CA2666925A1 - Polytherapie utilisee dans le traitement de la douleur - Google Patents

Polytherapie utilisee dans le traitement de la douleur Download PDF

Info

Publication number: CA2666925A1
Authority: CA; Canada
Prior art keywords: pain; pharmaceutically acceptable; acceptable salt; group; quinoxaline
Prior art date: 2006-10-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002666925A

Other languages

English (en)

Inventor

James Conrad Eisenach

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

King Pharmaceuticals Research and Development Inc

Original Assignee

King Pharmaceuticals Research and Development Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-19

Filing date

2007-10-17

Publication date

2008-05-02

2007-10-16 Priority claimed from US11/872,878 external-priority patent/US20080113969A1/en

2007-10-16 Priority claimed from US11/872,859 external-priority patent/US20080108622A1/en

2007-10-16 Priority claimed from US11/872,800 external-priority patent/US20080108603A1/en

2007-10-17 Application filed by King Pharmaceuticals Research and Development Inc filed Critical King Pharmaceuticals Research and Development Inc

2008-05-02 Publication of CA2666925A1 publication Critical patent/CA2666925A1/fr

Status Abandoned legal-status Critical Current

Links

208000002193 Pain Diseases 0.000 title claims abstract description 184
230000036407 pain Effects 0.000 title claims abstract description 121
238000011282 treatment Methods 0.000 title abstract description 12
238000002648 combination therapy Methods 0.000 title description 2
JSFLFNPZGIDUBV-UHFFFAOYSA-N 3-(2-amino-3-hydroxy-5-methyl-3h-1,2-oxazol-4-yl)propanoic acid Chemical compound CC1=C(CCC(O)=O)C(O)N(N)O1 JSFLFNPZGIDUBV-UHFFFAOYSA-N 0.000 claims abstract description 63
239000005557 antagonist Substances 0.000 claims abstract description 62
VLSMHEGGTFMBBZ-OOZYFLPDSA-M Kainate Chemical compound CC(=C)[C@H]1C[NH2+][C@H](C([O-])=O)[C@H]1CC([O-])=O VLSMHEGGTFMBBZ-OOZYFLPDSA-M 0.000 claims abstract description 52
230000003281 allosteric effect Effects 0.000 claims abstract description 52
239000003623 enhancer Substances 0.000 claims abstract description 52
208000004296 neuralgia Diseases 0.000 claims abstract description 50
208000021722 neuropathic pain Diseases 0.000 claims abstract description 50
208000004550 Postoperative Pain Diseases 0.000 claims abstract description 46
206010065390 Inflammatory pain Diseases 0.000 claims abstract description 32
208000005298 acute pain Diseases 0.000 claims abstract description 30
208000000094 Chronic Pain Diseases 0.000 claims abstract description 29
208000019695 Migraine disease Diseases 0.000 claims abstract description 29
206010027599 migraine Diseases 0.000 claims abstract description 29
108010060263 Adenosine A1 Receptor Proteins 0.000 claims abstract 6
102000030814 Adenosine A1 receptor Human genes 0.000 claims abstract 6
150000003839 salts Chemical class 0.000 claims description 140
OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims description 124
BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims description 100
239000002126 C01EB10 - Adenosine Substances 0.000 claims description 62
229960005305 adenosine Drugs 0.000 claims description 62
239000003814 drug Substances 0.000 claims description 58
108020003175 receptors Proteins 0.000 claims description 58
102000005962 receptors Human genes 0.000 claims description 58
238000000034 method Methods 0.000 claims description 52
229960005181 morphine Drugs 0.000 claims description 50
UQNAFPHGVPVTAL-UHFFFAOYSA-N 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline Chemical compound N1C(=O)C(=O)NC2=C1C=C([N+]([O-])=O)C1=C2C=CC=C1S(=O)(=O)N UQNAFPHGVPVTAL-UHFFFAOYSA-N 0.000 claims description 47
239000008194 pharmaceutical composition Substances 0.000 claims description 45
229940124597 therapeutic agent Drugs 0.000 claims description 36
-1 cyclorphen Chemical compound 0.000 claims description 33
XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims description 31
OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims description 31
OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims description 27
239000000203 mixture Substances 0.000 claims description 27
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JACAAXNEHGBPOQ-LLVKDONJSA-N Talampanel Chemical compound C([C@H](N(N=1)C(C)=O)C)C2=CC=3OCOC=3C=C2C=1C1=CC=C(N)C=C1 JACAAXNEHGBPOQ-LLVKDONJSA-N 0.000 claims description 23
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ZXFRFPSZAKNPQQ-YTWAJWBKSA-N tezampanel Chemical compound C([C@@H]1C[C@@H]2C[C@H](NC[C@@H]2CC1)C(=O)O)CC=1N=NNN=1 ZXFRFPSZAKNPQQ-YTWAJWBKSA-N 0.000 claims description 23
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BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 22
ABFMMCZFKUIJGQ-UHFFFAOYSA-N becampanel Chemical compound N1C(=O)C(=O)NC2=C1C=C([N+]([O-])=O)C=C2CNCP(O)(=O)O ABFMMCZFKUIJGQ-UHFFFAOYSA-N 0.000 claims description 22
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LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims description 22
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WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims description 22
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PRMWGUBFXWROHD-UHFFFAOYSA-N perampanel Chemical compound O=C1C(C=2C(=CC=CC=2)C#N)=CC(C=2N=CC=CC=2)=CN1C1=CC=CC=C1 PRMWGUBFXWROHD-UHFFFAOYSA-N 0.000 claims description 22
229960005198 perampanel Drugs 0.000 claims description 22
LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims description 22
UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims description 21
229960005118 oxymorphone Drugs 0.000 claims description 21
UIQMVEYFGZJHCZ-SSTWWWIQSA-N Nalorphine Chemical compound C([C@@H](N(CC1)CC=C)[C@@H]2C=C[C@@H]3O)C4=CC=C(O)C5=C4[C@@]21[C@H]3O5 UIQMVEYFGZJHCZ-SSTWWWIQSA-N 0.000 claims description 18
DEXMFYZAHXMZNM-UHFFFAOYSA-N Narceine Chemical compound OC(=O)C1=C(OC)C(OC)=CC=C1C(=O)CC1=C(CCN(C)C)C=C(OCO2)C2=C1OC DEXMFYZAHXMZNM-UHFFFAOYSA-N 0.000 claims description 18
229960004126 codeine Drugs 0.000 claims description 18
229960000805 nalbuphine Drugs 0.000 claims description 18
NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 claims description 18
229960000938 nalorphine Drugs 0.000 claims description 18
ZHVWWEYETMPAMX-PCWWUVHHSA-N naltriben Chemical compound N1([C@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CC=2C3=CC=CC=C3OC=25)O)CC1)O)CC1CC1 ZHVWWEYETMPAMX-PCWWUVHHSA-N 0.000 claims description 18
DKJCUVXSBOMWAV-PCWWUVHHSA-N naltrindole Chemical compound N1([C@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CC2=C3[CH]C=CC=C3N=C25)O)CC1)O)CC1CC1 DKJCUVXSBOMWAV-PCWWUVHHSA-N 0.000 claims description 18
230000001225 therapeutic effect Effects 0.000 claims description 17
CFJRSKULEDUDKL-UHFFFAOYSA-N 2-[[5-[4-(dimethylsulfamoyl)phenyl]-8-methyl-2-oxo-7,9-dihydro-6h-pyrrolo[3,2-h]isoquinolin-3-yl]amino]oxy-4-hydroxybutanoic acid Chemical compound C1=CC(S(=O)(=O)N(C)C)=CC=C1C1=CC2=C(NOC(CCO)C(O)=O)C(=O)N=C2C2=C1CCN(C)C2 CFJRSKULEDUDKL-UHFFFAOYSA-N 0.000 claims description 12
GDSGJOIKTYTOQG-UHFFFAOYSA-N 9-methyl-6-nitro-3-oxo-7,8,9,10-tetrahydro-4h-pyrido[4,3-h]quinoxalin-9-ium-2-olate Chemical compound N1C(=O)C(=O)NC2=C(CN(C)CC3)C3=C([N+]([O-])=O)C=C21 GDSGJOIKTYTOQG-UHFFFAOYSA-N 0.000 claims description 10
229960004127 naloxone Drugs 0.000 claims description 10
UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims description 10
YQYVFVRQLZMJKJ-JBBXEZCESA-N (+)-cyclazocine Chemical compound C([C@@]1(C)C2=CC(O)=CC=C2C[C@@H]2[C@@H]1C)CN2CC1CC1 YQYVFVRQLZMJKJ-JBBXEZCESA-N 0.000 claims description 9
UVITTYOJFDLOGI-UHFFFAOYSA-N (1,2,5-trimethyl-4-phenylpiperidin-4-yl) propanoate Chemical compound C=1C=CC=CC=1C1(OC(=O)CC)CC(C)N(C)CC1C UVITTYOJFDLOGI-UHFFFAOYSA-N 0.000 claims description 9
YFGBQHOOROIVKG-BHDDXSALSA-N (2R)-2-[[(2R)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid Chemical compound C([C@H](C(=O)N[C@H](CCSC)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 YFGBQHOOROIVKG-BHDDXSALSA-N 0.000 claims description 9
SEJUQQOPVAUETF-QHLBDZCJSA-N (2r,6r,11s)-3-(cyclopropylmethyl)-6-ethyl-8-hydroxy-11-methyl-3,4,5,6-tetrahydro-2,6-methano-3-benzazocin-1(2h)-one Chemical compound C([C@@]1([C@@H]([C@@H]2C(=O)C=3C1=CC(O)=CC=3)C)CC)CN2CC1CC1 SEJUQQOPVAUETF-QHLBDZCJSA-N 0.000 claims description 9
AGTSSZRZBSNTGQ-ITZCFHCWSA-N (2s,3r)-2-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[(2s)-2-[[2-[[2-[[(2s)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomet Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 AGTSSZRZBSNTGQ-ITZCFHCWSA-N 0.000 claims description 9
JVLBPIPGETUEET-WIXLDOGYSA-O (3r,4r,4as,7ar,12bs)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one Chemical compound C([N@+]1(C)[C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)C1CC1 JVLBPIPGETUEET-WIXLDOGYSA-O 0.000 claims description 9
LGFMXOTUSSVQJV-NEYUFSEYSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;(4r,4ar,7s,7ar,12bs)-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;1-[(3,4-dimethoxyphenyl)methyl]-6 Chemical compound Cl.Cl.Cl.O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C1=C(OC)C(OC)=CC=C1CC1=NC=CC2=CC(OC)=C(OC)C=C12 LGFMXOTUSSVQJV-NEYUFSEYSA-N 0.000 claims description 9
ICONPJDAXITIPI-UXYWFNEESA-N (4r,4as,7ar,12bs)-4a,9-dihydroxy-3-methyl-3-prop-2-enyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one;iodide Chemical compound [I-].O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CC[N+](C)(CC=C)[C@@H]3CC5=CC=C4O ICONPJDAXITIPI-UXYWFNEESA-N 0.000 claims description 9
DZUOQMBJJSBONO-CQSZACIVSA-N (6ar)-10-methoxy-6-methyl-5,6,6a,7-tetrahydro-4h-dibenzo[de,g]quinoline-11-ol Chemical compound CN1CCC2=CC=CC3=C2[C@H]1CC1=CC=C(OC)C(O)=C13 DZUOQMBJJSBONO-CQSZACIVSA-N 0.000 claims description 9
TVYLLZQTGLZFBW-ZBFHGGJFSA-N (R,R)-tramadol Chemical compound COC1=CC=CC([C@]2(O)[C@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-ZBFHGGJFSA-N 0.000 claims description 9
VFUGCQKESINERB-UHFFFAOYSA-N 3-(1-methyl-3-propylpyrrolidin-3-yl)phenol Chemical compound C=1C=CC(O)=CC=1C1(CCC)CCN(C)C1 VFUGCQKESINERB-UHFFFAOYSA-N 0.000 claims description 9
USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims description 9
RPXVIAFEQBNEAX-UHFFFAOYSA-N 6-Cyano-7-nitroquinoxaline-2,3-dione Chemical compound N1C(=O)C(=O)NC2=C1C=C([N+](=O)[O-])C(C#N)=C2 RPXVIAFEQBNEAX-UHFFFAOYSA-N 0.000 claims description 9
FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 claims description 9
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 9
IJVCSMSMFSCRME-KBQPJGBKSA-N Dihydromorphine Chemical compound O([C@H]1[C@H](CC[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O IJVCSMSMFSCRME-KBQPJGBKSA-N 0.000 claims description 9
OIJXLIIMXHRJJH-KNLIIKEYSA-N Diprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)C(C)(C)O)OC)CN2CC1CC1 OIJXLIIMXHRJJH-KNLIIKEYSA-N 0.000 claims description 9
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108010065372 Dynorphins Proteins 0.000 claims description 9
OGDVEMNWJVYAJL-LEPYJNQMSA-N Ethyl morphine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OCC OGDVEMNWJVYAJL-LEPYJNQMSA-N 0.000 claims description 9
OGDVEMNWJVYAJL-UHFFFAOYSA-N Ethylmorphine Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OCC OGDVEMNWJVYAJL-UHFFFAOYSA-N 0.000 claims description 9
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ALFGKMXHOUSVAD-UHFFFAOYSA-N Ketobemidone Chemical compound C=1C=CC(O)=CC=1C1(C(=O)CC)CCN(C)CC1 ALFGKMXHOUSVAD-UHFFFAOYSA-N 0.000 claims description 9
102400000243 Leu-enkephalin Human genes 0.000 claims description 9
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OZYUPQUCAUTOBP-QXAKKESOSA-N Levallorphan Chemical compound C([C@H]12)CCC[C@@]11CCN(CC=C)[C@@H]2CC2=CC=C(O)C=C21 OZYUPQUCAUTOBP-QXAKKESOSA-N 0.000 claims description 9
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102400000988 Met-enkephalin Human genes 0.000 claims description 9
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ZTVQQQVZCWLTDF-UHFFFAOYSA-N Remifentanil Chemical compound C1CN(CCC(=O)OC)CCC1(C(=O)OC)N(C(=O)CC)C1=CC=CC=C1 ZTVQQQVZCWLTDF-UHFFFAOYSA-N 0.000 claims description 9
101800001440 Rimorphin Proteins 0.000 claims description 9
102400000235 Rimorphin Human genes 0.000 claims description 9
GKNOXJZTQMLWTH-BBWFWOEESA-N [(1R,9R,10R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-trien-6-yl]methanol Chemical compound C1CCC[C@H]2[C@]3([H])NCC[C@@]21C1=CC=CC(CO)=C1C3 GKNOXJZTQMLWTH-BBWFWOEESA-N 0.000 claims description 9
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KGYFOSCXVAXULR-UHFFFAOYSA-N allylprodine Chemical compound C=1C=CC=CC=1C1(OC(=O)CC)CCN(C)CC1CC=C KGYFOSCXVAXULR-UHFFFAOYSA-N 0.000 claims description 9
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002666925A 2006-10-19 2007-10-17 Polytherapie utilisee dans le traitement de la douleur Abandoned CA2666925A1 (fr)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
US85281506P	2006-10-19	2006-10-19
US60/852,815		2006-10-19
US11/872,878		2007-10-16
US11/872,859		2007-10-16
US11/872,878 US20080113969A1 (en)	2006-10-19	2007-10-16	Combination therapy for the treatment of pain
US11/872,859 US20080108622A1 (en)	2006-10-19	2007-10-16	Combination therapy for the treatment of pain
US11/872,800		2007-10-16
US11/872,800 US20080108603A1 (en)	2006-10-19	2007-10-16	Combination therapy for the treatment of pain
PCT/US2007/081598 WO2008051760A2 (fr)	2006-10-19	2007-10-17	Polytherapie utilisee dans le traitement de la douleur

Publications (1)

Publication Number	Publication Date
CA2666925A1 true CA2666925A1 (fr)	2008-05-02

Family

ID=39325248

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002666925A Abandoned CA2666925A1 (fr)	2006-10-19	2007-10-17	Polytherapie utilisee dans le traitement de la douleur

Country Status (2)

Country	Link
CA (1)	CA2666925A1 (fr)
WO (1)	WO2008051760A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2100517A1 (fr)	2008-03-07	2009-09-16	Bayer CropScience Aktiengesellschaft	Utilisation d'alternan en tant qu'agent de texture pour des aliments et des produits cosmétiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6284794B1 (en) *	1996-11-05	2001-09-04	Head Explorer Aps	Method for treating tension-type headache with inhibitors of nitric oxide and nitric oxide synthase
US6489356B2 (en) *	2000-09-05	2002-12-03	Edward Leung	Method for treating pain in humans
US20060009478A1 (en) *	2003-10-15	2006-01-12	Nadav Friedmann	Methods for the treatment of back pain

2007
- 2007-10-17 CA CA002666925A patent/CA2666925A1/fr not_active Abandoned
- 2007-10-17 WO PCT/US2007/081598 patent/WO2008051760A2/fr not_active Ceased

Also Published As

Publication number	Publication date
WO2008051760A2 (fr)	2008-05-02
WO2008051760A3 (fr)	2008-07-31

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US7034036B2 (en)	2006-04-25	Inhibitors of ABC drug transporters at the blood-brain barrier
US20050038062A1 (en)	2005-02-17	Methods and materials for the treatment of pain comprising opioid antagonists
US6451857B1 (en)	2002-09-17	Analgesic compositions comprising anti-epileptic compounds and methods of using same
RU2541159C2 (ru)	2015-02-10	Композиции и способы для смягчения дыхательной недостаточности, вызванной передозировкой опиоидов
JP2001527554A (ja)	2001-12-25	抗うつ薬とｎｍｄａレセプター拮抗薬とを組み合わせる神経障害痛の治療用組成物及び治療方法
US20100227876A1 (en)	2010-09-09	Methods of Reducing Side Effects of Analgesics
JP2000508341A (ja)	2000-07-04	片頭痛の治療法及び薬効の強化組成物
JP2004501094A (ja)	2004-01-15	オピオイドアゴニストの効力を増強するか、またはオピオイドアゴニストの有害な副作用を減弱するための新規な組成物および方法
US20080108603A1 (en)	2008-05-08	Combination therapy for the treatment of pain
CA2666925A1 (fr)	2008-05-02	Polytherapie utilisee dans le traitement de la douleur
US20080113969A1 (en)	2008-05-15	Combination therapy for the treatment of pain
US20080108622A1 (en)	2008-05-08	Combination therapy for the treatment of pain
AU2004233582B2 (en)	2008-05-15	Pharmaceutical compositon comprising a cathepsin S inhibitor and an opioid
CA2427330A1 (fr)	2002-05-30	Inhibiteurs des transporteurs du medicament d'abc au niveau de la barriere hemato-encephalique
WO2012041258A1 (fr)	2012-04-05	Compositions et méthodes de traitement de l'hypertension au moyen de l'éprosartane et de l'amlodipine
AU2019201397A1 (en)	2019-03-21	Formulations and methods for attenuating respiratory depression induced by opioid overdose
EP1797883A2 (fr)	2007-06-20	Composition pharmaceutique comprenant un inhibiteur de la cathepsine S et un opiode
WO2016193456A2 (fr)	2016-12-08	Antagoniste de récepteur d'opioïde destiné à être utilisé dans le traitement de patients souffrant de constipation sévère
EP3302476A2 (fr)	2018-04-11	Antagoniste de récepteur d'opioïde destiné à être utilisé dans le traitement de patients souffrant de constipation sévère
WO2009106574A2 (fr)	2009-09-03	Combinaisons pour traiter la douleur associée au vih

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2010-10-18	FZDE	Dead