CA2527109A1 - Arn oligobicatenaire inhibant l'expression de bcl-2 et composition medicinale contenant cet arn - Google Patents
Arn oligobicatenaire inhibant l'expression de bcl-2 et composition medicinale contenant cet arn Download PDFInfo
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- CA2527109A1 CA2527109A1 CA002527109A CA2527109A CA2527109A1 CA 2527109 A1 CA2527109 A1 CA 2527109A1 CA 002527109 A CA002527109 A CA 002527109A CA 2527109 A CA2527109 A CA 2527109A CA 2527109 A1 CA2527109 A1 CA 2527109A1
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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| JP2004-104036 | 2004-03-31 | ||
| JP2004104036 | 2004-03-31 | ||
| PCT/JP2004/007378 WO2004106511A1 (fr) | 2003-05-30 | 2004-05-28 | Arn oligobicatenaire inhibant l'expression de bcl-2 et composition medicinale contenant cet arn |
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| CA (1) | CA2527109A1 (fr) |
| WO (1) | WO2004106511A1 (fr) |
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| US7767802B2 (en) * | 2001-01-09 | 2010-08-03 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| US7423142B2 (en) | 2001-01-09 | 2008-09-09 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of anti-apoptotic genes |
| DK2284266T3 (da) | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| CA2527301A1 (fr) * | 2003-05-30 | 2004-12-09 | Nippon Shinyaku Co., Ltd. | Composite contenant un acide oligonucleique et composition pharmaceutique contenant ledit composite |
| WO2005079533A2 (fr) * | 2004-02-17 | 2005-09-01 | University Of Massachusetts | Procedes et compositions de mediation du silençage genique |
| DE102004023187A1 (de) * | 2004-05-11 | 2005-12-01 | Ganymed Pharmaceuticals Ag | Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie |
| WO2006129594A1 (fr) | 2005-05-30 | 2006-12-07 | Nippon Shinyaku Co., Ltd. | Procédé servant à produire une préparation complexe contenant des acides nucléiques |
| CN103290009B (zh) | 2006-06-08 | 2015-02-11 | 阿明诺化学株式会社 | 具有促进iNOS mRNA的分解的NO产生抑制活性的正义寡核苷酸以及iNOS产生量的抑制方法 |
| NZ574033A (en) | 2006-06-08 | 2013-03-28 | Amino Up Chemical Co Ltd | Method for controlling the amount of gene product, and agent for controlling the amount of gene product |
| US20100279408A1 (en) * | 2006-11-27 | 2010-11-04 | Enzon Pharmaceuticals, Inc. | Polymeric short interfering rna conjugates |
| WO2009152500A2 (fr) * | 2008-06-13 | 2009-12-17 | University Of Massachusetts | Procédés et compositions pour médier l'inhibition de l'expression génique |
| RU2476204C2 (ru) | 2008-06-19 | 2013-02-27 | Ниппон Синяку Ко., Лтд. | Носитель лекарственного средства |
| EP2310021A4 (fr) * | 2008-07-10 | 2012-06-27 | Merck Sharp & Dohme | Procédés d'utilisation de compositions comportant mir-192 et/ou mir-215 pour le traitement d'un cancer |
| CN108165548B (zh) * | 2008-09-22 | 2022-10-14 | 菲奥医药公司 | 减小大小的自递送RNAi化合物 |
| JP2012509066A (ja) * | 2008-11-17 | 2012-04-19 | エンゾン ファーマシューティカルズ，インコーポレーテッド | 核酸送達系のための放出可能接合体 |
| JP2012147677A (ja) * | 2009-05-14 | 2012-08-09 | Nippon Shinyaku Co Ltd | 二本鎖修飾ｒｎａ |
| EP2270510A1 (fr) * | 2009-07-02 | 2011-01-05 | EMBL (European Molecular Biology Laboratory) | Procédé de diagnostic pour prédire le risque de récurrence de cancer basé sur des isoformes macroH2A d'histone |
| CN101974532A (zh) * | 2010-10-28 | 2011-02-16 | 百奥迈科生物技术有限公司 | 一种干扰Bcl-2基因表达的siRNA分子及其应用 |
| CN101974533B (zh) * | 2010-10-28 | 2017-09-15 | 百奥迈科生物技术有限公司 | 一种抑制Bcl‑2基因表达的siRNA分子及其应用 |
| MX394957B (es) * | 2015-09-03 | 2025-03-24 | Ono Pharmaceutical Co | Agente mejorador de la inmunidad contra el cancer por el antagonista de "allergin-1". |
| JP2019500591A (ja) * | 2015-11-13 | 2019-01-10 | マサチューセッツ・インスティトュート・オブ・テクノロジー | がん細胞を検出及び修飾するための方法及び組成物 |
| KR101966246B1 (ko) * | 2015-11-17 | 2019-04-05 | 서울대학교산학협력단 | FCHo1 조절제를 포함하는 세포 분열 조절용 조성물 및 이를 이용한 세포 분열 조절 방법 |
| CN110546277B (zh) | 2017-03-01 | 2024-06-11 | 豪夫迈·罗氏有限公司 | 用于癌症的诊断和治疗方法 |
| TW201841934A (zh) * | 2017-04-10 | 2018-12-01 | 德商英麥提克生物技術股份有限公司 | 用於治療癌症免疫治療的新穎肽及其肽組合物 |
| CN111533799A (zh) | 2017-04-10 | 2020-08-14 | 伊玛提克斯生物技术有限公司 | 用于白血病和其他癌症免疫治疗的肽和肽组合物 |
| EA201992416A1 (ru) * | 2017-04-10 | 2020-02-25 | Имматикс Байотекнолоджиз Гмбх | Пептиды и комбинации пептидов для применения в иммунотерапии лейкозов и других видов рака |
| CN111533796A (zh) | 2017-04-10 | 2020-08-14 | 伊玛提克斯生物技术有限公司 | 用于癌症免疫治疗的肽及其肽组合物 |
| JP7264382B2 (ja) * | 2018-05-17 | 2023-04-25 | オリーブス バイオセラピューティクス インコーポレイテッド | 網膜疾患を予防又は治療するための、有効成分としてｃｃｎ５を含む医薬組成物 |
| CN115697374A (zh) * | 2020-05-12 | 2023-02-03 | 得克萨斯州大学系统董事会 | 用于治疗胶质母细胞瘤的方法 |
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|---|---|---|---|---|
| KR100334858B1 (ko) * | 1993-02-19 | 2006-01-27 | 니뽄 신야쿠 가부시키가이샤 | 핵산공중합체를함유하는의약조성물 |
| PT1584682E (pt) | 1993-09-20 | 2009-08-03 | Univ Pennsylvania | Regulação da expressão do gene bcl-2 |
| IT1275862B1 (it) | 1995-03-03 | 1997-10-24 | Consiglio Nazionale Ricerche | Trascritto antisenso associato ad alcuni tipi di cellule tumorali ed oligodeossinucleotidi sintetici utili nella diagnosi e nel trattamento |
| US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| GB9711919D0 (en) | 1997-06-09 | 1997-08-06 | Ciba Geigy Ag | Oligonucleotide derivatives |
| TW524693B (en) * | 1997-10-16 | 2003-03-21 | Nippon Shinyaku Co Ltd | Cancer cell nuclease activator |
| US6506559B1 (en) | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| WO1999061032A1 (fr) * | 1998-05-25 | 1999-12-02 | Nippon Shinyaku Co., Ltd. | Procede de production d'une preparation composite contenant de l'acide nucleique |
| DE10100586C1 (de) * | 2001-01-09 | 2002-04-11 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines Ziegens |
| DE10160151A1 (de) | 2001-01-09 | 2003-06-26 | Ribopharma Ag | Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens |
| AU2001245793A1 (en) | 2000-03-16 | 2001-09-24 | Cold Spring Harbor Laboratory | Methods and compositions for rna interference |
| EP1309726B2 (fr) | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Mediateurs d'interference arn specifiques de sequences arn |
| US7795232B1 (en) | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| RU2322500C2 (ru) * | 2000-12-01 | 2008-04-20 | Макс-Планк-Гезелльшафт Цур Фердерунг Дер Виссеншафтен Е.Ф. | Малые молекулы рнк, опосредующие интерференцию рнк |
| CA2433680A1 (fr) * | 2000-12-28 | 2002-08-01 | Gregory M Arndt | Suppression de gene mediee par arn bicatenaire |
| AU2003213119A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF BCL2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US20040072769A1 (en) * | 2002-09-16 | 2004-04-15 | Yin James Qinwei | Methods for design and selection of short double-stranded oligonucleotides, and compounds of gene drugs |
| DK2284266T3 (da) * | 2002-11-14 | 2014-01-13 | Thermo Fisher Scient Biosciences Inc | sIRNA-MOLEKYLE MOD TP53 |
| CN101914532A (zh) * | 2002-11-22 | 2010-12-15 | 生物智囊团株式会社 | Rna干扰的目标碱基序列的搜索方法 |
-
2004
- 2004-05-28 EP EP04745414A patent/EP1640452A4/fr not_active Withdrawn
- 2004-05-28 WO PCT/JP2004/007378 patent/WO2004106511A1/fr not_active Ceased
- 2004-05-28 EP EP10168680A patent/EP2251039A3/fr not_active Withdrawn
- 2004-05-28 CA CA002527109A patent/CA2527109A1/fr not_active Abandoned
- 2004-05-28 JP JP2005506507A patent/JP4505749B2/ja not_active Expired - Fee Related
- 2004-05-28 KR KR1020057022831A patent/KR20060013426A/ko not_active Ceased
- 2004-05-28 US US10/559,083 patent/US20080020990A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2251039A2 (fr) | 2010-11-17 |
| US20080020990A1 (en) | 2008-01-24 |
| WO2004106511A1 (fr) | 2004-12-09 |
| KR20060013426A (ko) | 2006-02-09 |
| EP1640452A4 (fr) | 2009-12-23 |
| EP2251039A3 (fr) | 2010-12-08 |
| EP1640452A1 (fr) | 2006-03-29 |
| JPWO2004106511A1 (ja) | 2006-07-20 |
| JP4505749B2 (ja) | 2010-07-21 |
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| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130528 |