CA2557959A1 - Compositions de peroxyde stabilisees - Google Patents

Compositions de peroxyde stabilisees Download PDF

Info

Publication number: CA2557959A1
Authority: CA; Canada
Prior art keywords: gum; peroxide; composition according; beaker; water soluble
Prior art date: 2004-03-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Abandoned

Application number

CA002557959A

Other languages

English (en)

Inventor

Constantine Argy Georgiades

Seema Kirtikumar Mody

Andre Anatoly Soshinsky

Zhen Zhang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Warner Lambert Co LLC

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-03-03

Filing date

2005-02-21

Publication date

2005-10-06

2004-03-03 Priority claimed from US10/792,370 external-priority patent/US20050196348A1/en

2005-02-21 Application filed by Individual filed Critical Individual

2005-10-06 Publication of CA2557959A1 publication Critical patent/CA2557959A1/fr

Status Abandoned legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 124
150000002978 peroxides Chemical class 0.000 title claims description 22
-1 peroxide compounds Chemical class 0.000 claims abstract description 22
MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 52
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 29
229920000591 gum Polymers 0.000 claims description 27
229920000084 Gum arabic Polymers 0.000 claims description 16
235000010489 acacia gum Nutrition 0.000 claims description 16
239000000205 acacia gum Substances 0.000 claims description 16
229920001285 xanthan gum Polymers 0.000 claims description 15
235000010418 carrageenan Nutrition 0.000 claims description 14
239000000679 carrageenan Substances 0.000 claims description 14
229920001525 carrageenan Polymers 0.000 claims description 14
229940113118 carrageenan Drugs 0.000 claims description 14
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 14
244000215068 Acacia senegal Species 0.000 claims description 13
235000010493 xanthan gum Nutrition 0.000 claims description 13
239000000230 xanthan gum Substances 0.000 claims description 13
229940082509 xanthan gum Drugs 0.000 claims description 13
229920000161 Locust bean gum Polymers 0.000 claims description 12
235000010420 locust bean gum Nutrition 0.000 claims description 12
239000000711 locust bean gum Substances 0.000 claims description 12
230000000699 topical effect Effects 0.000 claims description 12
239000003795 chemical substances by application Substances 0.000 claims description 9
150000003839 salts Chemical class 0.000 claims description 7
AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 claims description 7
235000010443 alginic acid Nutrition 0.000 claims description 6
229920000615 alginic acid Polymers 0.000 claims description 6
239000004375 Dextrin Substances 0.000 claims description 5
229920001353 Dextrin Polymers 0.000 claims description 5
239000013543 active substance Substances 0.000 claims description 5
235000019425 dextrin Nutrition 0.000 claims description 5
230000009885 systemic effect Effects 0.000 claims description 5
229920000945 Amylopectin Polymers 0.000 claims description 4
UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 claims description 3
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical class O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 3
240000004507 Abelmoschus esculentus Species 0.000 claims description 3
241000512259 Ascophyllum nodosum Species 0.000 claims description 3
239000004343 Calcium peroxide Substances 0.000 claims description 3
229920001661 Chitosan Polymers 0.000 claims description 3
241000206575 Chondrus crispus Species 0.000 claims description 3
241001414597 Destria Species 0.000 claims description 3
KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 3
229920002148 Gellan gum Polymers 0.000 claims description 3
229920002907 Guar gum Polymers 0.000 claims description 3
229920000569 Gum karaya Polymers 0.000 claims description 3
244000090599 Plantago psyllium Species 0.000 claims description 3
235000010451 Plantago psyllium Nutrition 0.000 claims description 3
241001558929 Sclerotium <basidiomycota> Species 0.000 claims description 3
241000934878 Sterculia Species 0.000 claims description 3
240000004584 Tamarindus indica Species 0.000 claims description 3
235000004298 Tamarindus indica Nutrition 0.000 claims description 3
229920001615 Tragacanth Polymers 0.000 claims description 3
239000000783 alginic acid Substances 0.000 claims description 3
229960001126 alginic acid Drugs 0.000 claims description 3
150000004781 alginic acids Chemical class 0.000 claims description 3
AEMOLEFTQBMNLQ-BKBMJHBISA-N alpha-D-galacturonic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-BKBMJHBISA-N 0.000 claims description 3
239000000420 anogeissus latifolia wall. gum Substances 0.000 claims description 3
239000004599 antimicrobial Substances 0.000 claims description 3
239000000305 astragalus gummifer gum Substances 0.000 claims description 3
LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 claims description 3
235000019402 calcium peroxide Nutrition 0.000 claims description 3
229940078916 carbamide peroxide Drugs 0.000 claims description 3
150000002148 esters Chemical class 0.000 claims description 3
235000010492 gellan gum Nutrition 0.000 claims description 3
239000000216 gellan gum Substances 0.000 claims description 3
239000003193 general anesthetic agent Substances 0.000 claims description 3
235000010417 guar gum Nutrition 0.000 claims description 3
239000000665 guar gum Substances 0.000 claims description 3
229960002154 guar gum Drugs 0.000 claims description 3
235000019314 gum ghatti Nutrition 0.000 claims description 3
235000010494 karaya gum Nutrition 0.000 claims description 3
239000000231 karaya gum Substances 0.000 claims description 3
229940039371 karaya gum Drugs 0.000 claims description 3
235000013557 nattō Nutrition 0.000 claims description 3
235000010491 tara gum Nutrition 0.000 claims description 2
239000000213 tara gum Substances 0.000 claims description 2
239000007844 bleaching agent Substances 0.000 claims 1
239000011269 tar Substances 0.000 claims 1
229920003169 water-soluble polymer Polymers 0.000 claims 1
239000010410 layer Substances 0.000 description 59
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 27
230000002087 whitening effect Effects 0.000 description 25
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 21
238000002156 mixing Methods 0.000 description 19
239000000463 material Substances 0.000 description 18
235000019408 sucralose Nutrition 0.000 description 18
239000004615 ingredient Substances 0.000 description 16
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 16
229920000053 polysorbate 80 Polymers 0.000 description 16
239000000126 substance Substances 0.000 description 15
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 13
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 13
239000000796 flavoring agent Substances 0.000 description 13
235000019634 flavors Nutrition 0.000 description 13
235000011187 glycerol Nutrition 0.000 description 13
239000004376 Sucralose Substances 0.000 description 12
BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 12
229910000402 monopotassium phosphate Inorganic materials 0.000 description 11
235000019796 monopotassium phosphate Nutrition 0.000 description 11
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 11
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 10
229940068968 polysorbate 80 Drugs 0.000 description 10
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 8
229920001218 Pullulan Polymers 0.000 description 7
239000004373 Pullulan Substances 0.000 description 7
239000013256 coordination polymer Substances 0.000 description 7
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235000013855 polyvinylpyrrolidone Nutrition 0.000 description 7
229920000036 polyvinylpyrrolidone Polymers 0.000 description 7
235000019423 pullulan Nutrition 0.000 description 7
229920001800 Shellac Polymers 0.000 description 6
239000012790 adhesive layer Substances 0.000 description 6
150000001875 compounds Chemical class 0.000 description 6
239000003814 drug Substances 0.000 description 6
239000003995 emulsifying agent Substances 0.000 description 6
239000003925 fat Substances 0.000 description 6
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 6
239000003921 oil Substances 0.000 description 6
239000008213 purified water Substances 0.000 description 6
239000004208 shellac Substances 0.000 description 6
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 6
229940113147 shellac Drugs 0.000 description 6
235000013874 shellac Nutrition 0.000 description 6
238000003756 stirring Methods 0.000 description 6
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229940049294 glyceryl stearate se Drugs 0.000 description 5
210000000214 mouth Anatomy 0.000 description 5
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239000000047 product Substances 0.000 description 5
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
239000003054 catalyst Substances 0.000 description 4
XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical class [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 description 4
239000003002 pH adjusting agent Substances 0.000 description 4
239000000377 silicon dioxide Substances 0.000 description 4
210000001519 tissue Anatomy 0.000 description 4
229910019142 PO4 Inorganic materials 0.000 description 3
229920003082 Povidone K 90 Polymers 0.000 description 3
229920002472 Starch Polymers 0.000 description 3
239000000853 adhesive Substances 0.000 description 3
230000001070 adhesive effect Effects 0.000 description 3
QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical class OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
235000011180 diphosphates Nutrition 0.000 description 3
239000001257 hydrogen Substances 0.000 description 3
229910052739 hydrogen Inorganic materials 0.000 description 3
229910052751 metal Inorganic materials 0.000 description 3
239000002184 metal Substances 0.000 description 3
235000021317 phosphate Nutrition 0.000 description 3
150000003013 phosphoric acid derivatives Chemical class 0.000 description 3
239000007787 solid Substances 0.000 description 3
239000007921 spray Substances 0.000 description 3
239000008107 starch Substances 0.000 description 3
235000019698 starch Nutrition 0.000 description 3
YFVBASFBIJFBAI-UHFFFAOYSA-M 1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=CC=C1 YFVBASFBIJFBAI-UHFFFAOYSA-M 0.000 description 2
ANAAMBRRWOGKGU-UHFFFAOYSA-M 4-ethyl-1-tetradecylpyridin-1-ium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCC[N+]1=CC=C(CC)C=C1 ANAAMBRRWOGKGU-UHFFFAOYSA-M 0.000 description 2
GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 2
244000303965 Cyamopsis psoralioides Species 0.000 description 2
208000006558 Dental Calculus Diseases 0.000 description 2
240000000298 Elaeagnus multiflora Species 0.000 description 2
235000009245 Elaeagnus multiflora Nutrition 0.000 description 2
DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 2
208000004898 Herpes Labialis Diseases 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
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206010067152 Oral herpes Diseases 0.000 description 2
229920000388 Polyphosphate Polymers 0.000 description 2
INVGWHRKADIJHF-UHFFFAOYSA-N Sanguinarin Chemical compound C1=C2OCOC2=CC2=C3[N+](C)=CC4=C(OCO5)C5=CC=C4C3=CC=C21 INVGWHRKADIJHF-UHFFFAOYSA-N 0.000 description 2
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230000000844 anti-bacterial effect Effects 0.000 description 1
230000002272 anti-calculus Effects 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
230000002421 anti-septic effect Effects 0.000 description 1
208000002399 aphthous stomatitis Diseases 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
208000022362 bacterial infectious disease Diseases 0.000 description 1
229960000686 benzalkonium chloride Drugs 0.000 description 1
229960005274 benzocaine Drugs 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
229950005028 betoxycaine Drugs 0.000 description 1
CXYOBRKOFHQONJ-UHFFFAOYSA-N betoxycaine Chemical compound CCCCOC1=CC=C(C(=O)OCCOCCN(CC)CC)C=C1N CXYOBRKOFHQONJ-UHFFFAOYSA-N 0.000 description 1
238000004061 bleaching Methods 0.000 description 1
230000000740 bleeding effect Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
229960003150 bupivacaine Drugs 0.000 description 1
229960003369 butacaine Drugs 0.000 description 1
239000006227 byproduct Substances 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
235000010410 calcium alginate Nutrition 0.000 description 1
239000000648 calcium alginate Substances 0.000 description 1
229960002681 calcium alginate Drugs 0.000 description 1
OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
QXIKMJLSPJFYOI-UHFFFAOYSA-L calcium;dichlorite Chemical compound [Ca+2].[O-]Cl=O.[O-]Cl=O QXIKMJLSPJFYOI-UHFFFAOYSA-L 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
239000004075 cariostatic agent Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
239000012876 carrier material Substances 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
230000008859 change Effects 0.000 description 1
229960003260 chlorhexidine Drugs 0.000 description 1
235000019398 chlorine dioxide Nutrition 0.000 description 1
229910001919 chlorite Inorganic materials 0.000 description 1
229910052619 chlorite group Inorganic materials 0.000 description 1
IVHBBMHQKZBJEU-UHFFFAOYSA-N cinchocaine hydrochloride Chemical compound [Cl-].C1=CC=CC2=NC(OCCCC)=CC(C(=O)NCC[NH+](CC)CC)=C21 IVHBBMHQKZBJEU-UHFFFAOYSA-N 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
239000003086 colorant Substances 0.000 description 1
229920001577 copolymer Polymers 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
QSFOWAYMMZCQNF-UHFFFAOYSA-N delmopinol Chemical compound CCCC(CCC)CCCC1COCCN1CCO QSFOWAYMMZCQNF-UHFFFAOYSA-N 0.000 description 1
229960003854 delmopinol Drugs 0.000 description 1
201000002170 dentin sensitivity Diseases 0.000 description 1
238000000151 deposition Methods 0.000 description 1
229940045574 dibucaine hydrochloride Drugs 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000007598 dipping method Methods 0.000 description 1
235000019820 disodium diphosphate Nutrition 0.000 description 1
GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
TVQLLNFANZSCGY-UHFFFAOYSA-N disodium;dioxido(oxo)tin Chemical compound [Na+].[Na+].[O-][Sn]([O-])=O TVQLLNFANZSCGY-UHFFFAOYSA-N 0.000 description 1
229960001859 domiphen bromide Drugs 0.000 description 1
238000001035 drying Methods 0.000 description 1
229960000385 dyclonine Drugs 0.000 description 1
BZEWSEKUUPWQDQ-UHFFFAOYSA-N dyclonine Chemical compound C1=CC(OCCCC)=CC=C1C(=O)CCN1CCCCC1 BZEWSEKUUPWQDQ-UHFFFAOYSA-N 0.000 description 1
230000008030 elimination Effects 0.000 description 1
238000003379 elimination reaction Methods 0.000 description 1
238000004049 embossing Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000006260 foam Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
230000036541 health Effects 0.000 description 1
230000002439 hemostatic effect Effects 0.000 description 1
229940005740 hexametaphosphate Drugs 0.000 description 1
229960004867 hexetidine Drugs 0.000 description 1
238000009474 hot melt extrusion Methods 0.000 description 1
239000003906 humectant Substances 0.000 description 1
125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
229940054190 hydroxypropyl chitosan Drugs 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
238000007641 inkjet printing Methods 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
229960004194 lidocaine Drugs 0.000 description 1
KAGBQTDQNWOCND-UHFFFAOYSA-M lithium;chlorite Chemical compound [Li+].[O-]Cl=O KAGBQTDQNWOCND-UHFFFAOYSA-M 0.000 description 1
NWAPVVCSZCCZCU-UHFFFAOYSA-L magnesium;dichlorite Chemical compound [Mg+2].[O-]Cl=O.[O-]Cl=O NWAPVVCSZCCZCU-UHFFFAOYSA-L 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
INWLQCZOYSRPNW-UHFFFAOYSA-N mepivacaine Chemical compound CN1CCCCC1C(=O)NC1=C(C)C=CC=C1C INWLQCZOYSRPNW-UHFFFAOYSA-N 0.000 description 1
229960002409 mepivacaine Drugs 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
ZPUCINDJVBIVPJ-XGUBFFRZSA-N methyl (1s,3s,4s,5r)-3-benzoyloxy-8-methyl-8-azabicyclo[3.2.1]octane-4-carboxylate Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-XGUBFFRZSA-N 0.000 description 1
XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000003232 mucoadhesive effect Effects 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
229920001206 natural gum Polymers 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
229960003512 nicotinic acid Drugs 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
229950002404 octapinol Drugs 0.000 description 1
229960001774 octenidine Drugs 0.000 description 1
SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical compound Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 1
230000001706 oxygenating effect Effects 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
239000001814 pectin Substances 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
150000004965 peroxy acids Chemical class 0.000 description 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002643 polyglutamic acid Polymers 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
239000011591 potassium Substances 0.000 description 1
USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
VISKNDGJUCDNMS-UHFFFAOYSA-M potassium;chlorite Chemical compound [K+].[O-]Cl=O VISKNDGJUCDNMS-UHFFFAOYSA-M 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000003825 pressing Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
229960004919 procaine Drugs 0.000 description 1
MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
KCXFHTAICRTXLI-UHFFFAOYSA-N propane-1-sulfonic acid Chemical compound CCCS(O)(=O)=O KCXFHTAICRTXLI-UHFFFAOYSA-N 0.000 description 1
229960004948 propanidid Drugs 0.000 description 1
KEJXLQUPYHWCNM-UHFFFAOYSA-N propanidid Chemical compound CCCOC(=O)CC1=CC=C(OCC(=O)N(CC)CC)C(OC)=C1 KEJXLQUPYHWCNM-UHFFFAOYSA-N 0.000 description 1
229950008865 propanocaine Drugs 0.000 description 1
229960003981 proparacaine Drugs 0.000 description 1
STHAHFPLLHRRRO-UHFFFAOYSA-N propipocaine Chemical compound C1=CC(OCCC)=CC=C1C(=O)CCN1CCCCC1 STHAHFPLLHRRRO-UHFFFAOYSA-N 0.000 description 1
229950011219 propipocaine Drugs 0.000 description 1
229960004134 propofol Drugs 0.000 description 1
OLBCVFGFOZPWHH-UHFFFAOYSA-N propofol Chemical compound CC(C)C1=CC=CC(C(C)C)=C1O OLBCVFGFOZPWHH-UHFFFAOYSA-N 0.000 description 1
229950003255 propoxycaine Drugs 0.000 description 1
238000005096 rolling process Methods 0.000 description 1
229940084560 sanguinarine Drugs 0.000 description 1
YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229960001922 sodium perborate Drugs 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
229940079864 sodium stannate Drugs 0.000 description 1
YKLJGMBLPUQQOI-UHFFFAOYSA-M sodium;oxidooxy(oxo)borane Chemical compound [Na+].[O-]OB=O YKLJGMBLPUQQOI-UHFFFAOYSA-M 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000005507 spraying Methods 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
238000005728 strengthening Methods 0.000 description 1
229960002494 tetracaine hydrochloride Drugs 0.000 description 1
RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
MSLRPWGRFCKNIZ-UHFFFAOYSA-J tetrasodium;hydrogen peroxide;dicarbonate Chemical compound [Na+].[Na+].[Na+].[Na+].OO.OO.OO.[O-]C([O-])=O.[O-]C([O-])=O MSLRPWGRFCKNIZ-UHFFFAOYSA-J 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000036347 tooth sensitivity Effects 0.000 description 1
208000004371 toothache Diseases 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-I triphosphate(5-) Chemical compound [O-]P([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O UNXRWKVEANCORM-UHFFFAOYSA-I 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
VBIJGJLWKWLWHQ-UHFFFAOYSA-K trisodium;oxido phosphate Chemical compound [Na+].[Na+].[Na+].[O-]OP([O-])([O-])=O VBIJGJLWKWLWHQ-UHFFFAOYSA-K 0.000 description 1
WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
230000009385 viral infection Effects 0.000 description 1
230000029663 wound healing Effects 0.000 description 1
HLDCSYXMVXILQC-UHFFFAOYSA-N xenysalate Chemical compound CCN(CC)CCOC(=O)C1=CC=CC(C=2C=CC=CC=2)=C1O HLDCSYXMVXILQC-UHFFFAOYSA-N 0.000 description 1
229960003434 xenysalate Drugs 0.000 description 1
239000011746 zinc citrate Substances 0.000 description 1
229940068475 zinc citrate Drugs 0.000 description 1
235000006076 zinc citrate Nutrition 0.000 description 1
229940085658 zinc citrate trihydrate Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/732—Starch; Amylose; Amylopectin; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Birds (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Inorganic Chemistry (AREA)
Rheumatology (AREA)
Oral & Maxillofacial Surgery (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Medicinal Preparation (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

CA002557959A 2004-03-03 2005-02-21 Compositions de peroxyde stabilisees Abandoned CA2557959A1 (fr)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US10/792,370 US20050196348A1 (en)	2004-03-03	2004-03-03	Stabilized peroxide compositions
US10/792,370		2004-03-03
US11/030,845 US20050196350A1 (en)	2004-03-03	2005-01-07	Stabilized peroxide compositions
US11/030,845		2005-01-07
PCT/IB2005/000450 WO2005092278A1 (fr)	2004-03-03	2005-02-21	Compositions de peroxyde stabilisees

Publications (1)

Publication Number	Publication Date
CA2557959A1 true CA2557959A1 (fr)	2005-10-06

Family

ID=34960713

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA002557959A Abandoned CA2557959A1 (fr)	2004-03-03	2005-02-21	Compositions de peroxyde stabilisees

Country Status (10)

Country	Link
EP (1)	EP1732507A1 (fr)
JP (1)	JP2007526295A (fr)
KR (1)	KR20060120270A (fr)
AR (1)	AR047828A1 (fr)
AU (1)	AU2005225220A1 (fr)
BR (1)	BRPI0508279A (fr)
CA (1)	CA2557959A1 (fr)
NO (1)	NO20063533L (fr)
RU (1)	RU2006131558A (fr)
WO (1)	WO2005092278A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA2710583C (fr) *	2008-02-08	2015-10-06	Colgate-Palmolive Company	Compositions et dispositifs
SI25540A (sl) *	2019-01-14	2019-05-31	Tompa Majcen Dominika	Formulacije s spojinami aktivnega kisika in pripomočki za njihovo aplikacijo

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0256611A1 (fr) *	1986-08-08	1988-02-24	Squibb Japan Inc.	Systèmes d'apport de médicaments oraux
US5718886A (en) *	1996-03-11	1998-02-17	Laclede Professional Products, Inc.	Stabilized anhydrous tooth whitening gel
ATE368428T1 (de) *	1997-06-06	2007-08-15	Procter & Gamble	Vorrichtung zur verabreichung von zahnbleicher unter verwendung eines streifens mit geringer biegesteifigkeit
US6596298B2 (en) *	1998-09-25	2003-07-22	Warner-Lambert Company	Fast dissolving orally comsumable films
US6696043B2 (en) *	2000-09-20	2004-02-24	Scientific Pharmaceuticals, Inc.	Teeth whitening composition in the form of a chewing gum
ATE392863T1 (de) *	2001-08-17	2008-05-15	Smithkline Beecham Plc	Streifen zur abgabe eines mundpflegewirkstoffes

2005
- 2005-02-21 EP EP05708574A patent/EP1732507A1/fr not_active Withdrawn
- 2005-02-21 CA CA002557959A patent/CA2557959A1/fr not_active Abandoned
- 2005-02-21 AU AU2005225220A patent/AU2005225220A1/en not_active Abandoned
- 2005-02-21 BR BRPI0508279-0A patent/BRPI0508279A/pt not_active IP Right Cessation
- 2005-02-21 JP JP2007501365A patent/JP2007526295A/ja not_active Withdrawn
- 2005-02-21 WO PCT/IB2005/000450 patent/WO2005092278A1/fr not_active Ceased
- 2005-02-21 RU RU2006131558/15A patent/RU2006131558A/ru not_active Application Discontinuation
- 2005-02-21 KR KR1020067017887A patent/KR20060120270A/ko not_active Ceased
- 2005-03-02 AR ARP050100786A patent/AR047828A1/es not_active Application Discontinuation
2006
- 2006-08-02 NO NO20063533A patent/NO20063533L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
WO2005092278A1 (fr)	2005-10-06
JP2007526295A (ja)	2007-09-13
AR047828A1 (es)	2006-02-22
NO20063533L (no)	2006-08-30
BRPI0508279A (pt)	2007-12-18
WO2005092278A8 (fr)	2006-11-02
AU2005225220A1 (en)	2005-10-06
EP1732507A1 (fr)	2006-12-20
KR20060120270A (ko)	2006-11-24
RU2006131558A (ru)	2008-03-10

Publication	Publication Date	Title
US20050196350A1 (en)	2005-09-08	Stabilized peroxide compositions
JP3995274B2 (ja)	2007-10-24	低曲げ剛性を有する材料片を使用した口腔ケア物質供給システム
EP1691893B2 (fr)	2018-03-21	Systeme hydrophobe de blanchiment des dents et procedes d'utilisation associes
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