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CA2696185C - Utilisation de la taurolidine et ses derives dans le traitement du cancer par induction d'apoptose - Google Patents

Utilisation de la taurolidine et ses derives dans le traitement du cancer par induction d'apoptose Download PDF

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Publication number
CA2696185C
CA2696185C CA2696185A CA2696185A CA2696185C CA 2696185 C CA2696185 C CA 2696185C CA 2696185 A CA2696185 A CA 2696185A CA 2696185 A CA2696185 A CA 2696185A CA 2696185 C CA2696185 C CA 2696185C
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CA
Canada
Prior art keywords
cell
taurolidine
tumor
use according
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2696185A
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English (en)
Other versions
CA2696185A1 (fr
Inventor
Paul Calabresi
James Darnowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geistlich Pharma AG
Original Assignee
Geistlich Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27389609&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2696185(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Geistlich Pharma AG filed Critical Geistlich Pharma AG
Publication of CA2696185A1 publication Critical patent/CA2696185A1/fr
Application granted granted Critical
Publication of CA2696185C publication Critical patent/CA2696185C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Neurology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2696185A 1999-12-06 2000-12-06 Utilisation de la taurolidine et ses derives dans le traitement du cancer par induction d'apoptose Expired - Lifetime CA2696185C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16912799P 1999-12-06 1999-12-06
US16912299P 1999-12-06 1999-12-06
US16912899P 1999-12-06 1999-12-06
US60/169,127 1999-12-06
US60/169,122 1999-12-06
US60/169,128 1999-12-06
CA2393159A CA2393159C (fr) 1999-12-06 2000-12-06 Methodes de traitement de tumeurs

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2393159A Division CA2393159C (fr) 1999-12-06 2000-12-06 Methodes de traitement de tumeurs

Publications (2)

Publication Number Publication Date
CA2696185A1 CA2696185A1 (fr) 2001-06-07
CA2696185C true CA2696185C (fr) 2014-09-23

Family

ID=27389609

Family Applications (3)

Application Number Title Priority Date Filing Date
CA002393252A Abandoned CA2393252A1 (fr) 1999-12-06 2000-12-06 Utilisation de composes renfermant du methylol pour traiter des tumeurs
CA2393159A Expired - Lifetime CA2393159C (fr) 1999-12-06 2000-12-06 Methodes de traitement de tumeurs
CA2696185A Expired - Lifetime CA2696185C (fr) 1999-12-06 2000-12-06 Utilisation de la taurolidine et ses derives dans le traitement du cancer par induction d'apoptose

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CA002393252A Abandoned CA2393252A1 (fr) 1999-12-06 2000-12-06 Utilisation de composes renfermant du methylol pour traiter des tumeurs
CA2393159A Expired - Lifetime CA2393159C (fr) 1999-12-06 2000-12-06 Methodes de traitement de tumeurs

Country Status (9)

Country Link
US (6) US6964959B2 (fr)
EP (3) EP2332542B1 (fr)
JP (5) JP2003515558A (fr)
AT (1) ATE339207T1 (fr)
AU (2) AU784538B2 (fr)
CA (3) CA2393252A1 (fr)
DE (1) DE60030770T2 (fr)
ES (2) ES2438535T3 (fr)
WO (2) WO2001039763A2 (fr)

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US7345039B2 (en) * 1999-06-04 2008-03-18 Ed. Geistlich Soehne Ag Fuer Chemische Industrie Enhancement of effectiveness of 5-fluorouracil in treatment of tumor metastases and cancer
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US11541061B2 (en) 2016-01-11 2023-01-03 Cormedix Inc. Neuroblastoma treatment with taurolidine hydrolysis products
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KR20210050544A (ko) * 2018-08-28 2021-05-07 코르메딕스, 인코포레이티드 타우로리딘 가수분해 생성물을 이용한 신경모세포종 치료
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CA2393159C (fr) 2010-04-20
US20030078257A1 (en) 2003-04-24
US20060135513A1 (en) 2006-06-22
JP2016188244A (ja) 2016-11-04
EP2332542B1 (fr) 2015-02-11
ES2531547T3 (es) 2015-03-17
WO2001039762A2 (fr) 2001-06-07
JP5829948B2 (ja) 2015-12-09
JP2003515557A (ja) 2003-05-07
US20020111345A1 (en) 2002-08-15
JP5027369B2 (ja) 2012-09-19
EP1246617B1 (fr) 2006-09-13
AU784539B2 (en) 2006-04-27
EP2332542A2 (fr) 2011-06-15
ATE339207T1 (de) 2006-10-15
AU784538B2 (en) 2006-04-27
EP1246617A2 (fr) 2002-10-09
US6521616B2 (en) 2003-02-18
JP2012136540A (ja) 2012-07-19
CA2696185A1 (fr) 2001-06-07
JP2003515558A (ja) 2003-05-07
DE60030770T2 (de) 2007-09-06
AU2065001A (en) 2001-06-12
EP1248625A2 (fr) 2002-10-16
WO2001039763A2 (fr) 2001-06-07
ES2438535T3 (es) 2014-01-17
WO2001039762A3 (fr) 2002-05-02
CA2393252A1 (fr) 2001-06-07
US20020049200A1 (en) 2002-04-25
US6429224B1 (en) 2002-08-06
US6703413B2 (en) 2004-03-09
WO2001039763A3 (fr) 2002-07-11
JP2014198739A (ja) 2014-10-23
US6995164B2 (en) 2006-02-07
DE60030770D1 (de) 2006-10-26
US20020052366A1 (en) 2002-05-02
US6964959B2 (en) 2005-11-15
EP2332542A3 (fr) 2011-09-28
JP6234340B2 (ja) 2017-11-22
US20030100551A1 (en) 2003-05-29
AU2064901A (en) 2001-06-12

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