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CA2628924C - Spectrometre de masse - Google Patents

Spectrometre de masse Download PDF

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Publication number
CA2628924C
CA2628924C CA2628924A CA2628924A CA2628924C CA 2628924 C CA2628924 C CA 2628924C CA 2628924 A CA2628924 A CA 2628924A CA 2628924 A CA2628924 A CA 2628924A CA 2628924 C CA2628924 C CA 2628924C
Authority
CA
Canada
Prior art keywords
parent
ions
precursor ions
ion
mass
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2628924A
Other languages
English (en)
Other versions
CA2628924A1 (fr
Inventor
Robert Harold Bateman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Micromass UK Ltd
Original Assignee
Micromass UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/286,141 external-priority patent/US20060151689A1/en
Application filed by Micromass UK Ltd filed Critical Micromass UK Ltd
Priority to CA2835314A priority Critical patent/CA2835314A1/fr
Publication of CA2628924A1 publication Critical patent/CA2628924A1/fr
Application granted granted Critical
Publication of CA2628924C publication Critical patent/CA2628924C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0031—Step by step routines describing the use of the apparatus
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0068—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by collision with a surface, e.g. surface induced dissociation
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nanotechnology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Composite Materials (AREA)
  • General Physics & Mathematics (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

L'invention concerne un procédé de spectrométrie de masse dans lequel un dispositif fragmentation par dissociation par capture d'électrons, dissociation par transfert d'électrons ou dissociation induite par une surface passe de manière répétée d'un mode fragmentation ou réaction élevée à un mode fragmentation ou réaction faible. Des ions parents provenant d'un premier échantillon traversent le dispositif, et on obtient un spectre de masse d'ions parents et un spectre de masse d'ions issus de la fragmentation. Des ions parents provenant d'un second échantillon traversent ensuite le dispositif et on obtient un second ensemble de spectre de masse d'ions parents et de spectre de masse d'ions issus de la fragmentation. On compare ensuite les spectres de masse et, lorsque dans les deux exemples, certains ions parents ou certains ions issus de la fragmentation sont exprimés différemment, on effectue une analyse afin de les identifier.
CA2628924A 2005-11-23 2006-11-23 Spectrometre de masse Active CA2628924C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2835314A CA2835314A1 (fr) 2005-11-23 2006-11-23 Spectrometre de masse

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0523806.8 2005-11-23
GBGB0523806.8A GB0523806D0 (en) 2005-11-23 2005-11-23 Mass spectrometer
US11/286,141 US20060151689A1 (en) 2002-07-24 2005-11-23 Mass spectrometer
US11/286,141 2005-11-23
PCT/GB2006/004362 WO2007060421A2 (fr) 2005-11-23 2006-11-23 Spectrometre de masse

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2835314A Division CA2835314A1 (fr) 2005-11-23 2006-11-23 Spectrometre de masse

Publications (2)

Publication Number Publication Date
CA2628924A1 CA2628924A1 (fr) 2007-05-31
CA2628924C true CA2628924C (fr) 2017-09-05

Family

ID=35601028

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2628924A Active CA2628924C (fr) 2005-11-23 2006-11-23 Spectrometre de masse
CA2835314A Abandoned CA2835314A1 (fr) 2005-11-23 2006-11-23 Spectrometre de masse

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2835314A Abandoned CA2835314A1 (fr) 2005-11-23 2006-11-23 Spectrometre de masse

Country Status (5)

Country Link
EP (1) EP1952422A2 (fr)
JP (1) JP4959712B2 (fr)
CA (2) CA2628924C (fr)
GB (4) GB0523806D0 (fr)
WO (1) WO2007060421A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201122178D0 (en) 2011-12-22 2012-02-01 Thermo Fisher Scient Bremen Method of tandem mass spectrometry
WO2014080493A1 (fr) * 2012-11-22 2014-05-30 株式会社島津製作所 Spectromètre de masse à quadrupôle en tandem
US8889633B2 (en) 2013-03-15 2014-11-18 Mead Johnson Nutrition Company Nutritional compositions containing a peptide component with anti-inflammatory properties and uses thereof
US9138455B2 (en) 2013-03-15 2015-09-22 Mead Johnson Nutrition Company Activating adiponectin by casein hydrolysate
US9352020B2 (en) 2013-03-15 2016-05-31 Mead Johnson Nutrition Company Reducing proinflammatory response
US9289461B2 (en) 2013-03-15 2016-03-22 Mead Johnson Nutrition Company Reducing the risk of autoimmune disease
CN104345107B (zh) * 2013-07-24 2016-08-17 上海科倍斯生物科技有限公司 一种乳或乳制品中牛乳血清白蛋白定量检测试剂盒
GB201407123D0 (en) * 2014-04-23 2014-06-04 Micromass Ltd Self-calibration of spectra using precursor mass to charge ratio and fragment mass to charge ratio known differences
DE112015001964B4 (de) 2014-04-23 2025-09-11 Micromass Uk Limited Selbstkalibrierung von Spektren unter Verwendung bekannter Differenzen von Vorläufer-Masse-/Ladungsverhältnissen und Fragment-Masse-/ Ladungsverhältnissen
CN111936860B (zh) * 2018-04-10 2025-03-07 Dh科技发展私人贸易有限公司 用于质谱法中的抗体的自上而下分析的系统及方法
AU2020292464A1 (en) 2019-06-14 2021-12-09 Shanghai Polaris Biology Co., Ltd. Systems and methods for single particle analysis
JP7777068B2 (ja) * 2019-10-10 2025-11-27 ヤンセン バイオテツク，インコーポレーテツド 質量分析タンパク質分析のための材料及び方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3300602B2 (ja) * 1996-06-20 2002-07-08 株式会社日立製作所 大気圧イオン化イオントラップ質量分析方法及び装置
JP2000241390A (ja) * 1999-02-17 2000-09-08 Japan Atom Energy Res Inst 中性種の解離を用いる電荷逆転質量分析法
US6545268B1 (en) * 2000-04-10 2003-04-08 Perseptive Biosystems Preparation of ion pulse for time-of-flight and for tandem time-of-flight mass analysis
CA2340150C (fr) * 2000-06-09 2005-11-22 Micromass Limited Methodes et appareil pour la spectrometrie de masse
DE60210056T2 (de) * 2001-03-22 2006-11-16 Syddansk Universitet Massenspektrometrisches Verfahren mit Elektroneneinfang durch Ionen und Massenspektrometer zum Durchführen des Verfahrens
US6744040B2 (en) * 2001-06-13 2004-06-01 Bruker Daltonics, Inc. Means and method for a quadrupole surface induced dissociation quadrupole time-of-flight mass spectrometer
GB0121172D0 (en) * 2001-08-31 2001-10-24 Shimadzu Res Lab Europe Ltd A method for dissociating ions using a quadrupole ion trap device
JP4161125B2 (ja) * 2002-04-24 2008-10-08 滋雄 早川 質量分析法および質量分析装置
CA2487135C (fr) * 2002-05-31 2009-01-27 Analytica Of Branford, Inc. Procedes de fragmentation pour spectrometrie de masse
GB2390935A (en) * 2002-07-16 2004-01-21 Anatoli Nicolai Verentchikov Time-nested mass analysis using a TOF-TOF tandem mass spectrometer
GB0305796D0 (en) * 2002-07-24 2003-04-16 Micromass Ltd Method of mass spectrometry and a mass spectrometer
AU2002952747A0 (en) * 2002-11-18 2002-12-05 Ludwig Institute For Cancer Research Method for analysing peptides
GB2402260B (en) * 2003-05-30 2006-05-24 Thermo Finnigan Llc All mass MS/MS method and apparatus
JP4275545B2 (ja) * 2004-02-17 2009-06-10 株式会社日立ハイテクノロジーズ 質量分析装置
CA2559260C (fr) * 2004-03-12 2015-05-12 University Of Virginia Patent Foundation Dissociation par transfert d'electrons pour analyse de sequence de biopolymeres

Also Published As

Publication number Publication date
GB0623376D0 (en) 2007-01-03
GB2443571B (en) 2010-05-12
GB2443571A (en) 2008-05-07
GB2451962B (en) 2010-02-17
GB2435713A (en) 2007-09-05
JP4959712B2 (ja) 2012-06-27
JP2009516842A (ja) 2009-04-23
GB2451962A (en) 2009-02-18
WO2007060421A2 (fr) 2007-05-31
GB2435713B (en) 2010-06-16
GB0801093D0 (en) 2008-02-27
GB0816195D0 (en) 2008-10-15
CA2835314A1 (fr) 2007-05-31
EP1952422A2 (fr) 2008-08-06
WO2007060421A3 (fr) 2008-05-08
CA2628924A1 (fr) 2007-05-31
GB0523806D0 (en) 2006-01-04

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