[go: up one dir, main page]

CA2692637A1 - Procedes de traitement et de diagnostic pour des troubles lies a une fibrose - Google Patents

Procedes de traitement et de diagnostic pour des troubles lies a une fibrose Download PDF

Info

Publication number
CA2692637A1
CA2692637A1 CA 2692637 CA2692637A CA2692637A1 CA 2692637 A1 CA2692637 A1 CA 2692637A1 CA 2692637 CA2692637 CA 2692637 CA 2692637 A CA2692637 A CA 2692637A CA 2692637 A1 CA2692637 A1 CA 2692637A1
Authority
CA
Canada
Prior art keywords
crp
sap
patient
concentration
ratio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA 2692637
Other languages
English (en)
Inventor
Terry Surowy
Shawn Li
Mark L. Lupher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Promedior Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2692637A1 publication Critical patent/CA2692637A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4737C-reactive protein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4709Amyloid plaque core protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4737C-reactive protein
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/08Hepato-biliairy disorders other than hepatitis
    • G01N2800/085Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/38Pediatrics
    • G01N2800/382Cystic fibrosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
CA 2692637 2007-07-06 2008-07-07 Procedes de traitement et de diagnostic pour des troubles lies a une fibrose Abandoned CA2692637A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95863407P 2007-07-06 2007-07-06
US60/958,634 2007-07-06
US12/215,700 US9884899B2 (en) 2007-07-06 2008-06-27 Methods for treating fibrosis using CRP antagonists
US12/215,700 2008-06-27
PCT/US2008/008315 WO2009009019A2 (fr) 2007-07-06 2008-07-07 Procédés de traitement et de diagnostic pour des troubles liés à une fibrose

Publications (1)

Publication Number Publication Date
CA2692637A1 true CA2692637A1 (fr) 2009-01-15

Family

ID=40090306

Family Applications (1)

Application Number Title Priority Date Filing Date
CA 2692637 Abandoned CA2692637A1 (fr) 2007-07-06 2008-07-07 Procedes de traitement et de diagnostic pour des troubles lies a une fibrose

Country Status (7)

Country Link
US (1) US9884899B2 (fr)
EP (1) EP2176287A2 (fr)
JP (2) JP2010532872A (fr)
AU (1) AU2008275678B9 (fr)
CA (1) CA2692637A1 (fr)
SI (1) SI2185581T1 (fr)
WO (1) WO2009009019A2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9884899B2 (en) 2007-07-06 2018-02-06 Promedior, Inc. Methods for treating fibrosis using CRP antagonists
CN102405286A (zh) 2008-09-22 2012-04-04 阿克赛医药公司 减小大小的自递送RNAi化合物
CA2741420C (fr) * 2008-10-24 2016-08-16 Childrens Hospital Los Angeles Cellules de liquide amniotique et leurs utilisations
WO2010104959A1 (fr) * 2009-03-11 2010-09-16 Promedior, Inc. Procédés de traitement et de diagnostic pour troubles d'hypersensibilité
CA2755047C (fr) * 2009-03-11 2018-12-04 Promedior, Inc. Methodes de traitement de troubles auto-immuns
UA110323C2 (en) * 2009-06-04 2015-12-25 Promedior Inc Derivative of serum amyloid p and their receipt and application
AU2010262847B2 (en) * 2009-06-17 2016-06-02 Promedior, Inc. SAP variants and their use
CN106074591B (zh) * 2010-03-24 2020-01-14 菲奥医药公司 眼部症候中的rna干扰
US9340786B2 (en) 2010-03-24 2016-05-17 Rxi Pharmaceuticals Corporation RNA interference in dermal and fibrotic indications
WO2011132085A2 (fr) * 2010-04-21 2011-10-27 Kalluri, Raghu Procédés et compositions pour le traitement d'une fibrose
TWI497076B (zh) 2010-06-25 2015-08-21 Univ Nat Cheng Kung 適合體及c-反應蛋白檢測方法
CN105148269A (zh) 2011-02-21 2015-12-16 菲布他丁有限合伙公司 治疗和诊断疾病的方法
WO2013096847A1 (fr) * 2011-12-21 2013-06-27 Promedior, Inc. Protéines de fusion de p-anticorps sérum amyloïde
WO2013141816A1 (fr) * 2012-03-21 2013-09-26 Singapore Health Services Pte Ltd Méthode de diagnostic et/ou de traitement de la fibrose de la cornée
US11020451B2 (en) * 2013-10-08 2021-06-01 Promedior, Inc. Methods for treating fibrotic cancers
CN107073294A (zh) 2014-09-05 2017-08-18 阿克赛医药公司 使用靶向tyr或mmp1的核酸治疗老化和皮肤病症的方法
EP3265388B1 (fr) * 2015-03-02 2020-06-24 JT International SA Emballage avec mécanisme de fermeture magnétique
JP6799226B2 (ja) * 2015-07-24 2020-12-16 公立大学法人名古屋市立大学 骨髄線維症の状態の診断を補助する方法、予後の予測を補助する方法、及び治療効果のモニター方法、並びにそれらの方法に用いるマーカー及び装置
US20170029499A1 (en) * 2015-07-31 2017-02-02 Astrazeneca Pharmaceuticals Lp Methods for treating hepcidin-mediated disorders
JP7630906B2 (ja) 2017-02-01 2025-02-18 イェール・ユニヴァーシティー 利尿薬耐性の治療
MA51584A (fr) 2018-01-05 2020-11-11 Corvidia Therapeutics Inc Méthodes de traitement d'une inflammation médiée par il-6 sans immunosuppression
CN112839708A (zh) * 2018-06-20 2021-05-25 胺细拉健康公司 用于减少或治疗纤维化的组合物和方法
EP3911673A1 (fr) * 2019-01-16 2021-11-24 Institut National de la Santé et de la Recherche Médicale (INSERM) Utilisation d'agents capables d'induire une phagocytose associée à lc3 pour traiter une inflammation soutenue chez des patients souffrant d'une maladie hépatique chronique
SG11202111077RA (en) * 2019-05-03 2021-11-29 Dicerna Pharmaceuticals Inc Double-stranded nucleic acid inhibitor molecules with shortened sense strands
WO2021252344A2 (fr) * 2020-06-09 2021-12-16 The Texas A&M University System Agents thérapeutiques pour le traitement de symptômes de la covid-19
CN115154606B (zh) * 2022-06-20 2023-10-20 中国医学科学院基础医学研究所 FcγRⅢ抑制剂作为靶点在制备治疗肺纤维化药物中的应用

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1562244A (en) 1976-11-11 1980-03-05 Lock P M Wound dressing materials
GB1594389A (en) 1977-06-03 1981-07-30 Max Planck Gesellschaft Dressing material for wounds
GB8516081D0 (en) 1985-06-25 1985-07-31 Ciba Geigy Ag Assay & purification of amyloid components
US6071517A (en) 1986-07-07 2000-06-06 Medarex, Inc. Bispecific heteroantibodies with dual effector functions
DE3880647T2 (de) 1987-11-20 1993-11-18 Kanegafuchi Chemical Ind Sorbentmittel für Serum-Amyloid-Proteine.
US7070994B2 (en) 1988-03-21 2006-07-04 Oxford Biomedica (Uk) Ltd. Packaging cells
US5272258A (en) * 1989-06-29 1993-12-21 Rush-Presbyterian-St. Luke's Medical Center Monoclonal antibodies to C-reactive protein
US5092876A (en) 1989-08-30 1992-03-03 The United States Of America As Represented By The Department Of Health And Human Services Cell attachment peptides derived from amyloid P component
EP0587777A4 (fr) 1991-05-31 1995-05-10 New England Deaconess Hospital Proteines de liaison d'antigene carcinoembryonnaire et leurs procedes d'isolation et d'utilisation.
US5591709A (en) 1991-08-30 1997-01-07 Life Medical Sciences, Inc. Compositions and methods for treating wounds
US5804446A (en) 1993-02-26 1998-09-08 The Picower Institute For Medical Research Blood-borne mesenchymal cells
US6054121A (en) 1993-02-26 2000-04-25 The Picower Institute For Medical Research Modulation of immune responses in blood-borne mesenchymal cells
US5654186A (en) 1993-02-26 1997-08-05 The Picower Institute For Medical Research Blood-borne mesenchymal cells
WO1994027640A1 (fr) 1993-05-27 1994-12-08 The Regents Of The University Of Michigan Procede de traitement et de prevention des lesions du poumon induites par les complexes immuns
US5698589A (en) 1993-06-01 1997-12-16 International Medical Innovations, Inc. Water-based topical cream containing nitroglycerin and method of preparation and use thereof
GB9317120D0 (en) 1993-08-17 1993-09-29 Royal Postgrad Med School Human serum amyloid p component
US5981470A (en) 1994-06-07 1999-11-09 The University Of Birmingham Uterine fibroid treatment
US5989811A (en) * 1994-09-29 1999-11-23 Urocor, Inc. Sextant core biopsy predictive mechanism for non-organ confined disease status
US5750345A (en) 1995-10-31 1998-05-12 Evanston Hospital Corporation Detection of human α-thalassemia mutations and their use as predictors of blood-related disorders
ES2185900T3 (es) 1996-01-25 2003-05-01 Profylakse Aps Composicion farmacologica que comprende un componente p serico del amiloide para el tratamiento profilactico o terapeutico de infecciones viricas y un hit para la deteccion de union entre dicha composicion y componentes viricos.
US6365570B1 (en) 1997-10-10 2002-04-02 Universiteit Utrecht Pharmaceutical and diagnostic use of Serum Amyloid P component
SI20475A (sl) 1998-02-17 2001-08-31 Medarex, Inc. Zdravljenje in diagnosticiranje z makrofagi posredovanih bolezni z uporabo Fc receptorskih ligandov
CN1663559B (zh) 1998-03-11 2010-10-06 株式会社创研 皮肤健全剂
JPH11319542A (ja) 1998-05-08 1999-11-24 Tokuyama Corp 超薄層の製造方法
US6660843B1 (en) 1998-10-23 2003-12-09 Amgen Inc. Modified peptides as therapeutic agents
US6600019B2 (en) 2000-01-06 2003-07-29 Curagen Corporation Polypeptides and nucleic acids encoding same
AU2001250875A1 (en) 2000-03-30 2001-10-15 Brennen Medical, Inc. Anti-microbial and immunostimulating composition
US20040068095A1 (en) 2001-03-14 2004-04-08 Shimkets Richard A. Novel human proteins, polynucleotides encoding them and methods of using the same
US7713705B2 (en) * 2002-12-24 2010-05-11 Biosite, Inc. Markers for differential diagnosis and methods of use thereof
US6872541B2 (en) 2001-07-25 2005-03-29 Coulter International Corp. Method and compositions for analysis of pentraxin receptors as indicators of disease
US6537811B1 (en) 2001-08-01 2003-03-25 Isis Pharmaceuticals, Inc. Antisense inhibition of SAP-1 expression
US20030199442A1 (en) 2001-10-09 2003-10-23 Alsobrook John P. Therapeutic polypeptides, nucleic acids encoding same, and methods of use
US7022476B2 (en) * 2002-02-26 2006-04-04 New York Society For Ruptured And Crippled Maintaining The Hospital For Special Surgery Human FcγRIIB gene polymorphisms for assessing development of systemic lupus erythematosus and compositions for use thereof
GB0211136D0 (en) 2002-05-15 2002-06-26 Univ London Treatment and prevention of tissue damage
PL219032B1 (pl) 2002-05-17 2015-03-31 Novartis Ag Kompozycja farmaceutyczna zawierająca alskiren, amlodypinę i hydrochlortiazyd, kombinacja zawierająca te składniki, zastosowanie wspomnianej kombinacji oraz zestaw handlowy zawierający wspomnianą kombinację
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
JP4459810B2 (ja) 2002-08-14 2010-04-28 マクロジェニクス,インコーポレーテッド FcγRIIB特異的抗体とその利用法
US8946387B2 (en) 2002-08-14 2015-02-03 Macrogenics, Inc. FcγRIIB specific antibodies and methods of use thereof
US8012472B2 (en) 2002-12-23 2011-09-06 William Marsh Rice University Compositions and methods for suppressing fibrocytes
WO2004059318A2 (fr) 2002-12-23 2004-07-15 William Marsh Rice University Techniques de detection d'inhibition de formation de fibroblastes, techniques et compositions permettant de renforcer la formation de fibroblastes
US7763256B2 (en) 2002-12-23 2010-07-27 William Marsh Rice University Compositions and methods for suppressing fibrocytes and for detecting fibrocyte differentiation
JP2006526140A (ja) 2002-12-24 2006-11-16 バイオサイト インコーポレイテッド 鑑別診断のためのマーカーおよびその使用方法
CA2517037A1 (fr) 2003-02-27 2004-09-10 Theravision Gmbh Methode de diminution des niveaux de proteine c-reactive
MXPA06011796A (es) 2004-04-16 2007-05-07 Macrogenics Inc Anticuerpos especificos de fc(riib y metodos para el uso de los mismos.
US7521542B2 (en) 2004-05-10 2009-04-21 Macrogenics, Inc. Humanized FcγRIIB-specific antibodies and methods of use thereof
CA2568661A1 (fr) 2004-06-03 2006-01-05 Medarex, Inc. Anticorps humains monoclonaux anti-recepteur gamma (cd64) de la region fc
WO2006002930A2 (fr) 2004-06-30 2006-01-12 Friedrich-Alexander- Universitaet Erlangen- Nuernberg Polymorphisme fcgammariia et son utilisation dans un diagnostic
WO2006008661A2 (fr) * 2004-07-19 2006-01-26 Neurochem (International) Limited Methodes diagnostiques d'amylose affectant de multiples organes
ZA200701783B (en) 2004-09-02 2009-10-28 Genentech Inc Anti-Fc-gamma RIIB receptor antibody and uses therefor
AU2005286763A1 (en) 2004-09-17 2006-03-30 Biomarin Pharmaceutical, Inc. Variants and chemically-modified variants of phenylalanine ammonia-lyase
EP1846454A2 (fr) 2004-09-30 2007-10-24 Medarex, Inc. Anticorps monoclonaux humains pour recepteur ii fc gamma (cd32)
US7405302B2 (en) 2005-10-11 2008-07-29 Amira Pharmaceuticals, Inc. 5-lipoxygenase-activating protein (FLAP) inhibitors
US20070099251A1 (en) 2005-10-17 2007-05-03 Institute For Systems Biology Tissue-and serum-derived glycoproteins and methods of their use
PT2029173T (pt) 2006-06-26 2016-11-02 Macrogenics Inc Anticorpos específicos fc rib e seus métodos de uso
WO2008070117A1 (fr) 2006-12-04 2008-06-12 Promedior, Inc. Thérapie conjointe pour le traitement de maladies fibrotiques
DK2185581T3 (en) 2007-07-06 2015-12-14 Promedior Inc Methods and compositions suitable for treating mucositis
US8497243B2 (en) 2007-07-06 2013-07-30 Promedior, Inc. Methods and compositions useful in the treatment of mucositis
US9884899B2 (en) 2007-07-06 2018-02-06 Promedior, Inc. Methods for treating fibrosis using CRP antagonists
CA2755047C (fr) 2009-03-11 2018-12-04 Promedior, Inc. Methodes de traitement de troubles auto-immuns
WO2010104959A1 (fr) 2009-03-11 2010-09-16 Promedior, Inc. Procédés de traitement et de diagnostic pour troubles d'hypersensibilité
WO2010115032A1 (fr) 2009-04-01 2010-10-07 Promedior, Inc. Administration pulmonaire et nasale d'une substance amyloïde p sérique
UA110323C2 (en) 2009-06-04 2015-12-25 Promedior Inc Derivative of serum amyloid p and their receipt and application
AU2010262847B2 (en) 2009-06-17 2016-06-02 Promedior, Inc. SAP variants and their use

Also Published As

Publication number Publication date
AU2008275678A1 (en) 2009-01-15
EP2176287A2 (fr) 2010-04-21
US9884899B2 (en) 2018-02-06
AU2008275678B9 (en) 2014-11-27
AU2008275678B2 (en) 2014-06-26
SI2185581T1 (sl) 2016-01-29
US20090202520A1 (en) 2009-08-13
WO2009009019A3 (fr) 2009-04-23
JP2010532872A (ja) 2010-10-14
WO2009009019A2 (fr) 2009-01-15
JP2016001196A (ja) 2016-01-07

Similar Documents

Publication Publication Date Title
AU2008275678B9 (en) Treatment and diagnostic methods for fibrosis related disorders
Singh et al. Soluble vascular endothelial growth factor receptor 3 is essential for corneal alymphaticity
Trujillo et al. A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis
Cynis et al. The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions
Vourc'h et al. Oligodendrocyte myelin glycoprotein (OMgp): evolution, structure and function
Wan et al. GDF15 as a key disease target and biomarker: linking chronic lung diseases and ageing
Gu et al. Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis
US20100136001A1 (en) Methods and compositions for the treatment and diagnosis of vascular inflammatory disorders or endothelial cell disorders
US20160025745A1 (en) Methods of diagnosing and treating fibrosis
KR102284780B1 (ko) T 세포 활성화 저해제, 이것을 함유하는 의약 조성물 및 t 세포 활성화 저해 물질의 스크리닝 방법
Jiang et al. Ang II–stimulated migration of vascular smooth muscle cells is dependent on LR11 in mice
WO2013155512A2 (fr) Traitement de rétinopathies ischémiques
JP2009501521A (ja) 炎症応答を診断および処置する方法
US11136383B2 (en) Methods and compositions for modulaton of transforming growth factor beta-regulated functions
Zhan et al. Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination
CN102712686B (zh) 生物材料及其用途
JP2008522162A (ja) Merの診断用および治療用の作用薬
WO2010072684A1 (fr) Utilisation de la protéine norrin dans le traitement de maladies associées à une augmentation de l'activité de tgf-bêta
JP2016516726A (ja) ネフローゼ症候群及び関連状態の治療方法
US20130251702A1 (en) Method for screening compounds for treating sepsis targeting nod2 signalling pathway and composition for treating sepsis comprising nod2 signalling pathway inhibitors
JP2024546924A (ja) 抗pilra抗体、その使用、ならびに関連する方法及び試薬
Kuwahara et al. Angiogenin expression in the sera and skin of patients with rheumatic diseases
JP5093578B2 (ja) 受容体型プロテインチロシンホスファターゼPtprzによるErbB4シグナルの抑制
JP2011508730A (ja) Udp−n−アセチル−アルファ−d−ガラクトサミン:ポリペプチドn−アセチルガラクトサミニルトランスフェラーゼ(galnt)モジュレーションによる高比重リポタンパク質レベルの改変
Black et al. 11th International Workshop on Scleroderma Research

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20130606

FZDE Discontinued

Effective date: 20170515