CA2682432A1 - Dispositif et procede pour administrer un medicament - Google Patents

Dispositif et procede pour administrer un medicament Download PDF

Info

Publication number: CA2682432A1
Authority: CA; Canada
Prior art keywords: nicotine; gaseous carrier; enhancing compound; medicament; delivery enhancing
Prior art date: 2007-03-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA002682432A

Other languages

English (en)

Other versions

CA2682432C (fr

Inventor

Jed E. Rose

Seth D. Rose

James Edward Turner

Thangaraju Murugesan

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Philip Morris Products SA

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-03-30

Filing date

2008-03-25

Publication date

2008-10-09

2008-03-25 Application filed by Individual filed Critical Individual

2008-03-25 Priority to CA2963423A priority Critical patent/CA2963423C/fr

2008-10-09 Publication of CA2682432A1 publication Critical patent/CA2682432A1/fr

2017-06-06 Application granted granted Critical

2017-06-06 Publication of CA2682432C publication Critical patent/CA2682432C/fr

Status Expired - Fee Related legal-status Critical Current

2028-03-25 Anticipated expiration legal-status Critical

Links

238000000034 method Methods 0.000 title claims abstract description 170
239000003814 drug Substances 0.000 title claims abstract description 77
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract description 385
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract description 383
229960002715 nicotine Drugs 0.000 claims abstract description 383
230000002708 enhancing effect Effects 0.000 claims abstract description 142
235000019505 tobacco product Nutrition 0.000 claims abstract description 17
201000010099 disease Diseases 0.000 claims abstract description 13
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 13
238000006467 substitution reaction Methods 0.000 claims abstract description 10
230000009467 reduction Effects 0.000 claims abstract description 9
150000001875 compounds Chemical class 0.000 claims description 159
LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 claims description 104
239000002253 acid Substances 0.000 claims description 58
239000002245 particle Substances 0.000 claims description 54
229940107700 pyruvic acid Drugs 0.000 claims description 52
238000004891 communication Methods 0.000 claims description 45
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 22
QHKABHOOEWYVLI-UHFFFAOYSA-N 3-methyl-2-oxobutanoic acid Chemical compound CC(C)C(=O)C(O)=O QHKABHOOEWYVLI-UHFFFAOYSA-N 0.000 claims description 20
239000007788 liquid Substances 0.000 claims description 20
GPPUPQFYDYLTIY-UHFFFAOYSA-N 2-oxooctanoic acid Chemical compound CCCCCCC(=O)C(O)=O GPPUPQFYDYLTIY-UHFFFAOYSA-N 0.000 claims description 18
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 18
238000010438 heat treatment Methods 0.000 claims description 18
230000001965 increasing effect Effects 0.000 claims description 18
235000019504 cigarettes Nutrition 0.000 claims description 16
238000001179 sorption measurement Methods 0.000 claims description 16
-1 Chlorpheneramine Chemical compound 0.000 claims description 12
239000011521 glass Substances 0.000 claims description 12
230000000391 smoking effect Effects 0.000 claims description 12
229940071648 metered dose inhaler Drugs 0.000 claims description 11
229920000139 polyethylene terephthalate Polymers 0.000 claims description 11
239000001388 3-methyl-2-oxobutanoic acid Substances 0.000 claims description 10
241000208125 Nicotiana Species 0.000 claims description 10
235000002637 Nicotiana tabacum Nutrition 0.000 claims description 10
238000011282 treatment Methods 0.000 claims description 10
MVJLYXCJBPXRCY-UHFFFAOYSA-N 2-methylbutyl propanoate Chemical compound CCC(C)COC(=O)CC MVJLYXCJBPXRCY-UHFFFAOYSA-N 0.000 claims description 9
KDVFRMMRZOCFLS-UHFFFAOYSA-N 2-oxopentanoic acid Chemical compound CCCC(=O)C(O)=O KDVFRMMRZOCFLS-UHFFFAOYSA-N 0.000 claims description 9
BKAJNAXTPSGJCU-UHFFFAOYSA-N 4-methyl-2-oxopentanoic acid Chemical compound CC(C)CC(=O)C(O)=O BKAJNAXTPSGJCU-UHFFFAOYSA-N 0.000 claims description 9
239000001142 4-methyl-2-oxopentanoic acid Substances 0.000 claims description 9
150000007524 organic acids Chemical class 0.000 claims description 9
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 8
229920001343 polytetrafluoroethylene Polymers 0.000 claims description 8
239000004810 polytetrafluoroethylene Substances 0.000 claims description 8
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 7
229920000295 expanded polytetrafluoroethylene Polymers 0.000 claims description 7
229920001707 polybutylene terephthalate Polymers 0.000 claims description 7
DMULVCHRPCFFGV-UHFFFAOYSA-N N,N-dimethyltryptamine Chemical compound C1=CC=C2C(CCN(C)C)=CNC2=C1 DMULVCHRPCFFGV-UHFFFAOYSA-N 0.000 claims description 6
206010057852 Nicotine dependence Diseases 0.000 claims description 6
229910021529 ammonia Inorganic materials 0.000 claims description 6
239000002243 precursor Substances 0.000 claims description 6
239000012629 purifying agent Substances 0.000 claims description 6
229920006395 saturated elastomer Polymers 0.000 claims description 6
229920001824 Barex® Polymers 0.000 claims description 5
102000019315 Nicotinic acetylcholine receptors Human genes 0.000 claims description 5
108050006807 Nicotinic acetylcholine receptors Proteins 0.000 claims description 5
208000025569 Tobacco Use disease Diseases 0.000 claims description 5
229910052782 aluminium Inorganic materials 0.000 claims description 5
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 5
239000000470 constituent Substances 0.000 claims description 5
239000000796 flavoring agent Substances 0.000 claims description 5
235000013355 food flavoring agent Nutrition 0.000 claims description 5
229910052757 nitrogen Inorganic materials 0.000 claims description 5
KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 claims description 4
208000024827 Alzheimer disease Diseases 0.000 claims description 4
206010009900 Colitis ulcerative Diseases 0.000 claims description 4
RKUNBYITZUJHSG-UHFFFAOYSA-N Hyosciamin-hydrochlorid Natural products CN1C(C2)CCC1CC2OC(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-UHFFFAOYSA-N 0.000 claims description 4
FXFANIORDKRCCA-UHFFFAOYSA-N Norcotinine Chemical compound N1C(=O)CCC1C1=CC=CN=C1 FXFANIORDKRCCA-UHFFFAOYSA-N 0.000 claims description 4
208000008589 Obesity Diseases 0.000 claims description 4
208000018737 Parkinson disease Diseases 0.000 claims description 4
201000006704 Ulcerative Colitis Diseases 0.000 claims description 4
SLRCCWJSBJZJBV-UHFFFAOYSA-N alpha-isosparteine Natural products C1N2CCCCC2C2CN3CCCCC3C1C2 SLRCCWJSBJZJBV-UHFFFAOYSA-N 0.000 claims description 4
HJJPJSXJAXAIPN-UHFFFAOYSA-N arecoline Chemical compound COC(=O)C1=CCCN(C)C1 HJJPJSXJAXAIPN-UHFFFAOYSA-N 0.000 claims description 4
DLNKOYKMWOXYQA-IONNQARKSA-N cathine Chemical compound C[C@H](N)[C@@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-IONNQARKSA-N 0.000 claims description 4
KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 claims description 4
DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 claims description 4
ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims description 4
KUBCEEMXQZUPDQ-UHFFFAOYSA-N hordenine Chemical compound CN(C)CCC1=CC=C(O)C=C1 KUBCEEMXQZUPDQ-UHFFFAOYSA-N 0.000 claims description 4
201000006417 multiple sclerosis Diseases 0.000 claims description 4
DPNGWXJMIILTBS-UHFFFAOYSA-N myosmine Chemical compound C1CCN=C1C1=CC=CN=C1 DPNGWXJMIILTBS-UHFFFAOYSA-N 0.000 claims description 4
235000020824 obesity Nutrition 0.000 claims description 4
AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 claims description 4
SLRCCWJSBJZJBV-AJNGGQMLSA-N sparteine Chemical compound C1N2CCCC[C@H]2[C@@H]2CN3CCCC[C@H]3[C@H]1C2 SLRCCWJSBJZJBV-AJNGGQMLSA-N 0.000 claims description 4
229960001945 sparteine Drugs 0.000 claims description 4
APJYDQYYACXCRM-UHFFFAOYSA-N tryptamine Chemical compound C1=CC=C2C(CCN)=CNC2=C1 APJYDQYYACXCRM-UHFFFAOYSA-N 0.000 claims description 4
125000001931 aliphatic group Chemical group 0.000 claims description 3
235000019270 ammonium chloride Nutrition 0.000 claims description 3
230000009286 beneficial effect Effects 0.000 claims description 3
229960003609 cathine Drugs 0.000 claims description 3
229940079593 drug Drugs 0.000 claims description 3
IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims description 3
229910000041 hydrogen chloride Inorganic materials 0.000 claims description 3
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
CEMAWMOMDPGJMB-UHFFFAOYSA-N (+-)-Oxprenolol Chemical compound CC(C)NCC(O)COC1=CC=CC=C1OCC=C CEMAWMOMDPGJMB-UHFFFAOYSA-N 0.000 claims description 2
XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims description 2
MXYUKLILVYORSK-UHFFFAOYSA-N (+/-)-allo-lobeline Natural products C1CCC(CC(=O)C=2C=CC=CC=2)N(C)C1CC(O)C1=CC=CC=C1 MXYUKLILVYORSK-UHFFFAOYSA-N 0.000 claims description 2
UIKROCXWUNQSPJ-VIFPVBQESA-N (-)-cotinine Chemical compound C1CC(=O)N(C)[C@@H]1C1=CC=CN=C1 UIKROCXWUNQSPJ-VIFPVBQESA-N 0.000 claims description 2
MXYUKLILVYORSK-HBMCJLEFSA-N (-)-lobeline Chemical compound C1([C@@H](O)C[C@H]2N([C@H](CCC2)CC(=O)C=2C=CC=CC=2)C)=CC=CC=C1 MXYUKLILVYORSK-HBMCJLEFSA-N 0.000 claims description 2
IGLYMJRIWWIQQE-QUOODJBBSA-N (1S,2R)-2-phenylcyclopropan-1-amine (1R,2S)-2-phenylcyclopropan-1-amine Chemical compound N[C@H]1C[C@@H]1C1=CC=CC=C1.N[C@@H]1C[C@H]1C1=CC=CC=C1 IGLYMJRIWWIQQE-QUOODJBBSA-N 0.000 claims description 2
MTXSIJUGVMTTMU-JTQLQIEISA-N (S)-anabasine Chemical compound N1CCCC[C@H]1C1=CC=CN=C1 MTXSIJUGVMTTMU-JTQLQIEISA-N 0.000 claims description 2
RKUNBYITZUJHSG-FXUDXRNXSA-N (S)-atropine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@H]3CC[C@@H](C2)N3C)=CC=CC=C1 RKUNBYITZUJHSG-FXUDXRNXSA-N 0.000 claims description 2
SGTNSNPWRIOYBX-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile Chemical compound C1=C(OC)C(OC)=CC=C1CCN(C)CCCC(C#N)(C(C)C)C1=CC=C(OC)C(OC)=C1 SGTNSNPWRIOYBX-UHFFFAOYSA-N 0.000 claims description 2
WAOQONBSWFLFPE-VIFPVBQESA-N 3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxybenzamide Chemical compound CCN1CCC[C@H]1CNC(=O)C1=C(O)C(Cl)=CC(Cl)=C1OC WAOQONBSWFLFPE-VIFPVBQESA-N 0.000 claims description 2
MXUNKHLAEDCYJL-UHFFFAOYSA-N 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one Chemical compound CC1=CC=CC(N2C(OC(CO)C2)=O)=C1 MXUNKHLAEDCYJL-UHFFFAOYSA-N 0.000 claims description 2
XKFPYPQQHFEXRZ-UHFFFAOYSA-N 5-methyl-N'-(phenylmethyl)-3-isoxazolecarbohydrazide Chemical compound O1C(C)=CC(C(=O)NNCC=2C=CC=CC=2)=N1 XKFPYPQQHFEXRZ-UHFFFAOYSA-N 0.000 claims description 2
229930000680 A04AD01 - Scopolamine Natural products 0.000 claims description 2
SOPPBXUYQGUQHE-JTQLQIEISA-N Anatabine Chemical compound C1C=CCN[C@@H]1C1=CC=CN=C1 SOPPBXUYQGUQHE-JTQLQIEISA-N 0.000 claims description 2
SOPPBXUYQGUQHE-UHFFFAOYSA-N Anatabine Natural products C1C=CCNC1C1=CC=CN=C1 SOPPBXUYQGUQHE-UHFFFAOYSA-N 0.000 claims description 2
229930003347 Atropine Natural products 0.000 claims description 2
239000005528 B01AC05 - Ticlopidine Substances 0.000 claims description 2
229930008564 C01BA04 - Sparteine Natural products 0.000 claims description 2
UIKROCXWUNQSPJ-UHFFFAOYSA-N Cotinine Natural products C1CC(=O)N(C)C1C1=CC=CN=C1 UIKROCXWUNQSPJ-UHFFFAOYSA-N 0.000 claims description 2
NLPRAJRHRHZCQQ-UHFFFAOYSA-N Epibatidine Natural products C1=NC(Cl)=CC=C1C1C(N2)CCC2C1 NLPRAJRHRHZCQQ-UHFFFAOYSA-N 0.000 claims description 2
STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 claims description 2
NYMGNSNKLVNMIA-UHFFFAOYSA-N Iproniazid Chemical compound CC(C)NNC(=O)C1=CC=NC=C1 NYMGNSNKLVNMIA-UHFFFAOYSA-N 0.000 claims description 2
JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims description 2
NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 claims description 2
LELBFTMXCIIKKX-QVRQZEMUSA-N Mitragynine Chemical compound C1=CC(OC)=C2C(CCN3C[C@H]([C@H](C[C@H]33)\C(=C/OC)C(=O)OC)CC)=C3NC2=C1 LELBFTMXCIIKKX-QVRQZEMUSA-N 0.000 claims description 2
LELBFTMXCIIKKX-SUCIZOKWSA-N Mitragynine Natural products C1=CC(OC)=C2C(CCN3C[C@H]([C@H](C[C@H]33)\C(=C\OC)C(=O)OC)CC)=C3NC2=C1 LELBFTMXCIIKKX-SUCIZOKWSA-N 0.000 claims description 2
RYENLSMHLCNXJT-UHFFFAOYSA-N Mitragynine hydroxyindolenine Natural products C1=CC(OC)=C2C3(O)CCN4CC(CC)C(C(=COC)C(=O)OC)CC4C3=NC2=C1 RYENLSMHLCNXJT-UHFFFAOYSA-N 0.000 claims description 2
UQOFGTXDASPNLL-XHNCKOQMSA-N Muscarine Chemical compound C[C@@H]1O[C@H](C[N+](C)(C)C)C[C@H]1O UQOFGTXDASPNLL-XHNCKOQMSA-N 0.000 claims description 2
STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 claims description 2
RMUCZJUITONUFY-UHFFFAOYSA-N Phenelzine Chemical compound NNCCC1=CC=CC=C1 RMUCZJUITONUFY-UHFFFAOYSA-N 0.000 claims description 2
BHHGXPLMPWCGHP-UHFFFAOYSA-N Phenethylamine Chemical compound NCCC1=CC=CC=C1 BHHGXPLMPWCGHP-UHFFFAOYSA-N 0.000 claims description 2
PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 claims description 2
RVOLLAQWKVFTGE-UHFFFAOYSA-N Pyridostigmine Chemical compound CN(C)C(=O)OC1=CC=C[N+](C)=C1 RVOLLAQWKVFTGE-UHFFFAOYSA-N 0.000 claims description 2
125000002015 acyclic group Chemical group 0.000 claims description 2
229930014345 anabasine Natural products 0.000 claims description 2
230000001088 anti-asthma Effects 0.000 claims description 2
239000003416 antiarrhythmic agent Substances 0.000 claims description 2
239000000924 antiasthmatic agent Substances 0.000 claims description 2
125000003118 aryl group Chemical group 0.000 claims description 2
RKUNBYITZUJHSG-SPUOUPEWSA-N atropine Chemical compound O([C@H]1C[C@H]2CC[C@@H](C1)N2C)C(=O)C(CO)C1=CC=CC=C1 RKUNBYITZUJHSG-SPUOUPEWSA-N 0.000 claims description 2
229960000396 atropine Drugs 0.000 claims description 2
238000009835 boiling Methods 0.000 claims description 2
SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims description 2
229960001058 bupropion Drugs 0.000 claims description 2
229960001747 cinchocaine Drugs 0.000 claims description 2
PUFQVTATUTYEAL-UHFFFAOYSA-N cinchocaine Chemical compound C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCCN(CC)CC)=C21 PUFQVTATUTYEAL-UHFFFAOYSA-N 0.000 claims description 2
229950006073 cotinine Drugs 0.000 claims description 2
229960001056 dimemorfan Drugs 0.000 claims description 2
KBEZZLAAKIIPFK-NJAFHUGGSA-N dimemorfan Chemical compound C1C2=CC=C(C)C=C2[C@@]23CCN(C)[C@@H]1[C@H]2CCCC3 KBEZZLAAKIIPFK-NJAFHUGGSA-N 0.000 claims description 2
229960000520 diphenhydramine Drugs 0.000 claims description 2
229940112141 dry powder inhaler Drugs 0.000 claims description 2
239000003623 enhancer Substances 0.000 claims description 2
229960002179 ephedrine Drugs 0.000 claims description 2
NLPRAJRHRHZCQQ-IVZWLZJFSA-N epibatidine Chemical compound C1=NC(Cl)=CC=C1[C@@H]1[C@H](N2)CC[C@H]2C1 NLPRAJRHRHZCQQ-IVZWLZJFSA-N 0.000 claims description 2
229960003980 galantamine Drugs 0.000 claims description 2
ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims description 2
125000000623 heterocyclic group Chemical group 0.000 claims description 2
229940071490 hordenine Drugs 0.000 claims description 2
229930005342 hyoscyamine Natural products 0.000 claims description 2
229960003210 hyoscyamine Drugs 0.000 claims description 2
GGECDTUJZOXAAR-UHFFFAOYSA-N iproclozide Chemical compound CC(C)NNC(=O)COC1=CC=C(Cl)C=C1 GGECDTUJZOXAAR-UHFFFAOYSA-N 0.000 claims description 2
229960002589 iproclozide Drugs 0.000 claims description 2
229940070023 iproniazide Drugs 0.000 claims description 2
229960002672 isocarboxazid Drugs 0.000 claims description 2
229960003406 levorphanol Drugs 0.000 claims description 2
229960004194 lidocaine Drugs 0.000 claims description 2
TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 claims description 2
229960003907 linezolid Drugs 0.000 claims description 2
229960002339 lobeline Drugs 0.000 claims description 2
229930013610 lobeline Natural products 0.000 claims description 2
IMYZQPCYWPFTAG-IQJOONFLSA-N mecamylamine Chemical compound C1C[C@@H]2C(C)(C)[C@@](NC)(C)[C@H]1C2 IMYZQPCYWPFTAG-IQJOONFLSA-N 0.000 claims description 2
229960002525 mecamylamine Drugs 0.000 claims description 2
230000008018 melting Effects 0.000 claims description 2
238000002844 melting Methods 0.000 claims description 2
YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 claims description 2
229960000582 mepyramine Drugs 0.000 claims description 2
DAHIQPJTGIHDGO-IAGOWNOFSA-N mesembrine Chemical compound C1=C(OC)C(OC)=CC=C1[C@]1(CCC(=O)C2)[C@@H]2N(C)CC1 DAHIQPJTGIHDGO-IAGOWNOFSA-N 0.000 claims description 2
DAHIQPJTGIHDGO-UHFFFAOYSA-N mesembrine Natural products C1=C(OC)C(OC)=CC=C1C1(CCC(=O)C2)C2N(C)CC1 DAHIQPJTGIHDGO-UHFFFAOYSA-N 0.000 claims description 2
LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 claims description 2
SVXZBICQLNEMLC-UHFFFAOYSA-N methyl 1-methyl-3,6-dihydro-2h-pyridine-4-carboxylate Chemical compound COC(=O)C1=CCN(C)CC1 SVXZBICQLNEMLC-UHFFFAOYSA-N 0.000 claims description 2
239000002899 monoamine oxidase inhibitor Substances 0.000 claims description 2
239000006199 nebulizer Substances 0.000 claims description 2
LBHIOVVIQHSOQN-UHFFFAOYSA-N nicorandil Chemical compound [O-][N+](=O)OCCNC(=O)C1=CC=CN=C1 LBHIOVVIQHSOQN-UHFFFAOYSA-N 0.000 claims description 2
229960002497 nicorandil Drugs 0.000 claims description 2
125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
229960002657 orciprenaline Drugs 0.000 claims description 2
229960004570 oxprenolol Drugs 0.000 claims description 2
229960000964 phenelzine Drugs 0.000 claims description 2
PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 claims description 2
229960001697 physostigmine Drugs 0.000 claims description 2
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 claims description 2
229960004919 procaine Drugs 0.000 claims description 2
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239000000376 reactant Substances 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
238000005067 remediation Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
210000002345 respiratory system Anatomy 0.000 description 1
208000023504 respiratory system disease Diseases 0.000 description 1
238000007789 sealing Methods 0.000 description 1
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239000002904 solvent Substances 0.000 description 1
241000894007 species Species 0.000 description 1
230000000087 stabilizing effect Effects 0.000 description 1
230000003068 static effect Effects 0.000 description 1
238000003860 storage Methods 0.000 description 1
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ZHYZQXUYZJNEHD-UHFFFAOYSA-N trans-geranic acid Natural products CC(C)=CCCC(C)=CC(O)=O ZHYZQXUYZJNEHD-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- A24B15/10—Chemical features of tobacco products or tobacco substitutes
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- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
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- A24F42/00—Simulated smoking devices other than electrically operated; Component parts thereof; Manufacture or testing thereof
- A24F42/20—Devices without heating means
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- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/10—Devices using liquid inhalable precursors
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- A24F—SMOKERS' REQUISITES; MATCH BOXES; SIMULATED SMOKING DEVICES
- A24F40/00—Electrically operated smoking devices; Component parts thereof; Manufacture thereof; Maintenance or testing thereof; Charging means specially adapted therefor
- A24F40/40—Constructional details, e.g. connection of cartridges and battery parts
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- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/04—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised
- A61M11/041—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters
- A61M11/047—Sprayers or atomisers specially adapted for therapeutic purposes operated by the vapour pressure of the liquid to be sprayed or atomised using heaters by exothermic chemical reaction
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- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Biomedical Technology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Cardiology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Child & Adolescent Psychology (AREA)
Obesity (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Manufacture Of Tobacco Products (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA2682432A 2007-03-30 2008-03-25 Dispositif et procede pour administrer un medicament Expired - Fee Related CA2682432C (fr)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
CA2963423A CA2963423C (fr)	2007-03-30	2008-03-25	Dispositif et procede pour administrer un medicament

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US90930207P	2007-03-30	2007-03-30
US60/909,302		2007-03-30
PCT/US2008/058122 WO2008121610A1 (fr)	2007-03-30	2008-03-25	Dispositif et procédé pour administrer un médicament

Related Child Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2963423A Division CA2963423C (fr)	2007-03-30	2008-03-25	Dispositif et procede pour administrer un medicament

Publications (2)

Publication Number	Publication Date
CA2682432A1 true CA2682432A1 (fr)	2008-10-09
CA2682432C CA2682432C (fr)	2017-06-06

Family

ID=39794782

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CA2963423A Expired - Fee Related CA2963423C (fr)	2007-03-30	2008-03-25	Dispositif et procede pour administrer un medicament
CA2682432A Expired - Fee Related CA2682432C (fr)	2007-03-30	2008-03-25	Dispositif et procede pour administrer un medicament

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CA2963423A Expired - Fee Related CA2963423C (fr)	2007-03-30	2008-03-25	Dispositif et procede pour administrer un medicament

Country Status (7)

Country	Link
US (2)	US10668058B2 (fr)
EP (2)	EP2134395B1 (fr)
JP (2)	JP2010532672A (fr)
CN (3)	CN104906669A (fr)
AU (1)	AU2008232897B2 (fr)
CA (2)	CA2963423C (fr)
WO (1)	WO2008121610A1 (fr)

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- 2008-03-25 CA CA2963423A patent/CA2963423C/fr not_active Expired - Fee Related
- 2008-03-25 EP EP13184266.8A patent/EP2708256A3/fr not_active Withdrawn
- 2008-03-25 JP JP2010501159A patent/JP2010532672A/ja active Pending
- 2008-03-25 CN CN201510173107.0A patent/CN104906669A/zh active Pending
- 2008-03-25 CN CN201310077083.XA patent/CN103418062B/zh active Active
- 2008-03-25 WO PCT/US2008/058122 patent/WO2008121610A1/fr not_active Ceased
- 2008-03-25 AU AU2008232897A patent/AU2008232897B2/en not_active Ceased
- 2008-03-25 US US12/054,883 patent/US10668058B2/en active Active
- 2008-03-25 CA CA2682432A patent/CA2682432C/fr not_active Expired - Fee Related
- 2008-03-25 CN CN200880017582.7A patent/CN102014995B/zh active Active
2013
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2016
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Also Published As

Publication number	Publication date
AU2008232897A1 (en)	2008-10-09
EP2134395A4 (fr)	2015-06-24
JP2013144157A (ja)	2013-07-25
HK1156262A1 (en)	2012-06-08
JP2010532672A (ja)	2010-10-14
CN102014995A (zh)	2011-04-13
AU2008232897A2 (en)	2009-11-12
CA2963423A1 (fr)	2008-10-09
EP2708256A3 (fr)	2014-04-02
US20080241255A1 (en)	2008-10-02
CN103418062B (zh)	2017-04-12
EP2134395B1 (fr)	2020-03-18
WO2008121610A1 (fr)	2008-10-09
US10668058B2 (en)	2020-06-02
CN103418062A (zh)	2013-12-04
CN102014995B (zh)	2015-05-13
JP5714637B2 (ja)	2015-05-07
AU2008232897B2 (en)	2014-03-13
CA2963423C (fr)	2020-07-28
CN104906669A (zh)	2015-09-16
EP2134395A1 (fr)	2009-12-23
EP2708256A2 (fr)	2014-03-19
US20160250201A1 (en)	2016-09-01
CA2682432C (fr)	2017-06-06

Publication	Publication Date	Title
CA2682432C (fr)	2017-06-06	Dispositif et procede pour administrer un medicament
CA2774264C (fr)	2014-09-23	Dispositif et methodes perfectionnes pour la distribution d'un medicament
US9380810B2 (en)	2016-07-05	Tobacco-based nicotine aerosol generation system
AU2018203039A1 (en)	2018-05-17	Device and method for delivery of a medicament
AU2014200827A1 (en)	2014-03-06	Device and method for delivery of a medicament
HK1191580A (en)	2014-08-01	Device and method for delivery of a medicament
HK1192491A (en)	2014-08-22	Device and method for delivery of a medicament
HK1192491B (en)	2018-04-06	Device and method for delivery of a medicament
HK1156262B (en)	2015-10-30	Device and method for delivery of a medicament

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