CA2664148A1 - Inhibiteurs de vegfr3 - Google Patents

Inhibiteurs de vegfr3 Download PDF

Info

Publication number: CA2664148A1
Authority: CA; Canada
Prior art keywords: cancer; represents hydrogen; compound; methoxy; vegfr3
Prior art date: 2006-10-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002664148A

Other languages

English (en)

Inventor

Timothy Pietro Suren Perera

Matthias Luc A. Versele

Martin John Page

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceutica NV

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-10-27

Filing date

2007-10-25

Publication date

2008-05-02

2007-10-25 Application filed by Individual filed Critical Individual

2008-05-02 Publication of CA2664148A1 publication Critical patent/CA2664148A1/fr

Status Abandoned legal-status Critical Current

Links

229940127432 VEGFR3 Inhibitors Drugs 0.000 title description 3
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230000001404 mediated effect Effects 0.000 claims abstract description 18
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108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 claims abstract description 7
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102100038234 Vascular endothelial growth factor D Human genes 0.000 claims abstract 3
206010028980 Neoplasm Diseases 0.000 claims description 76
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-1 avastin Chemical compound 0.000 claims description 38
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125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 37
238000011282 treatment Methods 0.000 claims description 36
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230000004936 stimulating effect Effects 0.000 description 1
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IHIXIJGXTJIKRB-UHFFFAOYSA-N trisodium vanadate Chemical compound [Na+].[Na+].[Na+].[O-][V]([O-])([O-])=O IHIXIJGXTJIKRB-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Reproductive Health (AREA)
Neurology (AREA)
Pregnancy & Childbirth (AREA)
Gynecology & Obstetrics (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

CA002664148A 2006-10-27 2007-10-25 Inhibiteurs de vegfr3 Abandoned CA2664148A1 (fr)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US86319806P	2006-10-27	2006-10-27
EP06123056		2006-10-27
EP06123056.1		2006-10-27
US60/863,198		2006-10-27
US97621007P	2007-09-28	2007-09-28
US60/976,210		2007-09-28
PCT/EP2007/061499 WO2008049902A2 (fr)	2006-10-27	2007-10-25	Inhibiteurs de vegfr3

Publications (1)

Publication Number	Publication Date
CA2664148A1 true CA2664148A1 (fr)	2008-05-02

Family

ID=39324960

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002664148A Abandoned CA2664148A1 (fr)	2006-10-27	2007-10-25	Inhibiteurs de vegfr3

Country Status (11)

Country	Link
EP (1)	EP2077845A2 (fr)
JP (1)	JP2010507626A (fr)
KR (1)	KR20090089849A (fr)
AU (1)	AU2007310843A1 (fr)
BR (1)	BRPI0718061A2 (fr)
CA (1)	CA2664148A1 (fr)
EA (1)	EA200970419A1 (fr)
IL (1)	IL198346A0 (fr)
MX (1)	MX2009004436A (fr)
NO (1)	NO20092045L (fr)
WO (1)	WO2008049902A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2549869C (fr)	2003-12-18	2015-05-05	Janssen Pharmaceutica N.V.	Anti-proliferants a base de derives pyrido- et pyrimidopyrimidine
NI200700147A (es)	2004-12-08	2019-05-10	Janssen Pharmaceutica Nv	Derivados de quinazolina inhibidores de cinasas dirigidos a multip
MX2009000456A (es)	2006-07-13	2009-01-27	Janssen Pharmaceutica Nv	Derivados de quinazolina mtki.
WO2009016132A1 (fr)	2007-07-27	2009-02-05	Janssen Pharmaceutica Nv	Pyrrolopyrimidines
US20120207671A1 (en) *	2010-04-15	2012-08-16	Vegenics Pty Limited	Combination treatment with vegf-c antagonists
CA2872979C (fr) *	2011-05-19	2020-02-18	Joaquin Pastor Fernandez	Composes macrocycliques en tant qu'inhibiteurs de proteine kinases

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JO2785B1 (en) *	2003-05-27	2014-03-15	شركة جانسين فارماسوتيكا ان. في	Quinazoline derivatives
CA2549869C (fr) *	2003-12-18	2015-05-05	Janssen Pharmaceutica N.V.	Anti-proliferants a base de derives pyrido- et pyrimidopyrimidine
JO3088B1 (ar) *	2004-12-08	2017-03-15	Janssen Pharmaceutica Nv	مشتقات كوينازولين كبيرة الحلقات و استعمالها بصفتها موانع كينيز متعددة الاهداف

2007
- 2007-10-25 JP JP2009533850A patent/JP2010507626A/ja not_active Withdrawn
- 2007-10-25 AU AU2007310843A patent/AU2007310843A1/en not_active Abandoned
- 2007-10-25 EA EA200970419A patent/EA200970419A1/ru unknown
- 2007-10-25 CA CA002664148A patent/CA2664148A1/fr not_active Abandoned
- 2007-10-25 WO PCT/EP2007/061499 patent/WO2008049902A2/fr not_active Ceased
- 2007-10-25 KR KR1020097009081A patent/KR20090089849A/ko not_active Withdrawn
- 2007-10-25 EP EP07821862A patent/EP2077845A2/fr not_active Withdrawn
- 2007-10-25 BR BRPI0718061-6A patent/BRPI0718061A2/pt not_active Application Discontinuation
- 2007-10-25 MX MX2009004436A patent/MX2009004436A/es unknown
2009
- 2009-04-23 IL IL198346A patent/IL198346A0/en unknown
- 2009-05-26 NO NO20092045A patent/NO20092045L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
JP2010507626A (ja)	2010-03-11
EP2077845A2 (fr)	2009-07-15
BRPI0718061A2 (pt)	2013-11-05
EA200970419A1 (ru)	2009-10-30
WO2008049902A2 (fr)	2008-05-02
IL198346A0 (en)	2010-02-17
NO20092045L (no)	2009-06-26
MX2009004436A (es)	2009-05-22
KR20090089849A (ko)	2009-08-24
WO2008049902A3 (fr)	2008-10-02
AU2007310843A1 (en)	2008-05-02

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AU2015278765B2 (en)	2018-08-16	Intermittent dosing of MDM2 inhibitor
JP4701159B2 (ja)	2011-06-15	ミエローマ細胞の細胞増殖、移動もしくはアポトーシス、又は血管形成と関係する疾患の治療用の組み合わせ
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US20130012465A1 (en)	2013-01-10	Bibw 2992 for use in the treatment of triple negative breast cancer
KR20090074202A (ko)	2009-07-06	Ｅｇｆｒ 돌연변이를 갖는 암을 치료하는 방법
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JP2019502675A (ja)	2019-01-31	ベンゾチオフェン系選択的エストロゲン受容体ダウンレギュレーター
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CA2664148A1 (fr)	2008-05-02	Inhibiteurs de vegfr3
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JP2018508563A (ja)	2018-03-29	Ｕｓｐ７阻害剤化合物及び使用方法
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JP2020143068A (ja)	2020-09-10	組み合わせ療法
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Legal Events

Date	Code	Title	Description
2011-10-25	FZDE	Discontinued