CA2647360C - Procedes et compositions de dissuasion d'abus de produits pharmaceutiques a administration orale - Google Patents

Procedes et compositions de dissuasion d'abus de produits pharmaceutiques a administration orale Download PDF

Info

Publication number: CA2647360C
Authority: CA; Canada
Prior art keywords: alkyl; esters; irritant; present; composition
Prior art date: 2006-03-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

CA2647360A

Other languages

English (en)

Other versions

CA2647360A1 (fr

Inventor

James F. Emigh

Andrew D. Reddick

Ron J. Spivey

Ronald L. Leech, Jr.

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Acura Pharmaceuticals Inc

Original Assignee

Acura Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-03-15

Filing date

2007-03-14

Publication date

2012-05-15

2007-03-14 Application filed by Acura Pharmaceuticals Inc filed Critical Acura Pharmaceuticals Inc

2007-09-20 Publication of CA2647360A1 publication Critical patent/CA2647360A1/fr

2012-05-15 Application granted granted Critical

2012-05-15 Publication of CA2647360C publication Critical patent/CA2647360C/fr

Status Expired - Fee Related legal-status Critical Current

2027-03-14 Anticipated expiration legal-status Critical

Links

239000000203 mixture Substances 0.000 title claims abstract description 189
238000000034 method Methods 0.000 title description 85
239000000825 pharmaceutical preparation Substances 0.000 title description 7
229940127557 pharmaceutical product Drugs 0.000 title description 7
229920000642 polymer Polymers 0.000 claims abstract description 54
238000011010 flushing procedure Methods 0.000 claims abstract description 50
-1 polyoxyethylene Polymers 0.000 claims description 103
231100000021 irritant Toxicity 0.000 claims description 89
239000002085 irritant Substances 0.000 claims description 89
239000000499 gel Substances 0.000 claims description 68
210000001519 tissue Anatomy 0.000 claims description 61
239000008194 pharmaceutical composition Substances 0.000 claims description 41
229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 34
230000000202 analgesic effect Effects 0.000 claims description 32
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 30
235000001968 nicotinic acid Nutrition 0.000 claims description 29
239000011664 nicotinic acid Substances 0.000 claims description 29
229960003512 nicotinic acid Drugs 0.000 claims description 27
210000004400 mucous membrane Anatomy 0.000 claims description 26
239000002904 solvent Substances 0.000 claims description 23
230000001225 therapeutic effect Effects 0.000 claims description 19
229920001577 copolymer Polymers 0.000 claims description 18
239000000014 opioid analgesic Substances 0.000 claims description 18
150000001298 alcohols Chemical class 0.000 claims description 11
150000001412 amines Chemical class 0.000 claims description 11
235000014113 dietary fatty acids Nutrition 0.000 claims description 11
229930195729 fatty acid Natural products 0.000 claims description 11
239000000194 fatty acid Substances 0.000 claims description 11
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 9
229910019142 PO4 Inorganic materials 0.000 claims description 9
239000002202 Polyethylene glycol Chemical class 0.000 claims description 9
235000021317 phosphate Nutrition 0.000 claims description 9
150000004665 fatty acids Chemical class 0.000 claims description 8
229920001223 polyethylene glycol Polymers 0.000 claims description 8
150000002334 glycols Chemical class 0.000 claims description 7
231100000331 toxic Toxicity 0.000 claims description 7
230000002588 toxic effect Effects 0.000 claims description 7
239000004166 Lanolin Chemical class 0.000 claims description 6
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235000019388 lanolin Nutrition 0.000 claims description 6
150000004760 silicates Chemical class 0.000 claims description 6
235000021355 Stearic acid Nutrition 0.000 claims description 5
239000002738 chelating agent Substances 0.000 claims description 5
150000002148 esters Chemical class 0.000 claims description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 5
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 5
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 5
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 5
239000008117 stearic acid Substances 0.000 claims description 5
150000003871 sulfonates Chemical class 0.000 claims description 5
JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical class OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims description 4
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 4
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 4
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 4
239000005642 Oleic acid Substances 0.000 claims description 4
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 4
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical class OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
125000000217 alkyl group Chemical group 0.000 claims description 4
235000019270 ammonium chloride Nutrition 0.000 claims description 4
239000003599 detergent Substances 0.000 claims description 4
239000002270 dispersing agent Substances 0.000 claims description 4
239000003974 emollient agent Substances 0.000 claims description 4
239000003995 emulsifying agent Substances 0.000 claims description 4
239000003623 enhancer Substances 0.000 claims description 4
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 4
239000004088 foaming agent Substances 0.000 claims description 4
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims description 4
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 4
229920000847 nonoxynol Polymers 0.000 claims description 4
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239000004721 Polyphenylene oxide Substances 0.000 claims description 3
150000003973 alkyl amines Chemical class 0.000 claims description 3
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125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 3
150000001735 carboxylic acids Chemical class 0.000 claims description 3
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235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 3
AMTWCFIAVKBGOD-UHFFFAOYSA-N dioxosilane;methoxy-dimethyl-trimethylsilyloxysilane Chemical compound O=[Si]=O.CO[Si](C)(C)O[Si](C)(C)C AMTWCFIAVKBGOD-UHFFFAOYSA-N 0.000 claims description 3
125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 3
MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical class CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 claims description 3
150000002170 ethers Chemical class 0.000 claims description 3
239000003925 fat Substances 0.000 claims description 3
239000000787 lecithin Substances 0.000 claims description 3
235000010445 lecithin Nutrition 0.000 claims description 3
JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 3
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150000007524 organic acids Chemical class 0.000 claims description 3
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150000003013 phosphoric acid derivatives Chemical class 0.000 claims description 3
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239000010773 plant oil Chemical class 0.000 claims description 3
229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 3
229920001748 polybutylene Polymers 0.000 claims description 3
102000004169 proteins and genes Human genes 0.000 claims description 3
108090000623 proteins and genes Proteins 0.000 claims description 3
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150000003467 sulfuric acid derivatives Chemical class 0.000 claims description 3
239000003760 tallow Substances 0.000 claims description 3
XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 3
CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical class C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 2
ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 claims 4
239000002518 antifoaming agent Substances 0.000 claims 3
239000000080 wetting agent Substances 0.000 claims 3
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 2
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical class OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
125000005210 alkyl ammonium group Chemical group 0.000 claims 2
150000008055 alkyl aryl sulfonates Chemical class 0.000 claims 2
125000005599 alkyl carboxylate group Chemical group 0.000 claims 2
125000005211 alkyl trimethyl ammonium group Chemical group 0.000 claims 2
125000005233 alkylalcohol group Chemical group 0.000 claims 2
150000003868 ammonium compounds Chemical class 0.000 claims 2
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 claims 2
150000002306 glutamic acid derivatives Chemical class 0.000 claims 2
150000002314 glycerols Chemical class 0.000 claims 2
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
150000004702 methyl esters Chemical class 0.000 claims 2
PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 claims 2
239000010702 perfluoropolyether Substances 0.000 claims 2
229920000570 polyether Polymers 0.000 claims 2
229920005606 polypropylene copolymer Polymers 0.000 claims 2
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125000001453 quaternary ammonium group Chemical group 0.000 claims 2
231100000323 severe irritant Toxicity 0.000 claims 2
150000003445 sucroses Chemical class 0.000 claims 2
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239000003826 tablet Substances 0.000 description 71
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VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 48
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Inorganic Chemistry (AREA)
Botany (AREA)
Zoology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CA2647360A 2006-03-15 2007-03-14 Procedes et compositions de dissuasion d'abus de produits pharmaceutiques a administration orale Expired - Fee Related CA2647360C (fr)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US78244806P	2006-03-15	2006-03-15
US60/782,448		2006-03-15
PCT/US2007/006519 WO2007106550A2 (fr)	2006-03-15	2007-03-14	Procédés et compositions de dissuasion d'abus de produits pharmaceutiques à administration orale

Publications (2)

Publication Number	Publication Date
CA2647360A1 CA2647360A1 (fr)	2007-09-20
CA2647360C true CA2647360C (fr)	2012-05-15

Family

ID=38510088

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA2647360A Expired - Fee Related CA2647360C (fr)	2006-03-15	2007-03-14	Procedes et compositions de dissuasion d'abus de produits pharmaceutiques a administration orale

Country Status (5)

Country	Link
EP (1)	EP1993519A4 (fr)
AU (1)	AU2007225101A1 (fr)
CA (1)	CA2647360C (fr)
IL (1)	IL193766A0 (fr)
WO (1)	WO2007106550A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8486449B2 (en)	2008-12-16	2013-07-16	Paladin Labs Inc.	Misuse preventative, controlled release formulation

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2003024429A1 (fr)	2001-09-21	2003-03-27	Egalet A/S	Systeme de liberation a base de polymere
US20040253310A1 (en)	2001-09-21	2004-12-16	Gina Fischer	Morphine polymer release system
EP1610767B1 (fr)	2003-03-26	2011-01-19	Egalet A/S	Systeme de liberation regulee de morphine
WO2008148798A2 (fr)	2007-06-04	2008-12-11	Egalet A/S	Compositions pharmaceutiques à libération contrôlée pour un effet prolongé
AU2008338442A1 (en) *	2007-12-17	2009-06-25	Alpharma Pharmaceuticals, Llc	Pharmaceutical composition
CN101969930A (zh)	2007-12-17	2011-02-09	莱博法姆公司	防滥用控制释放制剂
AU2015200313B2 (en) *	2007-12-17	2016-12-01	Alpharma Pharmaceuticals, Llc	Pharmaceutical composition
CA2751667C (fr)	2009-02-06	2016-12-13	Egalet Ltd.	Composition a liberation immediate resistant a une maltraitance par prise d'alcool
EP2445487A2 (fr)	2009-06-24	2012-05-02	Egalet Ltd.	Formulations à libération contrôlée
MX2014015880A (es)	2012-07-06	2015-08-05	Egalet Ltd	Composiciones farmaceuticas disuasivas de abuso para liberacion controlada.
WO2015023675A2 (fr)	2013-08-12	2015-02-19	Pharmaceutical Manufacturing Research Services, Inc.	Comprimé extrudé anti-abus à libération immédiate
US10172797B2 (en)	2013-12-17	2019-01-08	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
US9492444B2 (en)	2013-12-17	2016-11-15	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
AU2015290098B2 (en)	2014-07-17	2018-11-01	Pharmaceutical Manufacturing Research Services, Inc.	Immediate release abuse deterrent liquid fill dosage form
US9132096B1 (en)	2014-09-12	2015-09-15	Alkermes Pharma Ireland Limited	Abuse resistant pharmaceutical compositions
AU2015336065A1 (en)	2014-10-20	2017-05-04	Pharmaceutical Manufacturing Research Services, Inc.	Extended release abuse deterrent liquid fill dosage form

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10250084A1 (de) *	2002-10-25	2004-05-06	Grünenthal GmbH	Gegen Missbrauch gesicherte Darreichungsform
US7201920B2 (en) *	2003-11-26	2007-04-10	Acura Pharmaceuticals, Inc.	Methods and compositions for deterring abuse of opioid containing dosage forms
US20060177380A1 (en) *	2004-11-24	2006-08-10	Acura Pharmaceuticals, Inc.	Methods and compositions for deterring abuse of orally administered pharmaceutical products
US20060110327A1 (en) *	2004-11-24	2006-05-25	Acura Pharmaceuticals, Inc.	Methods and compositions for deterring abuse of orally administered pharmaceutical products

2007
- 2007-03-14 EP EP07753168A patent/EP1993519A4/fr not_active Withdrawn
- 2007-03-14 CA CA2647360A patent/CA2647360C/fr not_active Expired - Fee Related
- 2007-03-14 WO PCT/US2007/006519 patent/WO2007106550A2/fr not_active Ceased
- 2007-03-14 AU AU2007225101A patent/AU2007225101A1/en not_active Abandoned
2008
- 2008-08-28 IL IL193766A patent/IL193766A0/en unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8486449B2 (en)	2008-12-16	2013-07-16	Paladin Labs Inc.	Misuse preventative, controlled release formulation

Also Published As

Publication number	Publication date
WO2007106550A2 (fr)	2007-09-20
WO2007106550A3 (fr)	2008-06-12
IL193766A0 (en)	2011-08-01
EP1993519A4 (fr)	2011-12-21
CA2647360A1 (fr)	2007-09-20
EP1993519A2 (fr)	2008-11-26
AU2007225101A1 (en)	2007-09-20

Publication	Publication Date	Title
CA2647360C (fr)	2012-05-15	Procedes et compositions de dissuasion d'abus de produits pharmaceutiques a administration orale
US20120202839A1 (en)	2012-08-09	Methods and compositions for deterring abuse of orally administered pharmaceutical products
US20070231268A1 (en)	2007-10-04	Methods and compositions for deterring abuse of orally administered pharmaceutical products
US20060110327A1 (en)	2006-05-25	Methods and compositions for deterring abuse of orally administered pharmaceutical products
US20060177380A1 (en)	2006-08-10	Methods and compositions for deterring abuse of orally administered pharmaceutical products
US20240108726A1 (en)	2024-04-04	Methods and compositions for self-regulated release of active pharmaceutical ingredient
CA2502965C (fr)	2016-04-12	Forme galenique protegee contre un usage detourne
AU2004264667B2 (en)	2008-11-06	Abuse-proofed dosage form
US10632113B2 (en)	2020-04-28	Abuse-resistant drug formulations with built-in overdose protection
NZ545202A (en)	2010-03-26	Abuse-proofed dosage form comprising opiods and a high molecular weight polyethylene oxide
AU2012201450A1 (en)	2012-04-05	Methods and compositions for deterring abuse of orally administered pharmaceutical products
US20170056501A1 (en)	2017-03-02	Methods and compositions for self-regulated release of active pharmaceutical ingredient
IL183362A (en)	2014-09-30	Preparations to discourage the misuse of oral pharmaceutical products

Legal Events

Date	Code	Title	Description
2009-03-24	EEER	Examination request
2019-04-25	MKLA	Lapsed	Effective date: 20190314

CA2647360C - Procedes et compositions de dissuasion d'abus de produits pharmaceutiques a administration orale - Google Patents

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Applications Claiming Priority (3)

Publications (2)

Family

ID=38510088

Family Applications (1)

Country Status (5)

Cited By (1)

Families Citing this family (16)

Family Cites Families (4)

Cited By (1)

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