CA2668184A1 - Techniques d'administration transdermique pour des medicaments, des nutraceutiques et d'autres substances actives - Google Patents

Techniques d'administration transdermique pour des medicaments, des nutraceutiques et d'autres substances actives Download PDF

Info

Publication number: CA2668184A1
Authority: CA; Canada
Prior art keywords: treating; active substance; delivery; disease; drug
Prior art date: 2006-10-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002668184A

Other languages

English (en)

Inventor

Guy Dipierro

Steven A. Giannos

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Chrono Therapeutics Inc

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-31

Filing date

2007-10-31

Publication date

2008-05-08

2007-10-31 Application filed by Individual filed Critical Individual

2008-05-08 Publication of CA2668184A1 publication Critical patent/CA2668184A1/fr

Status Abandoned legal-status Critical Current

Links

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OOGJQPCLVADCPB-HXUWFJFHSA-N tolterodine Chemical compound C1([C@@H](CCN(C(C)C)C(C)C)C=2C(=CC=C(C)C=2)O)=CC=CC=C1 OOGJQPCLVADCPB-HXUWFJFHSA-N 0.000 description 1
229960004045 tolterodine Drugs 0.000 description 1
208000004371 toothache Diseases 0.000 description 1
229940035305 topamax Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
229960004394 topiramate Drugs 0.000 description 1
231100000440 toxicity profile Toxicity 0.000 description 1
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
230000007704 transition Effects 0.000 description 1
230000014616 translation Effects 0.000 description 1
230000008733 trauma Effects 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
JOFWLTCLBGQGBO-UHFFFAOYSA-N triazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1Cl JOFWLTCLBGQGBO-UHFFFAOYSA-N 0.000 description 1
229960003386 triazolam Drugs 0.000 description 1
230000001960 triggered effect Effects 0.000 description 1
229960001032 trihexyphenidyl Drugs 0.000 description 1
229940061414 trileptal Drugs 0.000 description 1
229960001641 troglitazone Drugs 0.000 description 1
GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
229940072651 tylenol Drugs 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
229940045136 urea Drugs 0.000 description 1
206010046494 urge incontinence Diseases 0.000 description 1
BDIAUFOIMFAIPU-UHFFFAOYSA-N valepotriate Natural products CC(C)CC(=O)OC1C=C(C(=COC2OC(=O)CC(C)C)COC(C)=O)C2C11CO1 BDIAUFOIMFAIPU-UHFFFAOYSA-N 0.000 description 1
206010047302 ventricular tachycardia Diseases 0.000 description 1
229960001722 verapamil Drugs 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1
230000005186 women's health Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/20—Applying electric currents by contact electrodes continuous direct currents
- A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Radiology & Medical Imaging (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Dermatology (AREA)
Medical Informatics (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Hematology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicinal Preparation (AREA)

CA002668184A 2006-10-31 2007-10-31 Techniques d'administration transdermique pour des medicaments, des nutraceutiques et d'autres substances actives Abandoned CA2668184A1 (fr)

Applications Claiming Priority (21)

Application Number	Priority Date	Filing Date	Title
US86360706P	2006-10-31	2006-10-31
US86368606P	2006-10-31	2006-10-31
US86367706P	2006-10-31	2006-10-31
US86364006P	2006-10-31	2006-10-31
US86366606P	2006-10-31	2006-10-31
US86361306P	2006-10-31	2006-10-31
US86365406P	2006-10-31	2006-10-31
US86367106P	2006-10-31	2006-10-31
US86360806P	2006-10-31	2006-10-31
US86361806P	2006-10-31	2006-10-31
US60/863,608		2006-10-31
US60/863,671		2006-10-31
US60/863,654		2006-10-31
US60/863,613		2006-10-31
US60/863,686		2006-10-31
US60/863,640		2006-10-31
US60/863,677		2006-10-31
US60/863,607		2006-10-31
US60/863,666		2006-10-31
US60/863,618		2006-10-31
PCT/US2007/023006 WO2008054788A2 (fr)	2006-10-31	2007-10-31	Techniques d'administration transdermique pour des médicaments, des nutraceutiques et d'autres substances actives

Publications (1)

Publication Number	Publication Date
CA2668184A1 true CA2668184A1 (fr)	2008-05-08

Family

ID=39344904

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002668184A Abandoned CA2668184A1 (fr)	2006-10-31	2007-10-31	Techniques d'administration transdermique pour des medicaments, des nutraceutiques et d'autres substances actives

Country Status (2)

Country	Link
CA (1)	CA2668184A1 (fr)
WO (1)	WO2008054788A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10881622B2 (en)	2018-09-17	2021-01-05	Xinova, LLC	Smart transdermal microdispensing system for integrated weight management

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8252321B2 (en)	2004-09-13	2012-08-28	Chrono Therapeutics, Inc.	Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
CA2833354C (fr)	2006-03-14	2015-12-15	University Of Southern California	Dispositif mems et procede de livraison d'agents therapeutiques
JP5542691B2 (ja)	2007-12-20	2014-07-09	ユニバーシティオブサザンカリフォルニア	治療薬を送達するための装置および方法
WO2009137780A2 (fr)	2008-05-08	2009-11-12	Replenish Pumps, Llc	Pompes implantables et canules à cet effet
US8231609B2 (en)	2008-05-08	2012-07-31	Minipumps, Llc	Drug-delivery pumps and methods of manufacture
US9849238B2 (en)	2008-05-08	2017-12-26	Minipumps, Llc	Drug-delivery pump with intelligent control
US9199035B2 (en)	2008-05-08	2015-12-01	Minipumps, Llc.	Drug-delivery pumps with dynamic, adaptive control
WO2010120892A2 (fr) *	2009-04-14	2010-10-21	The Regents Of The University Of California	Dispositifs améliorés pour médicaments à usage oral et formulations médicamenteuses
EP2729148A4 (fr)	2011-07-06	2015-04-22	Parkinson S Inst	Compositions et méthodes de traitement de symptômes chez des patients atteints de la maladie de parkinson
CA3006962A1 (fr)	2014-12-01	2016-06-09	Achelios Therapeutics Inc.	Methodes et compositions pour le traitement de la migraine et d'etats pathologiques associes a la douleur
CA2974324A1 (fr)	2015-01-28	2016-08-04	Zita S. Netzel	Procedes et systemes d'administration de medicament
US10679516B2 (en)	2015-03-12	2020-06-09	Morningside Venture Investments Limited	Craving input and support system
CA3049529A1 (fr)	2017-01-06	2018-07-12	Chrono Therapeutics Inc.	Dispositifs et methodes d'administration transdermique de medicament
JP7420797B2 (ja)	2018-05-29	2024-01-23	モーニングサイドベンチャーインベストメンツリミテッド	薬剤送達の方法及びシステム
TR201808384A2 (tr) *	2018-06-12	2018-07-23	Yahya Yagiz Kemikoglu	İlaç taşiyici saat
CU20200106A7 (es) *	2018-06-20	2021-08-06	Axcella Health Inc	Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias
EP3880175A4 (fr)	2018-11-16	2022-08-17	Morningside Venture Investments Limited	Système d'administration transdermique de médicaments à régulation thermique
CN113425602B (zh) *	2021-06-29	2023-05-23	四川省肿瘤医院	一种药片管喂方法
CN119803848B (zh) *	2025-03-14	2025-05-27	大连理工大学	一种温变环境下压电陶瓷输出力自适应控制方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4917676A (en) *	1986-11-20	1990-04-17	Ciba-Geigy Corporation	User-activated transdermal therapeutic system
US5013293A (en) *	1987-05-28	1991-05-07	Drug Delivery Systems Inc.	Pulsating transdermal drug delivery system
US5415629A (en) *	1993-09-15	1995-05-16	Henley; Julian L.	Programmable apparatus for the transdermal delivery of drugs and method

2007
- 2007-10-31 CA CA002668184A patent/CA2668184A1/fr not_active Abandoned
- 2007-10-31 WO PCT/US2007/023006 patent/WO2008054788A2/fr not_active Ceased

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10881622B2 (en)	2018-09-17	2021-01-05	Xinova, LLC	Smart transdermal microdispensing system for integrated weight management

Also Published As

Publication number	Publication date
WO2008054788A3 (fr)	2008-11-13
WO2008054788A9 (fr)	2008-07-10
WO2008054788A2 (fr)	2008-05-08

Publication	Publication Date	Title
US10258738B2 (en)	2019-04-16	Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, AIDs, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
CA2668184A1 (fr)	2008-05-08	Techniques d'administration transdermique pour des medicaments, des nutraceutiques et d'autres substances actives
US7780981B2 (en)	2010-08-24	Biosynchronous transdermal drug delivery
US7973058B2 (en)	2011-07-05	Transdermal methods and systems for the delivery of anti-migraine compounds
US20140207047A1 (en)	2014-07-24	Transdermal drug delivery system and method
AU2015203213A1 (en)	2015-07-16	Transdermal methods and systems for the delivery of anti-migraine compounds
AU2012261753A1 (en)	2013-01-10	Transdermal methods and systems for the delivery of anti-migraine compounds

Legal Events

Date	Code	Title	Description
2012-10-16	EEER	Examination request
2016-01-05	FZDE	Discontinued	Effective date: 20151124

CA2668184A1 - Techniques d'administration transdermique pour des medicaments, des nutraceutiques et d'autres substances actives - Google Patents

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Classifications

Landscapes

Applications Claiming Priority (21)

Publications (1)

Family

ID=39344904

Family Applications (1)

Country Status (2)

Cited By (1)

Families Citing this family (19)

Family Cites Families (3)

Cited By (1)

Also Published As

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