CA2536305C - Epitopes sod-1 et anticorps - Google Patents
Epitopes sod-1 et anticorps Download PDFInfo
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- CA2536305C CA2536305C CA2536305A CA2536305A CA2536305C CA 2536305 C CA2536305 C CA 2536305C CA 2536305 A CA2536305 A CA 2536305A CA 2536305 A CA2536305 A CA 2536305A CA 2536305 C CA2536305 C CA 2536305C
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- polypeptide
- antibody
- epitope
- disease
- protein
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- Expired - Lifetime
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Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne un dosage de protection d'épitope destiné à servir dans le diagnostic, le pronostic et l'intervention thérapeutique dans le cas de maladies qui impliquent, par exemple, l'agrégation de polypeptides, telles que des infections par le prion. Les procédés selon l'invention permettent de bloquer en premier lieu l'épitope cible de polypeptide accessible au moyen d'un agent bloquant. Après dénaturation du polypeptide, on utilise un agent de détection pour détecter la protéine renfermant l'épitope cible qui était accessible lors du contact avec l'agent bloquant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2536305A CA2536305C (fr) | 2003-08-20 | 2004-08-20 | Epitopes sod-1 et anticorps |
Applications Claiming Priority (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49638103P | 2003-08-20 | 2003-08-20 | |
| CA002437675A CA2437675A1 (fr) | 2003-08-20 | 2003-08-20 | Methodes de detection de proteine prion |
| CA2,437,675 | 2003-08-20 | ||
| US60/496,381 | 2003-08-20 | ||
| US49736203P | 2003-08-21 | 2003-08-21 | |
| CA2,437,999 | 2003-08-21 | ||
| CA2437999A CA2437999C (fr) | 2003-08-20 | 2003-08-21 | Methodes de detection d'une proteine prion |
| US60/497,362 | 2003-08-21 | ||
| PCT/CA2004/001503 WO2005019828A1 (fr) | 2003-08-20 | 2004-08-20 | Dosage de protection d'epitope et procede de detection de conformations proteiques |
| CA2536305A CA2536305C (fr) | 2003-08-20 | 2004-08-20 | Epitopes sod-1 et anticorps |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2536305A1 CA2536305A1 (fr) | 2005-03-03 |
| CA2536305C true CA2536305C (fr) | 2015-10-27 |
Family
ID=36242730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2536305A Expired - Lifetime CA2536305C (fr) | 2003-08-20 | 2004-08-20 | Epitopes sod-1 et anticorps |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2536305C (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9637552B2 (en) | 2005-12-02 | 2017-05-02 | Promis Neurosciences Inc. | Methods and compositions to treat and detect misfolded-SOD1 mediated diseases |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070003977A1 (en) | 2003-08-20 | 2007-01-04 | Amorfix Life Sciences Ltd | Epitope protection assay and method for detecting protein conformations |
| US7887803B2 (en) | 2005-12-02 | 2011-02-15 | Amorfix Life Sciences | Methods and compositions to treat misfolded-SOD1 mediated diseases |
| US7794692B2 (en) | 2005-12-02 | 2010-09-14 | Amorfix Life Sciences Ltd. | Methods and compositions for detecting amyotrophic lateral sclerosis |
| BR112023001575A2 (pt) * | 2020-07-30 | 2023-04-04 | Diadem S P A | Método in vitro ou ex vivo para diagnóstico ou prognóstico de doença neurodegenerativa e uso de um kit diagnóstico para implementação do mesmo |
-
2004
- 2004-08-20 CA CA2536305A patent/CA2536305C/fr not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9637552B2 (en) | 2005-12-02 | 2017-05-02 | Promis Neurosciences Inc. | Methods and compositions to treat and detect misfolded-SOD1 mediated diseases |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2536305A1 (fr) | 2005-03-03 |
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