CA2709994A1 - Affichage alternatif de phage de fusion de proteine de support par la fusion en plx du phage m13 - Google Patents
Affichage alternatif de phage de fusion de proteine de support par la fusion en plx du phage m13 Download PDFInfo
- Publication number
- CA2709994A1 CA2709994A1 CA2709994A CA2709994A CA2709994A1 CA 2709994 A1 CA2709994 A1 CA 2709994A1 CA 2709994 A CA2709994 A CA 2709994A CA 2709994 A CA2709994 A CA 2709994A CA 2709994 A1 CA2709994 A1 CA 2709994A1
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- CA
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- Prior art keywords
- protein
- phage
- antibody
- seq
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1477807P | 2007-12-19 | 2007-12-19 | |
| US61/014,778 | 2007-12-19 | ||
| PCT/US2008/087696 WO2009086116A2 (fr) | 2007-12-19 | 2008-12-19 | Affichage alternatif de phage de fusion de protéine de support par la fusion en plx du phage m13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2709994A1 true CA2709994A1 (fr) | 2009-07-09 |
Family
ID=40825038
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2709994A Abandoned CA2709994A1 (fr) | 2007-12-19 | 2008-12-19 | Affichage alternatif de phage de fusion de proteine de support par la fusion en plx du phage m13 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP2238247A2 (fr) |
| JP (1) | JP2011507529A (fr) |
| AU (1) | AU2008345674A1 (fr) |
| CA (1) | CA2709994A1 (fr) |
| IL (1) | IL206409A0 (fr) |
| WO (1) | WO2009086116A2 (fr) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060129246A (ko) | 2003-12-05 | 2006-12-15 | 컴파운드 쎄라퓨틱스, 인크. | 타입 2 혈관 내피 성장 인자 수용체의 억제제 |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| CA2670471A1 (fr) | 2006-11-22 | 2008-06-05 | Adnexus, A Bristol-Myers Squibb R&D Company (A Delaware Corporation) | Substances therapeutiques a base de proteines modifiees ciblees sur des recepteurs de tyrosine kinases, dont l'igf-ir |
| CN102007145A (zh) | 2008-02-14 | 2011-04-06 | 百时美施贵宝公司 | 基于结合egfr的工程化蛋白质的靶向治疗剂 |
| EP2799448A1 (fr) | 2008-05-22 | 2014-11-05 | Bristol-Myers Squibb Company | Protéines de domaine d'échafaudage à base de fribronectine multivalente |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| CN102307896B (zh) | 2008-10-31 | 2016-10-12 | 森托科尔奥索生物科技公司 | 基于iii型纤连蛋白结构域的支架组合物、方法及用途 |
| TWI496582B (zh) | 2008-11-24 | 2015-08-21 | 必治妥美雅史谷比公司 | 雙重專一性之egfr/igfir結合分子 |
| US8241623B1 (en) | 2009-02-09 | 2012-08-14 | David Bermudes | Protease sensitivity expression system |
| US8524220B1 (en) | 2010-02-09 | 2013-09-03 | David Gordon Bermudes | Protease inhibitor: protease sensitivity expression system composition and methods improving the therapeutic activity and specificity of proteins delivered by bacteria |
| US8771669B1 (en) | 2010-02-09 | 2014-07-08 | David Gordon Bermudes | Immunization and/or treatment of parasites and infectious agents by live bacteria |
| US9597379B1 (en) | 2010-02-09 | 2017-03-21 | David Gordon Bermudes | Protease inhibitor combination with therapeutic proteins including antibodies |
| HUE029622T2 (en) * | 2010-04-30 | 2017-03-28 | Janssen Biotech Inc | Stabilized fibronectin domain compositions, methods and uses |
| TW201138808A (en) | 2010-05-03 | 2011-11-16 | Bristol Myers Squibb Co | Serum albumin binding molecules |
| EP2576615B1 (fr) | 2010-05-26 | 2016-03-30 | Bristol-Myers Squibb Company | Protéines d'échafaudage à base de fibronectine ayant une stabilité améliorée |
| ES2608835T3 (es) | 2011-04-13 | 2017-04-17 | Bristol-Myers Squibb Company | Proteínas de fusión Fc que comprenden nuevos enlazadores o disposiciones |
| EP2709669A1 (fr) | 2011-05-17 | 2014-03-26 | Bristol-Myers Squibb Company | Procédés de maintien de la pegylation de polypeptides |
| WO2012158739A1 (fr) | 2011-05-17 | 2012-11-22 | Bristol-Myers Squibb Company | Procédés améliorés pour la sélection de protéines de liaison |
| EP2761066B1 (fr) | 2011-09-27 | 2018-12-05 | Janssen Biotech, Inc. | Echafaudages protéiques à base de répétition de fibronectine type iii avec de nouvelles surfaces de liaison |
| US9522951B2 (en) | 2011-10-31 | 2016-12-20 | Bristol-Myers Squibb Company | Fibronectin binding domains with reduced immunogenicity |
| LT3835310T (lt) | 2012-09-13 | 2024-04-25 | Bristol-Myers Squibb Company | Fibronektino pagrindo karkaso domeno baltymai, kurie rišasi prie miostatino |
| EP2951206A2 (fr) | 2013-02-01 | 2015-12-09 | Bristol-Myers Squibb Company | Protéines d'échafaudage à base de fibronectine |
| ES2689372T3 (es) | 2013-02-06 | 2018-11-13 | Bristol-Myers Squibb Company | Proteínas de dominio de fibronectina tipo III con solubilidad mejorada |
| US10183967B2 (en) | 2013-02-12 | 2019-01-22 | Bristol-Myers Squibb Company | Tangential flow filtration based protein refolding methods |
| ES2870802T3 (es) | 2013-02-12 | 2021-10-27 | Bristol Myers Squibb Co | Métodos de replegado de proteínas a elevado pH |
| US9593339B1 (en) | 2013-02-14 | 2017-03-14 | David Gordon Bermudes | Bacteria carrying bacteriophage and protease inhibitors for the treatment of disorders and methods of treatment |
| WO2014165093A2 (fr) | 2013-03-13 | 2014-10-09 | Bristol-Myers Squibb Company | Domaines d'échafaudage à base de fibronectine liés à une sérum albumine ou fragment se liant à celle-ci |
| US9737592B1 (en) | 2014-02-14 | 2017-08-22 | David Gordon Bermudes | Topical and orally administered protease inhibitors and bacterial vectors for the treatment of disorders and methods of treatment |
| EP3647322B1 (fr) | 2014-03-20 | 2021-10-20 | Bristol-Myers Squibb Company | Molécules de charpente à base de fibronectine stabilisée |
| WO2015143199A1 (fr) | 2014-03-20 | 2015-09-24 | Bristol-Myers Squibb Company | Domaines de fibronectine de type iii se liant à l'albumine sérique |
| CN107207379B (zh) | 2014-11-25 | 2021-08-10 | 百时美施贵宝公司 | 用于生物制品的18f-放射性标记的方法和组合物 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| ES2962885T3 (es) | 2015-05-15 | 2024-03-21 | Massachusetts Gen Hospital | Anticuerpos antagonistas de la superfamilia del receptor del factor de necrosis tumoral |
| EP3708580B1 (fr) | 2015-09-23 | 2023-11-01 | Bristol-Myers Squibb Company | Domaines de la fibronectine de type iii se liant à l'albumine sérique à vitesse de dissociation élevée |
| WO2017210335A1 (fr) | 2016-06-01 | 2017-12-07 | Bristol-Myers Squibb Company | Méthodes d'imagerie faisant intervenir des substances biologiques radiomarquées au 18f |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| WO2018111976A1 (fr) | 2016-12-14 | 2018-06-21 | Janssen Biotech, Inc. | Domaines de fibronectine de type iii se liant à pd-l1 |
| JP7104703B2 (ja) | 2016-12-14 | 2022-07-21 | ヤンセン バイオテツク,インコーポレーテツド | Cd8a結合フィブロネクチンiii型ドメイン |
| EP3554561B1 (fr) | 2016-12-14 | 2023-06-28 | Janssen Biotech, Inc. | Domaines de fibronectine de type iii à liaison au cd137 |
| EP4045061A4 (fr) | 2019-10-14 | 2024-04-17 | ARO Biotherapeutics Company | Domaines de type iii de fibronectine de liaison à cd137 |
| WO2021076543A1 (fr) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Domaines de type iii de fibronectine de liaison à cd137 |
| WO2021076574A2 (fr) | 2019-10-14 | 2021-04-22 | Aro Biotherapeutics Company | Conjugués domaine fn3-arnsi et leurs utilisations |
| CN116568341A (zh) | 2020-02-28 | 2023-08-08 | 百时美施贵宝公司 | 基于纤连蛋白的放射性标记的支架和抗体及其治疗诊断用途 |
| JP2024517610A (ja) | 2021-04-14 | 2024-04-23 | アロ・バイオセラピューティクス・カンパニー | Cd71に結合するフィブロネクチンiii型ドメイン |
| BR112023021318A2 (pt) | 2021-04-14 | 2023-12-19 | Aro Biotherapeutics Company | Conjugados de domínio fn3-sirna e usos dos mesmos |
Family Cites Families (1)
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|---|---|---|---|---|
| US20030148263A1 (en) * | 1997-08-29 | 2003-08-07 | Selective Genetics, Inc. | Methods and compositions using genetic package display |
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- 2008-12-19 CA CA2709994A patent/CA2709994A1/fr not_active Abandoned
- 2008-12-19 EP EP08868131A patent/EP2238247A2/fr not_active Withdrawn
- 2008-12-19 WO PCT/US2008/087696 patent/WO2009086116A2/fr not_active Ceased
- 2008-12-19 AU AU2008345674A patent/AU2008345674A1/en not_active Abandoned
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|---|---|
| JP2011507529A (ja) | 2011-03-10 |
| AU2008345674A1 (en) | 2009-07-09 |
| IL206409A0 (en) | 2010-12-30 |
| EP2238247A2 (fr) | 2010-10-13 |
| WO2009086116A2 (fr) | 2009-07-09 |
| WO2009086116A3 (fr) | 2009-10-08 |
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