CA2633962A1 - Dimeres et produits d'addition de 6-[phenyl (substitue)] triazolopyrimidines utilisables en tant qu'agents anticancereux - Google Patents
Dimeres et produits d'addition de 6-[phenyl (substitue)] triazolopyrimidines utilisables en tant qu'agents anticancereux Download PDFInfo
- Publication number
- CA2633962A1 CA2633962A1 CA002633962A CA2633962A CA2633962A1 CA 2633962 A1 CA2633962 A1 CA 2633962A1 CA 002633962 A CA002633962 A CA 002633962A CA 2633962 A CA2633962 A CA 2633962A CA 2633962 A1 CA2633962 A1 CA 2633962A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- mammal
- formula
- pharmaceutically acceptable
- effective amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002246 antineoplastic agent Substances 0.000 title claims abstract 5
- -1 6-[(substituted) phenyl] triazolopyrimidines Chemical class 0.000 title abstract 2
- 239000000539 dimer Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 60
- 241000124008 Mammalia Species 0.000 claims abstract 36
- 238000000034 method Methods 0.000 claims abstract 32
- 150000003839 salts Chemical class 0.000 claims abstract 22
- 206010048723 Multiple-drug resistance Diseases 0.000 claims abstract 12
- 206010028980 Neoplasm Diseases 0.000 claims abstract 11
- 230000002401 inhibitory effect Effects 0.000 claims abstract 9
- 201000010099 disease Diseases 0.000 claims abstract 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 6
- 210000004881 tumor cell Anatomy 0.000 claims abstract 6
- 230000002265 prevention Effects 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 2
- 102000004243 Tubulin Human genes 0.000 claims 12
- 108090000704 Tubulin Proteins 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 239000003937 drug carrier Substances 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 3
- MQLACMBJVPINKE-UHFFFAOYSA-N 10-[(3-hydroxy-4-methoxyphenyl)methylidene]anthracen-9-one Chemical compound C1=C(O)C(OC)=CC=C1C=C1C2=CC=CC=C2C(=O)C2=CC=CC=C21 MQLACMBJVPINKE-UHFFFAOYSA-N 0.000 claims 3
- 102000029749 Microtubule Human genes 0.000 claims 3
- 108091022875 Microtubule Proteins 0.000 claims 3
- 229940127089 cytotoxic agent Drugs 0.000 claims 3
- 210000004688 microtubule Anatomy 0.000 claims 3
- 230000001737 promoting effect Effects 0.000 claims 3
- 230000000087 stabilizing effect Effects 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 230000029115 microtubule polymerization Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75116605P | 2005-12-16 | 2005-12-16 | |
| US60/751,166 | 2005-12-16 | ||
| PCT/US2006/048013 WO2007075465A1 (fr) | 2005-12-16 | 2006-12-15 | Dimeres et produits d'addition de 6-[phenyl (substitue)] triazolopyrimidines utilisables en tant qu'agents anticancereux |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2633962A1 true CA2633962A1 (fr) | 2007-07-05 |
Family
ID=38006979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002633962A Abandoned CA2633962A1 (fr) | 2005-12-16 | 2006-12-15 | Dimeres et produits d'addition de 6-[phenyl (substitue)] triazolopyrimidines utilisables en tant qu'agents anticancereux |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1963330A1 (fr) |
| JP (1) | JP2009519954A (fr) |
| CN (1) | CN101370813A (fr) |
| AU (1) | AU2006329862A1 (fr) |
| BR (1) | BRPI0619918A2 (fr) |
| CA (1) | CA2633962A1 (fr) |
| WO (1) | WO2007075465A1 (fr) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11623927B2 (en) | 2018-03-02 | 2023-04-11 | The Trustees Of The University Of Pennsylvania | Substituted [1,2,4]triazolo[1,5-a]pyrimidines for stabilizing microtubules |
| CN117337267A (zh) * | 2021-04-05 | 2024-01-02 | 达纳－法伯癌症研究所公司 | 适用于点击/取消点击应用的生物正交反应 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR0112038A (pt) * | 2000-06-30 | 2003-04-01 | Wyeth Corp | Triazolopirimidinas substituìdas como agentes anticâncer |
| AU2004276240A1 (en) * | 2003-09-24 | 2005-04-07 | Wyeth Holdings Corporation | 6-[(substituted)phenyl]triazolopyrimidines as anticancer agents |
-
2006
- 2006-12-15 CN CNA2006800527348A patent/CN101370813A/zh active Pending
- 2006-12-15 AU AU2006329862A patent/AU2006329862A1/en not_active Abandoned
- 2006-12-15 JP JP2008545859A patent/JP2009519954A/ja active Pending
- 2006-12-15 EP EP06845599A patent/EP1963330A1/fr not_active Withdrawn
- 2006-12-15 CA CA002633962A patent/CA2633962A1/fr not_active Abandoned
- 2006-12-15 WO PCT/US2006/048013 patent/WO2007075465A1/fr not_active Ceased
- 2006-12-15 BR BRPI0619918-6A patent/BRPI0619918A2/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101370813A (zh) | 2009-02-18 |
| WO2007075465A1 (fr) | 2007-07-05 |
| AU2006329862A1 (en) | 2007-07-05 |
| BRPI0619918A2 (pt) | 2011-10-25 |
| JP2009519954A (ja) | 2009-05-21 |
| EP1963330A1 (fr) | 2008-09-03 |
| WO2007075465A8 (fr) | 2008-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |