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CA2692805A1 - Utilisation de composes liberant de l'oxyde nitrique dans le traitement de la douleur chronique - Google Patents

Utilisation de composes liberant de l'oxyde nitrique dans le traitement de la douleur chronique Download PDF

Info

Publication number
CA2692805A1
CA2692805A1 CA 2692805 CA2692805A CA2692805A1 CA 2692805 A1 CA2692805 A1 CA 2692805A1 CA 2692805 CA2692805 CA 2692805 CA 2692805 A CA2692805 A CA 2692805A CA 2692805 A1 CA2692805 A1 CA 2692805A1
Authority
CA
Canada
Prior art keywords
phenyl
nitrooxy
methyl
propenoic acid
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2692805
Other languages
English (en)
Inventor
Francesco Impagnatiello
Daniela Ronchetti
Ennio Ongini
Francesca Benedini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nicox SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2692805A1 publication Critical patent/CA2692805A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA 2692805 2007-07-09 2008-06-24 Utilisation de composes liberant de l'oxyde nitrique dans le traitement de la douleur chronique Abandoned CA2692805A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07013376 2007-07-09
EP07013376.4 2007-07-09
PCT/EP2008/057987 WO2009007230A1 (fr) 2007-07-09 2008-06-24 Utilisation de composés libérant de l'oxyde nitrique dans le traitement de la douleur chronique

Publications (1)

Publication Number Publication Date
CA2692805A1 true CA2692805A1 (fr) 2009-01-15

Family

ID=39745501

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2692805 Abandoned CA2692805A1 (fr) 2007-07-09 2008-06-24 Utilisation de composes liberant de l'oxyde nitrique dans le traitement de la douleur chronique

Country Status (5)

Country Link
US (1) US20100179192A1 (fr)
EP (1) EP2167070A1 (fr)
JP (1) JP2010532780A (fr)
CA (1) CA2692805A1 (fr)
WO (1) WO2009007230A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011347802B2 (en) 2010-12-20 2015-05-07 Dsm Ip Assets B.V. Use of nitrooxy organic molecules in feed for reducing methane emission in ruminants, and/or to improve ruminant performance
CN104478727A (zh) * 2014-12-22 2015-04-01 江西本草天工科技有限责任公司 一种阿魏酸释放一氧化氮的衍生物及其用途
CN106905159B (zh) * 2017-03-14 2019-10-08 大理大学 一个羟基丙酸化合物及其制备方法和医药用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62205052A (ja) 1986-03-05 1987-09-09 Terumo Corp 硝酸エステル誘導体およびこれを含有する血管拡張剤
WO1994021248A1 (fr) 1993-03-15 1994-09-29 Byk Nederland Bv Utilisation de nitrates d'alkyle substitues pour le traitement d'un accroissement pathologique de la pression intra-oculaire
IT1314184B1 (it) 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
CN1083824C (zh) 1999-09-24 2002-05-01 许景峰 具有心血管药理活性的合成化合物及制备方法
IT1319201B1 (it) * 2000-10-12 2003-09-26 Nicox Sa Farmaci per il diabete.
ITMI20010985A1 (it) 2001-05-15 2002-11-15 Nicox Sa Farmaci per il morbo di alzheimer
ITMI20011240A1 (it) 2001-06-13 2002-12-13 Nicox Sa Farmaci per le vasculopatie
ITMI20011308A1 (it) 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
US7163958B2 (en) * 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
EP1709155B1 (fr) 2003-12-31 2013-10-02 Chesterford Enterprises Limited Composés et compositions destinés au traitement de maladies dysplasiques, et leurs méthodes d'utilisation
WO2006015930A1 (fr) 2004-08-10 2006-02-16 Nicox S.A. Derives de phenol

Also Published As

Publication number Publication date
WO2009007230A1 (fr) 2009-01-15
US20100179192A1 (en) 2010-07-15
JP2010532780A (ja) 2010-10-14
EP2167070A1 (fr) 2010-03-31

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20130626