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CA2658559A1 - Induction de reponses immunes cellulaires au virus de la grippe grace a des compositions de peptides et d'acides nucleiques - Google Patents

Induction de reponses immunes cellulaires au virus de la grippe grace a des compositions de peptides et d'acides nucleiques Download PDF

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Publication number
CA2658559A1
CA2658559A1 CA002658559A CA2658559A CA2658559A1 CA 2658559 A1 CA2658559 A1 CA 2658559A1 CA 002658559 A CA002658559 A CA 002658559A CA 2658559 A CA2658559 A CA 2658559A CA 2658559 A1 CA2658559 A1 CA 2658559A1
Authority
CA
Canada
Prior art keywords
epitope
polynucleotide
hla
epitopes
htl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002658559A
Other languages
English (en)
Inventor
Jeffrey L. Alexander
Scott F. Southwood
Pamuk A. Bisel
Mark J. Newman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Epimmune Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2658559A1 publication Critical patent/CA2658559A1/fr
Abandoned legal-status Critical Current

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/39Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5256Virus expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55516Proteins; Peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55561CpG containing adjuvants; Oligonucleotide containing adjuvants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/555Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511Organic adjuvants
    • A61K2039/55566Emulsions, e.g. Freund's adjuvant, MF59
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/64Medicinal preparations containing antigens or antibodies characterised by the architecture of the carrier-antigen complex, e.g. repetition of carrier-antigen units
    • A61K2039/645Dendrimers; Multiple antigen peptides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
CA002658559A 2006-07-21 2007-07-23 Induction de reponses immunes cellulaires au virus de la grippe grace a des compositions de peptides et d'acides nucleiques Abandoned CA2658559A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83211206P 2006-07-21 2006-07-21
US60/832,112 2006-07-21
PCT/US2007/016529 WO2008039267A2 (fr) 2006-07-21 2007-07-23 Induction de réponses immunes cellulaires au virus de la grippe grâce à des compositions de peptides et d'acides nucléiques

Publications (1)

Publication Number Publication Date
CA2658559A1 true CA2658559A1 (fr) 2008-04-03

Family

ID=39230737

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002658559A Abandoned CA2658559A1 (fr) 2006-07-21 2007-07-23 Induction de reponses immunes cellulaires au virus de la grippe grace a des compositions de peptides et d'acides nucleiques

Country Status (4)

Country Link
EP (1) EP2069376A4 (fr)
AU (1) AU2007300663A1 (fr)
CA (1) CA2658559A1 (fr)
WO (1) WO2008039267A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111277B2 (en) 2016-12-28 2021-09-07 Invvax, Inc. Influenza vaccines

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0813922A2 (pt) * 2007-06-25 2017-05-09 Autoimmune Tech Llc composições de inibição de influenza e métodos.
ES2539818T3 (es) * 2007-08-02 2015-07-06 Biondvax Pharmaceuticals Ltd. Vacunas contra la gripe multiepitópicas multiméricas
EP2296688A2 (fr) * 2007-10-26 2011-03-23 Glykos Finland Oy Vaccin peptidique contre le virus de la grippe
FI20080333A0 (fi) * 2008-05-02 2008-05-02 Glykos Finland Oy Influenssaviruksen nukleiinihappoja ja peptidejä
EP2353610A4 (fr) * 2008-11-19 2013-12-11 Avi Mex S A De C V Lab Vaccin recombinant à vecteur viral inactivé
US8282938B2 (en) * 2008-11-28 2012-10-09 National Institute Of Infectious Diseases Immunogenic compositions comprising liposomes and an influenza PB2 CTL epitope obtained from the highly pathogenic H5N1 strain
JP2012516350A (ja) * 2009-01-28 2012-07-19 アンティジェン・エクスプレス・インコーポレーテッド インフルエンザに対する免疫応答を調節するIi−Keyハイブリッドペプチド
EP2391635B1 (fr) 2009-01-28 2017-04-26 Epimmune Inc. Polypeptides de liaison de pan-dr et leurs utilisations
CN101792745B (zh) * 2009-02-04 2014-09-17 中国科学院生物物理研究所 流感病毒聚合酶亚基pa氨基端多肽的表达纯化及pa氨基端多肽的晶体结构
CN101565455B (zh) * 2009-05-25 2012-03-14 中国科学院微生物研究所 禽流感h5n1病毒的ctl表位多肽及其应用
EP2437779B1 (fr) * 2009-06-01 2016-10-26 Her Majesty The Queen In Right of Canada as represented by The Minister of Health Réactifs et procédés de détection de protéines du virus de la grippe
RU2012107702A (ru) 2009-07-31 2013-09-10 Пэксвэкс, Инк. Векторы на основе аденовирусов
JP2013506682A (ja) * 2009-09-30 2013-02-28 セント ルイス ユニバーシティ 異種亜型インフルエンザt細胞応答を誘発するためのペプチド
CN102153621B (zh) * 2010-02-12 2014-07-02 广东省疾病预防控制中心 新型甲型h1n1流感na蛋白b细胞表位及其应用
WO2011101031A1 (fr) * 2010-02-19 2011-08-25 Université de Liège Polynucléotide pour utilisation dans le traitement de maladies induites par l'influenzavirus a, codant pour une protéine mx modifiée, ladite protéine mx modifiée, et animal transgénique exprimant un gène codant pour une protéine mx modifiée
WO2011138032A2 (fr) * 2010-05-05 2011-11-10 Artemev, Timur Vaccins antigrippaux universels et leurs procédés de production
CN105061534A (zh) 2010-09-22 2015-11-18 艾丽奥斯生物制药有限公司 取代的核苷酸类似物
CA2828068C (fr) 2011-02-22 2019-03-19 Biondvax Pharmaceuticals Ltd. Polypeptides multimeres multi-epitopes utilises dans des vaccins contre la grippe saisonniere et pandemique
WO2013059403A1 (fr) * 2011-10-19 2013-04-25 Immunotope, Inc. Immunogènes induisant des lymphocytes t cytotoxiques pour prévenir, traiter, et diagnostiquer l'infection par le virus de l'influenza
HK1203075A1 (en) 2011-12-22 2015-10-16 艾丽奥斯生物制药有限公司 Substituted phosphorothioate nucleotide analogs
WO2013093514A2 (fr) * 2011-12-23 2013-06-27 Retroscreen Virology Ltd Vaccins - peptides
EP2828277A1 (fr) 2012-03-21 2015-01-28 Vertex Pharmaceuticals Incorporated Formes solides d'un promédicament nucléotidique thiophosphoramidate
WO2013142157A1 (fr) 2012-03-22 2013-09-26 Alios Biopharma, Inc. Combinaisons pharmaceutiques comprenant un analogue thionucléotidique
EP2943221A1 (fr) * 2013-01-10 2015-11-18 Novartis AG Compositions immunogènes comprenant un virus influenza et utilisations associées
CN103333224B (zh) * 2013-05-10 2015-03-25 中国农业科学院哈尔滨兽医研究所 禽流感病毒ns1蛋白b细胞抗原表位多肽及其应用
JP6525214B2 (ja) * 2014-06-03 2019-06-05 国立研究開発法人農業・食品産業技術総合研究機構 抗体またはその可変領域を含む抗体断片、抗原ポリペプチド、およびその利用
CN106589105B (zh) * 2017-01-23 2020-09-15 中国医科大学 Hla-a2限制性ecm1特异性的ctl表位肽及其应用
EP3679056A1 (fr) 2017-09-08 2020-07-15 The University of Melbourne Procédés et compositions pour la prévention d'une infection grippale
US12239699B2 (en) * 2018-09-11 2025-03-04 Shanghai Public Health Clinical Center Immunogen for broad-spectrum influenza vaccine and application thereof
WO2020086927A1 (fr) 2018-10-26 2020-04-30 Saint Louis University Peptides pour induire des réponses hétérosubtypiques de lymphocytes t de la grippe
EP4168428A1 (fr) * 2020-06-19 2023-04-26 Intervet International B.V. Vaccin contre le virus de la grippe porcine comprenant une construction d'acide nucléique codant pour des antigènes de lignées de virus spécifiques
CN115768785A (zh) * 2020-06-19 2023-03-07 英特维特国际股份有限公司 包含含有编码病毒的不同神经氨酸酶抗原的第一、第二和第三核酸序列的核酸构建体的甲型猪流感病毒疫苗
WO2022032274A1 (fr) * 2020-08-02 2022-02-10 Richard Ascione Compositions de vaccins contre les virus de la grippe et méthodes d'utilisation
WO2022046895A2 (fr) * 2020-08-25 2022-03-03 Genentech, Inc. Dosages et réactifs pour la caractérisation de liaison peptidique mhci
CN116410271B (zh) * 2023-03-13 2024-07-19 华南农业大学 H5n1亚型aiv mhc b1限制性t细胞表位肽及其应用
CN120004989B (zh) * 2025-01-16 2025-12-05 华南农业大学 H5n1亚型aiv mhc b4限制性t细胞表位肽及其筛选方法和应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7572620B2 (en) * 2005-01-11 2009-08-11 Wisconsin Alumni Research Foundation H3 equine influenza A virus

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11111277B2 (en) 2016-12-28 2021-09-07 Invvax, Inc. Influenza vaccines
US11739127B2 (en) 2016-12-28 2023-08-29 Invvax, Inc. Influenza vaccines
US12234263B2 (en) 2016-12-28 2025-02-25 Invvax, Inc. Influenza vaccines

Also Published As

Publication number Publication date
WO2008039267A2 (fr) 2008-04-03
WO2008039267A3 (fr) 2008-12-31
EP2069376A4 (fr) 2013-10-16
EP2069376A2 (fr) 2009-06-17
AU2007300663A1 (en) 2008-04-03

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20140723