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CA2767028A1 - Procedes et compositions destines a detecter un materiel genetique - Google Patents

Procedes et compositions destines a detecter un materiel genetique Download PDF

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Publication number
CA2767028A1
CA2767028A1 CA2767028A CA2767028A CA2767028A1 CA 2767028 A1 CA2767028 A1 CA 2767028A1 CA 2767028 A CA2767028 A CA 2767028A CA 2767028 A CA2767028 A CA 2767028A CA 2767028 A1 CA2767028 A1 CA 2767028A1
Authority
CA
Canada
Prior art keywords
ligation
probe
target polynucleotide
probes
chromosome
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2767028A
Other languages
English (en)
Inventor
Benjamin Hindson
Serge Saxonov
Philip Belgrader
Kevin Ness
Michael Lucero
Billy Colston
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Laboratories Inc
Original Assignee
Quantalife Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Quantalife Inc filed Critical Quantalife Inc
Priority claimed from PCT/US2010/058124 external-priority patent/WO2011066476A1/fr
Publication of CA2767028A1 publication Critical patent/CA2767028A1/fr
Abandoned legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6818Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/682Signal amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855Ligating adaptors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2767028A 2009-11-25 2010-11-25 Procedes et compositions destines a detecter un materiel genetique Abandoned CA2767028A1 (fr)

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US26459109P 2009-11-25 2009-11-25
US61/264,591 2009-11-25
US30983710P 2010-03-02 2010-03-02
US30984510P 2010-03-02 2010-03-02
US61/309,837 2010-03-02
US61/309,845 2010-03-02
US31768410P 2010-03-25 2010-03-25
US31763510P 2010-03-25 2010-03-25
US34106510P 2010-03-25 2010-03-25
US34121810P 2010-03-25 2010-03-25
US31763910P 2010-03-25 2010-03-25
US61/317,639 2010-03-25
US61/317,684 2010-03-25
US61/341,218 2010-03-25
US61/341,065 2010-03-25
US61/317,635 2010-03-25
US38098110P 2010-09-08 2010-09-08
US61/380,981 2010-09-08
US40910610P 2010-11-01 2010-11-01
US61/409,106 2010-11-01
US10947310P 2010-11-02 2010-11-02
US61/109,473 2010-11-02
US41076910P 2010-11-05 2010-11-05
US61/410,769 2010-11-05
PCT/US2010/058124 WO2011066476A1 (fr) 2009-11-25 2010-11-25 Procédés et compositions destinés à détecter un matériel génétique

Publications (1)

Publication Number Publication Date
CA2767028A1 true CA2767028A1 (fr) 2011-06-03

Family

ID=44066935

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2767028A Abandoned CA2767028A1 (fr) 2009-11-25 2010-11-25 Procedes et compositions destines a detecter un materiel genetique

Country Status (3)

Country Link
CN (1) CN102985552B (fr)
CA (1) CA2767028A1 (fr)
GB (1) GB2485850C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4165184A4 (fr) * 2020-06-10 2024-09-04 Bonadea Diagnostics, LLC Réaction de conversion de séquence

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10221442B2 (en) 2012-08-14 2019-03-05 10X Genomics, Inc. Compositions and methods for sample processing
US10273541B2 (en) 2012-08-14 2019-04-30 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9701998B2 (en) 2012-12-14 2017-07-11 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10400280B2 (en) 2012-08-14 2019-09-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US9951386B2 (en) 2014-06-26 2018-04-24 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10323279B2 (en) 2012-08-14 2019-06-18 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10752949B2 (en) 2012-08-14 2020-08-25 10X Genomics, Inc. Methods and systems for processing polynucleotides
US11591637B2 (en) 2012-08-14 2023-02-28 10X Genomics, Inc. Compositions and methods for sample processing
EP2885418A4 (fr) 2012-08-14 2016-03-02 10X Genomics Inc Compositions de microcapsule et procédés
WO2014093676A1 (fr) 2012-12-14 2014-06-19 10X Technologies, Inc. Procédés et systèmes pour le traitement de polynucléotides
US10533221B2 (en) 2012-12-14 2020-01-14 10X Genomics, Inc. Methods and systems for processing polynucleotides
KR20230003659A (ko) * 2013-02-08 2023-01-06 10엑스 제노믹스, 인크. 폴리뉴클레오티드 바코드 생성
WO2014172288A2 (fr) * 2013-04-19 2014-10-23 Raindance Technologies, Inc. Analyse d'analyte numérique
EP3024948B1 (fr) * 2013-07-25 2020-01-15 Bio-rad Laboratories, Inc. Dosages génétiques pour déterminer une frequence de la recombination virale
US10395758B2 (en) 2013-08-30 2019-08-27 10X Genomics, Inc. Sequencing methods
CN104169929B (zh) * 2013-09-10 2016-12-28 深圳华大基因股份有限公司 用于确定胎儿是否存在性染色体数目异常的系统和装置
US9824068B2 (en) 2013-12-16 2017-11-21 10X Genomics, Inc. Methods and apparatus for sorting data
EP4219010A1 (fr) 2014-04-10 2023-08-02 10X Genomics, Inc. Procédés d'encapsulation et de partitionnement de réactifs
US12312640B2 (en) 2014-06-26 2025-05-27 10X Genomics, Inc. Analysis of nucleic acid sequences
CN106575322B (zh) 2014-06-26 2019-06-18 10X基因组学有限公司 核酸序列装配的方法和系统
MX2016016902A (es) 2014-06-26 2017-03-27 10X Genomics Inc Metodos para analizar acidos nucleicos de celulas individuales o poblaciones de celulas.
WO2015200869A1 (fr) 2014-06-26 2015-12-30 10X Genomics, Inc. Analyse de séquences d'acides nucléiques
CN104032031A (zh) * 2014-07-04 2014-09-10 华东理工大学 一种rna聚合酶和连接酶偶联反应介导的定量检测核酸的pcr分析方法
JP2017532042A (ja) 2014-10-29 2017-11-02 10エックス ゲノミクス,インコーポレイテッド 標的化核酸配列決定のための方法及び組成物
US9975122B2 (en) 2014-11-05 2018-05-22 10X Genomics, Inc. Instrument systems for integrated sample processing
EP3244992B1 (fr) 2015-01-12 2023-03-08 10X Genomics, Inc. Procédés de codage a barres d'acides nucléiques
CA2968417A1 (fr) 2015-01-13 2016-07-21 10X Genomics, Inc. Systemes et procedes de visualisation d'informations de variation structurelle et de phasage
EP3256606B1 (fr) 2015-02-09 2019-05-22 10X Genomics, Inc. Systèmes et procédés pour déterminer la variation structurale
CA2975958A1 (fr) 2015-02-24 2016-09-01 10X Genomics, Inc. Procedes pour la couverture ciblee de sequences d'acides nucleiques
US10697000B2 (en) 2015-02-24 2020-06-30 10X Genomics, Inc. Partition processing methods and systems
CN105936930A (zh) * 2015-03-04 2016-09-14 松下知识产权经营株式会社 Dna检测方法和dna检测装置
CN105969655A (zh) * 2015-03-10 2016-09-28 松下知识产权经营株式会社 多个核酸靶标的分析方法
CN108350500A (zh) * 2015-07-29 2018-07-31 普罗格尼迪公司 用于检测染色体异常的核酸和方法
WO2017074094A1 (fr) * 2015-10-29 2017-05-04 Biocore Co., Ltd. Procédé de diagnostic prénatal à l'aide de la pcr numérique.
KR101848438B1 (ko) * 2015-10-29 2018-04-13 바이오코아 주식회사 디지털 pcr을 이용한 산전진단 방법
PT3882357T (pt) 2015-12-04 2022-09-05 10X Genomics Inc Métodos e composições para análise de ácidos nucleicos
SG11201806757XA (en) 2016-02-11 2018-09-27 10X Genomics Inc Systems, methods, and media for de novo assembly of whole genome sequence data
CN105821482B (zh) * 2016-04-29 2018-04-10 李星军 一种生化微反应体系、高通量测序的建库仪及应用
WO2017197343A2 (fr) 2016-05-12 2017-11-16 10X Genomics, Inc. Filtres microfluidiques sur puce
WO2017197338A1 (fr) 2016-05-13 2017-11-16 10X Genomics, Inc. Systèmes microfluidiques et procédés d'utilisation
US10011872B1 (en) 2016-12-22 2018-07-03 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10550429B2 (en) 2016-12-22 2020-02-04 10X Genomics, Inc. Methods and systems for processing polynucleotides
US10815525B2 (en) 2016-12-22 2020-10-27 10X Genomics, Inc. Methods and systems for processing polynucleotides
US12264411B2 (en) 2017-01-30 2025-04-01 10X Genomics, Inc. Methods and systems for analysis
CN110214186B (zh) 2017-01-30 2023-11-24 10X基因组学有限公司 用于基于微滴的单细胞条形编码的方法和系统
WO2018213774A1 (fr) 2017-05-19 2018-11-22 10X Genomics, Inc. Systèmes et procédés d'analyse d'ensembles de données
CN116064732A (zh) 2017-05-26 2023-05-05 10X基因组学有限公司 转座酶可接近性染色质的单细胞分析
US10844372B2 (en) 2017-05-26 2020-11-24 10X Genomics, Inc. Single cell analysis of transposase accessible chromatin
CN107619827B (zh) * 2017-09-12 2020-11-13 广州阳普医疗科技股份有限公司 一种组合物及其制备方法与在全血游离dna保存领域的应用
WO2019099751A1 (fr) 2017-11-15 2019-05-23 10X Genomics, Inc. Perles de gel fonctionnalisées
US10829815B2 (en) 2017-11-17 2020-11-10 10X Genomics, Inc. Methods and systems for associating physical and genetic properties of biological particles
WO2019195166A1 (fr) 2018-04-06 2019-10-10 10X Genomics, Inc. Systèmes et procédés de contrôle de qualité dans un traitement de cellules uniques
WO2019204357A1 (fr) 2018-04-17 2019-10-24 ChromaCode, Inc. Procédés et systèmes d'analyse multiplexe
US12421558B2 (en) 2020-02-13 2025-09-23 10X Genomics, Inc. Systems and methods for joint interactive visualization of gene expression and DNA chromatin accessibility
CN116153393B (zh) * 2023-02-23 2025-12-02 宁波市妇女儿童医院 一种基于染色体单体间相对荧光强度的染色体拷贝数计数方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7537897B2 (en) * 2006-01-23 2009-05-26 Population Genetics Technologies, Ltd. Molecular counting
WO2007100243A1 (fr) * 2006-03-01 2007-09-07 Keygene N.V. Detection de snp a haut debit basee sur des sequences a l'aide de tests de ligature
EP4190448A3 (fr) * 2006-05-11 2023-09-20 Bio-Rad Laboratories, Inc. Dispositifs microfluidiques
EP4108780A1 (fr) * 2006-06-14 2022-12-28 Verinata Health, Inc. Analyse de cellules rares utilisant la division d'échantillons et les marqueurs d'adn
CA3075139C (fr) * 2008-09-23 2022-04-12 Bio-Rad Laboratories, Inc. Systeme de dosage base sur des gouttelettes
US9156010B2 (en) * 2008-09-23 2015-10-13 Bio-Rad Laboratories, Inc. Droplet-based assay system

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4165184A4 (fr) * 2020-06-10 2024-09-04 Bonadea Diagnostics, LLC Réaction de conversion de séquence

Also Published As

Publication number Publication date
CN102985552B (zh) 2016-02-17
GB2485850A (en) 2012-05-30
CN102985552A (zh) 2013-03-20
GB2485850C (en) 2019-01-23
GB2485850B (en) 2014-01-29
GB201100787D0 (en) 2011-03-02

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Effective date: 20151022