueurs d'ADN
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
WO2007147074A2 (fr) * 2006-06-14 2007-12-21 Living Microsystems, Inc. Utilisation de génotypage snp fortement parallèle pour diagnostic fœtal
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
CN101153336B (zh) 2006-09-27 2011-09-07 香港中文大学 检测dna甲基化程度的方法和试剂盒
US7902345B2 (en) 2006-12-05 2011-03-08 Sequenom, Inc. Detection and quantification of biomolecules using mass spectrometry
JP5211790B2 (ja) * 2007-03-26 2013-06-12 住友化学株式会社 Ｄｎａメチル化測定方法
ITTO20070307A1 (it) * 2007-05-04 2008-11-05 Silicon Biosystems Spa Metodo e dispositivo per la diagnosi prenatale non-invasiva
WO2008149237A2 (fr) 2007-06-08 2008-12-11 Epigenomics Ag Procédé pour une analyse de méthylation
KR102222378B1 (ko) 2007-07-23 2021-03-04 더 차이니즈 유니버시티 오브 홍콩 핵산 서열 불균형의 결정
AU2013202132C1 (en) * 2007-07-23 2019-07-04 The Chinese University Of Hong Kong Determining a nucleic acid sequence imbalance using multiple markers
US12180549B2 (en) 2007-07-23 2024-12-31 The Chinese University Of Hong Kong Diagnosing fetal chromosomal aneuploidy using genomic sequencing
ATE549419T1 (de) 2007-08-29 2012-03-15 Sequenom Inc Verfahren und zusammensetzungen für die universelle grössenspezifische polymerasekettenreaktion
CN101978269A (zh) 2008-01-18 2011-02-16 哈佛大学校长及研究员协会 在体液中检测疾病或病症标志的方法
CA2713313A1 (fr) 2008-02-01 2009-08-06 The University Of British Columbia Procedes et appareil pour l'introduction et la recuperation de particules
US20110027795A1 (en) * 2008-02-18 2011-02-03 Genetic Technologies Limited Cell processing and/or enrichment methods
US8709726B2 (en) * 2008-03-11 2014-04-29 Sequenom, Inc. Nucleic acid-based tests for prenatal gender determination
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
EP3770255A1 (fr) 2008-09-16 2021-01-27 Sequenom, Inc. Procédés et compositions pour enrichissement basé sur la méthylation d'acide nucléique f tal dans un échantillon maternel, utiles pour les diagnostics prénataux non invasifs
CA2737643C (fr) 2008-09-20 2020-10-06 Hei-Mun Fan Diagnostic non effractif d'aneuploidie foetale par sequencage
CN102428191A (zh) * 2009-03-18 2012-04-25 塞昆纳姆股份有限公司 热稳定性内切核酸酶在产生报道分子中的应用
EP2414545B1 (fr) 2009-04-03 2017-01-11 Sequenom, Inc. Compositions constituées d'une préparation d'acides nucléiques et procédés associés
US9447467B2 (en) 2009-04-21 2016-09-20 Genetic Technologies Limited Methods for obtaining fetal genetic material
US8877028B2 (en) 2009-04-21 2014-11-04 The University Of British Columbia System and methods for detection of particles
CA2767616A1 (fr) 2009-07-09 2011-01-13 The Scripps Research Institute Profils d'expression genique associes a une nephropathie chronique de l'allogreffe
HUE061110T2 (hu) * 2009-11-05 2023-05-28 Univ Hong Kong Chinese Magzati genomelemzés anyai biológiai mintából
GB2488289A (en) 2009-11-06 2012-08-22 Univ Leland Stanford Junior Non-invasive diagnosis of graft rejection in organ transplant patients
WO2011054936A1 (fr) 2009-11-06 2011-05-12 The Chinese University Of Hong Kong Analyse génomique basée sur la taille
JP2013511991A (ja) * 2009-11-25 2013-04-11 クアンタライフ， インコーポレイテッド 遺伝子材料を検出する方法および組成物
EP2516680B1 (fr) 2009-12-22 2016-04-06 Sequenom, Inc. Procédés et kits pour identifier une aneuploïdie
EP2513341B1 (fr) * 2010-01-19 2017-04-12 Verinata Health, Inc Identification de cellules polymorphes dans des mélanges d'adn génomique par séquençage du génome entier
CA2786565C (fr) 2010-01-19 2017-04-25 Verinata Health, Inc. Procedes de detection definis par des partitions
US9323888B2 (en) 2010-01-19 2016-04-26 Verinata Health, Inc. Detecting and classifying copy number variation
WO2011090556A1 (fr) 2010-01-19 2011-07-28 Verinata Health, Inc. Procédés pour déterminer une fraction d'acide nucléique fœtal dans des échantillons maternels
US10388403B2 (en) 2010-01-19 2019-08-20 Verinata Health, Inc. Analyzing copy number variation in the detection of cancer
US9260745B2 (en) 2010-01-19 2016-02-16 Verinata Health, Inc. Detecting and classifying copy number variation
EP2848704B1 (fr) 2010-01-19 2018-08-29 Verinata Health, Inc Procédés pour un séquençage du diagnostic prénatal
US20120100548A1 (en) 2010-10-26 2012-04-26 Verinata Health, Inc. Method for determining copy number variations
US20110312503A1 (en) 2010-01-23 2011-12-22 Artemis Health, Inc. Methods of fetal abnormality detection
US8774488B2 (en) 2010-03-11 2014-07-08 Cellscape Corporation Method and device for identification of nucleated red blood cells from a maternal blood sample
US12221653B2 (en) 2010-05-18 2025-02-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US12152275B2 (en) 2010-05-18 2024-11-26 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US20130184178A1 (en) 2010-07-23 2013-07-18 President And Fellows Of Harvard College Methods of Detecting Autoimmune or Immune-Related Diseases or Conditions
KR20130041961A (ko) 2010-07-23 2013-04-25 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 체액에서 질환 또는 상태의 특징을 검출하는 방법
CA2806304A1 (fr) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Methodes de depistage de maladies ou d'affections prenatales ou liees a la grossesse
WO2012012725A2 (fr) 2010-07-23 2012-01-26 President And Fellows Of Harvard College Méthodes de dépistage de maladies ou d'affections à l'aide de cellules phagocytaires
US8700338B2 (en) 2011-01-25 2014-04-15 Ariosa Diagnosis, Inc. Risk calculation for evaluation of fetal aneuploidy
US20140342940A1 (en) 2011-01-25 2014-11-20 Ariosa Diagnostics, Inc. Detection of Target Nucleic Acids using Hybridization
US11031095B2 (en) 2010-08-06 2021-06-08 Ariosa Diagnostics, Inc. Assay systems for determination of fetal copy number variation
US20120034603A1 (en) 2010-08-06 2012-02-09 Tandem Diagnostics, Inc. Ligation-based detection of genetic variants
US20130261003A1 (en) 2010-08-06 2013-10-03 Ariosa Diagnostics, In. Ligation-based detection of genetic variants
US10533223B2 (en) 2010-08-06 2020-01-14 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
US20130040375A1 (en) * 2011-08-08 2013-02-14 Tandem Diagnotics, Inc. Assay systems for genetic analysis
US10167508B2 (en) 2010-08-06 2019-01-01 Ariosa Diagnostics, Inc. Detection of genetic abnormalities
US11203786B2 (en) 2010-08-06 2021-12-21 Ariosa Diagnostics, Inc. Detection of target nucleic acids using hybridization
CN103534591B (zh) * 2010-10-26 2016-04-06 利兰·斯坦福青年大学托管委员会 通过测序分析进行的非侵入性胎儿遗传筛选
US8756020B2 (en) 2011-01-25 2014-06-17 Ariosa Diagnostics, Inc. Enhanced risk probabilities using biomolecule estimations
US11270781B2 (en) 2011-01-25 2022-03-08 Ariosa Diagnostics, Inc. Statistical analysis for non-invasive sex chromosome aneuploidy determination
US20230101627A1 (en) * 2011-01-25 2023-03-30 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
US9994897B2 (en) 2013-03-08 2018-06-12 Ariosa Diagnostics, Inc. Non-invasive fetal sex determination
US10131947B2 (en) * 2011-01-25 2018-11-20 Ariosa Diagnostics, Inc. Noninvasive detection of fetal aneuploidy in egg donor pregnancies
CA2824387C (fr) 2011-02-09 2019-09-24 Natera, Inc. Procedes de classification de ploidie prenatale non invasive
EP2673380B1 (fr) 2011-02-09 2018-12-12 Bio-Rad Laboratories, Inc. Analyse d'acides nucléiques
CA3252077A1 (en) 2011-02-24 2025-03-20 The Chinese University Of Hong Kong Molecular testing of multiple pregnancies
RS57837B1 (sr) * 2011-04-12 2018-12-31 Verinata Health Inc Razrešavanje genomskih frakcija upotrebom broja kopija polimorfizama
US9411937B2 (en) 2011-04-15 2016-08-09 Verinata Health, Inc. Detecting and classifying copy number variation
CA2834218C (fr) 2011-04-29 2021-02-16 Sequenom, Inc. Quantification d'une minorite d'especes d'acide nucleique utilisant des oligonucleotides inhibiteurs
CA2742327A1 (fr) 2011-05-20 2012-11-20 The University Of British Columiba Systemes et methodes pour amelioration de la scoda (separation, concentration, detection de molecules selon la difference d'affinite de liaison)
US20140235474A1 (en) 2011-06-24 2014-08-21 Sequenom, Inc. Methods and processes for non invasive assessment of a genetic variation
US8712697B2 (en) 2011-09-07 2014-04-29 Ariosa Diagnostics, Inc. Determination of copy number variations using binomial probability calculations
US10196681B2 (en) 2011-10-06 2019-02-05 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2850785C (fr) 2011-10-06 2022-12-13 Sequenom, Inc. Methodes et procedes pour evaluation non invasive de variations genetiques
US9367663B2 (en) 2011-10-06 2016-06-14 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013052913A2 (fr) 2011-10-06 2013-04-11 Sequenom, Inc. Procédés et processus d'évaluation non invasive de variations génétiques
US9984198B2 (en) 2011-10-06 2018-05-29 Sequenom, Inc. Reducing sequence read count error in assessment of complex genetic variations
US10424394B2 (en) 2011-10-06 2019-09-24 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
ES2624686T3 (es) 2011-10-11 2017-07-17 Sequenom, Inc. Métodos y procesos para la evaluación no invasiva de variaciones genéticas
US8688388B2 (en) 2011-10-11 2014-04-01 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013104994A2 (fr) 2012-01-13 2013-07-18 The University Of British Columbia Appareil à bras multiples et procédés pour la séparation de particules
AU2013209499B2 (en) 2012-01-20 2018-05-10 Sequenom, Inc. Diagnostic processes that factor experimental conditions
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2013138527A1 (fr) 2012-03-13 2013-09-19 The Chinese University Of Hong Kong Procédés d'analyse de données de séquençage massivement parallèle pour un diagnostic prénatal non invasif
WO2013166444A2 (fr) 2012-05-04 2013-11-07 Boreal Genomics Corp. Analyse de biomarqueurs utilisant la scodaphorèse
DK3663409T3 (da) 2012-05-21 2021-12-13 Sequenom Inc Fremgangsmåder og processer til ikke-invasiv bedømmelse af genetiske variationer
US10289800B2 (en) 2012-05-21 2019-05-14 Ariosa Diagnostics, Inc. Processes for calculating phased fetal genomic sequences
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CA2874343C (fr) 2012-05-21 2021-11-09 Fluidigm Corporation Analyse de particules uniques de populations de particules
US10497461B2 (en) 2012-06-22 2019-12-03 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
WO2014015269A1 (fr) 2012-07-19 2014-01-23 Ariosa Diagnostics, Inc. Détection à base de ligature séquentielle multiplexe de variants génétiques
US20140100126A1 (en) 2012-08-17 2014-04-10 Natera, Inc. Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
LT3354747T (lt) 2012-09-20 2021-04-12 The Chinese University Of Hong Kong Neinvazinis naviko metilomos nustatymas iš plazmos
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
US10482994B2 (en) 2012-10-04 2019-11-19 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
WO2014055790A2 (fr) 2012-10-04 2014-04-10 Sequenom, Inc. Procédés et processus d'évaluation non invasive de variations génétiques
US20130309666A1 (en) 2013-01-25 2013-11-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3385717A3 (fr) 2013-03-09 2018-10-24 Harry Stylli Procédés de detection du cancer de la prostate
EP2965077B1 (fr) 2013-03-09 2022-07-13 Harry Stylli Procédés de détection de cancer
US20130189684A1 (en) 2013-03-12 2013-07-25 Sequenom, Inc. Quantification of cell-specific nucleic acid markers
EP2971100A1 (fr) 2013-03-13 2016-01-20 Sequenom, Inc. Amorces pour analyse de la méthylation de l'adn
EP2971126B1 (fr) 2013-03-15 2018-11-07 The Chinese University Of Hong Kong Détermination de génomes foeaux pour grossesses à foetus multiples
CA2905517C (fr) 2013-03-15 2024-11-12 Lineage Biosciences, Inc. Procedes et compositions d'etiquetage et d'analyse d'echantillons
US9340835B2 (en) 2013-03-15 2016-05-17 Boreal Genomics Corp. Method for separating homoduplexed and heteroduplexed nucleic acids
LT2981921T (lt) 2013-04-03 2023-02-27 Sequenom, Inc. Neinvazinio genetinių variacijų vertinimo būdai ir procesai
WO2014190286A2 (fr) 2013-05-24 2014-11-27 Sequenom, Inc. Méthodes et systèmes d'évaluation non invasive de variations génétiques
KR102784584B1 (ko) 2013-06-21 2025-03-19 시쿼넘, 인코포레이티드 유전적 변이의 비침습 평가를 위한 방법 및 프로세스
EP3029148B1 (fr) * 2013-07-30 2018-06-27 BGI Genomics Co., Limited Méthode de détermination de la composition en acides nucléiques d'un mélange constitué d'acides nucléiques
US10964409B2 (en) 2013-10-04 2021-03-30 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN111863131A (zh) 2013-10-07 2020-10-30 塞昆纳姆股份有限公司 用于非侵入性评估染色体改变的方法和过程
US11365447B2 (en) 2014-03-13 2022-06-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3957749A1 (fr) 2014-04-21 2022-02-23 Natera, Inc. Détection de mutations spécifiques d'un tumeur dans les biopsies par séquençage exome entier et dans les échantillons acellulaires
US12492429B2 (en) 2014-04-21 2025-12-09 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
CN107223159A (zh) 2014-05-09 2017-09-29 科戴克斯生命股份公司 源自特定细胞类型的dna的检测及相关方法
EP2942400A1 (fr) 2014-05-09 2015-11-11 Lifecodexx AG Détection multiplexe d'ADN qui provient d'un type cellulaire spécifique
US11104951B2 (en) 2014-05-22 2021-08-31 The Scripps Research Institute Molecular signatures for distinguishing liver transplant rejections or injuries
US10443100B2 (en) 2014-05-22 2019-10-15 The Scripps Research Institute Gene expression profiles associated with sub-clinical kidney transplant rejection
EP3598452B1 (fr) 2014-05-30 2023-07-26 Sequenom, Inc. Déterminations de représentation de chromosomes
US20180173846A1 (en) 2014-06-05 2018-06-21 Natera, Inc. Systems and Methods for Detection of Aneuploidy
KR102696857B1 (ko) 2014-07-25 2024-08-19 유니버시티 오브 워싱톤 무세포 dna를 생성하는 조직 및/또는 세포 유형을 결정하는 방법 및 이를 사용하여 질환 또는 장애를 확인하는 방법
EP3175000B1 (fr) 2014-07-30 2020-07-29 Sequenom, Inc. Méthodes et procédés d'évaluation non invasive de variations génétiques
WO2016040843A1 (fr) 2014-09-11 2016-03-17 Harry Stylli Procédés pour détecter le cancer de la prostate
EP3204512B1 (fr) 2014-10-10 2020-05-06 Sequenom, Inc. Méthodes pour la partitionnement des séquences génomiques
US11242559B2 (en) 2015-01-13 2022-02-08 The Chinese University Of Hong Kong Method of nuclear DNA and mitochondrial DNA analysis
US10364467B2 (en) 2015-01-13 2019-07-30 The Chinese University Of Hong Kong Using size and number aberrations in plasma DNA for detecting cancer
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
WO2016185284A1 (fr) 2015-05-20 2016-11-24 Boreal Genomics, Inc. Procédé pour isoler un acide nucléique cible à l'aide des protéines de liaison hétéroduplexes
ES2990200T3 (es) 2015-05-22 2024-11-29 Medicover Public Co Ltd Análisis paralelo múltiplex de regiones genómicas blanco para análisis prenatales no invasivos
EP3168309B8 (fr) 2015-11-10 2020-06-03 Eurofins LifeCodexx GmbH Détection d'aneuploïdies chromosomiques foetales au moyen de régions d'adn qui sont méthylées de manière différentielle entre le foetus et la femme enceinte
JP7280044B2 (ja) 2016-04-15 2023-05-23 ナテラ， インコーポレイテッド 肺癌の検出方法
WO2017205826A1 (fr) 2016-05-27 2017-11-30 Sequenom, Inc. Méthodes de détection de variations génétiques
US11299780B2 (en) 2016-07-15 2022-04-12 The Regents Of The University Of California Methods of producing nucleic acid libraries
EP3491561A1 (fr) 2016-07-27 2019-06-05 Sequenom, Inc. Procédés d'évaluation non invasive de l'instabilité génomique
US11200963B2 (en) 2016-07-27 2021-12-14 Sequenom, Inc. Genetic copy number alteration classifications
US11854666B2 (en) 2016-09-29 2023-12-26 Myriad Women's Health, Inc. Noninvasive prenatal screening using dynamic iterative depth optimization
WO2018067517A1 (fr) 2016-10-04 2018-04-12 Natera, Inc. Procédés pour caractériser une variation de nombre de copies à l'aide d'un séquençage de ligature de proximité
GB201618485D0 (en) 2016-11-02 2016-12-14 Ucl Business Plc Method of detecting tumour recurrence
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CA3198931A1 (fr) 2017-01-20 2018-07-26 Sequenom, Inc. Procedes d'evaluation non invasive d'alterations genetique
CA3049455C (fr) 2017-01-20 2023-06-13 Sequenom, Inc. Fabrication et utilisation d'adaptateur de sequencage
US11929143B2 (en) 2017-01-20 2024-03-12 Sequenom, Inc Methods for non-invasive assessment of copy number alterations
IL319365A (en) 2017-01-24 2025-05-01 Sequenom Inc Methods and processes for assessing genetic variations
PT3596233T (pt) 2017-03-17 2022-08-22 Sequenom Inc Métodos e processos para avaliação de mosaicismo genético
WO2019118926A1 (fr) 2017-12-14 2019-06-20 Tai Diagnostics, Inc. Évaluation de la compatibilité d'une greffe pour la transplantation
US11584929B2 (en) 2018-01-12 2023-02-21 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
US12024738B2 (en) 2018-04-14 2024-07-02 Natera, Inc. Methods for cancer detection and monitoring
EP3802864A1 (fr) 2018-06-06 2021-04-14 The Regents Of The University Of California Procédés de production de bibliothèques d'acides nucléiques et compositions et kits pour leur mise en oeuvre
US12234509B2 (en) 2018-07-03 2025-02-25 Natera, Inc. Methods for detection of donor-derived cell-free DNA
CA3134831A1 (fr) 2019-04-05 2020-10-08 Claret Bioscience, Llc Procedes et compositions d'analyse d'acide nucleique
WO2020247263A1 (fr) 2019-06-06 2020-12-10 Natera, Inc. Procédés de détection d'adn de cellules immunitaires et de surveillance du système immunitaire
CN110734966B (zh) * 2019-09-19 2021-06-25 广州医科大学附属肿瘤医院 一种用于检测sav1基因启动子区甲基化位点的检测体系及试剂盒
US20230014607A1 (en) 2019-10-09 2023-01-19 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
AU2020372908A1 (en) 2019-10-29 2022-06-02 Quantum-Si Incorporated Peristaltic pumping of fluids and associated methods, systems, and devices
US20240395357A1 (en) 2019-10-31 2024-11-28 Sequenom, Inc. Application of mosaicism ratio in multifetal gestations and personalized risk assessment
AU2021297880A1 (en) 2020-06-24 2023-01-19 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
US20240395358A1 (en) 2020-10-08 2024-11-28 Claret Bioscience, Llc Methods and compositions for analyzing nucleic acid
MX2023010650A (es) * 2021-03-09 2023-11-28 Illumina Inc Preparacion de genotecas y ensayos epigeneticos dirigidos usando riblonucleoproteinas cas-arng.
WO2024186778A1 (fr) 2023-03-03 2024-09-12 Laboratory Corporation Of America Holdings Procédés et systèmes de criblage d'adncf positif sur des variations génétiques à l'aide d'un rapport de mosaïcisme
CN121153082A (zh) 2023-05-15 2025-12-16 美国控股实验室公司 用于在全基因组测序中进行泛癌筛查的机器学习方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017704A (en) * 1996-06-03 2000-01-25 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
GB9704444D0 (en) 1997-03-04 1997-04-23 Isis Innovation Non-invasive prenatal diagnosis
US6251594B1 (en) * 1997-06-09 2001-06-26 Usc/Norris Comprehensive Cancer Ctr. Cancer diagnostic method based upon DNA methylation differences
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
US6331393B1 (en) * 1999-05-14 2001-12-18 University Of Southern California Process for high-throughput DNA methylation analysis
JP2004505612A (ja) * 2000-03-31 2004-02-26 ユニバーシティ・オブ・サザン・カリフォルニア 食道腺ガンに関する後成的配列
US6927028B2 (en) * 2001-08-31 2005-08-09 Chinese University Of Hong Kong Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
US7709194B2 (en) * 2004-06-04 2010-05-04 The Chinese University Of Hong Kong Marker for prenatal diagnosis and monitoring
US7901884B2 (en) * 2006-05-03 2011-03-08 The Chinese University Of Hong Kong Markers for prenatal diagnosis and monitoring

Also Published As

Publication number Publication date
ATE353977T1 (de) 2007-03-15
CN100352939C (zh) 2007-12-05
US6927028B2 (en) 2005-08-09
US8962280B2 (en) 2015-02-24
JP2005501566A (ja) 2005-01-20
AU2002324135A1 (en) 2003-03-18
PT1421211E (pt) 2007-03-30
CN1665936A (zh) 2005-09-07
US20150232949A1 (en) 2015-08-20
DK1421211T3 (da) 2007-05-29
DE60218182D1 (de) 2007-03-29
CA2973165C (fr) 2018-08-28
CA2973165A1 (fr) 2003-03-13
US20050282185A1 (en) 2005-12-22
US20030044388A1 (en) 2003-03-06
US20090170102A1 (en) 2009-07-02
CA2456140C (fr) 2015-06-23
HK1076840A1 (en) 2006-01-27
US20120190029A1 (en) 2012-07-26
EP1421211A2 (fr) 2004-05-26
CA3012120C (fr) 2021-08-10
US8431343B2 (en) 2013-04-30
US20200208225A1 (en) 2020-07-02
ES2280562T3 (es) 2007-09-16
CA2456140A1 (fr) 2003-03-13
EP1421211B1 (fr) 2007-02-14
CA3012120A1 (fr) 2003-03-13
WO2003020974A2 (fr) 2003-03-13
DE60218182T2 (de) 2008-02-07
US8168382B2 (en) 2012-05-01
CA2887218C (fr) 2017-08-22
US20130337443A1 (en) 2013-12-19
WO2003020974A3 (fr) 2003-09-18

Similar Documents

Publication Publication Date Title
CA2887218C (fr) Systeme d'amplification d'une espece d'adn foetal
Pertl et al. Detection of male and female fetal DNA in maternal plasma by multiplex fluorescent polymerase chain reaction amplification of short tandem repeats
JP2023115354A (ja) 非侵襲性の出生前診断のために有用な、母体サンプル由来の胎児核酸のメチル化に基づく濃縮のためのプロセスおよび組成物
US8394582B2 (en) Identification of fetal DNA and fetal cell markers in maternal plasma or serum
GB2488358A (en) Enrichment of foetal DNA in maternal plasma
WO2010065470A2 (fr) Compositions et méthodes pour détecter un adn masculin pendant la détermination du sexe foetal
US20100092959A1 (en) Single nucleotide polymorphisms as genetic markers for childhood leukemia
US9879314B2 (en) Method for detecting HLA-A*31:01 allele
US20140315196A1 (en) DNA Diagnostic Screening for Turner Syndrome and Sex Chromosome Disorders
KR101546364B1 (ko) 태아 특이적 후성학적 메틸화 마커 검출용 조성물 및 검출방법
KR101696707B1 (ko) 태아 특이적 후성학적 메틸화 마커 검출용 조성물 및 검출방법
HK1076840B (en) Methods for detecting dna originating from different individuals in one sample
KR101546366B1 (ko) 태아 특이적 후성학적 메틸화 마커 검출용 조성물 및 검출방법
US20120100537A1 (en) Method of Prenatal Molecular Diagnosis of Down Syndrome and Other Trisomic Disorders
van den Oever Noninvasive prenatal detection of genetic defects.
WO2010008809A2 (fr) Compositions et procédés pour la détermination du sexe à un stade précoce

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150402

MKEX Expiry

Effective date: 20220830