CA2709903A1 - Compositions opioides orales comportant un antagoniste opioide - Google Patents

Compositions opioides orales comportant un antagoniste opioide Download PDF

Info

Publication number: CA2709903A1
Authority: CA; Canada
Prior art keywords: antagonist; release; missing; opioid; rule
Prior art date: 2007-12-17
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2709903A

Other languages

English (en)

Inventor

Alfred Liang

Frank Matthews

Garth Boehm

Lijuan Tang

Frank Johnson

Joseph Stauffer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Alpharma Pharmaceuticals LLC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-17

Filing date

2008-12-16

Publication date

2009-06-25

2008-12-16 Application filed by Individual filed Critical Individual

2009-06-25 Publication of CA2709903A1 publication Critical patent/CA2709903A1/fr

Status Abandoned legal-status Critical Current

Links

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XJKQCILVUHXVIQ-UHFFFAOYSA-N properidine Chemical compound C=1C=CC=CC=1C1(C(=O)OC(C)C)CCN(C)CC1 XJKQCILVUHXVIQ-UHFFFAOYSA-N 0.000 description 1
229950004345 properidine Drugs 0.000 description 1
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ZBAFFZBKCMWUHM-UHFFFAOYSA-N propiram Chemical compound C=1C=CC=NC=1N(C(=O)CC)C(C)CN1CCCCC1 ZBAFFZBKCMWUHM-UHFFFAOYSA-N 0.000 description 1
229950003779 propiram Drugs 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
230000009325 pulmonary function Effects 0.000 description 1
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239000010453 quartz Substances 0.000 description 1
239000011044 quartzite Substances 0.000 description 1
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229960001225 rifampicin Drugs 0.000 description 1
RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
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229940071089 sarcosinate Drugs 0.000 description 1
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APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
DBKCLWTWMFVXQN-UHFFFAOYSA-M sodium sulfuric acid chloride Chemical compound [Na+].[Cl-].OS(O)(=O)=O DBKCLWTWMFVXQN-UHFFFAOYSA-M 0.000 description 1
HJHVQCXHVMGZNC-JCJNLNMISA-M sodium;(2z)-2-[(3r,4s,5s,8s,9s,10s,11r,13r,14s,16s)-16-acetyloxy-3,11-dihydroxy-4,8,10,14-tetramethyl-2,3,4,5,6,7,9,11,12,13,15,16-dodecahydro-1h-cyclopenta[a]phenanthren-17-ylidene]-6-methylhept-5-enoate Chemical compound [Na+].O[C@@H]([C@@H]12)C[C@H]3\C(=C(/CCC=C(C)C)C([O-])=O)[C@@H](OC(C)=O)C[C@]3(C)[C@@]2(C)CC[C@@H]2[C@]1(C)CC[C@@H](O)[C@H]2C HJHVQCXHVMGZNC-JCJNLNMISA-M 0.000 description 1
JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 description 1
239000007962 solid dispersion Substances 0.000 description 1
235000019721 spearmint oil Nutrition 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
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230000003637 steroidlike Effects 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
210000004304 subcutaneous tissue Anatomy 0.000 description 1
208000011117 substance-related disease Diseases 0.000 description 1
229940013883 sucrose octaacetate Drugs 0.000 description 1
150000003445 sucroses Chemical class 0.000 description 1
229950005175 sudoxicam Drugs 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
150000003871 sulfonates Chemical class 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
238000012353 t test Methods 0.000 description 1
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239000012085 test solution Substances 0.000 description 1
238000004448 titration Methods 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
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230000001988 toxicity Effects 0.000 description 1
239000003204 tranquilizing agent Substances 0.000 description 1
230000002936 tranquilizing effect Effects 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000007704 transition Effects 0.000 description 1
238000012384 transportation and delivery Methods 0.000 description 1
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229960002622 triacetin Drugs 0.000 description 1
150000003626 triacylglycerols Chemical class 0.000 description 1
YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
239000001069 triethyl citrate Substances 0.000 description 1
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
235000013769 triethyl citrate Nutrition 0.000 description 1
GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
238000009810 tubal ligation Methods 0.000 description 1
229940053347 vicoprofen Drugs 0.000 description 1
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230000002618 waking effect Effects 0.000 description 1
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229920001285 xanthan gum Polymers 0.000 description 1
229950007802 zidometacin Drugs 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
229960003414 zomepirac Drugs 0.000 description 1
ZXVNMYWKKDOREA-UHFFFAOYSA-N zomepirac Chemical compound C1=C(CC(O)=O)N(C)C(C(=O)C=2C=CC(Cl)=CC=2)=C1C ZXVNMYWKKDOREA-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)

CA2709903A 2007-12-17 2008-12-16 Compositions opioides orales comportant un antagoniste opioide Abandoned CA2709903A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US788207P	2007-12-17	2007-12-17
US61/007,882		2007-12-17
PCT/US2008/087030 WO2009079518A1 (fr)	2007-12-17	2008-12-16	Composition pharmaceutique

Publications (1)

Publication Number	Publication Date
CA2709903A1 true CA2709903A1 (fr)	2009-06-25

Family

ID=40795902

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2709903A Abandoned CA2709903A1 (fr)	2007-12-17	2008-12-16	Compositions opioides orales comportant un antagoniste opioide

Country Status (4)

Country	Link
EP (1)	EP2224806A4 (fr)
AU (1)	AU2008338439A1 (fr)
CA (1)	CA2709903A1 (fr)
WO (1)	WO2009079518A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60138706D1 (de)	2000-02-08	2009-06-25	Euro Celtique Sa	Missbrauchssichere orale opioid-agonist zubereitungen
MY135852A (en)	2003-04-21	2008-07-31	Euro Celtique Sa	Pharmaceutical products
AU2008343267A1 (en) *	2007-12-17	2009-07-09	Alpharma Pharmaceuticals, Llc	Pharmaceutical composition
AU2008346870A1 (en) *	2007-12-17	2009-07-16	Alpharma Pharmaceuticals, Llc	Pharmaceutical composition
AU2018390826B2 (en)	2017-12-20	2024-09-12	Purdue Pharma L.P.	Abuse deterrent morphine sulfate dosage forms

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1997033566A2 (fr) *	1996-03-12	1997-09-18	Alza Corporation	Composition et forme galenique contenant un antagoniste des opioides
DE60138706D1 (de) *	2000-02-08	2009-06-25	Euro Celtique Sa	Missbrauchssichere orale opioid-agonist zubereitungen
PT1551372T (pt) *	2002-09-20	2018-07-23	Alpharma Pharmaceuticals Llc	Subunidade de sequestração e composições e métodos relacionados
US20050191244A1 (en) *	2002-10-25	2005-09-01	Gruenenthal Gmbh	Abuse-resistant pharmaceutical dosage form
US20040202717A1 (en) *	2003-04-08	2004-10-14	Mehta Atul M.	Abuse-resistant oral dosage forms and method of use thereof
US8790689B2 (en) *	2003-04-30	2014-07-29	Purdue Pharma L.P.	Tamper resistant transdermal dosage form
ES2281851T3 (es) *	2003-12-09	2007-10-01	Euro-Celtique S.A.	Forma de dosis co-extruida resistente a la manipulacion conteniendo un agente activo y un agente adverso y proceso para preparar el mismo.
WO2007013975A2 (fr) *	2005-07-20	2007-02-01	Pharmorx Inc.	Compositions et procedes destines a controler l'abus de medicaments
MX2008016372A (es) *	2006-06-19	2009-05-28	Alpharma Inc	Composiciones farmaceuticas.
WO2008027442A2 (fr) *	2006-08-30	2008-03-06	Theraquest Biosciences, Llc	Formulations pharmaceutiques orales anti-abus à base d'opioïdes et procédé d'utilisation
AU2007322269A1 (en) *	2006-10-11	2008-05-29	Alpharma Pharmaceuticals, Llc	Pharmaceutical compositions
WO2009032270A2 (fr) *	2007-09-04	2009-03-12	Alpharma, Inc.	Compositions pharmaceutiques
AU2008343267A1 (en) *	2007-12-17	2009-07-09	Alpharma Pharmaceuticals, Llc	Pharmaceutical composition
AU2008346870A1 (en) *	2007-12-17	2009-07-16	Alpharma Pharmaceuticals, Llc	Pharmaceutical composition

2008
- 2008-12-16 EP EP08862226.1A patent/EP2224806A4/fr not_active Withdrawn
- 2008-12-16 AU AU2008338439A patent/AU2008338439A1/en not_active Abandoned
- 2008-12-16 WO PCT/US2008/087030 patent/WO2009079518A1/fr not_active Ceased
- 2008-12-16 CA CA2709903A patent/CA2709903A1/fr not_active Abandoned

Also Published As

Publication number	Publication date
EP2224806A4 (fr)	2014-02-19
AU2008338439A1 (en)	2009-06-25
WO2009079518A1 (fr)	2009-06-25
EP2224806A1 (fr)	2010-09-08

Publication	Publication Date	Title
US8623418B2 (en)	2014-01-07	Pharmaceutical composition
CN101677963B (zh)	2012-05-30	药物组合物
US20130122065A1 (en)	2013-05-16	Pharmaceutical Composition
CA2714921C (fr)	2016-04-05	Compositions pharmaceutiques
JP2010506833A (ja)	2010-03-04	医薬組成物
WO2009085778A1 (fr)	2009-07-09	Compositions pharmaceutiques
US20150104519A1 (en)	2015-04-16	Pharmaceutical Compositions
CA2709903A1 (fr)	2009-06-25	Compositions opioides orales comportant un antagoniste opioide
AU2014216032B2 (en)	2016-11-03	Pharmaceutical composition
AU2014250614B2 (en)	2016-11-10	A multilayer pharmaceutical composition comprising an antagonist in a first layer and an agonist in a second layer
AU2018219999A1 (en)	2018-09-06	Pharmaceutical composition
AU2018202217A1 (en)	2018-04-26	Pharmaceutical composition
AU2014216026A1 (en)	2014-09-11	Pharmaceutical composition
AU2015200402A1 (en)	2015-02-19	Pharmaceutical composition
AU2017239533A1 (en)	2017-10-26	Pharmaceutical compositions

Legal Events

Date	Code	Title	Description
2014-01-18	EEER	Examination request	Effective date: 20131213
2019-03-05	FZDE	Discontinued	Effective date: 20190122