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CA2558659A1 - Genetically engineered canary poxvirus-based vaccine strain - Google Patents

Genetically engineered canary poxvirus-based vaccine strain Download PDF

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Publication number
CA2558659A1
CA2558659A1 CA002558659A CA2558659A CA2558659A1 CA 2558659 A1 CA2558659 A1 CA 2558659A1 CA 002558659 A CA002558659 A CA 002558659A CA 2558659 A CA2558659 A CA 2558659A CA 2558659 A1 CA2558659 A1 CA 2558659A1
Authority
CA
Canada
Prior art keywords
virus
inactivated
recombinant
genetic functions
poxvirus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002558659A
Other languages
French (fr)
Other versions
CA2558659C (en
Inventor
Enzo Paoletti
Marion E. Perkus
Jill Taylor
James Tartaglia
Elizabeth K. Norton
Michel Riviere
Charles De Taisne
Keith J. Limbach
Gerard P. Johnson
Steven E. Pincus
William I. Cox
Jean-Christophe F. Audonnet
Russell Robert Gettig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Connaught Technology Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Priority to CA2621088A priority Critical patent/CA2621088C/en
Priority claimed from CA002105277A external-priority patent/CA2105277C/en
Publication of CA2558659A1 publication Critical patent/CA2558659A1/en
Application granted granted Critical
Publication of CA2558659C publication Critical patent/CA2558659C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant canary poxvirus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence.
In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor.
In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
CA002558659A 1991-03-07 1992-03-09 Genetically engineered canary poxvirus-based vaccine strain Expired - Lifetime CA2558659C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2621088A CA2621088C (en) 1991-03-07 1992-03-09 Genetically engineered fowlpox-based vaccine strain

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US66605691A 1991-03-07 1991-03-07
US666,056 1991-03-07
US71396791A 1991-06-11 1991-06-11
US713,967 1991-06-11
US84795192A 1992-03-06 1992-03-06
US847,951 1992-03-06
CA002105277A CA2105277C (en) 1991-03-07 1992-03-09 Genetically engineered vaccine strain

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002105277A Division CA2105277C (en) 1991-03-07 1992-03-09 Genetically engineered vaccine strain

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2621088A Division CA2621088C (en) 1991-03-07 1992-03-09 Genetically engineered fowlpox-based vaccine strain

Publications (2)

Publication Number Publication Date
CA2558659A1 true CA2558659A1 (en) 1992-09-17
CA2558659C CA2558659C (en) 2008-06-03

Family

ID=37310264

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002558659A Expired - Lifetime CA2558659C (en) 1991-03-07 1992-03-09 Genetically engineered canary poxvirus-based vaccine strain

Country Status (1)

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CA (1) CA2558659C (en)

Also Published As

Publication number Publication date
CA2558659C (en) 2008-06-03

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