CA2748161A1 - Agents de liaison cibles diriges contre .alpha.5.beta.1 et leurs applications - Google Patents

Agents de liaison cibles diriges contre .alpha.5.beta.1 et leurs applications Download PDF

Info

Publication number: CA2748161A1
Authority: CA; Canada
Prior art keywords: antibody; binding agent; targeted binding; antibodies; cells
Prior art date: 2008-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA2748161A

Other languages

English (en)

Inventor

Simon Thomas Barry

Catherine Anne Eberlein

Jane Kendrew

Ian Foltz

Paul Kang

Avril Alfred

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

AstraZeneca AB

Original Assignee

AstraZeneca AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-12-23

Filing date

2009-12-21

Publication date

2010-07-01

2009-12-21 Application filed by AstraZeneca AB filed Critical AstraZeneca AB

2010-07-01 Publication of CA2748161A1 publication Critical patent/CA2748161A1/fr

Status Abandoned legal-status Critical Current

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Ophthalmology & Optometry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2748161A 2008-12-23 2009-12-21 Agents de liaison cibles diriges contre .alpha.5.beta.1 et leurs applications Abandoned CA2748161A1 (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US14033608P	2008-12-23	2008-12-23
US61/140,336		2008-12-23
PCT/EP2009/067707 WO2010072741A1 (fr)	2008-12-23	2009-12-21	Agents de liaison ciblés dirigés contre α5β1 et leurs applications

Publications (1)

Publication Number	Publication Date
CA2748161A1 true CA2748161A1 (fr)	2010-07-01

Family

ID=42115122

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2748161A Abandoned CA2748161A1 (fr)	2008-12-23	2009-12-21	Agents de liaison cibles diriges contre .alpha.5.beta.1 et leurs applications

Country Status (5)

Country	Link
EP (1)	EP2379596A1 (fr)
JP (1)	JP2012513195A (fr)
AU (1)	AU2009331529A1 (fr)
CA (1)	CA2748161A1 (fr)
WO (1)	WO2010072741A1 (fr)

Families Citing this family (5)

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CN103561761A (zh)	2011-03-23	2014-02-05	加利福尼亚大学董事会	用于使用抗-整合素改善抗血管生成疗法的方法和组合物
WO2022147222A1 (fr) *	2020-12-31	2022-07-07	Novarock Biotherapeutics, Ltd.	Anticorps dirigés contre tnfr2 et leurs utilisations
WO2023056243A1 (fr) *	2021-09-29	2023-04-06	Dragonfly Therapeutics, Inc.	Anticorps ciblant baff-r et leur utilisation
WO2024192280A2 (fr) *	2023-03-14	2024-09-19	Mapp Biopharmaceutical, Inc.	Anticorps dirigés contre des orthohantavirus
WO2025043103A2 (fr) *	2023-08-24	2025-02-27	The Trustees Of Columbia University In The City Of New York	Anticorps neutralisants et non neutralisants destinés à la protection humaine et leur utilisation contre des virus de la grippe

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2000080100A (ja) *	1998-06-17	2000-03-21	Japan Tobacco Inc	副甲状腺ホルモン関連タンパクに対するヒトモノクローナル抗体
MXPA05005558A (es) *	2002-11-26	2005-07-26	Protein Design Labs Inc	Anticuerpos quimericos y humanizados para integrina ( 5 ( 1 que modulan la angiogenesis.
CA2658612C (fr) *	2006-08-03	2015-11-17	Astrazeneca Ab	Anticorps diriges contre l'.alpha.v.beta.6 et utilisations desdits anticorps
WO2009135953A2 (fr) *	2008-05-09	2009-11-12	Ablynx Nv	Séquences d'acides aminés dirigées contre des intégrines et leurs utilisations

2009
- 2009-12-21 CA CA2748161A patent/CA2748161A1/fr not_active Abandoned
- 2009-12-21 AU AU2009331529A patent/AU2009331529A1/en not_active Abandoned
- 2009-12-21 EP EP09796383A patent/EP2379596A1/fr not_active Withdrawn
- 2009-12-21 WO PCT/EP2009/067707 patent/WO2010072741A1/fr not_active Ceased
- 2009-12-21 JP JP2011541508A patent/JP2012513195A/ja active Pending

Also Published As

Publication number	Publication date
WO2010072741A9 (fr)	2011-12-08
WO2010072741A1 (fr)	2010-07-01
EP2379596A1 (fr)	2011-10-26
AU2009331529A1 (en)	2011-08-11
JP2012513195A (ja)	2012-06-14

Publication	Publication Date	Title
US20120107324A1 (en)	2012-05-03	TARGETED BINDING AGENTS DIRECTED TO a5ß1 AND USES THEREOF
US8119130B2 (en)	2012-02-21	Targeted binding agents directed to KDR and uses thereof—035
US9206255B2 (en)	2015-12-08	Nucleic acid molecule encoding target antibodies directed to DLL4
AU2016203758C1 (en)	2018-04-12	Targeted binding agents against b7-h1
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